Plasma sterilization is a new generation of high-tech sterilization method that is fast,safe,and pollution free.It is widely used in medical,food,and environmental protection fields.Home air sterilization is an emergi...Plasma sterilization is a new generation of high-tech sterilization method that is fast,safe,and pollution free.It is widely used in medical,food,and environmental protection fields.Home air sterilization is an emerging field of plasma application,which puts higher requirements on the miniaturization,operational stability,and operating cost of plasma device.In this study,a novel magnetically driven rotating gliding arc(MDRGA)discharge device was used to sterilize Lactobacillus fermentation.Compared with the traditional gas-driven gliding arc,this device has a simple structure and a more stable gliding arc.Simulation using COMSOL Multiphysics showed that adding permanent magnets can form a stable magnetic field,which is conducive to the formation of gliding arcs.Experiments on the discharge performance,ozone concentration,and sterilization effect were conducted using different power supply parameters.The results revealed that the MDRGA process can be divided into three stages:starting,gliding,and extinguishing.Appropriate voltage was the key factor for stable arc gliding,and both high and low voltages were not conducive to stable arc gliding and ozone production.In this experimental setup,the sterilization effect was the best at 6.6 kV.A high modulation duty ratio was beneficial for achieving stable arc gliding.However,when the duty ratio exceeded a certain value,the improvement in the sterilization effect was slow.Therefore,considering the sterilization effect and energy factors comprehensively,we chose 80%as the optimal modulation duty ratio for this experimental device.展开更多
Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent characteristics.However,the unique and complex structure of the gastrointestinal tract is still an ob...Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent characteristics.However,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon tumors.Here,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the colon.In order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification technique.The average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic environment.In vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer cells.Meanwhile,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.展开更多
Non-thermal plasma at atmosphere was generated through glidarc discharge driven by magnetic field and observed by using a high speed charge coupled device （CCD） and photo multiplier tube （PMT）. The arc diameter pr...Non-thermal plasma at atmosphere was generated through glidarc discharge driven by magnetic field and observed by using a high speed charge coupled device （CCD） and photo multiplier tube （PMT）. The arc diameter projecting in the direction of arc motion （front-viewed diameter） and the diameter projecting in the perpendicular direction of arc motion （side-viewed diameter） were measured. The effect of both the arc current and the magnetic field was analysed. The front-viewed diameter was compared with the side-viewed one. Simultaneously the electricfield intensity was measured directly and analysed by considering the effect of the external magnetic field and arc current.展开更多
The gliding arc is an important approach to production of non-thermal plasma at atmospheric pressure, it can offer high-energy efficiency and high-electivity for chemical reactions. In this paper, the gliding arc driv...The gliding arc is an important approach to production of non-thermal plasma at atmospheric pressure, it can offer high-energy efficiency and high-electivity for chemical reactions. In this paper, the gliding arc driven by the transverse magnetic field is described and its velocity is measured by using a photo-multiplier. The mean velocity of the gliding arc increases with increasing magnetic induced-intensity, and its value varies from 7.8 m/s to 32 m/s.展开更多
The implosion plasma drive fusion pellet of inertial confinement is a concept related to nuclear fusion,a process in which atomic nuclei combine to form heavier nuclei,releasing a large amount of energy in the process...The implosion plasma drive fusion pellet of inertial confinement is a concept related to nuclear fusion,a process in which atomic nuclei combine to form heavier nuclei,releasing a large amount of energy in the process.The implosion plasma drive fusion pellet is a potential fuel source for achieving controlled nuclear fusion.ICF(inertial confinement fusion)is a technique used to achieve fusion by compressing a small target containing fusion fuel to extremely high densities and temperatures using lasers or other methods.The implosion plasma drive fusion pellet concept involves using a small pellet of deuterium and tritium(two isotopes of hydrogen)as fusion fuel,and then rapidly heating and compressing it using a pulsed power system.The implosion process creates a high-pressure plasma that ignites the fusion reactions,releasing energy in the form of neutrons and charged particles.The resulting energy can be captured and used for power generation.This technology is still in the experimental stage,and significant research and development is required to make it commercially viable.However,it has the potential to provide a virtually limitless source of clean energy with no greenhouse gas emissions or long-term radioactive waste.Be that as it may,ICF has to get exact control of the implosion process,mitigate insecurities,and create modern materials and advances to resist the extraordinary conditions of the combined response.展开更多
基金supported by National Natural Science Foundation of China(Nos.52077129 and 52277150)the Natural Science Foundation of Shandong Province(No.ZR2022ME037).
