BACKGROUND Jaffe-Campanacci syndrome(JCS)is a very rare syndrome.The treatment of JCS is more conservative,and most authors recommend that no surgery should be done in asymptomatic patients.The conventional concept ho...BACKGROUND Jaffe-Campanacci syndrome(JCS)is a very rare syndrome.The treatment of JCS is more conservative,and most authors recommend that no surgery should be done in asymptomatic patients.The conventional concept holds that the natural course of non-ossifying fibromas(NOFs)grows with the development of bones,and the osteolytic region gradually stops expanding and self-healing through bone ossifying around the lesion and ossification within the lesion.But in this case,the bone lesions were potentially biologically aggressive,which led to severe limb deformities and pain.CASE SUMMARY We present the case of a 5-year-old girl with JCS presenting with not only NOF sand café-au-lait macules,but also showed features not mentioned before,severe limb pain,and at last resulted in amputation.She was admitted to our hospital after presenting with claudication and mild pain over her right thigh,which worsened when stretching or being touched.Skin examination revealed multiple café-au-lait macules on the neck,arm,axilla,and torso,including the nipples and perineum.Radiographs revealed multiple lytic lesions in the proximal part of the right humerus,distal part of the right clavicle,proximal and distal parts of the right femur,and proximal parts of the right tibia and fibula.Curettage and biopsy were performed on the distal part of the right femur.At the age of 7,the girl was re-admitted to our hospital for a pathological fracture in the middle in the right femur and underwent Intralesional excision,internal fixation,bone grafting,and spica casting.At the age of 10,the girl came to our hospital again for severe pain of the right leg.Amputation from the middle level of the right femur was performed.We present the case of a 5-year-old girl with JCS presenting with not only NOFs and café-au-lait macules,but also showed features not mentioned before,severe limb pain,and at last resulted in amputation.She was admitted to our hospital after presenting with claudication and mild pain over her right thigh,which worsened when stretching or being touched.Skin examination revealed multiple café-au-lait macules on the neck,arm,armpit,and torso,including the nipples and perineum.Radiographs revealed multiple lytic lesions in the proximal part of the right humerus,distal part of the right clavicle,proximal and distal parts of the right femur,and proximal parts of the right tibia and fibula.Curettage and biopsy were performed on the distal part of the right femur.At the age of 7,the girl was re-admitted to our hospital for a pathological fracture in the middle in the right femur and underwent Intralesional excision,internal fixation,bone grafting,and spica casting.At the age of 10,the girl came to our hospital again for severe pain of the right leg.Amputation from the middle level of the right femur was performed.CONCLUSION In our opinion,education on preventing pathological fractures and explaining the consequent serious consequences to the parents is a matter of prime significance.At the same time,prophylactic treatment(restricted exercise,support,or surgery)is also considerable for JSC.展开更多
为了解和对比近些年来国内外福寿螺领域研究趋势和热点内容,本文以中国知网(CNKI)和Web of Science(WOS)核心文集TM的科学引文索引扩展版SCI-E数据库为数据来源,运用CiteSpace和VOSviewer软件对2009—2021年福寿螺属中入侵能力最强、入...为了解和对比近些年来国内外福寿螺领域研究趋势和热点内容,本文以中国知网(CNKI)和Web of Science(WOS)核心文集TM的科学引文索引扩展版SCI-E数据库为数据来源,运用CiteSpace和VOSviewer软件对2009—2021年福寿螺属中入侵能力最强、入侵范围最广的两种物种(Pomacea canaliculata和Pomacea maculate)研究领域的813篇相关文献(中文文献398篇,英文文献415篇)进行年度发文量、作者和国家合作网络、关键词共现、聚类和突现以及文献共被引分析.结果显示:自2009年来,国际上福寿螺领域研究热度持续,发文总体呈波浪式增长;国内研究热度有所减缓,发文总体呈下降趋势.在该领域内,国内发文地区主要集中在我国长江中下游以南及沿海地区;国际上,中国、阿根廷、美国、巴西是主要的发文国家.我国发文量位居第一,与阿根廷、美国构成该领域研究的主要国家力量.国家间合作密切,合作网络覆盖亚洲、南美、北美、西欧和澳大利亚各大区域.国内外近年来在该领域的研究热点有所不同,广州管圆线虫病、福寿螺的抗逆性和防治是我国近些年甚至未来很长一段时间研究关注的重点;在世界范围内,近年来的研究热点则是个体识别与鉴定、系统发育分析、物种地理起源和进化方面.此外,蛋白质组、卵、渐渗杂交福寿螺的危害和可利用化是目前国际在该领域的研究前沿.展开更多
