Ibrutinib and atrial fibrillation:An in-depth review of clinical implications and management strategies

Ibrutinib,a targeted therapy for B-cell malignancies,has shown remarkable efficacy in treating various hematologic cancers.However,its clinical use has raised concerns regarding cardiovascular complications,notably atrial fibrillation(AF).This comprehensive review critically evaluates the association between ibrutinib and AF by examining incidence,risk factors,mechanistic links,and management strategies.Through an extensive analysis of original research articles,this review elucidates the complex interplay between ibrutinib’s therapeutic benefits and cardiovascular risks.Moreover,it highlights the need for personalized treatment approaches,vigilant monitoring,and interdisciplinary collaboration to optimize patient outcomes and safety in the context of ibrutinib therapy.The review provides a valuable resource for healthcare professionals aiming to navigate the intricacies of ibrutinib’s therapeutic landscape while prioritizing patient well-being.

New Basle Capital Agreement and Risk Management of China＇s Banking Industry

Adjustment of Basle Capital Agreement will influence the risk management and capital arrangement demand of the banks with different scales, operation level and environment. It will have widespread and profound effect on the competition strength of every country＇s banks in the global market. Starting with illustration of the present cond（tion of risk management in China＇s banks, the paper analyzes the major problems existing in the risk management system of China＇s banking industry, then puts forward some clues and suggestions to improve and better the risk management system of China＇s banking industry.

Production Well Microbial Mitigation and H2S Risk Management

One Field has been eternally acknowledged as a sweet arena without the presence of any souring phenomena.On the other hand,the Sulfate Reducing Bacteria(SRB)growth which has been lately observed in the field Water Injection System played a major role in increasing the H2S concentrations in particular A fields.The objective of this study is to mitigate the SRB growth in the A Water Injection System and manage the risk of the Hydrogen Sulfide(H2S).In order to reduce the H2S concentrations and the return the Fields back to their original states.Thereafter,Biocide Treatment usage;based on the thorough evaluation performed in both the Lab and Fields by collecting more than 100 samples from designated wellheads and identified sampling points in the field Water Injection System network.Biocide field trial for one year was conducted with a persistent monitoring program.It appealed that the Biocide Treatment is influential,efficient and functional,carving deeper in the SRB mitigation and H2S risk management,the averaged H2S concentrations and trends in the Fields are being controlled and minimized in both the oil and gas phases.

Artificial Neural Networks in Risk Management: A Bibliometric Study

This study presents a bibliometric analysis of Artificial Neural Networks in Risk Management.The study considered articles from the I.S.I.Web of Knowledge and Scopus databases,Identification of publishers,countries,periodicals and the keywords most frequently cited.We used the CiteSpace® software to analyze this material,which provides a set of features to support bibliometrics,including the reference maps.This study provides data collection on Artificial Neural Networks applied to risk management.The number of works identified in this study is significant,and in the last ten years,the number of citations has increased.We did not identify the increase in paper count within the same period.

基于T-S模糊故障树和贝叶斯网络的建筑施工风险评估模型建立及应用

作为国民经济发展的支柱产业,建筑业安全事故频发,施工安全形势严峻。为有效评估和降低建筑施工安全风险,将T-S模糊故障树和贝叶斯网络进行结合,建立一种建筑施工风险评估模型。利用T-S门规则和贝叶斯网络的条件概率,建立T-S模糊故障树的贝叶斯网络转化模型,引入模糊理论对事件风险概率进行模糊化,最终借助贝叶斯网络双向推理算法计算故障概率、重要度及后验概率。结果表明,该模型能够根据基本事件风险概率进行量化计算,以正向推理方式计算体系事故发生概率;能够量化根节点的模糊重要度,确定事件重点管控顺序;且可以通过反向推理计算根节点后验概率,确定故障排查顺序。该计算模型最大限度贴近实际施工情形,更加科学合理地进行建筑施工风险评估,可为建筑施工的安全风险评估和精准化管理提供理论支持。

