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抗奥合剂通过p38 MAPK/NF-κB信号通路和ACE2/Ang1-7/Mas轴缓解急性肺损伤研究
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作者 陈思琪 严佳煜 +1 位作者 李瑞 顾宁 《南京中医药大学学报》 CAS CSCD 北大核心 2024年第5期446-456,共11页
目的探讨抗奥合剂(KAHJ)治疗小鼠急性肺损伤(ALI)的作用及机制,为其可能作为缓解新型冠状病毒(COVID-19)感染后症状的药物提供依据。方法采用网络药理学方法预测KAHJ治疗ALI的主要活性成分、潜在靶点和相关信号通路。将C57BL/6J小鼠随... 目的探讨抗奥合剂(KAHJ)治疗小鼠急性肺损伤(ALI)的作用及机制,为其可能作为缓解新型冠状病毒(COVID-19)感染后症状的药物提供依据。方法采用网络药理学方法预测KAHJ治疗ALI的主要活性成分、潜在靶点和相关信号通路。将C57BL/6J小鼠随机分为对照组、LPS组和LPS+KAHJ组。LPS+KAHJ组小鼠灌胃KAHJ(4.76 g·kg^(-1)·d^(-1),8.8 mL·kg^(-1)·d^(-1)),其余组小鼠灌胃生理盐水(8.8 mL·kg^(-1)·d^(-1))。14 d后,腹腔注射LPS(5 mg·kg^(-1))诱导ALI模型。收集小鼠血清和肺组织,通过组织病理学观察肺组织的病理变化。采用Western blot、qPCR、ELISA和IHC等方法评估KAHJ对ALI的改善作用。结果通过网络药理学筛选出疾病和药物共同的70个核心靶基因,并显示与多个信号通路密切相关,如MAPK、NF-κB、Apoptosis、COVID-19和肾素-血管紧张素系统(Ras)信号通路等。此外,通过实验验证发现KAHJ能改善小鼠ALI后的炎症和细胞凋亡,减少肺损伤和肺水肿,抑制肺纤维化。同时,KAHJ的作用机制与p38 MAPK和NF-κB的磷酸化以及ACE2/Ang1-7/Mas轴的调控也有着密切关系。结论KAHJ可能通过抑制p38 MAPK/NF-κB信号通路和调控ACE2/Ang1-7/Mas轴缓解ALI,为缓解COVID-19感染后症状提供了补充和替代药物。 展开更多
关键词 急性肺损伤 p38 maPK/NF-κB信号通路 ACE2/Ang1-7/mas轴 新型冠状病毒
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Serum metrix metalloproteinase-9 combined with homocysteine, IL-6, TNF-α, CRP, HbA11c and lipid profile in the incipient diabetic nephropathy with or without macrovascular diseases
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作者 贾伟 袁强 +5 位作者 梁永平 王惠敏 韩向群 尹淑巧 朱晓梅 刘桂芝 《Journal of Medical Colleges of PLA(China)》 CAS 2007年第2期111-114,共4页
Objective : To evaluate the changes of serum matrix metalloproteinase-9 (romp-9) in patients of incipient diabetic nephropathy with or without macrovascular disease and to analyze the factors associated with homocy... Objective : To evaluate the changes of serum matrix metalloproteinase-9 (romp-9) in patients of incipient diabetic nephropathy with or without macrovascular disease and to analyze the factors associated with homocysteine(hcy), interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-α), highly sensitive C-reactive protein (hsCRP), HbAlc and lipid profile in those patients in order to know whether this marker or other factors are more important to induce diabetic macrovascular disease. Methods: Type 2 diabetes mellitus(T2DM) subjects with incipient diabetic nephropathy with or without macrovascular disease were selected for participation and divided into 2 groups. The patients in group 1 (n= 38) used insulin, and patients in group 2 (n=34) were treated with an oral antidiabetic drug. Then serum mmp-9, hey, IL-6 and TNF-α in these patients were measured, and compared to the healthy subjects as control (n= 16). The results were analyzed by SPSS13. Results: Serum romp-9 and hcy of the patients having incipient diabetic nephropathy with macrovascular disease were higher than that of patients without macrovascular disease (P〈0.01). For insulin-injected patients, whether they accompanied with macrovascular diseases or not, the serum levels of romp-9, hcy, IL-6 and TNF-α were all lower, but no significant statistics compared with non-insulin used patients or the healthy subjects. The serum level of romp-9 was more correlated with the serum hcy in antidiabetic drug used patients. (P〈0. 000) Conclusion: The serum level of romp-9 plays an important role of pathogenesis in the macrovascular disease in the incipient diabetic patients, and the serum level of hcy also can reflect the severely degree of macrovascular disease in these patients, insulin can reduce these markers. 展开更多
关键词 mmp-9 type-2 diabetic mellitus macrovascular disease HOMOCYSTEINE IL-6 TNF-Α
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Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population
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作者 WANG Jia Lu CAO Qiu Yu +12 位作者 XIN Zhuo Jun LIU Shan Shan XU Min WANG Tian Ge LU Jie Li CHEN Yu Hong WANG Shuang Yuan ZHAO Zhi Yun XU Yu NING Guang WANG Wei Qing BI Yu Fang LI Mian 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2022年第1期4-12,共9页