BACKGROUND Granuloma annulare(GA)has diverse clinical manifestations including papules,plaques,and nodules on the extremities that are skin-colored,pink,or purple.Approximately 15%of all GA cases are considered genera...BACKGROUND Granuloma annulare(GA)has diverse clinical manifestations including papules,plaques,and nodules on the extremities that are skin-colored,pink,or purple.Approximately 15%of all GA cases are considered generalized GA.CASE SUMMARY Herein,we describe the case of a pediatric patient who initially presented with papules and later developed generalized atrophic macules.Upon examination,two different morphologic lesions were histopathologically confirmed:Epithelioid nodular GA and scattered histiocytic infiltrative GA.This patient exhibited rare clinical manifestations that differed throughout the course of the disease.The varying histopathological types and clinical manifestations of GA may be linked to the different stages of the disease.CONCLUSION This rare case demonstrates the different histopathological features of different stages and clinical manifestations of granuloma annulare in an infant.展开更多
D. maculates is a kind of specialized Schizothoracinae fish has been locally listed as a protected animal in Xinjiang Province, China. Ill River located in north of Tianshan Mountain and Tarim River located in north o...D. maculates is a kind of specialized Schizothoracinae fish has been locally listed as a protected animal in Xinjiang Province, China. Ill River located in north of Tianshan Mountain and Tarim River located in north of Qinghai-Tibetan Plateau were two main distribution areas of this fish. To investigate the genetic diversity and genetic structure ofD. maculates, four populations from Tarim River system and two populations from Ili River system were collected in this study. A 570-bp sequence of the control region was obtained for 105 specimens. Twenty-four haplotypes were detected from six populations, only Kunes River population and Kashi River population shared haplotypes with each other. For all the populations examined, the haplotype diversity （h） was 0.904 8±0.012 6, nucleotide diversity （n） was 0.027 9±0.013 9, and the average number of pairwise nucleotide differences （k） was 15.878 3±7.139 1. The analysis of molecular variance （AMOVA） showed that 86.31% of the total genetic variation was apportioned among populations, and the variation within sampled populations was 13.69%. Genetic differences among sampled populations were highly significant. Fst statistical test indicated that all populations were significantly divergent from each other （P〈0.01）. The largest Fst value was between Yurungkash River population and Muzat River population, while the smallest fst value was between Kunes River population and Kashi River population. NJ phylogenetic tree of D-loop haplotypes revealed two main clades. The neutrality test and mismatch distribution analysis suggested that the fish had went through a recent population expansion. The uplift of Tianshan Mountain and movement of Qinghai-Tibetan Plateau might contribute to the wide genetic divergence of D. maculates in northwest China.展开更多
Otolith shape is species-specific in fish.In this study,161 samples of Trumpeter sillago Sillago maculata and 164 of Silver sillago Sillago sihama were collected from Beibu Gulf in July 2009.The main objective of this...Otolith shape is species-specific in fish.In this study,161 samples of Trumpeter sillago Sillago maculata and 164 of Silver sillago Sillago sihama were collected from Beibu Gulf in July 2009.The main objective of this study was to use morphological variables and Fourier harmonics to describe otolith characteristics and use discriminant analyses to separate the two species.Otoliths were measured by traditional one and two dimensional measures(otolith length,width,diameters,area,perimeter,rectangularity and circularity),as well as by Fourier analysis to capture the finer regions of the otolith.Analysis of covariance(ANCOVA) showed that there was significant correlation between morphological variables(diameter,perimeter,otolith length,otolith width,otolith area,density,harmonics 3,harmonics 4,harmonics 5,harmonics 13,harmonics 15,and harmonics 16) and body length.To minimize size effects on the morphological variables between species,only fish with a body length between 90 and 140 mm were included in the data analysis and the variables which had significant relation with body length were transformed using the residual.The result showed that the accuracy of discriminant analysis was 97.8% and 100% for Trumpeter sillago and Silver sillago,respectively.This high accuracy indicated that otolith shape was described accurately by morphological variables and Fourier harmonics,and discriminant analysis was an effective way to identify and separate the two species.展开更多
