Objective This study aimed to compare the clinical effects of double ovulation stimulation(DouStim)applied during the follicular and luteal phases with the antagonist protocol in patients with diminished ovarian reser...Objective This study aimed to compare the clinical effects of double ovulation stimulation(DouStim)applied during the follicular and luteal phases with the antagonist protocol in patients with diminished ovarian reserve(DOR)and asynchronous follicular development undergoing assisted reproductive technology(ART).Methods The clinical data of patients with DOR and asynchronous follicular development receiving ART from January 2020 to December 2021 were retrospectively analyzed.The patients were divided into two groups according to their ovulation stimulation protocol:DouStim group(n=30)and antagonist group(n=62).Assisted reproduction and clinical pregnancy outcomes were compared between the two groups.Results In the DouStim group,the number of oocytes retrieved,metaphase II(MII)oocytes,two-pronuclei(2PN),day 3(D3)embryos,D3 high-quality embryos as well as blastocyst formation,implantation,and human chorionic gonadotropin-positive rates were significantly greater than those in the antagonist group(all P<0.05).No significant differences were found in MII,fertilization,or continued pregnancy rates at the first frozen embryo transfer(FET),in-vitro fertilization(IVF)cancellation,or early medical abortion rates between the groups(all P>0.05).Except for the early medical abortion rate,the DouStim group generally had favorable outcomes.In the DouStim group,the dosage and duration of gonadotropin and the fertilization rate were significantly greater in the first ovulation stimulation induction than in the second ovulation stimulation induction(P<0.05).Conclusion The DouStim protocol efficiently and economically obtained more mature oocytes and high-quality embryos for patients with DOR and asynchronous follicular development.展开更多
[ Objective] To explore the effects of FSH （ Follicle-stimulating hormone）, seasons and treatment frequency on super-ovulation in donor goats and to provide necessary data for research about embryo transfer and embr...[ Objective] To explore the effects of FSH （ Follicle-stimulating hormone）, seasons and treatment frequency on super-ovulation in donor goats and to provide necessary data for research about embryo transfer and embryo biotechnology in Yangzhou area. [ Method] Two FSH dosages （240 and 300 I U）, two seasons （April- June and October- December）, and two treatment frequencies （one or two times） were used to induce super-ovulation in goats. [ Result] Both average ovulation point and number of transferable embryos were significantly different between the goats given 240 IU FSH and those given 300 lU FSH （average ovulation point, 10.12 vs 15.55; number of transferable embryos, 8.82 vs 13.15） at the 0.05 level. Both average ovulation point and number of transferable embryos were also significantly different between April -June and October- December （ average ovulation point, 9.05 vs 15.55; number of transferable embryos, 7.05 vs 13.15） at the 0.05 level. Super-ovulation effect was not significantly different between the two treatment frequencies. [ Conduslonl The FSH dosages and seasons have significant impact on super-ovu- lation, but repeat super-ovulation does not have the same impact.展开更多
Malignancy is a serious disease that can lead to serious morbidity and mortality. However, the survival rates for women with cancers have increased significantly during the past decades, reflecting improved diagnosis ...Malignancy is a serious disease that can lead to serious morbidity and mortality. However, the survival rates for women with cancers have increased significantly during the past decades, reflecting improved diagnosis and treatment. With the increased survival in young women with cancer, more attention is being paid to preservation of fertility, which is potentially jeopardized by chemotherapy and radiation therapy, aiming to limit the devastating sequelae of this serious illness by providing these young women with a hope for motherhood. In vitro fertilization with oocyte or embryo cryopreservation has emerged as an astounding method to preserve fertility. It entails induction of ovulation to produce oocytes, the number and quality of which are imperative factors predicting the potential efficacy of the fertility preservation procedure. The aim of this review is to discuss ovarian stimulation for fertility preservation in women with gynecological cancer.展开更多
基金supported by a Chinese Military family planning project grant(No.17JS014).
文摘Objective This study aimed to compare the clinical effects of double ovulation stimulation(DouStim)applied during the follicular and luteal phases with the antagonist protocol in patients with diminished ovarian reserve(DOR)and asynchronous follicular development undergoing assisted reproductive technology(ART).Methods The clinical data of patients with DOR and asynchronous follicular development receiving ART from January 2020 to December 2021 were retrospectively analyzed.The patients were divided into two groups according to their ovulation stimulation protocol:DouStim group(n=30)and antagonist group(n=62).Assisted reproduction and clinical pregnancy outcomes were compared between the two groups.Results In the DouStim group,the number of oocytes retrieved,metaphase II(MII)oocytes,two-pronuclei(2PN),day 3(D3)embryos,D3 high-quality embryos as well as blastocyst formation,implantation,and human chorionic gonadotropin-positive rates were significantly greater than those in the antagonist group(all P<0.05).No significant differences were found in MII,fertilization,or continued pregnancy rates at the first frozen embryo transfer(FET),in-vitro fertilization(IVF)cancellation,or early medical abortion rates between the groups(all P>0.05).Except for the early medical abortion rate,the DouStim group generally had favorable outcomes.In the DouStim group,the dosage and duration of gonadotropin and the fertilization rate were significantly greater in the first ovulation stimulation induction than in the second ovulation stimulation induction(P<0.05).Conclusion The DouStim protocol efficiently and economically obtained more mature oocytes and high-quality embryos for patients with DOR and asynchronous follicular development.
基金funded by the National Major Special Program of Breeding of Transgenetic Organisms New Variety(2009ZX08008-009B 2011ZX08008-004)Key Technology R&D Program of Jiangsu Provinve ( BZ2009328)
文摘[ Objective] To explore the effects of FSH （ Follicle-stimulating hormone）, seasons and treatment frequency on super-ovulation in donor goats and to provide necessary data for research about embryo transfer and embryo biotechnology in Yangzhou area. [ Method] Two FSH dosages （240 and 300 I U）, two seasons （April- June and October- December）, and two treatment frequencies （one or two times） were used to induce super-ovulation in goats. [ Result] Both average ovulation point and number of transferable embryos were significantly different between the goats given 240 IU FSH and those given 300 lU FSH （average ovulation point, 10.12 vs 15.55; number of transferable embryos, 8.82 vs 13.15） at the 0.05 level. Both average ovulation point and number of transferable embryos were also significantly different between April -June and October- December （ average ovulation point, 9.05 vs 15.55; number of transferable embryos, 7.05 vs 13.15） at the 0.05 level. Super-ovulation effect was not significantly different between the two treatment frequencies. [ Conduslonl The FSH dosages and seasons have significant impact on super-ovu- lation, but repeat super-ovulation does not have the same impact.
文摘Malignancy is a serious disease that can lead to serious morbidity and mortality. However, the survival rates for women with cancers have increased significantly during the past decades, reflecting improved diagnosis and treatment. With the increased survival in young women with cancer, more attention is being paid to preservation of fertility, which is potentially jeopardized by chemotherapy and radiation therapy, aiming to limit the devastating sequelae of this serious illness by providing these young women with a hope for motherhood. In vitro fertilization with oocyte or embryo cryopreservation has emerged as an astounding method to preserve fertility. It entails induction of ovulation to produce oocytes, the number and quality of which are imperative factors predicting the potential efficacy of the fertility preservation procedure. The aim of this review is to discuss ovarian stimulation for fertility preservation in women with gynecological cancer.