Tunnel Engineering Construction Schedule Analysis and Management Based on Visual Simulation

The methodology of visual simulation for a tunnel engineering construction schedule is presented. Visualization of simulation model, calculation and result of construction schedule simulation is realized, and the construction simulation and the resource optimization of tunnel engineering are made. A risk analysis and a decision-making method of tunnel engineering construction schedule based on visual simulation are presented. Furthermore, using S curve theory and schedule management method, the real-time management and control method of tunnel engineering construction based on visual simulation is presented. The application to the tunnel engineering construction schedule analysis and management shows the feasibility and effectiveness of the method presented in this paper.

Risk signal, financial derivatives transactions and the Indonesian GAAP

Motivated by the accounting events of firm＇s default related to derivatives and other financial instruments transactions, this study is aimed to investigate the capability of accounting information to signal the risks associated with the use of financial derivatives for hedging. Hypothesis are developed based on the theory and empirical evidences of manager＇s motive to use derivatives for hedging （Berkman ＆ Bradbury, 1968; Dune, et al., 2003） as well as signaling theory of accounting information （Ball ＆ Brown, 1968; Beaver ＆ Dukes, 1972; Jensen ＆ Meckling, 1976; Megginson, 1997）. The hypotheses are formulated in the Ordinary Least Square model. The study uses Statistical Product and Service Solutions （SPSS） version 14 as software to conduct the statistical tests. Non-bank and non-financial institutions firms with financial derivatives transactions listed in Indonesian Stock Exchange during 2001 to 2006 are chosen as the sample. Determinations of the time frame has considered the timing of introduction of revisions of accounting standard on derivatives and other financial instruments in Indonesia PSAK 50 Financial Instruments： Presentations and Disclosures which was published in July, 1998, as well as PSAK 55 Financial Instruments： Recognition and Measurements which was published in 1998. Based on the sample selections procedure and the completeness of the data required by the model, 24 firms listed during 2001-2006 or equal to 66 firm-years observations were identified as the data to be tested. Empirical evidences suggests that Indonesian GAAP is capable of providing signal associated with： （1） Fair value exposures related to manager＇s motive to reduce the cost of financial distress; （2） Cash flow exposures related to manager＇s motive to practice tax arbitrage as well as to overcome underinvestment problems; （3） Interest rate risks related to manager＇s motive to avoid the risk default due to limitations of debt covenants; （4） Forex risk related to manager＇s motive to control forex exposures caused by foreign operations as well as foreign sales.

PIC/S及欧美基于风险制定GMP检查计划对我国药品检查的启示

目的:将我国GMP药品检查管理要求与药品检查合作计划(PIC/S)进行比较研究,为提高我国药品GMP检查管理的规范性、系统性,提升检查排查风险的能力提供对策建议。方法:通过文献研究分析PIC/S及欧美药品监管机构执行基于风险制定药品GMP检查计划情况,探索我国实施基于风险制定GMP检查计划的路径。结果与结论:基于风险制定GMP检查计划的理念已在PIC/S和欧美药品监管检查体系中广泛实施,并形成当地适用的较为成熟的模型,发挥了集约检查资源、有效排查隐患的效能。本文结合我国药品监管法规体系中对检查程序的相关要求,分析我国基于风险制定GMP检查计划的实施现状和挑战,从制定基于风险的检查计划、明细检查程序、保障检查资源等方面提出对策建议,以统一规范药品监管机构药品检查运行机制和标准,提高药品检查效能。

PIC/S GMP无菌药品附录对我国无菌药品检查的影响

目的:通过分析PIC/S GMP附录《无菌药品的生产》,为我国无菌药品检查与国际化接轨提供借鉴。方法:通过对PIC/S GMP无菌药品附录的主要内容以及与我国现行版GMP无菌药品附录进行对比分析,结合我国无菌药品生产检查中的常见问题,为完善我国无菌药品GMP检查提供建议。结果与结论:修订后的PIC/S GMP无菌药品附录对比我国现有的GMP无菌药品附录从概念和内容都有了相当大的更新,体现了药品监管的与时俱进,提示我们在规范检查、提升检查水平的同时,应引导企业主动了解国际先进的质量管理理念,向国际水平和国际标准靠拢,提升我国无菌药品生产行业的整体水平。

