River bank erosion is a natural process that occurs when the water flow of a river exceeds the bank’s ability to withstand it. It is a common phenomenon that causes extensive land damage, displacement of people, loss...River bank erosion is a natural process that occurs when the water flow of a river exceeds the bank’s ability to withstand it. It is a common phenomenon that causes extensive land damage, displacement of people, loss of crops, and infrastructure damage. The Gorai River, situated on the right bank of the Ganges, is a significant branch of the river that flows into the Bay of Bengal via the Mathumati and Baleswar rivers. The erosion of the banks of the Gorai River in Kushtia district is not a recent occurrence. Local residents have been dealing with this issue for the past hundred years, and according to the elderly members of the community, the erosion has become more severe activities. Therefore, the main objective of this research is to quantify river bank erosion and accretion and bankline shifting from 2003 to 2022 using multi-temporal Landsat images data with GIS and remote sensing technique. Bank-line migration occurs as a result of the interplay and interconnectedness of various factors such as the degree of river-related processes such as erosion, transportation, and deposition, the amount of water in the river during the high season, the geological and soil makeup, and human intervention in the river. The results show that the highest eroded area was 4.6 square kilometers during the period of 2016 to 2019, while the highest accreted area was 7.12 square kilometers during the period of 2013 to 2016. However, the erosion and accretion values fluctuated from year to year.展开更多
目的探讨甲基转移酶5(methyltransferase-like 5,METTL5)在三阴乳腺癌(triple-negative breast cancer,TNBC)中的作用和潜在机制。方法采用免疫组织化学方法和Western blot检测TNBC肿瘤组织和细胞系中METTL5的表达情况。用靶向METTL5的s...目的探讨甲基转移酶5(methyltransferase-like 5,METTL5)在三阴乳腺癌(triple-negative breast cancer,TNBC)中的作用和潜在机制。方法采用免疫组织化学方法和Western blot检测TNBC肿瘤组织和细胞系中METTL5的表达情况。用靶向METTL5的shRNA(shRNA-METTL5)转染TNBC细胞后,用CCK-8、集落形成、伤口愈合以及Transwell实验分别检测细胞增殖活性、迁移与侵袭,Western blot检测Wnt/β-catenin信号关键蛋白的表达。构建异种移植瘤模型,验证敲降METTL5对TNBC细胞在体内生长以及Wnt/β-catenin信号活性的影响。结果METTL5在TNBC肿瘤组织和细胞系中表达上调(P<0.01)。敲降METTL5可抑制TNBC细胞的增殖、迁移和侵袭并降低了Wnt/β-catenin信号分子β-catenin、细胞周期蛋白(Cyclin)D1、基质金属蛋白酶(MMP)-2和MMP-7的表达(均P<0.01)。体内实验显示,敲降METTL5减缓了移植瘤生长和Wnt/β-catenin信号活性。结论敲降METTL5能抑制TNBC细胞的增殖、迁移与侵袭,其作用可能与抑制Wnt/β-catenin信号通路有关。展开更多
文摘River bank erosion is a natural process that occurs when the water flow of a river exceeds the bank’s ability to withstand it. It is a common phenomenon that causes extensive land damage, displacement of people, loss of crops, and infrastructure damage. The Gorai River, situated on the right bank of the Ganges, is a significant branch of the river that flows into the Bay of Bengal via the Mathumati and Baleswar rivers. The erosion of the banks of the Gorai River in Kushtia district is not a recent occurrence. Local residents have been dealing with this issue for the past hundred years, and according to the elderly members of the community, the erosion has become more severe activities. Therefore, the main objective of this research is to quantify river bank erosion and accretion and bankline shifting from 2003 to 2022 using multi-temporal Landsat images data with GIS and remote sensing technique. Bank-line migration occurs as a result of the interplay and interconnectedness of various factors such as the degree of river-related processes such as erosion, transportation, and deposition, the amount of water in the river during the high season, the geological and soil makeup, and human intervention in the river. The results show that the highest eroded area was 4.6 square kilometers during the period of 2016 to 2019, while the highest accreted area was 7.12 square kilometers during the period of 2013 to 2016. However, the erosion and accretion values fluctuated from year to year.