Objective:To investigate the bioecological relationship between Chagas disease peridomestic vectors and reptiles as source of feeding.Methods:In a three-story building,triatomines were captured by direct search and el...Objective:To investigate the bioecological relationship between Chagas disease peridomestic vectors and reptiles as source of feeding.Methods:In a three-story building,triatomines were captured by direct search and electric vacuum cleaner search in and outside the building.Then,age structure of the captured Triatoma maculata(T.maculata) were identified and recorded.Reptiles living in sympatric with the triatomines were also searched.Results:T.maculata were found living sympatric with geckos(Thecadactylus rapicauda) and they bit residents of the apartment building in study.A total of 1 448 individuals of T.maculata were captured within three days,of which 74.2%(1 074 eggs) were eggs,21.5%were nymphs at different stages,and 4.3%were adults.Conclusions:The association of T.maculata and T.rapicauda is an effective strategy of colonizing dwellings located in the vicinity of the habitat where both species are present;and therefore,could have implications of high importance in the intradomiciliary transmission of Chagas disease.展开更多
We report the case of a 10-year-old girl with congenital complete heterochromia iridis and segmental pigmentation disorder in its hyperpigmented form. We have found no publication that mentions the combination of thes...We report the case of a 10-year-old girl with congenital complete heterochromia iridis and segmental pigmentation disorder in its hyperpigmented form. We have found no publication that mentions the combination of these 2 disorders.展开更多
Introduction: Xeroderma pigmentosum is an autosomal recessive disease with sun sensitivity, photophobia, early onset of freckling, and subsequent neoplastic changes on sun-exposed surfaces. There is cellular hypersens...Introduction: Xeroderma pigmentosum is an autosomal recessive disease with sun sensitivity, photophobia, early onset of freckling, and subsequent neoplastic changes on sun-exposed surfaces. There is cellular hypersensitivity to UV radiation and to certain chemicals in association with abnormal DNA repair. Patients with defective DNA nucleotide excision repair (NER) have defects in one of seven NER genes;xeroderma pigmentosum variants have normal NER and a defect in a polymerase gene. Study design: This is a case presentation of five patients with the features of xeroderma pigmentosum, aged 48, 26, 15, 14 and 8 years. The first and last patients were males. Each of the first four patients presented with areas of hyper- and hypo-pigmentation over sun exposed body surfaces. Each of them had a minimum of two cutaneous malignancies, distributed on the upper chest, face or scalp. The fifth patient had skin atrophy, with mottled hyperpigmentation and hypopigmentation but had no malignant lesions. Result: The first, second and fourth patients had their lesions surgically excised and the defects were skin grafted. The third patient was treated with radiotherapy. All the lesions were confirmed histologically as squamous cell carcinoma. No recurrence has been observed. Conclusion: Xeroderma pigmentosum in Ghanaians presents with squamous cell carcinoma involving the head, neck and upper trunk. A minimum period of exposure to UV radiation, not precisely known, is required for the development of the lesions. Education on sun avoidance and protective clothing is necessary to prevent morbidity and mortality.展开更多
Objective:Q-switched lasers,including 1064-nm Nd:YAG nansecond laser (QSNYL),755-nm alexandrite nanosecond laser (QSAL),and 694-nm nanosecond ruby laser (QSRL),are clinically available for the treatment of acquired bi...Objective:Q-switched lasers,including 1064-nm Nd:YAG nansecond laser (QSNYL),755-nm alexandrite nanosecond laser (QSAL),and 694-nm nanosecond ruby laser (QSRL),are clinically available for the treatment of acquired bilateral nevus of Ota-like macules (ABNOM).However,no reliable evidence from large-scale comparative studies identifies which type of laser works best.This study aims to determine the differences in the effectiveness,complications,and risk factors of QSNYL,QSAL,and QSRL in the treatment of ABNOM,further to provide evidence for clinician to make optimal choice according to the condition of patients.Methods:We collected the data from 685 ABNOM patients,including clinical features,medical treatments,and follow-up,since 1999 to 2014.The Kruskal-Wallis test was used to compare therapeutic differences between the three groups.The risk factors were analyzed using univariate analysis (x2 test) and multivariate logistic regression analysis.Results:The overall treatment efficiency