Objective The association between neutrophil-to-lymphocyte ratio(NLR)with subclinical macrovascular and microvascular diseases has been less investigated.We sought to examine the association between NLR and new-onset ... Objective The association between neutrophil-to-lymphocyte ratio(NLR)with subclinical macrovascular and microvascular diseases has been less investigated.We sought to examine the association between NLR and new-onset subclinical macrovascular and microvascular abnormalities in the Chinese population.Methods From a community cohort,we included 6,430 adults aged≥40 years without subclinical macrovascular and microvascular diseases at baseline.We measured subclinical macrovascular and microvascular abnormalities separately using the ankle-brachial index(ABI),brachial-ankle pulse wave velocity(baPWV),and albuminuria.Results During a mean follow-up of 4.3 years,110 participants developed incident abnormal ABI,746 participants developed incident elevated baPWV,and 503 participants developed incident albuminuria.Poisson regression analysis indicated that NLR was significantly associated with an increased risk of newonset abnormal ABI,elevated baPWV,and albuminuria.Compared to overweight/obese participants,we found a much stronger association between NLR and subclinical vascular abnormalities in participants with normal weight.Furthermore,we found an interaction between the NLR and body mass index(BMI)on the risk of new-onset abnormal ABI(P for interaction:0.01).Conclusion NLR was associated with subclinical macrovascular and microvascular diseases in the Chinese population.Furthermore,in participants with normal weight,the association between NLR and subclinical vascular abnormalities was much stronger. 展开更多
关键词 Neutrophil-to-lymphocyte ratio Subclinical macrovascular and microvascular diseases Body mass index Prospective cohort study
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Prevention of macrovascular complications in patients with type 2 diabetes mellitus: Review of cardiovascular safety and efficacy of newer diabetes medications 被引量:6
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作者 Ravi Kant Kashif M Munir +1 位作者 Arshpreet Kaur Vipin Verma 《World Journal of Diabetes》 SCIE CAS 2019年第6期324-332,共9页
Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications has been very frustrating for clinicians involved in care of patients with diabetes mellitus (DM). Highly publicized cont... Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications has been very frustrating for clinicians involved in care of patients with diabetes mellitus (DM). Highly publicized controversy surrounding cardiovascular (CV) safety of rosiglitazone resulted in major changes in United States Food and Drug Administration policy in 2008 regarding approval process of new antidiabetic medications, which has resulted in revolutionary data from several large CV outcome trials over the last few years. All drugs in glucagon-like peptide-1 receptor agonist (GLP-1 RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitor classes have shown to be CV safe with heterogeneous results on CV efficacy. Given twofold higher CV disease mortality in patients with DM than without DM, GLP-1 RAs and SGLT-2-inhibitors are important additions to clinician’s armamentarium and should be second line-therapy particularly in patients with T2DM and established atherosclerotic CV disease or high risks for CV disease. Abundance of data and heterogeneity in CV outcome trials results can make it difficult for clinicians, particularly primary care physicians, to stay updated with all the recent evidence. The scope of this comprehensive review will focus on all major CV outcome studies evaluating CV safety and efficacy of GLP-1 RAs and SGLT-2 inhibitors. 展开更多
关键词 Newer antidiabetic MEDICATIONS Glucagon-like peptide-1 receptor agonist Sodium-glucose cotransporter-2 inhibitors Type 2 DIABETES MELLITUS macrovascular complications CARDIOVASCULAR outcome trials major CARDIOVASCULAR events HEART failure PREVENTION of HEART disease
