Biome Makers将BeCrop技术扩展到澳大利亚和巴西

土壤微生物组智能领域的主要创新者Biome Makers宣布,全球农民和顾问可以更多地使用BeCrop技术。通过与多个实验室的战略合作,Biome Makers将业务扩展到澳大利亚和巴西等关键农业地区。这一扩展保证了BeCrop Technology这一行业标准土壤健康评估工具可以获得更大的可用性,为更广泛的农业专业人员提供有价值的土壤微生物组数据。

Primary Study on ISSR Molecular Makers of Resistant Gene against Sclerotinia trifoliorum in Medicago sativa L.

[ Objective] The paper was to study ISSR molecular makers of resistant gene against Sclerotinia trifoliorum in Medicago sativa L. [ Method] Using mi- crosatellite markers （ISSR） molecular maker technology, combined with bulked-segregant analysis （BSA） method, the molecular makers for gene linkage with re- sistance against S. trifoliorum were screened from five resistant plants and seven susceptible plants. Leaf in vitro inoculation method was used to carry out resistant verification on 94 hybrid plants in Ft generation of high resistant No. 83 ~ high susceptible No. 4. [ Result] Among 93 ISSR primers, 35 primers could produce clear and stable amplification bands, and six of them could produce 9 specific bands between resistant and susceptible DNA pools. Resistance verification result showed that 825 - 1400, 831 - 1480, 850 - 1800, 858 - 1600, 866 - 1900, 888 - 1400 could be used as ISSR molecular makers of the resistant gene against S. trifoliorum in M. sativa. [Conclusion] The results provided basis for the further research on mapping,, cloning and genetically modified of resistant gene against S. trifoliorum in M. sativa.

基于沉浸式虚拟现实的电力检修技术测评系统设计

针对现有电力检修训练方式效率低下且存在危险的问题,开发基于沉浸式虚拟现实(VR)技术的电力检修测评系统。该系统在设备三维精确模型与VR仿真技术的基础上,通过MakeReal3D平台导入电厂场景及设备精确模型来进行内容开发。利用模型轻量化、3D UI展示与VR多手段交互等关键技术,建立沉浸式虚拟检修和虚拟场景运行仿真平台。同时,搭建五面LED-CAVE、可移动虚拟平台及头盔式沉浸仿真环境并进行渲染展示。系统根据实际作业的现场环境与设备的真实构造,建立测评所需的检修作业、运行维护等三维虚拟场景,补充了测评所需的精确模型数据。根据测评内容的需求对电站实际工作环境进行重现构造,有助于提升专业技术人员对作业场景的真实感。

Role of inflammatory markers in the evaluation of indeterminate pulmonary nodules:a review

The global mortality rate of lung cancer surpasses that of any other type of cancer,establishing it as the foremost cause of cancer-related deaths worldwide.The objectives of lung nodule assessment are to expedite the diagnosis and treatment of patients with malignant nodules while minimizing unnecessary diagnostic procedures for those with benign nodules.The systemic inflammatory response is closely linked to tumorigenesis.Serum levels of inflammatory markers and their derived parameters markers including neutrophil-to-lymphocyte ratio(NLR),lymphocyte-to-monocyte ratio(LMR),monocyte-to-albumin ratio(MAR),platelet-to-lymphocyte ratio(PLR)and systemic immune‐inflammation index(SII),closely associated with lung cancer.The objective of this article is to comprehensively evaluate the differentiation between benign and malignant pulmonary nodules in terms of inflammatory response indicators,aim at provide practical recommendations for the clinical diagnosis,treatment,and management of pulmonary nodules.

