The diagnosis of sporadic Creutzfeldt-Jakob disease （sCJD） is extremely difficult. Diffusion-weighted imaging has been shown to be the most sensitive technique for the detection of signal alterations in sCJD patient...The diagnosis of sporadic Creutzfeldt-Jakob disease （sCJD） is extremely difficult. Diffusion-weighted imaging has been shown to be the most sensitive technique for the detection of signal alterations in sCJD patients. The present study analyzed the diagnostic value of diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in the early stage of sCJD in one female patient and correlated the clinical symptoms during disease course and magnetic resonance manifestations. Thalamic and basal ganglia hyperintensities were observed on magnetic resonance images in a very early stage, i.e., when the clinical typical manifestations of the disease were not present. With the progression of the disease, cortical and basal ganglia hyperintensities were observed on magnetic resonance images, showing an obvious cerebral atrophy. These findings suggest that diffusion-weighted imaging and fluid-attenuated inversion recovery sequence are helpful in diagnosing sCJD.展开更多
Objective:Late gadolinium enhancement(LGE) patterns of cardiovascular magnetic resonance (CMR) relying on PSIR(phase-sensitive inversion recovery sequence) techniques had been used to determine the characteristics of ...Objective:Late gadolinium enhancement(LGE) patterns of cardiovascular magnetic resonance (CMR) relying on PSIR(phase-sensitive inversion recovery sequence) techniques had been used to determine the characteristics of LGE in apical hypertrophic cardiomyopathy(ApHCM). Methods:Forty patients pure ApHCM[age,(60.2±10.4) years,31 men]were enrolled.LGE images were acquired using PSIR,and analyzed using a 17-segment model.Summing the LGE areas in all short axis slices yielded the total volume of late enhancement,which was subsequently presented as a proportion of total LV myocardium(%LGE).Results:Mean maximal apical wall thickness was(17.9±2.3) mm,and mean left ventricular(LV) ejection fraction was(67.7±8.0)%.LGE was detected in 130 segments of 30 patients(75.0%),occupying(4.9±5.5)% of LV myocardium.LGE was mainly detected at the junction between left and right ventricles in 12(30%) and at the apex in 28(70%),although LGE-positive areas were widely distributed,and not limited to the apex.Focal LGE at the non-hypertrophic LV segments was found in some ApHCM patients,even without LGE of hypertrophied apical segments.Conclusions:LGE was frequently observed not only in the thickened apex of the heart but also in other LV segments,irrespective of the presence or absence of hypertrophy.The simple presence of LGE on CMR was not representative of adverse prognosis in this population.展开更多
目的探讨急性脑梗死(ACI)患者弥散加权成像(DWI)病变体积(VDWI)、T2液体衰减反转恢复序列(T2Flair)病变体积(VFlair)与发病时间的关系,及ACI患者DWI与磁敏感加权成像(SWI)区域显示一致程度与预后的关系。方法选取2019年8月至2021年12月...目的探讨急性脑梗死(ACI)患者弥散加权成像(DWI)病变体积(VDWI)、T2液体衰减反转恢复序列(T2Flair)病变体积(VFlair)与发病时间的关系,及ACI患者DWI与磁敏感加权成像(SWI)区域显示一致程度与预后的关系。方法选取2019年8月至2021年12月包钢集团第三职工医院收治的93例ACI患者作为研究对象。运用线性回归分析VFlair、VDWI的体积差与发病时间(T)的关系,分析DWI图像、SWI图像显示区域一致程度与预后的关系。结果线性回归分析结果显示,症状出现6 h内ACI患者VFlair、VDWI与发病时间(T)存在以下关系:(VFlair−VDWI)/VDWI=−0.573+0.103×T;症状出现6~48 h ACI患者VFlair、VDWI与T存在以下关系:(VFlair−VDWI)/VDWI=−0.049+0.013×T。DWI-SWI图像显示区域一致22例,溶栓有效12例(54.55%);DWI-SWI图像显示区域不一致19例,溶栓有效4例(21.05%),两者比较差异有统计学意义(P<0.05)。结论ACI患者VFlair与VDWI差异能有效预测ACI患者发病时间,DWI-SWI区域显示一致程度能够较好预测ACI患者的预后。展开更多
Background Detection rate of retropharyngeal lymph node metastasis in patients with nasopharyngeal carcinoma （NPC） needs to be improved. The purpose of this study was to compare three magnetic resonance （MR） seque...Background Detection rate of retropharyngeal lymph node metastasis in patients with nasopharyngeal carcinoma （NPC） needs to be improved. The purpose of this study was to compare three magnetic resonance （MR） sequences for detecting lymph nodes in patients with NPC. Methods Between July 2007 and March 2008, MR staging of pre-treated tumor was conducted on 120 patients with pathologically confirmed NPC. The