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Small bowel adenocarcinoma and Crohn's disease: Any further ahead than 50 years ago? 被引量:3
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作者 Caitlin Cahill Philip H Gordon +1 位作者 Andrea Petrucci Marylise Boutros 《World Journal of Gastroenterology》 SCIE CAS 2014年第33期11486-11495,共10页
This review of the literature on small bowel carcinoma associated with Crohn's disease specifically addresses the incidence, risk factors, and protective factors which have been identified. It also reviews the cli... This review of the literature on small bowel carcinoma associated with Crohn's disease specifically addresses the incidence, risk factors, and protective factors which have been identified. It also reviews the clinical presentation, the current modalities of diagnosis, the pathology, treatment, and surveillance. Finally, the prognosis and future direction are addressed. Our experience with small bowel adenocarcinoma in Crohn's disease is reported. Readers will be provided with a better understanding of this rare and often poorly recognized complication of Crohn's disease. 展开更多
关键词 Crohn's disease Small bowel adenocarcino-ma Cancer risk Cancer malignancy Incidental carcino-ma Late complications of Crohn's disease Inflammatory bowel disease
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A novel transgenic mouse model of Chinese CharcotMarie-Tooth disease type 2L 被引量:2
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作者 Ruxu Zhang Fufeng Zhang +8 位作者 Xiaobo Li Shunxiang Huang Xiaohong Zi Ting Liu Sanmei Liu Xuning Li Kun Xia Qian Pan Beisha Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第4期413-419,共7页
We previously found that the K141N mutation in heat shock protein B8 (HSPB8) was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family. The objective of the present study was to generate a tr... We previously found that the K141N mutation in heat shock protein B8 (HSPB8) was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family. The objective of the present study was to generate a transgenic mouse model bearing the K141N mutation in the human HSPB8 gene, and to determine whether this K141NHSPB8 transgenic mouse model would manifest the clinical phenotype of Charcot-Marie-Tooth disease type 2L, and consequently be suitable for use in studies of disease pathogenesis. Transgenic mice overexpressing K141N HSPB8 were generated using K141N mutant HSPB8 cDNA cloned into a pCAGGS plasmid driven by a human cytomegalovirus expression system. PCR and western blot analysis confirmed integration of the KI41NHSPB8 gene and widespread expression in tissues of the transgenic mice. The K141N HSPB8 transgenic mice exhibited decreased muscle strength in the hind limbs and impaired motor coordination, but no obvious sensory disturbance at 6 months of age by behavioral assessment. Electrophysiological analysis showed that the compound motor action potential amplitude in the sciatic nerve was significantly decreased, but motor nerve conduction velocity remained normal at 6 months of age. Pathological analysis of the sciatic nerve showed reduced myelinated fiber density, notable axonal edema and vacuolar degeneration in K141N HSPB8 transgenic mice, suggesting axonal involvement in the peripheral nerve damage in these animals. These findings indicate that the KI4mHSPB8 transgenic mouse successfully models Charcot-Marie-Tooth disease type 2L and can be used to study the pathogenesis of the disease. 展开更多
关键词 nerve regeneration peripheral nerve injury axonal injury animal models Charcot-ma-rie-Tooth disease type 2L gene mutation pronuclear injection transgenic model small heat shockprotein B8 NSFC grant neural regeneration
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Can Peripheral Venous Gases Replace Arterial Gases in a Patient with Chronic Kidney Disease?
