CXCL16 participates in pathogenesis of immunological liver injury by regulating T lymphocyte infiltration in liver tissue

AIM： To investigate the role of CXCL16 in the pathogenesis of immunological liver injury and to explore the possible mechanism ofT lymphocyte infiltration regulated by CXCL16. METHODS： Immunological liver injury in murine model was induced by Bacille Calmette-Guerin and lipopolysaccharide. Expression pattern and distribution of CXCL16 were examined by real-time quantitative RT-PCR and immunohistochemical analysis. Anti-CXCL16 antibody was administrated in vivo to investigate its effect on T-cell recruitment and acute hepatic necrosis. The survival of murine model was also evaluated. RESULTS, The murine immunological liver injury model was successfully established, CXCL16 expression increased and predominantly distributed in periportal areas and vascular endothelia in injured liver tissues. Administration of anti-CXCL16 Ab protected the mice from death and acute liver damage. Approximately 70% of the mice survived for 72 h in the anti-CXCL16 Ab treatment group, whereas 80% died within 72 h in control Ab group. The number of liver-infiltrating T lymphocytes was significantly reduced from 1.01×10^7 to 3.52×10^6/liver, compared with control Ab treatment. CONCLUSION： CXCL16 is involved in immunological liver injury by regulating T lymphocyte infiltration in liver tissue.

Immunological disturbance effect of exogenous histamine towards key immune cells

Histamine in food has attracted widespread attention due to the potential toxicity and associated health risk.However,its influences on immunological components,especially the function of key immune cells,are still poorly known.In this work,we explored the effects of exogenous histamine on the function of key immune cells such as intestinal epithelial cells,dendritic cells,and T cells.The results showed that histamine could affect the expression of allergy-related genes in CMT93 cells at a high dose of histamine.Moreover,it’s found that histamine could cause an imbalance in the levels of relevant immune factors secreted by dendritic cells and T cells,especially those related to allergy.At the same time,the proportion of MHC class IIpositive dendritic cells and the proportion of T helper 2(Th2)cells in CD4^(+)T cells increased after histamine stimulation.We concluded that the presence of a certain level of histamine in food may affect the expression of allergy-related cytokines,disrupt the balance of the immune homeostasis,and potentially lead to adverse immune reactions.This work demonstrated the importance of including the estimation of histamine’s immune safety in aquatic products rather than merely considering the potential risk of food poisoning.

Obstructive sleep apnea-hypopnea syndrome immunological relationship

Obstructive sleep apnea-hypopnea syndrome(OSAHS)is a complex disorder cha-racterized by symptoms resulting from intermittent hypoxia and hypopnea,with research indicating a crucial role of immune system dysregulation and genetic variations in its pathogenesis.A recent Zhao et al study utilizes Mendelian ran-domization analysis to explore the causal relationship between immune cell characteristics and OSAHS.The study identifies specific lymphocyte subsets as-sociated with OSAHS,providing valuable insights into the disease's pathophy-siology and potential targets for therapeutic intervention.The findings underscore the significance of genetic and immunological factors in sleep disorders,offering a fresh perspective on OSAHS's complexities.Compared to existing literature,Zhao et al's study stands out for its focus on genetic markers and specific immune responses associated with OSAHS,expanding upon previous research primarily centered on systemic inflammation.In conclusion,the study represents a signi-ficant advancement in the field,shedding light on the causal role of immune cells in OSAHS and paving the way for future research and targeted treatments.

Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma

AIM: To investigate the role of tumor inf iltrating lym-phocytes (TIL) in primary hepatocellular and cholangio-lar carcinomas of the liver.METHODS: Immunohistochemical analysis was per-formed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-f ixed and paraff in-embed-ded tissue of 35 liver resection specimens of hepatocel-lular or cholangiocellular carcinomas. Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver interface.RESULTS: All hepatocellular carcinomas showed in-filtration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power f ields (HPF)] and in the tumor itself of CD8+ cells (54.9/10 HPF). Cholangiocarcinomas contained a heterogeneous amount of TIL, composed mainly of CD3+ T cells with a predominance of CD8+ cells in the tumor tissue (52.6/10 HPF) and of CD4+ cells in the interface region (223.1/10 HPF). CD56+ cells of the innate immune system were scarce. There was no significant difference between hepatocellular or cholangiolar carcinoma. No correlation with the clinicopathological data was seen. CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells indepen-dent of histogenetic origin. Different functions of lym-phocytes in these regions seem possible.