of the QSNYL group (52.5%) and QSAL group (51.9%) was higher than that of the QSRL group (39.5%) (x2 =17.468,P < 0.001).The onset time of the QSRL and QSAL groups was shorter than that of the QSNYL group.The factors influencing efficacy in the QSNYL group were age at first treatment,number of treatments,coexistence with melesma,and the presence of hyperpigmentation;in the QSAL group was the number of treatments;and in the QSRL group was the number of treatments and hyperpigmentation.The prevalence of hyperpigrnentation in the QSNYL group (30.5%) and the QSAL group (27.5%) was lower than that of the QSRL group (47.3%) (X2=6.576,P<0.001).Concluslon:The QSNYL,QSAL,and QSRL are all effective and safe treatments for ABNOM.Considering the overall efficacy,duration of treatment,side effects,and risk factors,the QSAL is an optimal choice for ABNOM treatment.展开更多
文摘BACKGROUND Jaffe-Campanacci syndrome(JCS)is a very rare syndrome.The treatment of JCS is more conservative,and most authors recommend that no surgery should be done in asymptomatic patients.The conventional concept holds that the natural course of non-ossifying fibromas(NOFs)grows with the development of bones,and the osteolytic region gradually stops expanding and self-healing through bone ossifying around the lesion and ossification within the lesion.But in this case,the bone lesions were potentially biologically aggressive,which led to severe limb deformities and pain.CASE SUMMARY We present the case of a 5-year-old girl with JCS presenting with not only NOF sand café-au-lait macules,but also showed features not mentioned before,severe limb pain,and at last resulted in amputation.She was admitted to our hospital after presenting with claudication and mild pain over her right thigh,which worsened when stretching or being touched.Skin examination revealed multiple café-au-lait macules on the neck,arm,axilla,and torso,including the nipples and perineum.Radiographs revealed multiple lytic lesions in the proximal part of the right humerus,distal part of the right clavicle,proximal and distal parts of the right femur,and proximal parts of the right tibia and fibula.Curettage and biopsy were performed on the distal part of the right femur.At the age of 7,the girl was re-admitted to our hospital for a pathological fracture in the middle in the right femur and underwent Intralesional excision,internal fixation,bone grafting,and spica casting.At the age of 10,the girl came to our hospital again for severe pain of the right leg.Amputation from the middle level of the right femur was performed.We present the case of a 5-year-old girl with JCS presenting with not only NOFs and café-au-lait macules,but also showed features not mentioned before,severe limb pain,and at last resulted in amputation.She was admitted to our hospital after presenting with claudication and mild pain over her right thigh,which worsened when stretching or being touched.Skin examination revealed multiple café-au-lait macules on the neck,arm,armpit,and torso,including the nipples and perineum.Radiographs revealed multiple lytic lesions in the proximal part of the right humerus,distal part of the right clavicle,proximal and distal parts of the right femur,and proximal parts of the right tibia and fibula.Curettage and biopsy were performed on the distal part of the right femur.At the age of 7,the girl was re-admitted to our hospital for a pathological fracture in the middle in the right femur and underwent Intralesional excision,internal fixation,bone grafting,and spica casting.At the age of 10,the girl came to our hospital again for severe pain of the right leg.Amputation from the middle level of the right femur was performed.CONCLUSION In our opinion,education on preventing pathological fractures and explaining the consequent serious consequences to the parents is a matter of prime significance.At the same time,prophylactic treatment(restricted exercise,support,or surgery)is also considerable for JSC.
文摘为了解和对比近些年来国内外福寿螺领域研究趋势和热点内容,本文以中国知网(CNKI)和Web of Science(WOS)核心文集TM的科学引文索引扩展版SCI-E数据库为数据来源,运用CiteSpace和VOSviewer软件对2009—2021年福寿螺属中入侵能力最强、入侵范围最广的两种物种(Pomacea canaliculata和Pomacea maculate)研究领域的813篇相关文献(中文文献398篇,英文文献415篇)进行年度发文量、作者和国家合作网络、关键词共现、聚类和突现以及文献共被引分析.结果显示:自2009年来,国际上福寿螺领域研究热度持续,发文总体呈波浪式增长;国内研究热度有所减缓,发文总体呈下降趋势.在该领域内,国内发文地区主要集中在我国长江中下游以南及沿海地区;国际上,中国、阿根廷、美国、巴西是主要的发文国家.我国发文量位居第一,与阿根廷、美国构成该领域研究的主要国家力量.国家间合作密切,合作网络覆盖亚洲、南美、北美、西欧和澳大利亚各大区域.国内外近年来在该领域的研究热点有所不同,广州管圆线虫病、福寿螺的抗逆性和防治是我国近些年甚至未来很长一段时间研究关注的重点;在世界范围内,近年来的研究热点则是个体识别与鉴定、系统发育分析、物种地理起源和进化方面.此外,蛋白质组、卵、渐渗杂交福寿螺的危害和可利用化是目前国际在该领域的研究前沿.