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作者 Jose Lucas Daza Yaroslad de la Cruz +6 位作者 Gerardo Gutierrez Luis Puello Victor Aldana Antonio Vasquez Orlando Ariza Alexander Ariza Andres Cardenas 《Open Journal of Nephrology》 2023年第2期150-160,共11页
Introduction: Metabolic acidosis (MA) is a frequent alteration in chronic kidney disease (CKD) that is associated with numerous complications, which is why its correction is recommended. Oral sodium bicarbonate is cur... Introduction: Metabolic acidosis (MA) is a frequent alteration in chronic kidney disease (CKD) that is associated with numerous complications, which is why its correction is recommended. Oral sodium bicarbonate is currently the treatment of choice. Objective: The objective is to determine if venous bicarbonate is equal to arterial bicarbonate in the follow-up of a patient with chronic kidney disease. Materials Methods: Single-center Cross-sectional studies in a cohort of adult patients with stage 4 - 5 CKD. Samples were taken between January 2022 and January 2023, in a Clinic in the city of Ibague/ Colombia obtained from the radial artery. The inclusion criteria were: not being treated with alkaline at the time of inclusion. Results: A total of 71 patients were included, 73.2% male (52) and 26.8% female (19), with different stages: stage 3 with 5.6% (4), stage 4 with 60.6% (43), stage 5 with 33.8% (23). 66.2% were diabetic, 88.7% had arterial hypertension, and 15.5% of the patients presented hematoma as a complication and pain associated with arterial puncture. The result of mean venous bicarbonate was 18.8 with a standard deviation of 2.3, arterial bicarbonate a mean of 19.4 with a standard deviation of 2.1 with a value of P 0.46, venous pH with a mean of 7.37 with a standard deviation of 0.48 and a mean arterial pH of 7.38 with a standard deviation of 0.48 with a P value of 0.01. Values of venous bicarbonate compared to arterial bicarbonate showed no statistically significant difference in patients with chronic kidney disease, but there were more complications such as hematoma and pain in patients in the arterial puncture cohort, because of this result venous bicarbonate corresponds to arterial bicarbonate, but has less risk of complications associated with the procedure. Conclusion: Metabolic acidosis is a frequent alteration in advanced chronic kidney disease, these results showed that the values of arterial and venous bicarbonate have no statistically significant differences, but there is a greater risk of complications with arterial blood gases, due to this, venous bicarbonate could be a useful tool for patients with chronic kidney disease. 展开更多