Peripheral blood lymphocytes DNA in patients with chronic liver diseases

BACKGROUND: Viral replication in blood cells with nucleases may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions. AIM: Of this investigation is to reveal the damage to peripheral blood lymphocytes (PBL) DNA in the patients with chronic liver diseases. MATERIALS AND METHODS: Sixteen-nine patients with chronic liver diseases (37 patients with chronic viral hepatitis, 2 patients with liver cirrhosis of mixed etiology (alcohol+virus G), 30 women with primary biliary cirrhosis-PBC) were examined. The condition of DNA structure of PBL was measured by the fluorescence analysis of DNA unwinding (FADU) technique with modification. Changes of fluorescence (in %) reflected the DNA distractions degree (the presence of DNA single-stranded breaks and alkalinelabile sights). RESULTS AND CONCLUSION: The quantity of DNA single-stranded breaks and alkalinelabile sights in DNA in all patients with chronic viral hepatitis didn't differ from the control group, excluding the patients with chronic hepatitis (CH) C+G. Patients with HGV and TTV monoinfection had demonstrated the increase of the DNA single-stranded breaks PBL quantity. This fact may be connected with hypothesis about the viruses replication in white blood cells discussed in the literature. Tendency to increase quantity of DNA PBL damages in the patients with primary biliary cirrhosis (PBC) accordingly to the alkaline phosphatase activity increase was revealed. Significant decrease of the DNA single-stranded breaks and alkalinelabile sights in the PBC patients that were treated with prednisone was demonstrated. Probably, the tendency to increase the quantity of DNA single stranded breaks and alkalinelabile sights in lymphocytes of the PBC patients was depended on the surplus of the blood bile acid content.

Suppressive effects of antigens on the activity of specific activated lymphocytes : A test to define the specificity of activated lymphocytes

Objective：With the regular mixed lymphocytes culture （MLC） to detect the allograft rejection, the reactivity of the activated lymphocytes （primed lymphocytes） of a recipient shows sometimes increase and sometimes decrease against the antigens from the donor, which is inconsistent with the clinical results. In order to establish a convenient method for testing the specificity of the activated lymphocytes in vitro, so as to know the rejection occurred or not by testing the existence of the specific activated lymphocytes against donor＇s HLA antigens in the recipient＇s peripheral blood. Methods： Anti-IL-2 neutralizing monoclonal antibody （anti-IL-2 N-mAb） and immunosuppressors were introduced in this test system in the presence of specific stimulators and activated lymphocytes. Results ： When the activated lymphocytes were chosen from the one-way MLC 4 d to undergo re-stimulation by specific stimulators, the activity of activated lymphocytes in the treatment group was suppressed significantly compared with that in the control group. The result of this test method is consistent with the biopsy in the clinical diagnosis of rejection. Conclusion：h suggests that the activated lymphocytes can be inactivated by specific antigens in certain conditions. This can be a useful tool to define the specificity of the activated lymphocytes.

T淋巴细胞、炎症细胞因子与卵巢子宫内膜异位症的相关性及诊断价值

目的探讨外周血中T淋巴细胞、炎症细胞因子与卵巢子宫内膜异位症(OMs)的相关性及诊断价值。方法选取2020年10月—2022年6月我院收治行开腹或腹腔镜手术经病理确诊OMs患者72例为观察组,根据修正子宫内膜异位症分期(r-AFS)分为I~II期37例,III~IV期35例,另选取同期术后诊断为单纯性卵巢囊肿或良性畸胎瘤的患者72例为对照组。利用流式细胞检测法检测外周血中T淋巴细胞(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、炎症细胞因子(IL-2、IL-4、IL-6、IL-10、IL-17A、IFN-γ和TNF-α含量),收集相关临床资料进行单因素及Logistic多因素回归分析讨论OMs影响因素,I~II、III~IV期EMs患者中比较外周血独立影响指标CD4^(+)、TNF-α表达差异。ROC曲线评估CD4^(+)、CD8^(+)和TNF-α3项指标单独及联合对OMs的诊断效能。结果CD8^(+)、IL-2、IL6、IL-10、TNF-α、月经初潮年龄<13岁,经期天数>6天、痛经、人流手术或宫腔操作史和剖宫产史为OMs危险因素,CD4^(+)及CD4^(+)/CD8^(+)为OMs保护因素;CD8^(+)、TNF-α、经期天数>6天、痛经和人流手术或宫腔操作史为OMs独立危险因素,CD4^(+)为OMs独立保护因素;I~II、III~IV期OMs CD4^(+)、CD8^(+)和TNF-α差异有统计学意义(P<0.05);CD4^(+)、CD8^(+)与TNF-α联合检测可提高OMs诊断效能。结论外周血T淋巴细胞亚群、炎症细胞因子在OMs发生中发挥着一定作用,CD4^(+)、CD8^(+)和TNF-α参与疾病进展且3者联合检测在OMs诊断方面可能具有较高应用价值。

