Plasma sterilization is a new generation of high-tech sterilization method that is fast,safe,and pollution free.It is widely used in medical,food,and environmental protection fields.Home air sterilization is an emergi...Plasma sterilization is a new generation of high-tech sterilization method that is fast,safe,and pollution free.It is widely used in medical,food,and environmental protection fields.Home air sterilization is an emerging field of plasma application,which puts higher requirements on the miniaturization,operational stability,and operating cost of plasma device.In this study,a novel magnetically driven rotating gliding arc(MDRGA)discharge device was used to sterilize Lactobacillus fermentation.Compared with the traditional gas-driven gliding arc,this device has a simple structure and a more stable gliding arc.Simulation using COMSOL Multiphysics showed that adding permanent magnets can form a stable magnetic field,which is conducive to the formation of gliding arcs.Experiments on the discharge performance,ozone concentration,and sterilization effect were conducted using different power supply parameters.The results revealed that the MDRGA process can be divided into three stages:starting,gliding,and extinguishing.Appropriate voltage was the key factor for stable arc gliding,and both high and low voltages were not conducive to stable arc gliding and ozone production.In this experimental setup,the sterilization effect was the best at 6.6 kV.A high modulation duty ratio was beneficial for achieving stable arc gliding.However,when the duty ratio exceeded a certain value,the improvement in the sterilization effect was slow.Therefore,considering the sterilization effect and energy factors comprehensively,we chose 80%as the optimal modulation duty ratio for this experimental device.展开更多
Non-thermal plasma at atmosphere was generated through glidarc discharge driven by magnetic field and observed by using a high speed charge coupled device (CCD) and photo multiplier tube (PMT). The arc diameter pr...Non-thermal plasma at atmosphere was generated through glidarc discharge driven by magnetic field and observed by using a high speed charge coupled device (CCD) and photo multiplier tube (PMT). The arc diameter projecting in the direction of arc motion (front-viewed diameter) and the diameter projecting in the perpendicular direction of arc motion (side-viewed diameter) were measured. The effect of both the arc current and the magnetic field was analysed. The front-viewed diameter was compared with the side-viewed one. Simultaneously the electricfield intensity was measured directly and analysed by considering the effect of the external magnetic field and arc current.展开更多
Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent characteristics.However,the unique and complex structure of the gastrointestinal tract is still an ob...Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent characteristics.However,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon tumors.Here,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the colon.In order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification technique.The average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic environment.In vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer cells.Meanwhile,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.展开更多
With ificreasing demand for large cylindrical forgings, a new technology--electroslag remelting (ESR) for direct manufacture of hollow ingots rather than solid ingots has been developed. The main features of the pro...With ificreasing demand for large cylindrical forgings, a new technology--electroslag remelting (ESR) for direct manufacture of hollow ingots rather than solid ingots has been developed. The main features of the process include a T-shaped current supplying mould (CSM), double power supply, an ingot withdrawing system, a metal level automatic control system based on a level sensor using the electromagnetic eddy current method, and the exchange of a consumable multi-electrode. ANSYS software was used to calculate the fluid flow and heat transfer in the slag bath 1 and metal pool of this ESR hollow ingot process with its T-shaped CSM. The mathematmal model was Verified by measuring the geometry of the liquid metal pool as observed in the macrostructure of 4650 mm (external diameter)/ 4450 mm (internal diameter) hollow ingots by sulphur print method: the. observed shape and depth of the s!ag bath were consistent with the simulated results. Simulation of the ESR process can improve understanding of the process and allow better operating parameters to be selected.展开更多
Rotating speed is a critical parameter affecting the performance of rotor gyroscopes. Rotor gyroscopes must operate at the rated rotating speed. To shorten the start time of the ball-disk rotor gyroscope, this paper p...Rotating speed is a critical parameter affecting the performance of rotor gyroscopes. Rotor gyroscopes must operate at the rated rotating speed. To shorten the start time of the ball-disk rotor gyroscope, this paper presents a new design of the drive system for a ball-disk rotor gyroscope. The drive system is monitored by a microeontroUer. First, the microcontroller generates a sine pulse width modulation signal to drive the permanent magnet rotor. Second, the position of the rotor is detected according to the back electromotive force in the non-energized coil. Third, a piecewise closed-loop control algorithm is implemented to keep the angular acceleration of the rotor within the safe range automatically during the acceleration process and when running at a constant speed. This control algorithm can avoid rotor stalling due to loss of steps. Experimental result shows that with the help of adaptive quick-start technique, the start time of the device can be shortened by up to 36.6%.展开更多
基金supported by National Natural Science Foundation of China(Nos.52077129 and 52277150)the Natural Science Foundation of Shandong Province(No.ZR2022ME037).
