The cycle of G-protein activation and deactivation is a key in the signaling pathway of GPCRs (G protein coupled receptors). GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by increasing the rates...The cycle of G-protein activation and deactivation is a key in the signaling pathway of GPCRs (G protein coupled receptors). GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by increasing the rates at which the (subunits hydrolyze bound GTP to GDP. RGSs (regulators of G protein signaling) is a novel family and, in most cases, implicated in accelerating the hydrolysis of GTP. The opioid receptors are all seven serpentine transmembrane receptors coupled with G proteins Gi, Go, even Gs. Adenylate cyclase (AC) is展开更多
文摘The cycle of G-protein activation and deactivation is a key in the signaling pathway of GPCRs (G protein coupled receptors). GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by increasing the rates at which the (subunits hydrolyze bound GTP to GDP. RGSs (regulators of G protein signaling) is a novel family and, in most cases, implicated in accelerating the hydrolysis of GTP. The opioid receptors are all seven serpentine transmembrane receptors coupled with G proteins Gi, Go, even Gs. Adenylate cyclase (AC) is