文摘BACKGROUND Granuloma annulare(GA)has diverse clinical manifestations including papules,plaques,and nodules on the extremities that are skin-colored,pink,or purple.Approximately 15%of all GA cases are considered generalized GA.CASE SUMMARY Herein,we describe the case of a pediatric patient who initially presented with papules and later developed generalized atrophic macules.Upon examination,two different morphologic lesions were histopathologically confirmed:Epithelioid nodular GA and scattered histiocytic infiltrative GA.This patient exhibited rare clinical manifestations that differed throughout the course of the disease.The varying histopathological types and clinical manifestations of GA may be linked to the different stages of the disease.CONCLUSION This rare case demonstrates the different histopathological features of different stages and clinical manifestations of granuloma annulare in an infant.
基金Supported by the National Natural Science Foundation of China(No.31360637)the Natural Science Foundation of Xinjiang Province,China(No.2012211B57)the State Special Funds for the Foundation Work of Science and Technology(No.2012FY112700)
文摘D. maculates is a kind of specialized Schizothoracinae fish has been locally listed as a protected animal in Xinjiang Province, China. Ill River located in north of Tianshan Mountain and Tarim River located in north of Qinghai-Tibetan Plateau were two main distribution areas of this fish. To investigate the genetic diversity and genetic structure ofD. maculates, four populations from Tarim River system and two populations from Ili River system were collected in this study. A 570-bp sequence of the control region was obtained for 105 specimens. Twenty-four haplotypes were detected from six populations, only Kunes River population and Kashi River population shared haplotypes with each other. For all the populations examined, the haplotype diversity （h） was 0.904 8±0.012 6, nucleotide diversity （n） was 0.027 9±0.013 9, and the average number of pairwise nucleotide differences （k） was 15.878 3±7.139 1. The analysis of molecular variance （AMOVA） showed that 86.31% of the total genetic variation was apportioned among populations, and the variation within sampled populations was 13.69%. Genetic differences among sampled populations were highly significant. Fst statistical test indicated that all populations were significantly divergent from each other （P〈0.01）. The largest Fst value was between Yurungkash River population and Muzat River population, while the smallest fst value was between Kunes River population and Kashi River population. NJ phylogenetic tree of D-loop haplotypes revealed two main clades. The neutrality test and mismatch distribution analysis suggested that the fish had went through a recent population expansion. The uplift of Tianshan Mountain and movement of Qinghai-Tibetan Plateau might contribute to the wide genetic divergence of D. maculates in northwest China.
基金supported by the Natural Science Foundation of Shandong Province (Y2008D21)the National Basic Research Program of China (973 Program, No.2005CB422306)
文摘Otolith shape is species-specific in fish.In this study,161 samples of Trumpeter sillago Sillago maculata and 164 of Silver sillago Sillago sihama were collected from Beibu Gulf in July 2009.The main objective of this study was to use morphological variables and Fourier harmonics to describe otolith characteristics and use discriminant analyses to separate the two species.Otoliths were measured by traditional one and two dimensional measures(otolith length,width,diameters,area,perimeter,rectangularity and circularity),as well as by Fourier analysis to capture the finer regions of the otolith.Analysis of covariance(ANCOVA) showed that there was significant correlation between morphological variables(diameter,perimeter,otolith length,otolith width,otolith area,density,harmonics 3,harmonics 4,harmonics 5,harmonics 13,harmonics 15,and harmonics 16) and body length.To minimize size effects on the morphological variables between species,only fish with a body length between 90 and 140 mm were included in the data analysis and the variables which had significant relation with body length were transformed using the residual.The result showed that the accuracy of discriminant analysis was 97.8% and 100% for Trumpeter sillago and Silver sillago,respectively.This high accuracy indicated that otolith shape was described accurately by morphological variables and Fourier harmonics,and discriminant analysis was an effective way to identify and separate the two species.