纪检监察监测信息平台功能研发与实践

随着智慧医院的建设,医院信息化发展快速推进。纪检监察工作也必须适应信息化时代发展需要,因此在信息化时代下,利用网络数据的实时性及高效的统计能力,加大对人、财、物等重点岗位部门的监督力度,可以有效地提升医院纪检监察的精准化和专业化。文章通过研究和开发纪检监察监测信息平台,依托完善、稳定的医院内部网络资源,有效提高了纪检监察部门监督水平,构建了一套完善的网上监督系统,为医院纪检监察工作助力。

基于C/S和B/S结合模式的病理图文报告管理系统的设计和实现

文章在概括了病理图文报告管理系统背景知识的基础上,确定了以B/S和C/S结合模式的建设方案。详细地介绍了基于Internet和Intranet相结合技术的设计构想和程序设计原理,在系统功能部分介绍了系统的各个功能模块及其相应的功能,以及系统开发过程中使用的部分关键技术。

Altman’s Z-Score模型在企业风险管理中的应用研究

随着市场竞争的加剧,信息化、高科技化进程的加快,企业决策难度、经营成本和收益的波动增大,企业风险管理彰显出重要性。笔者通过对沪、深证券交易所2007年～2009年暂停上市或终止上市的32家公司的Z值分析,认为用Altman’s Z-Score模型预测企业风险是有效的。根据对Altman’s Z-Score模型组成变量的比较分析,笔者提出了企业防范风险的有关措施。

Life’s Essential 8 and risk of non-communicable chronic diseases:Outcome-wide analyses

Background:Life’s Simple 7,the former construct of cardiovascular health(CVH)has been used to evaluate adverse non-communicable chronic diseases(NCDs).However,some flaws have been recognized in recent years and Life’s Essential 8 has been established.In this study,we aimed to analyze the association between CVH defined by Life’s Essential 8 and risk of 44 common NCDs and further estimate the population attributable fractions(PAFs)of low-moderate CVH scores in the 44 NCDs.Methods:In the UK Biobank,170,726 participants free of 44 common NCDs at baseline were included.The Life’s Essential 8 composite measure consists of four health behaviours(diet,physical activity,nicotine exposure,and sleep)and four health factors(body mass index,non-high density lipoprotein cholesterol,blood glucose,and blood pressure),and the maximum CVH score was 100 points.CVH score was categorized into low,moderate,and high groups.Participants were followed up for 44 NCDs diagnosis across 10 human system disorders according to the International Classification of Diseases 10th edition(ICD-10)code using linkage to national health records until 2022.Cox proportional hazard models were used in this study.The hazard ratios(HRs)and PAFs of 44 NCDs associated with CVH score were examined.Results:During the median follow-up of 10.85 years,58,889 incident NCD cases were documented.Significant linear dose-response associations were found between higher CVH score and lower risk of 25(56.8%)of 44 NCDs.Low-moderate CVH(<80 points)score accounted for the largest proportion of incident cases in diabetes(PAF:80.3%),followed by gout(59.6%),sleep disorder(55.6%),chronic liver disease(45.9%),chronic kidney disease(40.9%),ischemic heart disease(40.8%),chronic obstructive pulmonary disease(40.0%),endometrium cancer(35.8%),lung cancer(34.0%),and heart failure(34.0%)as the top 10.Among the eight modifiable factors,overweight/obesity explained the largest number of cases of incident NCDs in endocrine,nutritional,and metabolic diseases(35.4%),digestive system disorders(21.4%),mental and behavioral disorders(12.6%),and cancer(10.3%);however,the PAF of ideal sleep duration ranked first in nervous system(27.5%)and neuropsychiatric disorders(9.9%).Conclusions:Improving CVH score based on Life’s Essential 8 may lower risk of 25 common NCDs.Among CVH metrics,avoiding overweight/obesity may be especially important to prevent new cases of metabolic diseases,NCDs in digestive system,mental and behavioral disorders,and cancer.

