The title compound C_(28)H_(48)O_4 (M_r=448. 8) crystallizes in the triclinic, space group P1 with a=12. 909(5) , b=10. 422(4) , c=11. 052(4) A, α=108. 35 (3), β=100. 07(3), γ=70. 06(3)°, Z=2, V=1322. 9(8) A￣...The title compound C_(28)H_(48)O_4 (M_r=448. 8) crystallizes in the triclinic, space group P1 with a=12. 909(5) , b=10. 422(4) , c=11. 052(4) A, α=108. 35 (3), β=100. 07(3), γ=70. 06(3)°, Z=2, V=1322. 9(8) A￣3,109. D_c=1. 13 gcm￣(-3), F(000)=496, μ(MoKa)=0. 80cm￣(-1). The final R=0. 067 and R_w=0. 074 for 1652 observed independent reflections (I≥3σ(I)). The conformation of the molecule is rather unusual , and there is not any symmetry element involved in it.The four units are different from each other in bond lengths and bond angles. The distances between two separate oxygen atoms are 5. 77 and 4. 25 A, respectively , and those between two adjacent oxygen atoms average 3. 59 A.展开更多
The precise control of the conformations of biomolecules adsorbed on a surface at the single-molecule level is significant. However, it remains a huge challenge because of the complex structure and conformation divers...The precise control of the conformations of biomolecules adsorbed on a surface at the single-molecule level is significant. However, it remains a huge challenge because of the complex structure and conformation diversity of biomolecules. Herein, a ＂nanopore-confined recognition＂ strategy is proposed to manipulate the adsorption of individual valinomycin molecules at room temperature through precise design of functionalized conjugated macrocycle （CPN8） supramolecular nanopores with complementary architectures and binding sites. We revealed that CPN8 prefers to selectively recognizing valinomycin with complementary architecture because of the strong synergistic interactions between the isopropyl groups of valinomycin and the amino groups of CPN8, with valinomycin- highly oriented pyrolytic graphite （HOPG） interactions. Our perspectives at the single-molecule level will provide valuable insights to improve the design of supramolecular nanopores for conformation-selective recognition of non-conjugated molecules.展开更多
文摘The title compound C_(28)H_(48)O_4 (M_r=448. 8) crystallizes in the triclinic, space group P1 with a=12. 909(5) , b=10. 422(4) , c=11. 052(4) A, α=108. 35 (3), β=100. 07(3), γ=70. 06(3)°, Z=2, V=1322. 9(8) A￣3,109. D_c=1. 13 gcm￣(-3), F(000)=496, μ(MoKa)=0. 80cm￣(-1). The final R=0. 067 and R_w=0. 074 for 1652 observed independent reflections (I≥3σ(I)). The conformation of the molecule is rather unusual , and there is not any symmetry element involved in it.The four units are different from each other in bond lengths and bond angles. The distances between two separate oxygen atoms are 5. 77 and 4. 25 A, respectively , and those between two adjacent oxygen atoms average 3. 59 A.
基金Acknowledgements The authors gratefully acknowledged Prof. Chen Wang （National Center for Nanoscience and Technology, China） and Prof. Guocong Guo （Fujian Institute of Research on the Structure of Matter, CAS） for their helpful discussions and advice. This work was supported by the National Basic Research Program of China （No. 2012CB933001）, the National Natural Science Foundation of China （Nos. 51173031, 21472029, 21303202, and 91127043）, the program of Chinese Academy of Sciences （No. YZ201318）, and the Open Project of State Key Laboratory of Supramolecular Structure and Materials （No. sklssm201607）.
文摘The precise control of the conformations of biomolecules adsorbed on a surface at the single-molecule level is significant. However, it remains a huge challenge because of the complex structure and conformation diversity of biomolecules. Herein, a ＂nanopore-confined recognition＂ strategy is proposed to manipulate the adsorption of individual valinomycin molecules at room temperature through precise design of functionalized conjugated macrocycle （CPN8） supramolecular nanopores with complementary architectures and binding sites. We revealed that CPN8 prefers to selectively recognizing valinomycin with complementary architecture because of the strong synergistic interactions between the isopropyl groups of valinomycin and the amino groups of CPN8, with valinomycin- highly oriented pyrolytic graphite （HOPG） interactions. Our perspectives at the single-molecule level will provide valuable insights to improve the design of supramolecular nanopores for conformation-selective recognition of non-conjugated molecules.
