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Changes of Lipid Peroxides and Superoxide Dismutase in Visceral Tissues during Endotoxic Shock in Rats
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作者 汪江淮 陈惠荪 +2 位作者 刁有芳 田昆仑 王涛 《Journal of Medical Colleges of PLA(China)》 CAS 1990年第2期141-145,共5页
As compared with the control,the malondialdehyde(MDA)levels in the cardi-ac,pulmonary,and intestinal tissues were elevated(P【0.05),and the superoxide dismu-tase activities in the cardiac,pulmonary,and intestinal tiss... As compared with the control,the malondialdehyde(MDA)levels in the cardi-ac,pulmonary,and intestinal tissues were elevated(P【0.05),and the superoxide dismu-tase activities in the cardiac,pulmonary,and intestinal tissues increased(P【0.05)at the30th min after endotoxic shock;the former in the cardiac,hepatic,renal,pulmonary,andintestinal tissues were elevated(P【0.05~0.001)and the latter in the cardiac,pulmona-ry,and intestinal tissues decreased in the 2nd h after shock;and the former were marke-dly elevated(P【0.01~0.001)and the latter severely decreased(P【【0.05~0.001)in allthe visceral tissues tested in the 4th h after shock.These data showed that lipid peroxid-ation mediated through oxygen-derived free radicals brought about tissue damage of theviscera listed above,which occurred earlier in the heart,the lungs and the intestines thanin the liver and the kidneys,and superoxide dismutase(SOD)activity was suppressed inthe late stage of endotoxic shock. 展开更多
关键词 malondialdchyde superoxide disrnutase shock ENDOTOXIN free RADICAL RAT
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