基金Supported by Proyecto Control de Vectores IMT-UCV
文摘Objective:To investigate the bioecological relationship between Chagas disease peridomestic vectors and reptiles as source of feeding.Methods:In a three-story building,triatomines were captured by direct search and electric vacuum cleaner search in and outside the building.Then,age structure of the captured Triatoma maculata(T.maculata) were identified and recorded.Reptiles living in sympatric with the triatomines were also searched.Results:T.maculata were found living sympatric with geckos(Thecadactylus rapicauda) and they bit residents of the apartment building in study.A total of 1 448 individuals of T.maculata were captured within three days,of which 74.2%(1 074 eggs) were eggs,21.5%were nymphs at different stages,and 4.3%were adults.Conclusions:The association of T.maculata and T.rapicauda is an effective strategy of colonizing dwellings located in the vicinity of the habitat where both species are present;and therefore,could have implications of high importance in the intradomiciliary transmission of Chagas disease.
文摘We report the case of a 10-year-old girl with congenital complete heterochromia iridis and segmental pigmentation disorder in its hyperpigmented form. We have found no publication that mentions the combination of these 2 disorders.
文摘Introduction: Xeroderma pigmentosum is an autosomal recessive disease with sun sensitivity, photophobia, early onset of freckling, and subsequent neoplastic changes on sun-exposed surfaces. There is cellular hypersensitivity to UV radiation and to certain chemicals in association with abnormal DNA repair. Patients with defective DNA nucleotide excision repair (NER) have defects in one of seven NER genes;xeroderma pigmentosum variants have normal NER and a defect in a polymerase gene. Study design: This is a case presentation of five patients with the features of xeroderma pigmentosum, aged 48, 26, 15, 14 and 8 years. The first and last patients were males. Each of the first four patients presented with areas of hyper- and hypo-pigmentation over sun exposed body surfaces. Each of them had a minimum of two cutaneous malignancies, distributed on the upper chest, face or scalp. The fifth patient had skin atrophy, with mottled hyperpigmentation and hypopigmentation but had no malignant lesions. Result: The first, second and fourth patients had their lesions surgically excised and the defects were skin grafted. The third patient was treated with radiotherapy. All the lesions were confirmed histologically as squamous cell carcinoma. No recurrence has been observed. Conclusion: Xeroderma pigmentosum in Ghanaians presents with squamous cell carcinoma involving the head, neck and upper trunk. A minimum period of exposure to UV radiation, not precisely known, is required for the development of the lesions. Education on sun avoidance and protective clothing is necessary to prevent morbidity and mortality.
基金supported by grants from National Nature Science Foundation of China(No.81502739)Jiang Su National Nature Science Foundation(No.BK20150068)Medical Science and Technology Innovation Project of Chinese Academy of Medical Sciences(No.CIFMS-2017-I2M-1-017)
文摘Objective:Q-switched lasers,including 1064-nm Nd:YAG nansecond laser (QSNYL),755-nm alexandrite nanosecond laser (QSAL),and 694-nm nanosecond ruby laser (QSRL),are clinically available for the treatment of acquired bilateral nevus of Ota-like macules (ABNOM).However,no reliable evidence from large-scale comparative studies identifies which type of laser works best.This study aims to determine the differences in the effectiveness,complications,and risk factors of QSNYL,QSAL,and QSRL in the treatment of ABNOM,further to provide evidence for clinician to make optimal choice according to the condition of patients.Methods:We collected the data from 685 ABNOM patients,including clinical features,medical treatments,and follow-up,since 1999 to 2014.The Kruskal-Wallis test was used to compare therapeutic differences between the three groups.The risk factors were analyzed using univariate analysis (x2 test) and multivariate logistic regression analysis.Results:The overall treatment efficiency of the QSNYL group (52.5%) and QSAL group (51.9%) was higher than that of the QSRL group (39.5%) (x2 =17.468,P < 0.001).The onset time of the QSRL and QSAL groups was shorter than that of the QSNYL group.The factors influencing efficacy in the QSNYL group were age at first treatment,number of treatments,coexistence with melesma,and the presence of hyperpigmentation;in the QSAL group was the number of treatments;and in the QSRL group was the number of treatments and hyperpigmentation.The prevalence of hyperpigrnentation in the QSNYL group (30.5%) and the QSAL group (27.5%) was lower than that of the QSRL group (47.3%) (X2=6.576,P<0.001).Concluslon:The QSNYL,QSAL,and QSRL are all effective and safe treatments for ABNOM.Considering the overall efficacy,duration of treatment,side effects,and risk factors,the QSAL is an optimal choice for ABNOM treatment.