Wavelength Dependent Nonlinear Spectroscopic Study of Third Harmonic Generation Probed by Rotational Maker Fringes Method

Efficient third-order nonlinearities of the Zinc Oxide and Al-doped Zinc Oxide were studied by Third Harmonic Generation (Third Harmonic Generation) Maker fringes to establish the effect Aluminum of Aluminum doping (Al-doping) on the cubic nonlinearities. Adding the Al-dopant to the Zinc Oxide crystal structure results in changes that affect the optical and nonlinear characteristics. Presented results indicate that the magnitude of X(3) was enhanced at single experimental wavelengths;however, across the broadband experimental spectrum, the effect of Al-doping remained relatively constant. The observed enhancement of third-order nonlinearity was purely from the bound electronic response. The observation is attributed to increased charge carriers and spontaneous polarization in the Zinc Oxide and Al-doped Zinc Oxide crystal structure.

面向新生入学教育的校园导览游戏设计

入学教育对于新生熟悉校园环境、塑造正确价值观等均有重要作用。以真实校园为原型,设计一款基于角色扮演的校园导览游戏案例,具体从对象、开发、应用等角度论证游戏案例的可行性,采用心流理论与归因理论指导游戏案例的教学组织设计,在虚拟场景中设计“二十四节气”游戏任务驱动用户探索校园并完成入学教育,开发技术方面采用RPG Maker引擎实现游戏程序各项功能内容。该设计可以为课程思政与游戏化教学的融合提供一种借鉴思路。

Automated market makers and decentralized exchanges:a DeFi primer

Recent advancements in decentralized finance(DeFi)have resulted in a rapid increase in the use of Automated Market Makers(AMMs)for creating decentralized exchanges(DEXs).In this paper,we organize these developments by treating an AMM as a neoclassical black-box characterized by the conversion of inputs(tokens)to outputs(prices).The conversion is governed by the technology of the AMM summarized by an‘exchange function’.Various types of AMMs are examined,including:Constant Product Market Makers;Constant Mean Market Makers;Constant Sum Market Makers;Hybrid Function Market Makers;and,Dynamic Automated Market Makers.The paper also looks at the impact of introducing concentrated liquidity in an AMM.Overall,the framework presented here provides an intuitive geometric representation of how an AMM operates,and a clear delineation of the similarities and differences across the various types of AMMs.

The Role of Private Water Vending in Nigeian Peri-Urban Informal Settlements: Implication for Policy Makers

This paper presents a study of water vending in 3 informal settlements of Yola North in Adamawa State of Nigeria. These settlements represent the fast growing urban areas often dwelling in unplanned and unsecured tenure. Access to safe water supply has great influence on the health, economic productivity and quality of life of the people. But meeting this need is one of the major challenges facing the urban communities of Nigeria today. A field survey was conducted in the area with 100 observations of households in each of the three informal settlements. These settlements are Sabongari -University village, Vinikilang and Wuro Jabbe. The survey solicited for response concerning household water source, water per capita use and household size. Findings revealed that about 92% of respondent in Sabongari-University village, 66% in Vinikilang and 87% in Wuro Jabbe depend on vended water from borehole, hand dug well as well as surface water sources which are delivered by hand pushed trucks. Owing to the absence of piped water networks in the study area, households are forced to rely on available water sources which are precursor to water borne diseases. It is advocated that the public agencies should evolve special programs for regularizing informal settlements, meaning the legalization of land tenure, layout corrections and service upgrading if service is to meet the poor informal dwellers.

Optimal Distribution of N-Team Interacting Decision Makers with Hierarchical Command Inputs That Are Predicated on Order Statistics

The spectral analysis of simulated N-team of interacting decision makers with bounded rationality constraints of Oladejo, which assumes triangular probability density function of command inputs is hereby restructured and analysed, to have hierarchical command inputs that are predicated on order statistics distributions. The results give optimal distributions.

Makers and Shakers

More and more professional women are trying their hands at entrepreneurial ventures to fulfill their creative urges. ChinAfrica reporter Sudeshna Sarkar spoke to two of them based in Nigeria and China to find out what drives their passion.