文摘Plasma sterilization is a new generation of high-tech sterilization method that is fast,safe,and pollution free.It is widely used in medical,food,and environmental protection fields.Home air sterilization is an emerging field of plasma application,which puts higher requirements on the miniaturization,operational stability,and operating cost of plasma device.In this study,a novel magnetically driven rotating gliding arc(MDRGA)discharge device was used to sterilize Lactobacillus fermentation.Compared with the traditional gas-driven gliding arc,this device has a simple structure and a more stable gliding arc.Simulation using COMSOL Multiphysics showed that adding permanent magnets can form a stable magnetic field,which is conducive to the formation of gliding arcs.Experiments on the discharge performance,ozone concentration,and sterilization effect were conducted using different power supply parameters.The results revealed that the MDRGA process can be divided into three stages:starting,gliding,and extinguishing.Appropriate voltage was the key factor for stable arc gliding,and both high and low voltages were not conducive to stable arc gliding and ozone production.In this experimental setup,the sterilization effect was the best at 6.6 kV.A high modulation duty ratio was beneficial for achieving stable arc gliding.However,when the duty ratio exceeded a certain value,the improvement in the sterilization effect was slow.Therefore,considering the sterilization effect and energy factors comprehensively,we chose 80%as the optimal modulation duty ratio for this experimental device.
基金supported by the National Key R&D Program of China(grant No.2019YFB1309703).
文摘Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent characteristics.However,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon tumors.Here,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the colon.In order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification technique.The average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic environment.In vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer cells.Meanwhile,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.
基金National Natural Science Foundation of China(No.10375065)Natural Science Foundation of Anhui Province(No.03045102)
文摘Non-thermal plasma at atmosphere was generated through glidarc discharge driven by magnetic field and observed by using a high speed charge coupled device （CCD） and photo multiplier tube （PMT）. The arc diameter projecting in the direction of arc motion （front-viewed diameter） and the diameter projecting in the perpendicular direction of arc motion （side-viewed diameter） were measured. The effect of both the arc current and the magnetic field was analysed. The front-viewed diameter was compared with the side-viewed one. Simultaneously the electricfield intensity was measured directly and analysed by considering the effect of the external magnetic field and arc current.
文摘The gliding arc is an important approach to production of non-thermal plasma at atmospheric pressure, it can offer high-energy efficiency and high-electivity for chemical reactions. In this paper, the gliding arc driven by the transverse magnetic field is described and its velocity is measured by using a photo-multiplier. The mean velocity of the gliding arc increases with increasing magnetic induced-intensity, and its value varies from 7.8 m/s to 32 m/s.
文摘The implosion plasma drive fusion pellet of inertial confinement is a concept related to nuclear fusion,a process in which atomic nuclei combine to form heavier nuclei,releasing a large amount of energy in the process.The implosion plasma drive fusion pellet is a potential fuel source for achieving controlled nuclear fusion.ICF(inertial confinement fusion)is a technique used to achieve fusion by compressing a small target containing fusion fuel to extremely high densities and temperatures using lasers or other methods.The implosion plasma drive fusion pellet concept involves using a small pellet of deuterium and tritium(two isotopes of hydrogen)as fusion fuel,and then rapidly heating and compressing it using a pulsed power system.The implosion process creates a high-pressure plasma that ignites the fusion reactions,releasing energy in the form of neutrons and charged particles.The resulting energy can be captured and used for power generation.This technology is still in the experimental stage,and significant research and development is required to make it commercially viable.However,it has the potential to provide a virtually limitless source of clean energy with no greenhouse gas emissions or long-term radioactive waste.Be that as it may,ICF has to get exact control of the implosion process,mitigate insecurities,and create modern materials and advances to resist the extraordinary conditions of the combined response.