慢性免疫性血小板减少症患者BLyS及其受体BAFF-R与血清免疫学指标的相关性

目的探讨慢性免疫性血小板减少症(ITP)患者B淋巴细胞刺激因子(BLyS)及其受体B淋巴细胞刺激因子受体(BAFF-R)与血清免疫学指标的相关性。方法纳入内蒙古医科大学附属医院血液科2020年1月-2022年1月住院的ITP患者50例行回顾性分析,将其设为观察组,另选取同期本院体检中心接诊的50例健康体检者,将其设为对照组。检测并比较两组血清BLyS、BAFF-R、免疫学指标。将观察组患者按疾病严重程度分为轻度组(11例)、中度组(29例)、重度组(10例),比较不同严重程度组血清BLyS、BAFF-R、免疫学指标;ITP患者均给予地塞米松、丙种球蛋白、泼尼松等对症治疗,比较预后不良组、预后良好组血清BLyS、BAFF-R、免疫学指标,Pearson分析BLyS、BAFF-R与免疫学指标的相关性,绘制受试者工作曲线(ROC),计算曲线下面积(AUC),分析BLyS、BAFF-R、免疫学指标对ITP患者预后不良的预测效能。结果观察组血清BLyS、BAFF-R、外周血IgG、IgA、IgM均高于对照组(P<0.05)。重度组血清BLyS、BAFF-R、外周血IgG、IgA、IgM均高于中度组、轻度组(P<0.05)。预后不良组血清BLyS、BAFF-R、外周血IgG、IgA、IgM均高于预后良好组(P<0.05)。BLyS、BAFF-R与IgG、IgA、IgM均呈正相关性(P<0.05)(r值=4.034、3.986、4.134、3.964、4.006、4.086)。BLyS、BAFF-R、IgG、IgA、IgM联合检测预测ITP预后不良的AUC是0.801(95%CI:0.734~0.959),灵敏度、特异度分别是93.62%、90.24%,均高于单独检测(P<0.05)。结论ITP患者BLyS及其受体BAFF-R表达量随着疾病的加重会逐渐增高,与血清免疫学指标IgG、IgA、IgM均呈正相关性,联合检测可提高对预后不良的预测灵敏度及特异度,具有一定的参考价值。

银翘散联合磷酸奥司他韦治疗甲型流感的临床效果及对淋巴细胞亚群的影响

目的分析甲型流感采用银翘散联合磷酸奥司他韦治疗的临床效果及治疗对淋巴细胞亚群的影响。方法将河南省汝州市第一人民医院2022年5月至2023年2月收治的98例甲型流感患儿按治疗方法分为对照组(49例)与试验组(49例),对照组行磷酸奥司他韦治疗,试验组行磷酸奥司他韦联合银翘散治疗,治疗周期为5 d。比较2组临床症状改善时间(病毒转阴时间、体温恢复时间、乏力缓解时间、咽痛消失时间)和不良反应,比较治疗前及治疗后3、5 d肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)、白细胞介素-8(IL-8)水平以及治疗前及治疗5 d后咳嗽,头痛,乏力评分,CD4^(+)、CD8^(+)百分比,CD4^(+)/CD8^(+)比值。结果相较于对照组,试验组的病毒转阴时间、体温恢复时间、乏力缓解时间、咽痛消失时间均缩短(P<0.05);治疗后3、5 d 2组TNF-α、IL-6、CRP、IL-8水平与治疗前比较降低,试验组与对照组比较更低;治疗5 d后2组咳嗽、头痛、乏力评分及CD8^(+)百分比与治疗前比较降低,试验组与对照组比较更低,CD4^(+)百分比、CD4^(+)/CD8^(+)比值与治疗前比较升高,试验组与对照组比较更高(P<0.05)。治疗期间,对照组出现头晕、腹泻、皮疹、恶心呕吐各1例,试验组出现头晕、皮疹各1例,腹泻、恶心呕吐各2例,2组不良反应总发生率(8%与12%)比较差异无统计学意义(χ^(2)=0.445,P>0.05)。结论甲型流感采用银翘散联合磷酸奥司他韦治疗可缩短临床症状改善时间,减轻炎症反应,改善患儿临床症状,同时提高患儿免疫能力,促进患儿康复,且安全、可靠。