关键词 ma (Metabolic Acidosis) CKD (Chronic Kidney disease) GFR (Glomerular Filtration Rate)
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马晓燕撷经典方剂治疗内科杂病经验浅谈
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作者 回世洋 马晓燕 倪帅 《辽宁中医杂志》 CAS 北大核心 2024年第3期30-33,共4页
郁证的主要临床表现为情绪抑郁不宁、心胸满闷、胸部以及胁肋部胀痛,或有善哭易怒,亦或咽中如有炙脔等不适。相当于现代医学中的神经衰弱、癔症及焦虑症等。常因喜怒忧思,郁滞不舒,而导致肝疏泄功能失职,脾脏失其健运之功,心失其养,脏... 郁证的主要临床表现为情绪抑郁不宁、心胸满闷、胸部以及胁肋部胀痛,或有善哭易怒,亦或咽中如有炙脔等不适。相当于现代医学中的神经衰弱、癔症及焦虑症等。常因喜怒忧思,郁滞不舒,而导致肝疏泄功能失职,脾脏失其健运之功,心失其养,脏腑、气血、阴阳功能紊乱;而消渴常因禀赋不足亦或是饮食不节等因素导致阴津亏损,燥热偏盛,而出现“三多一少”的症状,即多饮、多尿、多食以及形体消瘦,相当于现代医学的“糖尿病”。马教授投身于对于郁证和消渴的证候及治疗的研究,熟读经典、精求古训,并且在长期的诊疗疾病过程中,对于使用经典方剂加减化裁辨治郁证和消渴等内科杂病积累了丰富的临床经验。现撷马教授以经典方剂治疗郁证和消渴等内科杂病的经验作总结与探析。其临床疗效确切。 展开更多
关键词 经典方剂 内科杂病 马晓燕 经验 中医
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大黄糖络丸通过调控PI3K-Akt/NF-κB信号通路减轻糖尿病大鼠大血管炎症反应 被引量:2
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作者 姚建莉 梁永林 +1 位作者 任梦函 杨丽霞 《中国病理生理杂志》 CAS CSCD 北大核心 2024年第4期646-652,共7页
目的:基于磷脂酰肌醇3-激酶(PI3K)-蛋白激酶B(PKB/Akt)/核因子κB(NF-κB)信号通路,探讨大黄糖络丸(RSP)防治Zucker糖尿病肥胖(ZDF)大鼠大血管炎症反应的作用机制。方法:15只雄性ZDF(fa/+)大鼠作为对照组;高脂饲料诱导成模的75只雄性ZDF... 目的:基于磷脂酰肌醇3-激酶(PI3K)-蛋白激酶B(PKB/Akt)/核因子κB(NF-κB)信号通路,探讨大黄糖络丸(RSP)防治Zucker糖尿病肥胖(ZDF)大鼠大血管炎症反应的作用机制。方法:15只雄性ZDF(fa/+)大鼠作为对照组;高脂饲料诱导成模的75只雄性ZDF(fa/fa)大鼠随机分为模型组,高、中、低剂量RSP组,以及二甲双胍组,每组15只。药物干预12周后,处死大鼠,分离血清,检测高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)和总胆固醇(TC)水平;ELISA法检测大鼠血清CD4、白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)含量;HE染色观察大鼠腹主动脉组织病理改变;免疫组化染色检测腹主动脉中单核细胞趋化蛋白1(MCP-1)蛋白表达;RT-qPCR检测大鼠腹主动脉中PI3K、Akt和NF-κB p65的mRNA表达;Western blot观察腹主动脉组织中PI3K、Akt、p-Akt、p-IκB和NF-κB p65蛋白水平。结果:与模型组相比,RSP显著降低糖尿病大鼠空腹血糖及LDL-C、TG和TC水平(P<0.05),升高HDL-C水平(P<0.05或P<0.01),显著降低血清炎症介质表达,IL-6、TNF-α和CD4水平显著下降(P<0.05或P<0.01),腹主动脉组织病理学损伤程度显著减轻,腹主动脉中PI3K、Akt和NF-κB p65的mRNA及蛋白水平,以及MCP-1、p-Akt和p-IκB蛋白水平均显著降低(P<0.05或P<0.01)。结论:RSP可降糖调脂并减轻糖尿病大鼠大血管炎症损伤,其机制可能与抑制PI3K-Akt/NF-κB信号通路活化、减轻炎症反应有关。 展开更多
关键词 大黄糖络丸 糖尿病大血管病变 ZDF大鼠 炎症 PI3K-Akt/NF-κB信号通路
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应用ARIMA模型对呼吸系统疾病月住院量及住院费用的预测 被引量:23
