The title compound, (1α,6β, 11β,14α)-1,7:6,20-diepoxy-6,1 1-dihydroxy- 6,7-secoent- kaur- 16-ene-7,15-dione- 14-acetate (macrocalyxin J), is a diterpenoid which was isolated from the leaves of Rabdosia macroc...The title compound, (1α,6β, 11β,14α)-1,7:6,20-diepoxy-6,1 1-dihydroxy- 6,7-secoent- kaur- 16-ene-7,15-dione- 14-acetate (macrocalyxin J), is a diterpenoid which was isolated from the leaves of Rabdosia macrocalyx and characterized by single-crystal X-ray diffraction. It crystallizes in orthorhombic, space group P212121 with α= 9.3608(8), b = 14.9787(12), c = 15.5750(13) A, Z = 4, V = 2183.8(3) A^3, C22H30O9, Mr= 438.46, Dc= 1.334 g/m^3,μ(MoKα) = 0.103 mm^-1, F(000) = 936, the final R = 0.0532 and wR = 0.1262 for 2252 observed reflections (I 〉 2σ(I)). In the molecule, three six-membered rings adopt chair, boat and slightly distorted boat conformations, respectively, while both five-membered rings have approximate envelope conformations.展开更多
On the basis of the investigation on natural product antitumor agents,a new diterpenoid named macrocalyxin J was isolated from the leaves of Rabdosia macrocalyx(Dunn) Hara by silica gel column chromatography.Based o...On the basis of the investigation on natural product antitumor agents,a new diterpenoid named macrocalyxin J was isolated from the leaves of Rabdosia macrocalyx(Dunn) Hara by silica gel column chromatography.Based on IR,MS,1H NMR,13C NMR and 2D NMR spectroscopies,the structure of macrocalyxin J was determined as(1α,6β,11β,14α)-1,7∶6,20-diepoxy-6,11-dihydroxy-6,7-seco-ent-kaur-16-ene-7,15-dione-14-acetate.The antitumor activity of the compound was assayed by MTT method.Macrocalyxin J was shown to have a potency in vitro against the cultures of Hela cells.展开更多
Three crystalline components, a new kaurane type diterpenoid named macrocalyxin H and two known diterpenoid oridonin and enmenol, were isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on IR, MS, 1 H 1...Three crystalline components, a new kaurane type diterpenoid named macrocalyxin H and two known diterpenoid oridonin and enmenol, were isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on IR, MS, 1 H 1H COSY, 13 C 1H COSY and NOE spectroscopy, the structure of macrocalyxin H was determined as ent 7β 20 epoxy 1α, 6α, 7α, 15α, 16α pentahydroxy kaurene 17 acetate.展开更多
Known diterpenoid maoyerabdosin was isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on elemental analyses and spectra of MS,NMR,COSY and NOESY,the structure of maoyerabdosin was revised as ent 7β 20...Known diterpenoid maoyerabdosin was isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on elemental analyses and spectra of MS,NMR,COSY and NOESY,the structure of maoyerabdosin was revised as ent 7β 20 epoxy 1α,7α,15α,16α tetrahydro xy kaurene 6α,17 diacetate.展开更多
基金the National Natural Science Foundation of China (No. 20472073)the Natural Science Foundation of Zhejiang Province (No. Y404357)
文摘The title compound, (1α,6β, 11β,14α)-1,7:6,20-diepoxy-6,1 1-dihydroxy- 6,7-secoent- kaur- 16-ene-7,15-dione- 14-acetate (macrocalyxin J), is a diterpenoid which was isolated from the leaves of Rabdosia macrocalyx and characterized by single-crystal X-ray diffraction. It crystallizes in orthorhombic, space group P212121 with α= 9.3608(8), b = 14.9787(12), c = 15.5750(13) A, Z = 4, V = 2183.8(3) A^3, C22H30O9, Mr= 438.46, Dc= 1.334 g/m^3,μ(MoKα) = 0.103 mm^-1, F(000) = 936, the final R = 0.0532 and wR = 0.1262 for 2252 observed reflections (I 〉 2σ(I)). In the molecule, three six-membered rings adopt chair, boat and slightly distorted boat conformations, respectively, while both five-membered rings have approximate envelope conformations.
文摘On the basis of the investigation on natural product antitumor agents,a new diterpenoid named macrocalyxin J was isolated from the leaves of Rabdosia macrocalyx(Dunn) Hara by silica gel column chromatography.Based on IR,MS,1H NMR,13C NMR and 2D NMR spectroscopies,the structure of macrocalyxin J was determined as(1α,6β,11β,14α)-1,7∶6,20-diepoxy-6,11-dihydroxy-6,7-seco-ent-kaur-16-ene-7,15-dione-14-acetate.The antitumor activity of the compound was assayed by MTT method.Macrocalyxin J was shown to have a potency in vitro against the cultures of Hela cells.
文摘Three crystalline components, a new kaurane type diterpenoid named macrocalyxin H and two known diterpenoid oridonin and enmenol, were isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on IR, MS, 1 H 1H COSY, 13 C 1H COSY and NOE spectroscopy, the structure of macrocalyxin H was determined as ent 7β 20 epoxy 1α, 6α, 7α, 15α, 16α pentahydroxy kaurene 17 acetate.
文摘Known diterpenoid maoyerabdosin was isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on elemental analyses and spectra of MS,NMR,COSY and NOESY,the structure of maoyerabdosin was revised as ent 7β 20 epoxy 1α,7α,15α,16α tetrahydro xy kaurene 6α,17 diacetate.