outcome of three different sequences for MR NPC staging were compared： coronal short T1 inversion recovery （STIR）, axial proton density fat-suppressed （PDWI fs）, and coronal contrast enhanced fast spin echo T1 weighted fat-suppressed （CE FSE TlWl fs）. Nodal classification method （1999） was applied to count the number of retropharyngeal and cervical lymph nodes discovered by each MR sequence. Paired t tests were used for statistical analysis. Results A total of 2575 lymph nodes were found using coronal STIR sequence; 1816 lymph nodes for coronal CE FSE TIWI fs sequence and 2638 lymph nodes for axial PDWl fs sequence. Significant differences existed in the number of lymph nodes detected by axial PDWI fs and coronal CE FSE T1WI fs sequence （paired t test, P 〈0.05）, with the former sequence getting higher numbers. Statistical differences also existed between coronal STIR and coronal CE FSE TlWl fs sequence （paired ttest, P 〈0.05）, with the former sequence getting higher numbers. No significant difference was found between coronal STIR sequence and axial PDWI fs sequence （paired ttest, P 〉0.05）. Conclusions For the detection of retropharyngeal and cervical lymph nodes, coronal STIR sequence and axial PDWI fs sequence have similar performance and both sequences showed better detection than CE FSE TIWI fs sequence. Furthermore, by combining coronal STIR sequence and axial PDWI fs sequence, we can improve the detection of lymph nodes in NPC N-staging before treatment, especially for lymph nodes located in the thoracic entrance.展开更多
文摘The diagnosis of sporadic Creutzfeldt-Jakob disease （sCJD） is extremely difficult. Diffusion-weighted imaging has been shown to be the most sensitive technique for the detection of signal alterations in sCJD patients. The present study analyzed the diagnostic value of diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in the early stage of sCJD in one female patient and correlated the clinical symptoms during disease course and magnetic resonance manifestations. Thalamic and basal ganglia hyperintensities were observed on magnetic resonance images in a very early stage, i.e., when the clinical typical manifestations of the disease were not present. With the progression of the disease, cortical and basal ganglia hyperintensities were observed on magnetic resonance images, showing an obvious cerebral atrophy. These findings suggest that diffusion-weighted imaging and fluid-attenuated inversion recovery sequence are helpful in diagnosing sCJD.
基金Supported by Haikou Key Science and Technology Project (2012-075)Haikou Science and Technology Planning Project(2009-049-1)Science and Technology Fund of Haikou Health Bureau(2010-SWY-13-058)
文摘Objective:Late gadolinium enhancement(LGE) patterns of cardiovascular magnetic resonance (CMR) relying on PSIR(phase-sensitive inversion recovery sequence) techniques had been used to determine the characteristics of LGE in apical hypertrophic cardiomyopathy(ApHCM). Methods:Forty patients pure ApHCM[age,(60.2±10.4) years,31 men]were enrolled.LGE images were acquired using PSIR,and analyzed using a 17-segment model.Summing the LGE areas in all short axis slices yielded the total volume of late enhancement,which was subsequently presented as a proportion of total LV myocardium(%LGE).Results:Mean maximal apical wall thickness was(17.9±2.3) mm,and mean left ventricular(LV) ejection fraction was(67.7±8.0)%.LGE was detected in 130 segments of 30 patients(75.0%),occupying(4.9±5.5)% of LV myocardium.LGE was mainly detected at the junction between left and right ventricles in 12(30%) and at the apex in 28(70%),although LGE-positive areas were widely distributed,and not limited to the apex.Focal LGE at the non-hypertrophic LV segments was found in some ApHCM patients,even without LGE of hypertrophied apical segments.Conclusions:LGE was frequently observed not only in the thickened apex of the heart but also in other LV segments,irrespective of the presence or absence of hypertrophy.The simple presence of LGE on CMR was not representative of adverse prognosis in this population.