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作者 张越 王胜难 +1 位作者 刘媛 王伟炳 《中国卫生统计》 CSCD 北大核心 2015年第2期197-200,共4页
目的应用自回归移动平均模型(autoregressive integrated moving average model,ARIMA)分析和预测上海市居民呼吸系统疾病月住院量及住院费用情况。方法通过对2005-2011年呼吸系统疾病逐月住院人数与费用数据建立ARIMA模型,利用该模型预... 目的应用自回归移动平均模型(autoregressive integrated moving average model,ARIMA)分析和预测上海市居民呼吸系统疾病月住院量及住院费用情况。方法通过对2005-2011年呼吸系统疾病逐月住院人数与费用数据建立ARIMA模型,利用该模型预测2012年1-12月的呼吸系统疾病住院量与住院费用,用平均预测相对误差作为预测效果的评价指标。结果 ARIMA(0,1,1)(0,1,1)12与ARIMA(0,1,1)模型是上海市居民呼吸系统疾病月住院量及住院费用的最优拟合预测模型,用该模型进行回代预测,预测值与实际值吻合程度较高。结论 ARIMA模型较好地模拟了上海市居民呼吸系统疾病月住院量及住院费用在时间序列上的变化趋势,预测结果可为今后呼吸系统疾病的预防和控制提供理论支持。 展开更多
关键词 呼吸系统疾病 时间序列分析 ARIma模型 预测
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利用MAS技术培育水稻多抗、优质强恢复系桂恢663 被引量:10
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作者 刘驰 韦敏益 +7 位作者 秦钢 张月雄 罗同平 马增凤 岑贞陆 陈远孟 李振经 黄大辉 《西南农业学报》 CSCD 北大核心 2019年第2期225-231,共7页
【目的】培育新的兼抗稻瘟病、白叶枯病和细菌性条斑病,且米质较优的水稻强恢复系,为选育抗病、高产、优质的杂交稻组合提供良好的亲本材料。【方法】以抗稻瘟病品种合丰占为母本,与抗白叶枯病品系粤泰占杂交,通过分子标记辅助选择(MAS)... 【目的】培育新的兼抗稻瘟病、白叶枯病和细菌性条斑病,且米质较优的水稻强恢复系,为选育抗病、高产、优质的杂交稻组合提供良好的亲本材料。【方法】以抗稻瘟病品种合丰占为母本,与抗白叶枯病品系粤泰占杂交,通过分子标记辅助选择(MAS),获得多个抗病基因聚合的优良单株,再经过多代自交选育,并进行田间抗性及米质鉴定、农艺性状考察及恢复力测试。【结果】培育出聚合了抗稻瘟病基因Pi-ta、Pib、Pi54和抗白叶枯病兼抗细条病基因xa5的多抗、优质强恢复系桂恢663。桂恢663对白叶枯Ⅳ型菌和强毒Ⅴ型菌表现为抗,对广西细条病优势菌株JZ-8表现为抗,对14个稻瘟病菌株,有12个达到1级抗性。桂恢663除直链淀粉含量偏低外,其余6个主要米质指标均达到国标2级标准,其与丰田1A所配抗病、高产、优质组合丰田优663通过广西品种审定。桂恢663和丰田优663谷粒具有香味。【结论】桂恢663兼抗稻瘟病、白叶枯病和细条病,且恢复力强、米质较优具有香味,是组配抗病、高产、优质杂交组合的优良亲本,同时为水稻提供重要遗传基础材料。 展开更多
关键词 水稻 抗病性 米质 恢复系 分子标记辅助选择(maS)
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利用回交和MAS技术改良珍汕97B的白叶枯病抗性 被引量:11
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作者 林荔辉 陈志伟 +3 位作者 张积森 吴为人 周元昌 唐定中 《福建农林大学学报(自然科学版)》 CSCD 北大核心 2004年第3期280-283,共4页
以IRBB21为白叶枯抗病基因的供体亲本,珍汕97B为受体亲本,通过1次杂交、3次回交、1次自交,采用传统的回交育种和分子标记辅助选择技术相结合的方法获得了6个导入Xa21的珍汕97B导入系,其遗传背景恢复比例为92.8%-97.4%(平均为94.9%).
关键词 回交 maS技术 分子标记辅助选择 品种改良 育种 抗性 白叶枯病 水稻
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利用MAS技术改良四个水稻恢复系及其抗病性分析 被引量:9
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作者 周宇爝 邓其明 李平 《分子植物育种》 CAS CSCD 2008年第3期480-490,共11页