不同年龄儿童肺炎支原体所致大叶性肺炎的临床特征及免疫学指标分析

目的:分析不同年龄儿童肺炎支原体所致大叶性肺炎的临床特征及免疫学指标。方法:选取2020年2月—2023年4月中山市横栏医院收治的肺炎支原体所致大叶性肺炎患儿500例作为研究对象,按照年龄划分为≤3岁组(223例)和>3岁组(277例)。比较两组临床特征、体液免疫指标、淋巴细胞免疫指标。结果:>3岁组心肌损害比例及喘鸣音、呼吸困难、咳痰、喘息发生率低于≤3岁组,热程长于≤3岁组,消散后期的阿奇霉素疗程、病程短于≤3岁组,差异有统计学意义(P<0.05)。>3岁组免疫球蛋白A、免疫球蛋白G、免疫球蛋白M水平均高于≤3岁组,差异有统计学意义(P<0.001)。>3岁组CD8^(+)、CD3^(+)水平高于≤3岁组,CD19^(+)水平低于≤3岁组,差异有统计学意义(P<0.001);两组CD4^(+)、CD4^(+)/CD8^(+)水平比较,差异无统计学意义(P>0.05)。结论:不同年龄肺炎支原体所致大叶性肺炎患儿的适应性免疫功能、临床表现存在差异,且年龄≤3岁婴幼儿患病后更易出现呼吸困难、咳痰等症状。

Biological Effects of Cloth Containing Specific Ore Powder in Patients with Pollen Allergy

Objective The custom-homebuilding company, Cosmic Garden Co. Ltd., located in Okayama City, Japan was established in 1997 and uses specific natural ore powder （SNOP） in wall materials and surveys customers in order to improve allergic symptoms. Methods To investigate the biological effects of SNOP, patients with a pollen allergy were recruited to stay in a room surrounded by cloth containing SNOP （CCSNOP）, and their symptoms and various biological parameters were compared with those of individuals staying in a room surrounded by control non-woven cloth （NWC）. Each stay lasted 60 min. Before and immediately after the stay, a questionnaire regarding allergic symptoms, as well as POMS （Profile of Mood Status） and blood sampling, was performed. Post-stay minus pre-stay values were calculated and compared between CCSNOP and NWC groups. Results Results indicated that some symptoms, such as nasal obstruction and lacrimation, improved, and POMS evaluation showed that patients were calmer following a stay in CCSNOP. Relative eosinophils, non-specific Ig E, epidermal growth factor, monocyte chemotactic protein-I, and tumor necrosis factor-a increased following a stay in CCSNOP. Conclusion This ore powder improved allergic symptoms, and long-term monitoring involving 1 to 2 months may be necessary to fully explore the biological and physical effects of SNOP on allergic patients.

Immunological Manifestations in Paraphenylene Diamine Poisoning

Objective: Our aim is to establish the immunologic profile of PPD-intoxicated persons based on monitoring of the inflammatory reaction. Methods and patients: A prospective study of 21 patients hospitalized in a medical ICU with PPD intoxication during 2010. A follow-up of demographic, clinical, paraclinical, therapeutic and evolutive parameters as well as evaluation of the scores of gravity (SAPS II, APACHE II, OSF) was carried out in all our patients, and an inflammatory check-up (white blood cell, Creactive protein, C3 and C4 fractions of complement and lymphocyte subpopulations CD3, CD4, CD8 and CD19) was realized for all patients. The kinetic of these parameters was compared with clinical and paraclinical evolution. Results: The monitoring of the inflammatory reaction in our patients shows an evolution at three times for this reaction, with the first time of inflammatory stress during the first 3 days after the intoxication characterized by a relative immunodepression, the second time from the third day when the rhabdomyolysis exerts its pro-inflammatory power and the third time (from the sixth day) corresponds to the immunomodulative action of PPD and to its oxidative metabolism. It’s a systemic and specific inflammatory reaction to a cytotoxic cell support, which would explain the secondary worsening of the clinical and paraclinical parameters of our patients (hemodynamic shock, multivisceral failure, etc.). Conclusion: It seems that the immunological aspect may present the answer to several questions that rhabdomyolysis alone could not answer during PPD-poisoning. This study tried to establish a first immunologic profile of PPD-intoxicated persons, and to correlate it with their evolution.

