When normal, Lear can not even distinguish flattery and pat answers from sincerity and true love. While considered as insane, he learns to take care of the wretched and is able to discover the truth in life. The key c...When normal, Lear can not even distinguish flattery and pat answers from sincerity and true love. While considered as insane, he learns to take care of the wretched and is able to discover the truth in life. The key concept of anti-logo-centrism in deconstructive criticism provokes us to reconsider the boundary between madness and reason, and traditional Western philosophical ideas, thus enabling us to appreciate the despised madness in King Lear from the perspective of philosophy.展开更多
The role of madness has been an unexcavated part in studies of Foucault on transgression,especially with literary studies.This paper considers madness as the presence of transgression,and gives an account of madness f...The role of madness has been an unexcavated part in studies of Foucault on transgression,especially with literary studies.This paper considers madness as the presence of transgression,and gives an account of madness from two different perspectives:tragic experience and critical consciousness.Madness as a tragic experience provides Foucault a way of transgressing death which is a limit that cannot be transcended;madness as a critical consciousness helps Foucault conceptualize the relation between reason and madness.The image of madmen in literary works can be recognized as the most typical embodiment of the connection between madness and transgression.Rather than aiming at a detailed explanation of Foucault’s understanding of madness,it attaches vital importance that how madness as a tragic experience and a critical consciousness becomes the presence of transgression.展开更多
Shakespeare’s A Midsummer Night’s Dream is a play of love in which Shakespeare depicts a vivid picture of the madness and irrationality in romantic love.Yet Shakespeare entitles this play"a dream"and concl...Shakespeare’s A Midsummer Night’s Dream is a play of love in which Shakespeare depicts a vivid picture of the madness and irrationality in romantic love.Yet Shakespeare entitles this play"a dream"and concludes the play with a happy ending of marriage for all lovers.Shakespeare thus clearly views romantic love as an inevitable but short episode of life,an adolescent dream that should finally come to an end with the lovers’marriage which signifies their attainment of maturity and brings them back to reason and reality.展开更多
Big-hearted Chinese entrepreneur cherishes the spotlight HE isn’t as widely known as philanthropist heavyweights Bill Gates and Warren Buffett, but Chinese tycoon Chen Guangbiao is no stranger to publicity. Bucking t...Big-hearted Chinese entrepreneur cherishes the spotlight HE isn’t as widely known as philanthropist heavyweights Bill Gates and Warren Buffett, but Chinese tycoon Chen Guangbiao is no stranger to publicity. Bucking the Chinese tradition of remaining low-key when making donations, Chen widely publicizes every展开更多
Pyrus pyrifolia Nakai‘Whangkeumbae'is a sand pear fruit with excellent nutritional quality and taste.However,the industrial development of pear fruit is significantly limited by its short shelf life.Salicylic aci...Pyrus pyrifolia Nakai‘Whangkeumbae'is a sand pear fruit with excellent nutritional quality and taste.However,the industrial development of pear fruit is significantly limited by its short shelf life.Salicylic acid(SA),a well-known phytohormone,can delay fruit senescence and improve shelf life.However,the mechanism by which SA regulates CONSTANS-LIKE genes(COLs)during fruit senescence and the role of COL genes in mediating fruit senescence in sand pear are poorly understood.In this study,22 COL genes were identified in sand pear,including four COLs(Pp COL8,Pp COL9a,Pp COL9b,and Pp COL14)identified via transcriptome analysis and 18 COLs through genome-wide analysis.These COL genes were divided into three subgroups according to the structural domains of the COL protein.Pp COL8,with two B-box motifs and one CCT domain,belonged to the first subgroup.In contrast,the other three Pp COLs,Pp COL9a,Pp COL9b,and Pp COL14,with similar conserved protein domains and gene structures,were assigned to the third subgroup.The four COLs showed different expression patterns in pear tissues and were preferentially expressed at the early stage of fruit development.Moreover,the expression of Pp COL8 was inhibited by exogenous SA treatment,while SA up-regulated the expression of Pp COL9a and Pp COL9b.Interestingly,Pp COL8 interacts with Pp MADS,a MADS-box protein preferentially expressed in fruit,and SA up-regulated its expression.While the production of ethylene and the content of malondialdehyde(MDA)were increased in Pp COL8-overexpression sand pear fruit,the antioxidant enzyme(POD and SOD)activity and the expression of Pp POD1 and Pp SOD1 in the sand pear fruits were down-regulated,which showed that Pp COL8 promoted sand pear fruit senescence.In contrast,the corresponding changes were the opposite in Pp MADS-overexpression sand pear fruits,suggesting that Pp MADS delayed sand pear fruit senescence.The co-transformation of Pp COL8 and Pp MADS also delayed sand pear fruit senescence.The results of this study revealed that Pp COL8 can play a key role in pear fruit senescence by interacting with Pp MADS through the SA signaling pathway.展开更多