水稻白叶枯病作为世界范围内的水稻三大病害之一,给水稻的生产带来了严重的损失。培育抗病品种是解决水稻抗病性的主要措施。目前国内的杂交水稻携带的抗性基因普遍单一,长期大规模推广的情况下容易造成抗性的丧失从而引起某种病害的大... 水稻白叶枯病作为世界范围内的水稻三大病害之一,给水稻的生产带来了严重的损失。培育抗病品种是解决水稻抗病性的主要措施。目前国内的杂交水稻携带的抗性基因普遍单一,长期大规模推广的情况下容易造成抗性的丧失从而引起某种病害的大爆发。因此,拓宽抗谱,增强抗性并且抗性持久是今后水稻育种的主要方向之一。实验表明,将不同来源的抗性基因通过杂交或者转移聚合到同一单株中能够明显的增强抗性并且拓宽抗谱,这对培育广谱高抗的水稻来说无疑是一个很好的途径。本研究利用IRBB60(Xa-21和Xa-4)和WBB1(Xa-23)作为抗性基因供体,以宜恢1577、宜恢3551、盐恢559和明恢63等4个常用的水稻恢复系作为轮回亲本,通过3次回交和2次自交,在各个后代中分别用与三个目标基因Xa-23、Xa-21、Xa-4紧密连锁/共分离的标记RM206、pTA248、MP12在各个后代群体中进行选择并辅以接种验证,得到了抗性大幅度提高的改良后代。获得的改良后的宜恢1577、宜恢3551、盐恢559、明恢63双基因纯合累加系的抗病能力比不含任何抗性基因的对照株系大大加强,接种致病菌系P1后的病斑长度从分别从14.9cm、12.8cm、13.5cm、14.1cm下降到1.49cm、0.92cm、1.54cm、1.38cm;接种致病菌系P6后的病斑分别从14.8cm、13.2cm、13.6cm、14.8cm下降到1.47cm、1.12cm、1.33cm、1.71cm。并且对C1 ̄C7菌系的抗性也有了极大的提高。充分显示了多种抗性基因聚合后产生的强大抗性,也为以后生产中提供抗性优良的亲本提供了可能。 展开更多
关键词 水稻白叶枯病 抗性分析 抗病改良 分子标记辅助选择
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血管紧张素(1-7)/Mas——肺部疾病治疗的新靶点 被引量:3
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作者 刘玉静 李颖川 《上海交通大学学报(医学版)》 CAS CSCD 北大核心 2015年第9期1379-1383,共5页
肺组织是血管紧张素转化酶(ACE)表达和血管紧张素Ⅱ(AngⅡ)生成的主要场所。已有研究表明肾素—血管紧张素系统(RAS)参与了急性呼吸窘迫综合征、肺动脉高压、肺纤维化、哮喘及肺癌的发病过程。RAS内存在ACE/AngⅡ/血管紧张素Ⅱ1型受体(A... 肺组织是血管紧张素转化酶(ACE)表达和血管紧张素Ⅱ(AngⅡ)生成的主要场所。已有研究表明肾素—血管紧张素系统(RAS)参与了急性呼吸窘迫综合征、肺动脉高压、肺纤维化、哮喘及肺癌的发病过程。RAS内存在ACE/AngⅡ/血管紧张素Ⅱ1型受体(AT1R)和血管紧张素转化酶2(ACE2)/血管紧张素(1-7)[Ang-(1-7)]/Mas两大轴系。AngⅡ通过其特异性受体AT1R参与了多种肺部疾病的发生与进展,而Ang-(1-7)通过作用于其特异性受体Mas发挥对抗AngⅡ的作用。文章对Ang-(1-7)/Mas在几种常见肺部疾病中的保护性作用及其可能的分子机制进行综述。 展开更多
关键词 血管紧张素(1-7) maS 血管紧张素Ⅱ 肺疾病
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语音重复任务在轻度认知功能障碍检测中的应用
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作者 殷潇潇 王思文 +3 位作者 王贺 高琳琳 任智 王钦文 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2024年第4期247-251,共5页
轻度认知功能障碍(mild cognitive impairment,MCI)通常被视为痴呆的前驱阶段,其主要特征为认知功能轻度下降。研究表明,MCI患者中语言变化可能先于其他认知功能症状,这为早期识别和干预提供了机会。MCI患者语言特点包括语速、发音和语... 轻度认知功能障碍(mild cognitive impairment,MCI)通常被视为痴呆的前驱阶段,其主要特征为认知功能轻度下降。研究表明,MCI患者中语言变化可能先于其他认知功能症状,这为早期识别和干预提供了机会。MCI患者语言特点包括语速、发音和语调等异常。五个单词测验、数字延迟匹配测试和句子重复测试等语音重复任务,是评估MCI患者语言特点的有效方法,这些任务要求患者重复特定内容,分析重复准确性,从而评估其语言功能。机器学习和深度学习技术的应用,能自动提取语音重复任务数据中的MCI相关特征,提高诊断准确性。这些技术的结合应用有助于早期发现MCI,为及时干预提供依据。 展开更多
关键词 认知功能障碍 任务重复 阿尔茨海默病 语言 语音识别 机器学习 深度学习
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马云枝诊治运动神经元病经验介绍
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作者 史继鑫 张君君 《新中医》 CAS 2024年第12期204-208,共5页
介绍马云枝教授诊治运动神经元病的临床经验。马云枝教授认为,运动神经元病主要由先天禀赋不足,后天失养所致。其病位在肌肉筋脉,与脾胃、肝、肾相关,病性以虚证为多,虚实夹杂者亦不少见。诊治运动神经元病通过辨别疾病病程分期、脏腑... 介绍马云枝教授诊治运动神经元病的临床经验。马云枝教授认为,运动神经元病主要由先天禀赋不足,后天失养所致。其病位在肌肉筋脉,与脾胃、肝、肾相关,病性以虚证为多,虚实夹杂者亦不少见。诊治运动神经元病通过辨别疾病病程分期、脏腑病位、标本虚实、病情轻重,以及常证变证,进而分别从湿热、脾胃、肝肾及痰瘀诸方面对运动神经元病进行辨证论治,治法分别有清化湿热、通利筋脉,补脾益胃、健运升清,滋补肝肾、滋阴清热,温补脾肾、强壮筋骨,益气养营、活血化瘀。 展开更多