文摘Plasma sterilization is a new generation of high-tech sterilization method that is fast,safe,and pollution free.It is widely used in medical,food,and environmental protection fields.Home air sterilization is an emerging field of plasma application,which puts higher requirements on the miniaturization,operational stability,and operating cost of plasma device.In this study,a novel magnetically driven rotating gliding arc(MDRGA)discharge device was used to sterilize Lactobacillus fermentation.Compared with the traditional gas-driven gliding arc,this device has a simple structure and a more stable gliding arc.Simulation using COMSOL Multiphysics showed that adding permanent magnets can form a stable magnetic field,which is conducive to the formation of gliding arcs.Experiments on the discharge performance,ozone concentration,and sterilization effect were conducted using different power supply parameters.The results revealed that the MDRGA process can be divided into three stages:starting,gliding,and extinguishing.Appropriate voltage was the key factor for stable arc gliding,and both high and low voltages were not conducive to stable arc gliding and ozone production.In this experimental setup,the sterilization effect was the best at 6.6 kV.A high modulation duty ratio was beneficial for achieving stable arc gliding.However,when the duty ratio exceeded a certain value,the improvement in the sterilization effect was slow.Therefore,considering the sterilization effect and energy factors comprehensively,we chose 80%as the optimal modulation duty ratio for this experimental device.
基金National Natural Science Foundation of China(No.10375065)Natural Science Foundation of Anhui Province(No.03045102)
文摘Non-thermal plasma at atmosphere was generated through glidarc discharge driven by magnetic field and observed by using a high speed charge coupled device (CCD) and photo multiplier tube (PMT). The arc diameter projecting in the direction of arc motion (front-viewed diameter) and the diameter projecting in the perpendicular direction of arc motion (side-viewed diameter) were measured. The effect of both the arc current and the magnetic field was analysed. The front-viewed diameter was compared with the side-viewed one. Simultaneously the electricfield intensity was measured directly and analysed by considering the effect of the external magnetic field and arc current.
基金supported by the National Key R&D Program of China(grant No.2019YFB1309703).
文摘Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent characteristics.However,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon tumors.Here,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the colon.In order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification technique.The average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic environment.In vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer cells.Meanwhile,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.
基金Item Sponsored by National Natural Science Foundation of China(51204041)National High Technology Research and Development Program(863 Program) of China(2012AA03A502)+1 种基金Fundamental Research Funds for the Central Universities of China(N130402016)Program for Liaoning's Innovative Research Team in University of China(LT20120008)
文摘With ificreasing demand for large cylindrical forgings, a new technology--electroslag remelting (ESR) for direct manufacture of hollow ingots rather than solid ingots has been developed. The main features of the process include a T-shaped current supplying mould (CSM), double power supply, an ingot withdrawing system, a metal level automatic control system based on a level sensor using the electromagnetic eddy current method, and the exchange of a consumable multi-electrode. ANSYS software was used to calculate the fluid flow and heat transfer in the slag bath 1 and metal pool of this ESR hollow ingot process with its T-shaped CSM. The mathematmal model was Verified by measuring the geometry of the liquid metal pool as observed in the macrostructure of 4650 mm (external diameter)/ 4450 mm (internal diameter) hollow ingots by sulphur print method: the. observed shape and depth of the s!ag bath were consistent with the simulated results. Simulation of the ESR process can improve understanding of the process and allow better operating parameters to be selected.
基金Project supported by the National Basic Research Program of China (No. 2012CB934104), the National Natural Science Foundation of China (No. 61474034), the Natural Science Foundation of Heilongjiang Province of China (No. F201418), and the Fundamental Research Funds for the Central Universities, China (Nos. HIT.NSRIF. 2014040 and HIT.NSRIF.2013040)
文摘Rotating speed is a critical parameter affecting the performance of rotor gyroscopes. Rotor gyroscopes must operate at the rated rotating speed. To shorten the start time of the ball-disk rotor gyroscope, this paper presents a new design of the drive system for a ball-disk rotor gyroscope. The drive system is monitored by a microeontroUer. First, the microcontroller generates a sine pulse width modulation signal to drive the permanent magnet rotor. Second, the position of the rotor is detected according to the back electromotive force in the non-energized coil. Third, a piecewise closed-loop control algorithm is implemented to keep the angular acceleration of the rotor within the safe range automatically during the acceleration process and when running at a constant speed. This control algorithm can avoid rotor stalling due to loss of steps. Experimental result shows that with the help of adaptive quick-start technique, the start time of the device can be shortened by up to 36.6%.