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Mallinckrodt向FDA提交治疗假肥大型肌营养不良症的研究性新药申请
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作者 黄世杰 《国际药学研究杂志》 CAS CSCD 北大核心 2016年第4期607-607,共1页
Mallinckrodt生物制药公司宣布为其Synacthen Depot向FDA提交研究性新药申请,此药适用于假肥大型肌营养不良症(Duchenne muscular dystrophy)的治疗。该药是替可克肽(tetracosactide)长效制剂,为合成的24个氨基酸的黑皮质素受体激... Mallinckrodt生物制药公司宣布为其Synacthen Depot向FDA提交研究性新药申请,此药适用于假肥大型肌营养不良症(Duchenne muscular dystrophy)的治疗。该药是替可克肽(tetracosactide)长效制剂,为合成的24个氨基酸的黑皮质素受体激动剂的长效制剂。公司已实质性完成临床前研究, 展开更多
关键词 FDA mallinckrodt 新药申请 长效制剂 生物制药公司 DYSTROPHY DUCHENNE 激动剂 muscular 黑皮质素受体
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A Randomized Comparison of a Parker Endotracheal Tube and a Standard Tube Oriented 90°Counterclockwise
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作者 Wade A. Weigel Thomas C. Dean 《Open Journal of Anesthesiology》 2012年第5期219-223,共5页
Purpose: During oral fiberoptic intubation, advancement of an endotracheal tube (ETT) into the trachea is occasionally impeded by laryngeal structures. The curved flex tip Parker ETT has been shown to improve the like... Purpose: During oral fiberoptic intubation, advancement of an endotracheal tube (ETT) into the trachea is occasionally impeded by laryngeal structures. The curved flex tip Parker ETT has been shown to improve the likelihood of successful advancement as opposed to a standard ETT that is advanced in neutral orientation. However, a Parker tube has not been compared to a standard ETT oriented 90° counterclockwise from the neutral position. We hypothesize that fiber-optically-guided advancement of an ETT into the trachea will be more successful when using a Parker tube than a 90° counterclockwise-oriented standard ETT. Methods: This unblinded, randomized controlled trial compares the rate of successful advancement of a fiberoptically-guided endotracheal tube into the trachea. Two groups of randomly assigned patients with non-difficult airways are compared: a Parker flex-tip tube (Parker Group;n = 57) versus a standard ETT oriented 90° counterclockwise (Standard Group;n = 58). Our primary outcome is the first pass success rate of advanceing the ETT into the trachea. Results: First pass success occurred in 48 of 57 (84%) patients in the Parker Group vs. 39 of 58 (67%) of patients in the Standard Group (p = 0.0497). Conclusion: When advancing an ETT over an oral fiberoptic scope and into the trachea, a Parker curved flex tip ETT is statistically more likely to be placed successfully on the first pass than is a standard ETT oriented 90° counterclockwise. 展开更多
关键词 ENDOTRACHEAL INTUBATION Parker mallinckrodt Fiberoptic
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泰勒宁片和科洛曲片用于隆乳术后镇痛的比较 被引量:4
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作者 王克明 栾杰 +4 位作者 穆兰花 穆大力 刘晨 张卓奇 辛敏强 《中国美容医学》 CAS 2007年第9期1227-1229,共3页
目的:评价泰勒宁片和科洛曲片对隆乳手术后疼痛的疗效和不良反应。方法:采用随机开放平行对照试验。共完成60例,其中A组30例予泰勒宁片,单次1片;B组30例予科洛曲片,单次1片。结果:泰勒宁片对隆乳手术后引起的中度或重度疼痛总有效率可达... 目的:评价泰勒宁片和科洛曲片对隆乳手术后疼痛的疗效和不良反应。方法:采用随机开放平行对照试验。共完成60例,其中A组30例予泰勒宁片,单次1片;B组30例予科洛曲片,单次1片。结果:泰勒宁片对隆乳手术后引起的中度或重度疼痛总有效率可达96.7%,科洛曲片的总有效率可达83.3%。服药后泰勒宁片组的疼痛强度差均高于科洛曲组,经统计学处理,有显著性差异(P<0.05)。不良反应发生率较科洛曲片组高。结论:泰勒宁片为中强度镇痛药,对于隆乳手术后引起的中重度疼痛有良好的镇痛效果。 展开更多
关键词 泰勒宁 科洛曲 镇痛 隆乳术
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