By constructing a cell repair model after photodamage, we evaluated the photoresistance of FermentDFL, a lysate of Bifidus yeast fermentation products, of human immortalized keratinocytes(HaCaT) and human skin fibrobl...By constructing a cell repair model after photodamage, we evaluated the photoresistance of FermentDFL, a lysate of Bifidus yeast fermentation products, of human immortalized keratinocytes(HaCaT) and human skin fibroblasts(HDF) under UVB and UVA irradiation. The experimental data show that when human cells are damaged by light, Ferment-DFL with a concentration of 5% and 2% can significantly increase the level of cell viability, reduce the content of ROS reactive oxygen species in cells, and promote the secretion of type I collagen. The regeneration experiment evaluates the repair effect of Ferment-DFL, a lysate of two fission yeast fermentation products. At a concentration of 6%, after 48 h, the repairing promotion rate of zebrafish embryo tail fin reaches 15%, which can significantly promote the regeneration of zebrafish embryo tail fin.Promotes repairing effect.展开更多
The development of active yet stable catalysts for oxygen reduction reaction(ORR)is still a major issue for the extensive permeation of fuel cells into everyday technology.While nanostructured Pt catalysts are to date...The development of active yet stable catalysts for oxygen reduction reaction(ORR)is still a major issue for the extensive permeation of fuel cells into everyday technology.While nanostructured Pt catalysts are to date the best available systems in terms of activity,the same is not true for stability,particularly under operating conditions.In this work,Pt_(Х)Y alloy nanoparticles are proposed as active and durable electrocatalysts for ORR.Pt_(Х)Y nanoalloys are synthesized and further optimized by laser ablation in liquid followed by laser fragmentation in liquid.The novel integrated laser-assisted methodology succeeded in producing Pt_(Х)Y nanoparticles with the ideal size(<10 nm)of commercial Pt catalysts,yet resulting remarkably more active with E_(1/2)=0.943 V vs.RHE,specific activity=1095μA cm^(-2) and mass activity>1000 A g^(-1).At the same time,the nanoalloys are embedded in a fine Pt oxide matrix,which allows a greater stability of the catalyst than the commercial Pt reference,as directly verified on a gas diffusion electrode.展开更多
翻译了欧洲标准"EN 14569-2004 Foodstuffs-Microbiological screening for irradiated food using LAL/GNB procedures"。该方法已成功通过实验室验证,通常适用于新鲜的整禽或胸脯、腿、翅膀等器官以及去皮或未去皮的冷冻或...翻译了欧洲标准"EN 14569-2004 Foodstuffs-Microbiological screening for irradiated food using LAL/GNB procedures"。该方法已成功通过实验室验证,通常适用于新鲜的整禽或胸脯、腿、翅膀等器官以及去皮或未去皮的冷冻或冰冻畜体的鉴别。该方法还可以提供待辐照样品微生物学质量的情况,但只能说明样品可能经过电离辐射。展开更多
Knees are the most commonly impacted weight-bearing joints in osteoarthritis(OA),affecting millions of people worldwide.With increasing life spans and obesity rates,the incidence of knee OA will further increase,leadi...Knees are the most commonly impacted weight-bearing joints in osteoarthritis(OA),affecting millions of people worldwide.With increasing life spans and obesity rates,the incidence of knee OA will further increase,leading to a significant increase in the economic burden.Conventional treatment modalities utilized to manage knee OA have limitations.Over the last decade,the role of various autologous peripheral blood-derived orthobiologics(APBOs)for the treatment of knee OA has been extensively investigated.This editorial provided an overview and focused on defining and shedding light on the current state of evidence based on the most recent published clinical studies concerning the use of APBO for the management of knee OA.While numerous studies have demonstrated promising results for these preparations,a notable gap exists in the comparative analysis of these diverse formulations.This absence of head-to-head studies poses a considerable challenge for physicians/surgeons in determining the optimal preparation for managing knee OA and achieving sustained longterm results.Thus,more adequately powered,multicenter,prospective,doubleblind,randomized controlled trials with longer follow-ups are needed to establish the long-term efficacy and to aid physicians/surgeons in determining the optimal APBO for the management of knee OA.展开更多
文摘By constructing a cell repair model after photodamage, we evaluated the photoresistance of FermentDFL, a lysate of Bifidus yeast fermentation products, of human immortalized keratinocytes(HaCaT) and human skin fibroblasts(HDF) under UVB and UVA irradiation. The experimental data show that when human cells are damaged by light, Ferment-DFL with a concentration of 5% and 2% can significantly increase the level of cell viability, reduce the content of ROS reactive oxygen species in cells, and promote the secretion of type I collagen. The regeneration experiment evaluates the repair effect of Ferment-DFL, a lysate of two fission yeast fermentation products. At a concentration of 6%, after 48 h, the repairing promotion rate of zebrafish embryo tail fin reaches 15%, which can significantly promote the regeneration of zebrafish embryo tail fin.Promotes repairing effect.
基金the P-DISC Grant PROMETEO(project number:P-DiSC#03NExuS_BIRD2021-UNIPD)DYNAMO(project number:P-P-DiSC#01BIRD2020-UNIPD)the financial support of the Fellowship in Applied Electrochemistry 2020。
文摘The development of active yet stable catalysts for oxygen reduction reaction(ORR)is still a major issue for the extensive permeation of fuel cells into everyday technology.While nanostructured Pt catalysts are to date the best available systems in terms of activity,the same is not true for stability,particularly under operating conditions.In this work,Pt_(Х)Y alloy nanoparticles are proposed as active and durable electrocatalysts for ORR.Pt_(Х)Y nanoalloys are synthesized and further optimized by laser ablation in liquid followed by laser fragmentation in liquid.The novel integrated laser-assisted methodology succeeded in producing Pt_(Х)Y nanoparticles with the ideal size(<10 nm)of commercial Pt catalysts,yet resulting remarkably more active with E_(1/2)=0.943 V vs.RHE,specific activity=1095μA cm^(-2) and mass activity>1000 A g^(-1).At the same time,the nanoalloys are embedded in a fine Pt oxide matrix,which allows a greater stability of the catalyst than the commercial Pt reference,as directly verified on a gas diffusion electrode.
文摘翻译了欧洲标准"EN 14569-2004 Foodstuffs-Microbiological screening for irradiated food using LAL/GNB procedures"。该方法已成功通过实验室验证,通常适用于新鲜的整禽或胸脯、腿、翅膀等器官以及去皮或未去皮的冷冻或冰冻畜体的鉴别。该方法还可以提供待辐照样品微生物学质量的情况,但只能说明样品可能经过电离辐射。
文摘Knees are the most commonly impacted weight-bearing joints in osteoarthritis(OA),affecting millions of people worldwide.With increasing life spans and obesity rates,the incidence of knee OA will further increase,leading to a significant increase in the economic burden.Conventional treatment modalities utilized to manage knee OA have limitations.Over the last decade,the role of various autologous peripheral blood-derived orthobiologics(APBOs)for the treatment of knee OA has been extensively investigated.This editorial provided an overview and focused on defining and shedding light on the current state of evidence based on the most recent published clinical studies concerning the use of APBO for the management of knee OA.While numerous studies have demonstrated promising results for these preparations,a notable gap exists in the comparative analysis of these diverse formulations.This absence of head-to-head studies poses a considerable challenge for physicians/surgeons in determining the optimal preparation for managing knee OA and achieving sustained longterm results.Thus,more adequately powered,multicenter,prospective,doubleblind,randomized controlled trials with longer follow-ups are needed to establish the long-term efficacy and to aid physicians/surgeons in determining the optimal APBO for the management of knee OA.