Anew survey has come out that reveals Chinese people are seriously addicted to their phones.Surprised?We didn't think so.Reports have surfaced in recent years showing a disturbing trend in how much peo・pie use the...Anew survey has come out that reveals Chinese people are seriously addicted to their phones.Surprised?We didn't think so.Reports have surfaced in recent years showing a disturbing trend in how much peo・pie use their phones on a daily basis,and it doesn't seem to be improving anytime soon.China Youth Dailys survey center wenjuan.展开更多
Background:Colon adenocarcinoma(COAD)is the second leading cause of cancer death worldwide thus,identification of COAD biomarkers is critical.Mitotic Arrest Deficient 2 Like 2(MAD2L2)is a key factor in mammalian DNA d...Background:Colon adenocarcinoma(COAD)is the second leading cause of cancer death worldwide thus,identification of COAD biomarkers is critical.Mitotic Arrest Deficient 2 Like 2(MAD2L2)is a key factor in mammalian DNA damage repair and is highly expressed in many malignant tumors.This is a comprehensive study of MAD2L2 expression,its diagnostic value,prognostic analysis,potential biological function,and impact on the immune system of patients with COAD.Methods:Gene expression,clinical relevance,prognostic analysis,diagnostic value,GO/KEGG cluster analysis,data obtained from TCGA,and bioinformatics statistical analysis were performed using the R package.Immune responses to MAD2L2 expression in COAD were analyzed using TIMER.The expression of MAD2L2 in HCT116 cells induced by the inflammatory factor TNF-αwas detected using Western blot.Results:Our results underscore the clinical diagnostic value and potential biological significance of MAD2L2 in patients with COAD.A high level of MAD2L2 expression has been found in COAD and correlated with tumor status and colon polyps.ROC curve analysis showed that MAD2L2 expression has high diagnostic value in COAD.Analysis of immune infiltration results showed that MAD2L2 expression was positively correlated with neutrophil levels.The western blot results demonstrated that MAD2L2 was dose-dependently present with TNF-α.GO/KEGG revealed that MAD2L2 overexpressed and coexpressed genes were mostly involved in biological functions,including hypoxia response,response to reduced oxygen levels,mitochondrial translation elongation,and other processes.Conclusion:MAD2L2 as a new COAD biomarker contributes to our understanding of how alterations in gene expression and the immunological environment contribute to the development of colon cancer.Following further investigation,MAD2L2 may prove to be a viable target factor for clinical diagnosis and therapy of COAD.展开更多
The current study proposes a novel technique for feature selection by inculcating robustness in the conventional Signal to noise Ratio(SNR).The proposed method utilizes the robust measures of location i.e.,the“Median...The current study proposes a novel technique for feature selection by inculcating robustness in the conventional Signal to noise Ratio(SNR).The proposed method utilizes the robust measures of location i.e.,the“Median”as well as the measures of variation i.e.,“Median absolute deviation(MAD)and Interquartile range(IQR)”in the SNR.By this way,two independent robust signal-to-noise ratios have been proposed.The proposed method selects the most informative genes/features by combining the minimum subset of genes or features obtained via the greedy search approach with top-ranked genes selected through the robust signal-to-noise ratio(RSNR).The results obtained via the proposed method are compared with wellknown gene/feature selection methods on the basis of performance metric i.e.,classification error rate.A total of 5 gene expression datasets have been used in this study.Different subsets of informative genes are selected by the proposed and all the other methods included in the study,and their efficacy in terms of classification is investigated by using the classifier models such as support vector machine(SVM),Random forest(RF)and k-nearest neighbors(k-NN).The results of the analysis reveal that the proposed method(RSNR)produces minimum error rates than all the other competing feature selection methods in majority of the cases.For further assessment of the method,a detailed simulation study is also conducted.展开更多
A new prediction method based on the nonlinear autoregressive model is proposed to improve the accuracy of medium-term and long-term predictions of Satellite Clock Bias(SCB).Forecast experiments for three time periods...A new prediction method based on the nonlinear autoregressive model is proposed to improve the accuracy of medium-term and long-term predictions of Satellite Clock Bias(SCB).Forecast experiments for three time periods were implemented based on the precision SCB published on the International GNSS Server(IGS)server.The results show that the medium-term and long-term prediction accuracy of the proposed approach is significantly better compared to other traditional models,with the training time being much shorter than the wavelet neural network model.展开更多
文摘When normal, Lear can not even distinguish flattery and pat answers from sincerity and true love. While considered as insane, he learns to take care of the wretched and is able to discover the truth in life. The key concept of anti-logo-centrism in deconstructive criticism provokes us to reconsider the boundary between madness and reason, and traditional Western philosophical ideas, thus enabling us to appreciate the despised madness in King Lear from the perspective of philosophy.