文摘目的探讨急性脑梗死(ACI)患者弥散加权成像(DWI)病变体积(VDWI)、T2液体衰减反转恢复序列(T2Flair)病变体积(VFlair)与发病时间的关系,及ACI患者DWI与磁敏感加权成像(SWI)区域显示一致程度与预后的关系。方法选取2019年8月至2021年12月包钢集团第三职工医院收治的93例ACI患者作为研究对象。运用线性回归分析VFlair、VDWI的体积差与发病时间(T)的关系,分析DWI图像、SWI图像显示区域一致程度与预后的关系。结果线性回归分析结果显示,症状出现6 h内ACI患者VFlair、VDWI与发病时间(T)存在以下关系:(VFlair−VDWI)/VDWI=−0.573+0.103×T;症状出现6~48 h ACI患者VFlair、VDWI与T存在以下关系:(VFlair−VDWI)/VDWI=−0.049+0.013×T。DWI-SWI图像显示区域一致22例,溶栓有效12例(54.55%);DWI-SWI图像显示区域不一致19例,溶栓有效4例(21.05%),两者比较差异有统计学意义(P<0.05)。结论ACI患者VFlair与VDWI差异能有效预测ACI患者发病时间,DWI-SWI区域显示一致程度能够较好预测ACI患者的预后。
基金This study was supported by a grant from the Natural Science Foundation of Fujian Province （No. 2004Y008）.
文摘Background Detection rate of retropharyngeal lymph node metastasis in patients with nasopharyngeal carcinoma （NPC） needs to be improved. The purpose of this study was to compare three magnetic resonance （MR） sequences for detecting lymph nodes in patients with NPC. Methods Between July 2007 and March 2008, MR staging of pre-treated tumor was conducted on 120 patients with pathologically confirmed NPC. The outcome of three different sequences for MR NPC staging were compared： coronal short T1 inversion recovery （STIR）, axial proton density fat-suppressed （PDWI fs）, and coronal contrast enhanced fast spin echo T1 weighted fat-suppressed （CE FSE TlWl fs）. Nodal classification method （1999） was applied to count the number of retropharyngeal and cervical lymph nodes discovered by each MR sequence. Paired t tests were used for statistical analysis. Results A total of 2575 lymph nodes were found using coronal STIR sequence; 1816 lymph nodes for coronal CE FSE TIWI fs sequence and 2638 lymph nodes for axial PDWl fs sequence. Significant differences existed in the number of lymph nodes detected by axial PDWI fs and coronal CE FSE T1WI fs sequence （paired t test, P 〈0.05）, with the former sequence getting higher numbers. Statistical differences also existed between coronal STIR and coronal CE FSE TlWl fs sequence （paired ttest, P 〈0.05）, with the former sequence getting higher numbers. No significant difference was found between coronal STIR sequence and axial PDWI fs sequence （paired ttest, P 〉0.05）. Conclusions For the detection of retropharyngeal and cervical lymph nodes, coronal STIR sequence and axial PDWI fs sequence have similar performance and both sequences showed better detection than CE FSE TIWI fs sequence. Furthermore, by combining coronal STIR sequence and axial PDWI fs sequence, we can improve the detection of lymph nodes in NPC N-staging before treatment, especially for lymph nodes located in the thoracic entrance.