Significance of Immunoglobulin E in Umbilical Blood in Relation to an Allergic Family History, Seasonality, Child Immunity and the Impact of Applied Non-pathogenic E. coli on Children＇s Microbiome

We examined IgE levels in 4,312 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 1998-2015. At the age often days, those with high IgE were given Colinfant Newborn （a lyophilized non-pathogenic strain of E. coli） for one month, three times weekly. At 15 months and three years we investigated the levels of IgE, IgA and IgG, and the incidence of illness and allergy. The results revealed that allergy and high umbilical IgE is strongly linked with family history （p 〈 0.001）. We also detected differences in seasonality, especially with regards to pollen allergies. About 80% of children treated with Colinfant had significantly reduced IgE and morbidity at 13-15 months and 3 years, and furthermore without any clinical signs of allergy. Surprisingly 20% of treated children did not have reduced IgE, and yet they did not have any clinical signs of allergy. Normalization of IgA and IgG was seen in 90% of treated subjects （p 〈 0.001）. These levels significantly are correlated with an almost negligible morbidity up to 4 years of life. Our study strongly suggests a positive effect of physiological E. coli on the microbiome of children as evidenced by a significantly reduced incidence of allergy and morbidity when applied early in life.

Effect of DC-CIK in combined with chemotherapy on the immunological function in patients with advanced non-small cell lung cancer

Objective:To explore the effect of DC-CIK in combined with chemotherapy on the immunological function in patients with advanced non-small cell lung cancer (NSCLC). Methods:A total of 86 patients with NSCLC who were admitted in our hospital were included in the study and randomized into the observation group and the control group with 43 cases in each group. The patients in the two groups were given routine chemotherapy. On this basis, the patients in the observation group were given DC-CIK cellular immunotherapy. The patients in the two groups were treated for 3 courses. The peripheral blood T lymphocytes and cytokines after treatment in the two groups were compared. The clinical efficacy and adverse reactions in the two groups were evaluated.Results:The total effective rate and disease control rate after treatment in the observation group were slightly higher than those in the control group, but the comparison between the two groups was not statistically significant. CD8+ after treatment in the observation group was significantly reduced, while CD3+, CD4+, and CD4+/CD8+ were significantly elevated when compared with before treatment. CD3+ and NK contents, and CD4+/CD8+ after treatment in the observation group were significantly higher than those in the control group. IFN-γ, IL-4, TNF-α levels, and Th1/Th2 after treatment in the observation group were significantly higher than those in the control group, while TGF-β level was significantly lower than that in the control group. The occurrence rate of nausea and vomiting, and liver and renal function damage in the observation group was significantly lower than that in the control group, but the median progression free survival (PFS) was significantly longer than that in the control group, while the comparison of median overall survival (OS) between the two groups was not statistically significant, and 2-year survival rate was significantly higher than that in the control group.Conclusions: DC-CIK in combined with chemotherapy can correct the immunologic disorder in patients with advanced NSCLC, and strengthen the anti-tumor effect.

重组结核分枝杆菌变态反应原皮肤试验用制剂命名探讨

针对世界卫生组织于2022年推荐的结核感染检测新方法,基于结核分枝杆菌抗原检测结核分枝杆菌感染的皮肤试验检测技术(MTB antigen-based skin tests,TBST),作者对已上市与在研同类新品种的命名情况进行梳理,参考中国生物制品命名相关原则,对该类产品命名进行探讨,供研发、使用和监管部门的专家讨论参考。