基于Screen Maker的ABB机器人二次开发在激光熔覆中的应用

工业机器人激光熔覆零件具有特殊性、复杂性、小批量等特点,导致机器人编程和参数调节占用时间长,培训机器人操作者周期也长,为了解决这一问题,基于ABB机器人的Screen Maker功能,对示教器界面进行了二次开发,利用RobotStudio软件对机器人激光熔覆进行了仿真,并在真机上进行了验证,实现了机器人当前工作状态和信息的显示以及机器人运行关键参数的控制,满足激光熔覆工艺柔性生产的需要。

Role of biochemical markers and autoantibodies in diagnosis of early-stage primary biliary cholangitis

BACKGROUND Primary biliary cholangitis(PBC)is a chronic progressive autoimmune cholestatic disease.The main target organ of PBC is the liver,and nonsuppurative inflammation of the small intrahepatic bile ducts may eventually develop into cirrhosis or liver fibrosis.AIM To explore the clinical characteristics of early-stage PBC,identify PBC in the early clinical stage,and promptly treat and monitor PBC.METHODS The data of 82 patients with PBC confirmed by pathology at Tianjin Second People’s Hospital from January 2013 to November 2021 were collected,and the patients were divided into stage I,stage II,stage III,and stage IV according to the pathological stage.The general data,serum biochemistry,immunoglobulins,and autoimmune antibodies of patients in each stage were retrospectively analyzed.RESULTS In early-stage(stages I+II)PBC patients,50.0%of patients had normal alanine aminotransferase(ALT)levels,and 37.5%had normal aspartate aminotransferase(AST)levels.For the remaining patients,the ALT and AST levels were mildly elevated;all of these patients had levels of<3 times the upper limit of normal values.The AST levels were significantly different among the three groups(stages I+II vs stage III vs stage IV,P<0.05).In the early stage,29.2%of patients had normal alkaline phosphatase(ALP)levels.The remaining patients had different degrees of ALP elevation;6.3%had ALP levels>5 times the upper limit of normal value.Moreover,γ-glutamyl transferase(GGT)was more robustly elevated,as 29.2%of patients had GGT levels of>10 times the upper limit of normal value.The ALP values among the three groups were significantly different(P<0.05).In early stage,the jaundice index did not increase significantly,but it gradually increased with disease progression.However,the above indicators were significantly different(P<0.05)between the early-stage group and the stage IV group.With the progression of the disease,the levels of albumin and albumin/globulin ratio tended to decrease,and the difference among the three groups was statistically significant(P<0.05).In early-stage patients,IgM and IgG levels as well as cholesterol levels were mildly elevated,but there were no significant differences among the three groups.Triglyceride levels were normal in the early-stage group,and the differences among the three groups were statistically significant(P<0.05).The early detection rates of anti-mitochondria antibody(AMA)and AMA-M2 were 66.7%and 45.8%,respectively.The positive rate of anti-sp100 antibodies was significantly higher in patients with stage IV PBC.When AMA and AMA-M2 were negative,in the early stage,the highest autoantibody was anti-nuclear antibody(ANA)(92.3%),and in all ANA patterns,the highest was ANA centromere(38.5%).CONCLUSION In early-stage PBC patients,ALT and AST levels are normal or mildly elevated,GGT and ALP levels are not elevated in parallel,GGT levels are more robustly elevated,and ALP levels are normal in some patients.When AMA and AMA-M2 are negative,ANA especially ANA centromere positivity suggests the possibility of early PBC.Therefore,in the clinic,significantly elevated GGT levels with or without normal ALP levels and with ANA(particularly ANA centromere)positivity(when AMA and AMA-M2 are negative)may indicate the possibility of early PBC.

