The discovery that somatic mammalian cells can be epigeneti- cally reprogrammed to induced pluripotent stem cells （iPSCs） through the exogenous expression of the Oct4, Sox2, Klf4 and c-Myc （OSKM） has demonstrated ...The discovery that somatic mammalian cells can be epigeneti- cally reprogrammed to induced pluripotent stem cells （iPSCs） through the exogenous expression of the Oct4, Sox2, Klf4 and c-Myc （OSKM） has demonstrated a new way for cell-replace- ment therapy in regenerative medicine （Li et al., 2013; Nishimura and Takahashi, 2013; Takahashi and Yamanaka, 2013）. This novel technology has opened new therapeutic opportunities to gener- ate stem cells in any tissue for cell replacement therapy in a num- ber of disorders （Yamanaka, 2012; Li et al., 2013; Nishimura and Takahashi, 2013; Takahashi and Yamanaka, 2013）. Just last week, two papers published in Nature, describing a surprisingly sim- ple method to turn mature cells into embryonic-like stem ceils by culturing cells in a low pH medium （Obokata et al., 2014a, 2014b）. This method by Obokata and colleagues is truly the sim- plest, cheapest, and fastest method ever achieved for reprogram- min~ somatic cells into multiootent stem cells.展开更多
文摘The discovery that somatic mammalian cells can be epigeneti- cally reprogrammed to induced pluripotent stem cells （iPSCs） through the exogenous expression of the Oct4, Sox2, Klf4 and c-Myc （OSKM） has demonstrated a new way for cell-replace- ment therapy in regenerative medicine （Li et al., 2013; Nishimura and Takahashi, 2013; Takahashi and Yamanaka, 2013）. This novel technology has opened new therapeutic opportunities to gener- ate stem cells in any tissue for cell replacement therapy in a num- ber of disorders （Yamanaka, 2012; Li et al., 2013; Nishimura and Takahashi, 2013; Takahashi and Yamanaka, 2013）. Just last week, two papers published in Nature, describing a surprisingly sim- ple method to turn mature cells into embryonic-like stem ceils by culturing cells in a low pH medium （Obokata et al., 2014a, 2014b）. This method by Obokata and colleagues is truly the sim- plest, cheapest, and fastest method ever achieved for reprogram- min~ somatic cells into multiootent stem cells.