原发免疫性血小板减少症患者外周血淋巴细胞亚群、NKT细胞及Th1/Th2细胞因子水平分析

目的分析原发免疫性血小板减少症患者外周血淋巴细胞亚群、自然杀伤T细胞(natural killer T-cell,NKT)及Th1/Th2细胞因子水平的变化及临床意义。方法纳入2021年6月—2022年6月麻城市人民医院收治的60例原发免疫性血小板减少症患者为观察组,均施予流式细胞术检测,将血小板(platelet,PLT)<20×109/L患者分为观察1组(30例),将PLT≥20×109/L患者分为观察2组(30例);纳入同期30例健康体检者为对照组,对上述受试者的外周血淋巴细胞亚群、NKT细胞及Th1/Th2细胞因子水平进行测定。结果3组CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)、CD3-CD19^(+)、CD3-CD16^(+)CD56^(+)、CD4^(+)/CD8^(+)、NKT比较,差异有统计学意义(F_(CD3+)=16.806,F_(CD3+CD4+)=24.271,F_(CD3+CD8+)=4.880,F_(CD3-CD19+)=34.955,F_(CD3-CD16+CD56+)=11.051,F_(CD4+/CD8)=13.014,F_(NKT)=38.576,P<0.001);原发免疫性血小板减少症患者的CD3^(+)、CD3^(+)CD4^(+)、CD3-CD16^(+)CD56^(+)、CD4^(+)/CD8^(+)、NKT与PLT计数为正相关关系(P<0.001);CD3^(+)CD8^(+)、CD3-CD19^(+)、白细胞介素2、白细胞介素4、白细胞介素6、白细胞介素10、肿瘤坏死因素、干扰素-γ与PLT计数为负相关关系(P<0.001)。结论原发免疫性血小板减少症患者体内的淋巴细胞亚群、NKT细胞、Th1/Th2细胞因子紊乱,且病情进展与T、B淋巴细胞亚群与NKT细胞为正相关关系。

放疗联合卡瑞利珠单抗或替吉奥治疗局部晚期食管癌的疗效

目的探究放疗联合卡瑞利珠单抗免疫治疗及放疗联合替吉奥化疗在局部晚期食管癌患者中的疗效。方法选取中国科学院合肥肿瘤医院2020年1月至2022年12月间收治的80例局部晚期食管癌患者,根据患者化疗方案选择的不同,将其分为对照组放疗联合替吉奥化疗方案(40例)和观察组放疗联合卡瑞利珠单抗方案(40例)。比较两组临床疗效、免疫功能、肿瘤标志物水平、用药安全性及生存质量。结果观察组客观缓解率(ORR)和疾病控制率(DCR)均高于对照组(P<0.05)。治疗后,两组CD3^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,研究组高于对照组(P<0.05)。治疗后,两组癌胚抗原(CEA)、糖类抗原724(CA724)水平均低于治疗前,观察组低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。治疗后,两组KPS评分均高于治疗前,观察组高于对照组(P<0.05),两组食管癌患者补充量表(QLQ-OES18)评分均低于治疗前,观察组低于对照组(P<0.05)。结论在局部晚期食管癌患者临床治疗中予以放疗联合卡瑞利珠单抗治疗,可明显提升患者疗效,改善免疫功能及肿瘤标志物水平提升生存质量,同时用药具有较好安全性。

变态反应肿瘤学立场文件解读

变态反应肿瘤学(AllergoOncology)是由变态反应学与肿瘤学合成的名词。变态反应与肿瘤的关系早在数十年前就被关注和研究。1960年代首次发现了变态反应与肿瘤发病间存在负相关关系。此后,该领域中有关基础、转化和临床的相关研究层出不穷。2014年由Erika Jensen-Jarolim教授牵头在欧洲变态反应与临床免疫学会(EAACI)成立了跨学科、跨领域的变态反应肿瘤学工作组,旨在建立常态化的变态反应肿瘤学成果交流平台,促进该学科深入持续发展。工作组关注变态反应和肿瘤学的交叉点,致力于免疫监视、免疫调节和IgE介导的肿瘤免疫治疗等研究,发布了5个变态反应肿瘤学的立场文件,促进了变态反应的核心理论向抗肿瘤临床实用技术转化,希望进一步提高肿瘤临床疗效。本文结合变态反应与肿瘤学领域相关文献,从变态反应与肿瘤间的负相关性、变态反应重要分子IgE的抗肿瘤效应、免疫细胞和分子以及微生物群分别在变态反应和肿瘤中的作用和变态反应肿瘤学的转化应用等方面,对变态反应肿瘤学立场文件进行归纳、比较、总结及要点解读。

Allergy and Immunology

5.1 Autoimmune disease2007297 The clinical characteristics of systemic lupus erythematosus associated with coronary artery disease.