Objective:After the pregabalin has been approved for the treatment of neuropathic pain,preliminary clinical studies suggested a possible role in the perioperative period.To our knowledge,It has never been studied the ...Objective:After the pregabalin has been approved for the treatment of neuropathic pain,preliminary clinical studies suggested a possible role in the perioperative period.To our knowledge,It has never been studied the perioperative analgesic effect of pregabalin in patients with cancer bladder.In this study,we hypothesized that cancer bladder patients undergoing radical cystectomy and received oral pregabalin 75 mg twice daily for ten days preoperatively would get their postoperative pain reduced.Methods:Sixty patients scheduled for elective radical cystectomy were randomly assigned to one of 2 groups(control group or pregabalin group).Patients in the pregabalin group received 75 mg pregabalin twice daily for ten days before surgery.Standard anesthesia protocol was applied to all patients.Pain intensity,opioid consumption,level of sedation and other side effects were regularly assessed for 48h postoperative.Results:Mean time for the first request of analgesia was statistically longer in pregabalin group.Meanwhile,mean morphine consumption,VAS scores at rest(in the first 32h postoperatively),VAS scores during movement(in the first 20h postoperatively) were statistically significant lower in the pregabalin group than those in the control group.Patients in the pregabalin group were statistically more sedated in the first four hours postoperative than the control group.Conclusion:Preoperative pregabalin 75 mg twice daily for ten days resulted in 60% reduction in 24h postoperative morphine requirements in patients undergoing radical cystectomy.展开更多
1日本批准普瑞巴林口崩片上市
日本批准辉瑞日本公司的产品（商品名：Lyrica OD Tablets）上市，用于治疗神经病理性疼痛（压迫或神经功能失调造成的任何症状）。典型病例：带状疱疹后遗神经痛，糖尿病神经病引起的痛，坐骨神经痛和脊...1日本批准普瑞巴林口崩片上市
日本批准辉瑞日本公司的产品（商品名：Lyrica OD Tablets）上市，用于治疗神经病理性疼痛（压迫或神经功能失调造成的任何症状）。典型病例：带状疱疹后遗神经痛，糖尿病神经病引起的痛，坐骨神经痛和脊柱损伤造成的疼痛。患有这些症状的许多人是老年人，普瑞巴林口崩片为患者服药提供了方便。普瑞巴林口崩片放人口内，遇口腔中的唾液迅速崩解，使其成为老年人易服用的药物剂型。剂量规格：普瑞巴林（pregabalin）25，75和150mg／片。展开更多
文摘Objective:After the pregabalin has been approved for the treatment of neuropathic pain,preliminary clinical studies suggested a possible role in the perioperative period.To our knowledge,It has never been studied the perioperative analgesic effect of pregabalin in patients with cancer bladder.In this study,we hypothesized that cancer bladder patients undergoing radical cystectomy and received oral pregabalin 75 mg twice daily for ten days preoperatively would get their postoperative pain reduced.Methods:Sixty patients scheduled for elective radical cystectomy were randomly assigned to one of 2 groups(control group or pregabalin group).Patients in the pregabalin group received 75 mg pregabalin twice daily for ten days before surgery.Standard anesthesia protocol was applied to all patients.Pain intensity,opioid consumption,level of sedation and other side effects were regularly assessed for 48h postoperative.Results:Mean time for the first request of analgesia was statistically longer in pregabalin group.Meanwhile,mean morphine consumption,VAS scores at rest(in the first 32h postoperatively),VAS scores during movement(in the first 20h postoperatively) were statistically significant lower in the pregabalin group than those in the control group.Patients in the pregabalin group were statistically more sedated in the first four hours postoperative than the control group.Conclusion:Preoperative pregabalin 75 mg twice daily for ten days resulted in 60% reduction in 24h postoperative morphine requirements in patients undergoing radical cystectomy.
文摘1日本批准普瑞巴林口崩片上市
日本批准辉瑞日本公司的产品（商品名：Lyrica OD Tablets）上市，用于治疗神经病理性疼痛（压迫或神经功能失调造成的任何症状）。典型病例：带状疱疹后遗神经痛，糖尿病神经病引起的痛，坐骨神经痛和脊柱损伤造成的疼痛。患有这些症状的许多人是老年人，普瑞巴林口崩片为患者服药提供了方便。普瑞巴林口崩片放人口内，遇口腔中的唾液迅速崩解，使其成为老年人易服用的药物剂型。剂量规格：普瑞巴林（pregabalin）25，75和150mg／片。