Codominance Functional Marker of Bacterial Blight Resistance Gene Xa7 in Rice

[Objectives]A codominance functional marker of the broad-spectrum bacterial blight resistance gene,Xa7,of rice was identified for accurate detection,generation tracking,and differentiation between homozygous and hemizygous genotypes of the gene.[Methods]A potential functional marker containing four primers was designed using Premier 5 software and based on the differences on the sequences of Xa7,xa7,and allele-free genomes.The molecular distinctness of the marker in different materials was verified by PCR.Three crossbreed lines of Xa7 and their parents were inoculated with seven bacterial blight strains at the booting stage to examine the affected agronomic traits at maturation.[Results]The homozygous R084 of Xa7 could be amplified into a 91 bp band and the Nip free of allele with a 153 bp band,while the heterozygote Nip/R084,91 bp and 153 bp bands.The candidate codominance marker,Xa7fun,amplified fragments that matched the predicted target bands.No 91 bp fragment was amplified from 18 germplasms of varied types,indicating a lack of Xa7 in them.Whereas Ry1,Ry2 and Ry3 had a 91 bp band,suggesting the inclusion of homozygous Xa7.Under an elevated temperature,Huazhan responded to the seven bacterial blight pathogens as highly susceptible(HS),intermediate susceptible(MS),or susceptible(S);R084 to six of the seven pathogens(HNA1-4,FuJ,GDA2,GD1358,PX086,and YN24)as highly resistant(HR),intermediate resistant(MR)or resistant(R);Ry-1 to five pathogens(GDA2,HNA1-4,FuJ,GD1358,and YN24)as HR or MR;Ry-2 to five pathogens(GDA2,GD1358,HNA1-4,PXO86,and YN24)as HR or R;and Ry-3 to 6 pathogens(HNA1-4,FuJ,GDA2,GD1358,PXO86,and YN24)as HR or MR.Therefore,the infiltration of Xa7 in the improved crossbred lines RY-1,RY-2,and RY-3 significantly accentuated the blight resistance of Huazhan.[Conclusions]Homozygous or hemizygous Xa7 could be accurately differentiated by the currently identified codominance functional marker Xa7 fun.The Xa7 introgression did not significantly alter the critical agronomic traits in the hybridization from generation to generation and could be safely applied in breeding rice varieties with bacterial blight resistance.

渗透STEAM与MAKER教育理念发掘综合性学习资源

近年来,国内社会经济和科学技术快速发展,全阶段不同学科课程教育工作质量都得到了比较大的提升,其中之一就是小学阶段。但伴随着小学教育工作水平的不断提升,包含小学生学习主体在内的诸多对象对小学阶段教育工作提出了更高的要求。在这一趋势和背景下,在小学阶段教育工作开展过程中,需要注重融合STEAM及MAKER的小学综合性学习资源的开发和利用,以创新教学资源支持小学阶段教育工作的创新发展,从而满足小学生的学习需求,同时促进小学生的核心素养得到提升。这也是素质教育理念背景下小学教育工作的主要目标之一。本文针对融合STEAM及MAKER教育理念的小学综合性学习资源的开发利用进行系统研究和分析。

最古老的石器

Archaeologists in Kenya have dug up some of the oldest stone tools ever found,but who used them is a mystery.In the past,scientists assumed that our direct ancestors were the only toolmakers.But two big fossil teeth found along with the tools at the Kenyan site belong to an extinct human cousin known as Paranthropus,according to a study published in the journal Science.This adds to the evidence that our direct relatives may not have been the only tool users and makers during the Stone Age.

利用简并PCR克隆烟草节杆菌02181肌酸酶基因

目的用简并PCR从烟草节杆菌02181中扩增出肌酸酶部分序列,以期获得其全长编码基因。方法从NCBI查询已发表的肌酸酶蛋白质序列,将其递交到Block Maker服务器,利用工具软件CODEHOP设计简并引物,以烟草节杆菌02181基因组DNA为模板做PCR。结果将所得目的片段(414bp)在NCBI上BLASTx,结果表明,所得序列与不同菌种来源的肌酸酶高度同源,其中与节杆菌属肌酸酶基因的同源性最高,一致性达到了71%。结论从烟草节杆菌02181中成功克隆出了肌酸酶基因的部分序列。

LON智能节点开发及组网研究

针对LonW orks现场总线技术特点,论述了基于Neuron芯片开发智能节点的方法.利用这些节点,模拟工控现场进行组网.上位机选用LNS DDE Server和Lon总线设备进行通信.基于LNS的LonMaker forW indows网络集成工具将各网络变量捆绑,并负责管理整个网络.实验表明,用LonW orks技术组网,系统运行稳定、控制准确,而且组网简单、易于扩展.