文摘The role of madness has been an unexcavated part in studies of Foucault on transgression,especially with literary studies.This paper considers madness as the presence of transgression,and gives an account of madness from two different perspectives:tragic experience and critical consciousness.Madness as a tragic experience provides Foucault a way of transgressing death which is a limit that cannot be transcended;madness as a critical consciousness helps Foucault conceptualize the relation between reason and madness.The image of madmen in literary works can be recognized as the most typical embodiment of the connection between madness and transgression.Rather than aiming at a detailed explanation of Foucault’s understanding of madness,it attaches vital importance that how madness as a tragic experience and a critical consciousness becomes the presence of transgression.
文摘Shakespeare’s A Midsummer Night’s Dream is a play of love in which Shakespeare depicts a vivid picture of the madness and irrationality in romantic love.Yet Shakespeare entitles this play"a dream"and concludes the play with a happy ending of marriage for all lovers.Shakespeare thus clearly views romantic love as an inevitable but short episode of life,an adolescent dream that should finally come to an end with the lovers’marriage which signifies their attainment of maturity and brings them back to reason and reality.
文摘Big-hearted Chinese entrepreneur cherishes the spotlight HE isn’t as widely known as philanthropist heavyweights Bill Gates and Warren Buffett, but Chinese tycoon Chen Guangbiao is no stranger to publicity. Bucking the Chinese tradition of remaining low-key when making donations, Chen widely publicizes every
基金supported by the National Natural Science Foundation of China(32272654)the Natural Science Foundation of Hebei Province China(C2023204016)+2 种基金the Hebei Province Introduced Overseas-Scholar Fund China(C20220361)the S&T Program of Hebei China(20326330D)the Hebei Province Outstanding Youth Fund China(2016,2019)。
文摘Pyrus pyrifolia Nakai‘Whangkeumbae'is a sand pear fruit with excellent nutritional quality and taste.However,the industrial development of pear fruit is significantly limited by its short shelf life.Salicylic acid(SA),a well-known phytohormone,can delay fruit senescence and improve shelf life.However,the mechanism by which SA regulates CONSTANS-LIKE genes(COLs)during fruit senescence and the role of COL genes in mediating fruit senescence in sand pear are poorly understood.In this study,22 COL genes were identified in sand pear,including four COLs(Pp COL8,Pp COL9a,Pp COL9b,and Pp COL14)identified via transcriptome analysis and 18 COLs through genome-wide analysis.These COL genes were divided into three subgroups according to the structural domains of the COL protein.Pp COL8,with two B-box motifs and one CCT domain,belonged to the first subgroup.In contrast,the other three Pp COLs,Pp COL9a,Pp COL9b,and Pp COL14,with similar conserved protein domains and gene structures,were assigned to the third subgroup.The four COLs showed different expression patterns in pear tissues and were preferentially expressed at the early stage of fruit development.Moreover,the expression of Pp COL8 was inhibited by exogenous SA treatment,while SA up-regulated the expression of Pp COL9a and Pp COL9b.Interestingly,Pp COL8 interacts with Pp MADS,a MADS-box protein preferentially expressed in fruit,and SA up-regulated its expression.While the production of ethylene and the content of malondialdehyde(MDA)were increased in Pp COL8-overexpression sand pear fruit,the antioxidant enzyme(POD and SOD)activity and the expression of Pp POD1 and Pp SOD1 in the sand pear fruits were down-regulated,which showed that Pp COL8 promoted sand pear fruit senescence.In contrast,the corresponding changes were the opposite in Pp MADS-overexpression sand pear fruits,suggesting that Pp MADS delayed sand pear fruit senescence.The co-transformation of Pp COL8 and Pp MADS also delayed sand pear fruit senescence.The results of this study revealed that Pp COL8 can play a key role in pear fruit senescence by interacting with Pp MADS through the SA signaling pathway.