关键词 运动神经元病 湿热 脾胃 肝肾 痰瘀 马云枝
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糖尿病大血管病变临床诊断的研究进展
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作者 张世昭(综述) 吴红彦(审校) 《国际检验医学杂志》 CAS 2024年第18期2258-2263,共6页
糖尿病大血管病变作为糖尿病最主要的并发症之一,严重危害患者的生命健康。糖尿病大血管病变发展到后期往往不可逆,及时、准确的诊断至关重要。针对不同的病情采取适合的检查手段,有助于糖尿病大血管病变的早期筛查及预后监测,减少患者... 糖尿病大血管病变作为糖尿病最主要的并发症之一,严重危害患者的生命健康。糖尿病大血管病变发展到后期往往不可逆,及时、准确的诊断至关重要。针对不同的病情采取适合的检查手段,有助于糖尿病大血管病变的早期筛查及预后监测,减少患者经济负担,提高其生存质量。 展开更多
关键词 糖尿病大血管病变 影像学检查 实验室检查
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基于家庭医生巡诊的多元化健康干预对农村老年糖尿病患者大血管病变危险因素的影响
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作者 李振华 马秀君 孙晓伟 《中国初级卫生保健》 2024年第7期11-14,共4页
目的:探讨基于家庭医生巡诊的多元化健康干预对农村老年糖尿病患者大血管病变危险因素的影响。方法:收集2022年8—10月在上海市浦东新区祝桥社区卫生服务中心就诊的农村老年糖尿病患者100例,采用随机数字表法将其分为研究组(n=50)和对照... 目的:探讨基于家庭医生巡诊的多元化健康干预对农村老年糖尿病患者大血管病变危险因素的影响。方法:收集2022年8—10月在上海市浦东新区祝桥社区卫生服务中心就诊的农村老年糖尿病患者100例,采用随机数字表法将其分为研究组(n=50)和对照组(n=50)。给予研究组患者基于家庭医生巡诊的多元化健康干预;给予对照组患者常规的社区健康管理。干预前后比较两组患者大血管病变危险因素的相关指标和糖尿病自我管理行为量表得分。结果:干预1年后,对照组患者空腹血糖、血压较本组干预前有所下降,差异有统计学意义(P<0.05)。研究组患者空腹血糖、糖化血红蛋白、血脂、血压、体质指数(BMI)、腰围和糖尿病自我管理行为量表得分均优于本组干预前及对照组干预后,差异有统计学意义(P<0.05)。结论:基于家庭医生巡诊的多元化健康干预能有效改善农村老年糖尿病患者的自我管理行为,从而更好地控制血糖、血脂、血压和肥胖等大血管病变危险因素。 展开更多
关键词 家庭医生巡诊 多元化健康干预 糖尿病 大血管病变
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ADMA与糖尿病血管并发症的研究进展 被引量:9
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作者 杜美容 李元建 江俊麟 《中国动脉硬化杂志》 CAS 北大核心 2015年第8期845-850,共6页
非对称性二甲基精氨酸(ADMA)的蓄积不仅加速糖尿病的发生发展,还与糖尿病心脑血管疾病、糖尿病肾病和糖尿病视网膜病变等血管并发症密切相关。ADMA可通过抑制一氧化氮合酶(NOS)活性,减少NO合成,促使血管内皮功能受损,介导糖尿病血管疾... 非对称性二甲基精氨酸(ADMA)的蓄积不仅加速糖尿病的发生发展,还与糖尿病心脑血管疾病、糖尿病肾病和糖尿病视网膜病变等血管并发症密切相关。ADMA可通过抑制一氧化氮合酶(NOS)活性,减少NO合成,促使血管内皮功能受损,介导糖尿病血管疾病的发生发展。 展开更多
关键词 非对称二甲基精氨酸 糖尿病大血管病变 糖尿病微血管病变
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Ang-(1-7)及其Mas受体的研究进展 被引量:5
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作者 杜慧 缪朝玉 《第二军医大学学报》 CAS CSCD 北大核心 2011年第6期667-671,共5页
血管紧张素(angiotensin,Ang)-(1-7)是肾素-血管紧张素系统中除AngⅡ以外,另一种重要的调节肽,主要作用于Mas受体发挥作用。Ang-(1-7)通过与其Mas受体的结合,发挥血管扩张和抗细胞增殖等作用,抗衡AngⅡ与其AT1受体结合产生的血管收缩、... 血管紧张素(angiotensin,Ang)-(1-7)是肾素-血管紧张素系统中除AngⅡ以外,另一种重要的调节肽,主要作用于Mas受体发挥作用。Ang-(1-7)通过与其Mas受体的结合,发挥血管扩张和抗细胞增殖等作用,抗衡AngⅡ与其AT1受体结合产生的血管收缩、血压升高、细胞增殖、尿钠潴留等作用。近年来研究发现,Ang-(1-7)及其Mas受体在局部组织生理功能中具有积极作用,在多种疾病病理过程中具有保护作用。 展开更多
关键词 血管紧张素类 maS受体 组织 疾病
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