海恩法则和墨菲定律评价应用于急诊护理风险防控管理的效果

目的:探究海恩法则和墨菲定律评价应用于急诊护理管理的风险防控的效果。方法:选取2021年10月—2022年10月我院收治的200例急诊病人为研究对象,采用随机抽样法将其分为对照组和观察组,每组100例。对照组采用常规急诊护理管理,观察组在前述基础上加以海恩法则和墨菲定律评价管理。比较两组的不良事件发生情况急诊护理专项评分、急诊满意度问卷调查。结果:观察组和对照组的不良事件发生率为7%和19%,两组差异有统计学意义(P<0.05);观察组不同专项的急诊护理评分均高于对照组,差异有统计学意义(P<0.05);观察组护理满意度为97%,高于对照组(89%),差异有统计学意义(P<0.05)。结论:在急诊护理的风险防控管理中应用海恩法则和墨菲定律评价,可减少不良事件的发生,为病人救治提供基础与时间,可提高病人的护理满意。

从风险管理视角看B-S模型及其发展

金融风险是指由于金融资产价值的不利变动而使金融机构遭受损失的可能性。现实的经济和金融市场并非完美,因此,通过风险管理可以提升公司价值。论述了金融风险管理的理论和技术基础——Black-Scholes期权定价模型以及其演变发展,进一步分析了这一演进给对我国金融业发展的启示,从而对防范金融风险提出有益的建议。

一个B/S结构的软件项目管理平台的分析和设计

阐述了一个软件项目的管理平台分析和设计过程。该平台采用B/S结构构建,在Intranet/Internet环境下使用。以项目集中管理、共享资源、协同服务为宗旨,提供了一个完整的软件项目管理理念和流程,实现了项目立项登记、项目预算维护、项目实施计划制定、项目收款计划和实收、团队成员选取、实施方法论选取、项目文档上传、项目风险预警、项目费用维护、项目文档检索、专家资源检索等功能。

基于ESS的银行资金营运风险系统的研究

经理支持系统ESS(Executive Support System),作为企业高层管理人员直接使用的信息系统,利用计算机技术和通信技术,专门用以支持高层管理和决策人员对企业内、外部信息的查询分析,支持高层管理人员的日常管理和战略决策工作。将ESS技术应用到银行业的资金营运风险管理中,改变了银行原资金营运风险管理模式,为银行风险管理提供了一项可行性方案,并取得了良好的效果。

基于B/S架构的防雷综合管理系统设计

基于ASP.NET、C#开发语言,综合sqlServer网络数据库平台,设计实现了基于B/S架构的防雷管理、网上服务和风险防控三位一体的温州防雷综合管理系统。有效地将廉政风险防控工作融入到防雷实际业务中,实现了市和县两级防雷相关数据管理、查询统计分析以及便捷网上服务等功能,明显地提高了防雷管理水平、工作效率,为便民和高效服务提供了软件平台,同时也为防雷业务现代化管理有提供了有益的探索。

基于B/S结构的网上国网营销风险管理系统设计

考虑网上国网营销风险管理对系统功能需求,依据B/S结构将系统分为应用表现层、逻辑处理层、数据处理层和数据层四部分,设计网上国网营销风险管理系统框架;将网上国网营销风险管理分为评估和控制两部分,建立网上国网营销风险评估流程,评估网上国网营销风险,健全风险控制计划实施过程和风险控制准备过程,控制网上国网营销风险流程,完成网上国网营销风险管理系统设计。搭建系统测试软硬件环境,实验结果:在同一用户并发数条件下,设计系统承受用户并发数多,CPU占用率低,系统响应速度快,具有较优的运行性能。