文摘Anew survey has come out that reveals Chinese people are seriously addicted to their phones.Surprised?We didn't think so.Reports have surfaced in recent years showing a disturbing trend in how much peo・pie use their phones on a daily basis,and it doesn't seem to be improving anytime soon.China Youth Dailys survey center wenjuan.
基金supported by the Ningxia Hui Autonomous Region Key Research and Development Program(Grant No.2021BEG03084).
文摘Background:Colon adenocarcinoma(COAD)is the second leading cause of cancer death worldwide thus,identification of COAD biomarkers is critical.Mitotic Arrest Deficient 2 Like 2(MAD2L2)is a key factor in mammalian DNA damage repair and is highly expressed in many malignant tumors.This is a comprehensive study of MAD2L2 expression,its diagnostic value,prognostic analysis,potential biological function,and impact on the immune system of patients with COAD.Methods:Gene expression,clinical relevance,prognostic analysis,diagnostic value,GO/KEGG cluster analysis,data obtained from TCGA,and bioinformatics statistical analysis were performed using the R package.Immune responses to MAD2L2 expression in COAD were analyzed using TIMER.The expression of MAD2L2 in HCT116 cells induced by the inflammatory factor TNF-αwas detected using Western blot.Results:Our results underscore the clinical diagnostic value and potential biological significance of MAD2L2 in patients with COAD.A high level of MAD2L2 expression has been found in COAD and correlated with tumor status and colon polyps.ROC curve analysis showed that MAD2L2 expression has high diagnostic value in COAD.Analysis of immune infiltration results showed that MAD2L2 expression was positively correlated with neutrophil levels.The western blot results demonstrated that MAD2L2 was dose-dependently present with TNF-α.GO/KEGG revealed that MAD2L2 overexpressed and coexpressed genes were mostly involved in biological functions,including hypoxia response,response to reduced oxygen levels,mitochondrial translation elongation,and other processes.Conclusion:MAD2L2 as a new COAD biomarker contributes to our understanding of how alterations in gene expression and the immunological environment contribute to the development of colon cancer.Following further investigation,MAD2L2 may prove to be a viable target factor for clinical diagnosis and therapy of COAD.
基金King Saud University for funding this work through Researchers Supporting Project Number(RSP2022R426),King Saud University,Riyadh,Saudi Arabia.
文摘The current study proposes a novel technique for feature selection by inculcating robustness in the conventional Signal to noise Ratio(SNR).The proposed method utilizes the robust measures of location i.e.,the“Median”as well as the measures of variation i.e.,“Median absolute deviation(MAD)and Interquartile range(IQR)”in the SNR.By this way,two independent robust signal-to-noise ratios have been proposed.The proposed method selects the most informative genes/features by combining the minimum subset of genes or features obtained via the greedy search approach with top-ranked genes selected through the robust signal-to-noise ratio(RSNR).The results obtained via the proposed method are compared with wellknown gene/feature selection methods on the basis of performance metric i.e.,classification error rate.A total of 5 gene expression datasets have been used in this study.Different subsets of informative genes are selected by the proposed and all the other methods included in the study,and their efficacy in terms of classification is investigated by using the classifier models such as support vector machine(SVM),Random forest(RF)and k-nearest neighbors(k-NN).The results of the analysis reveal that the proposed method(RSNR)produces minimum error rates than all the other competing feature selection methods in majority of the cases.For further assessment of the method,a detailed simulation study is also conducted.
基金2022 Basic Scientific Research Project supported by Liaoning Provincial Education Department(No.LJKMZ20221686)。
文摘A new prediction method based on the nonlinear autoregressive model is proposed to improve the accuracy of medium-term and long-term predictions of Satellite Clock Bias(SCB).Forecast experiments for three time periods were implemented based on the precision SCB published on the International GNSS Server(IGS)server.The results show that the medium-term and long-term prediction accuracy of the proposed approach is significantly better compared to other traditional models,with the training time being much shorter than the wavelet neural network model.
