Objectives: To estimate the cost effectiveness of fluvoxamine against desvenlafaxine in Chinese patients with major depressive disorder (MDD). Methods: A cost effectiveness of treating Chinese patients with MDD for 6 ...Objectives: To estimate the cost effectiveness of fluvoxamine against desvenlafaxine in Chinese patients with major depressive disorder (MDD). Methods: A cost effectiveness of treating Chinese patients with MDD for 6 months maintenance period has been estimated by a decision tree model. The relative effectiveness on relapse rates came from a recent network meta analysis by Kishi et al. (2023) along with local drug cost data based on WHO defined daily dose (DDD) and relapse cost for the 6 months estimated from various sources were used in the model. Based on the Quality Adjusted Life Years (QALY) gain reported by Sobocki et al. (2007), QALY loss from a relapse was estimated. Univariate sensitivity analyses were presented by a Tornado diagram and extensive probabilistic sensitivity analysis based on 10,000 simulations was performed. The most recent cost effectiveness threshold of 1.5 times GDP suggested by Cai et al. (2022) was applied. Results: Fluvoxamine dominated desvenlafaxine (cost savings of 4003 CNY and 0.01 QALY higher in 6 months). The most sensitive parameters were relapse rates followed by desvenlafaxine cost and utility loss of relapse. However, the default result of fluvoxamine dominance was not changed for any univariate sensitivity analysis. The probabilistic sensitivity result showed the cost effectiveness acceptability at 1.5 times GDP as 99.93%. Conclusions: The cost effectiveness of fluvoxamine against desvenlafaxine among Chinese patients with MDD in a 6-month maintenance period was cost saving with better effectiveness (i.e., dominating) with low uncertainty.展开更多
As we know,English writing is an important part of communicative competence.But for many English majors,it is hard to express their thoughts clearly.In order to find out the main problems and corresponding measures,th...As we know,English writing is an important part of communicative competence.But for many English majors,it is hard to express their thoughts clearly.In order to find out the main problems and corresponding measures,the author analyzes many compositions written by English majors.With some academic opinions and the author’s own analysis,some problems existing in students’writing are listed.According to the problems,the author summarizes some influencing factors.Finally,the author gives some relevant solutions.Through analyzing those samples,the author hopes it has some help for English majors’writing.展开更多
This study aims to find if, and to what extent, Chinese students'metacognitive strategy use associates with their reading ability in English. Sixty-four sophomore English majors participated in the study. The quan...This study aims to find if, and to what extent, Chinese students'metacognitive strategy use associates with their reading ability in English. Sixty-four sophomore English majors participated in the study. The quantitative analyses of the data generated the following major findings: Of the five metacognitive strategy categories, the selective attention strategy category is most favored by the students, and the evaluating strategy category is least favored by them. Metacognitive strategies have meaningfully positive effect on English reading.展开更多
文摘Objectives: To estimate the cost effectiveness of fluvoxamine against desvenlafaxine in Chinese patients with major depressive disorder (MDD). Methods: A cost effectiveness of treating Chinese patients with MDD for 6 months maintenance period has been estimated by a decision tree model. The relative effectiveness on relapse rates came from a recent network meta analysis by Kishi et al. (2023) along with local drug cost data based on WHO defined daily dose (DDD) and relapse cost for the 6 months estimated from various sources were used in the model. Based on the Quality Adjusted Life Years (QALY) gain reported by Sobocki et al. (2007), QALY loss from a relapse was estimated. Univariate sensitivity analyses were presented by a Tornado diagram and extensive probabilistic sensitivity analysis based on 10,000 simulations was performed. The most recent cost effectiveness threshold of 1.5 times GDP suggested by Cai et al. (2022) was applied. Results: Fluvoxamine dominated desvenlafaxine (cost savings of 4003 CNY and 0.01 QALY higher in 6 months). The most sensitive parameters were relapse rates followed by desvenlafaxine cost and utility loss of relapse. However, the default result of fluvoxamine dominance was not changed for any univariate sensitivity analysis. The probabilistic sensitivity result showed the cost effectiveness acceptability at 1.5 times GDP as 99.93%. Conclusions: The cost effectiveness of fluvoxamine against desvenlafaxine among Chinese patients with MDD in a 6-month maintenance period was cost saving with better effectiveness (i.e., dominating) with low uncertainty.
文摘Majority(MAJ)运算和反相(INV)运算组成完备集,数字逻辑电路可以用基于"MAJ/INV"的MI(Majority-Inverter)逻辑来实现。三输入MAJ门是MI逻辑电路的一种基本门电路单元。本文设计了一种基于碳纳米管场效应晶体管(Carbon Nanotube Field Effect Transistor,CNFET)的三输入MAJ门电路,并用所设计的MAJ门实现三个多输入组合逻辑电路。实验结果表明,在采用相同的器件和工艺的条件下,与现有的设计相比,所设计的MAJ门在功耗和功耗延时积上的改进最高分别达到32.5%和45.3%。
文摘As we know,English writing is an important part of communicative competence.But for many English majors,it is hard to express their thoughts clearly.In order to find out the main problems and corresponding measures,the author analyzes many compositions written by English majors.With some academic opinions and the author’s own analysis,some problems existing in students’writing are listed.According to the problems,the author summarizes some influencing factors.Finally,the author gives some relevant solutions.Through analyzing those samples,the author hopes it has some help for English majors’writing.
文摘This study aims to find if, and to what extent, Chinese students'metacognitive strategy use associates with their reading ability in English. Sixty-four sophomore English majors participated in the study. The quantitative analyses of the data generated the following major findings: Of the five metacognitive strategy categories, the selective attention strategy category is most favored by the students, and the evaluating strategy category is least favored by them. Metacognitive strategies have meaningfully positive effect on English reading.
