Methylation reactions at dopaminergic nerve endings, serving as biological off-switches in managing dopaminergic functions

The mechanisms for the regulation of synaptic dopamine （DA） include its release from presynaptic vesicles, its interaction with post-synaptic and pre-synaptic DA receptors, the reuptake of DA, via dopamine transporter （DAT）, the diffusion of DA and its metabolism by mono-amine oxidase （MAO） and cate- chol-O-methyl transferase （COMT）. DA controls complex and specialized functions including, movements, behavior, mood, perception, reward, and more recently, neurogenesis （Popolo et al., 2004; Reimer et al., 2013） and neuroregeneration （Hoglinger et al., 2004; Yang et al., 2008）. These functions are varied and of high fidelity. Movement, as an example, requires regulatory mechanisms for initiating, stopping, slowing-down speed- ing-up, changing directions, for governing the relentless urges to move in the young and sedentariness in the old as well as in motor-freezing, catalepsy, tremor and stereotypy.

Security Monitoring and Management for the Network Services in the Orchestration of SDN-NFV Environment Using Machine Learning Techniques

Software Defined Network(SDN)and Network Function Virtualization(NFV)technology promote several benefits to network operators,including reduced maintenance costs,increased network operational performance,simplified network lifecycle,and policies management.Network vulnerabilities try to modify services provided by Network Function Virtualization MANagement and Orchestration(NFV MANO),and malicious attacks in different scenarios disrupt the NFV Orchestrator(NFVO)and Virtualized Infrastructure Manager(VIM)lifecycle management related to network services or individual Virtualized Network Function(VNF).This paper proposes an anomaly detection mechanism that monitors threats in NFV MANO and manages promptly and adaptively to implement and handle security functions in order to enhance the quality of experience for end users.An anomaly detector investigates these identified risks and provides secure network services.It enables virtual network security functions and identifies anomalies in Kubernetes(a cloud-based platform).For training and testing purpose of the proposed approach,an intrusion-containing dataset is used that hold multiple malicious activities like a Smurf,Neptune,Teardrop,Pod,Land,IPsweep,etc.,categorized as Probing(Prob),Denial of Service(DoS),User to Root(U2R),and Remote to User(R2L)attacks.An anomaly detector is anticipated with the capabilities of a Machine Learning(ML)technique,making use of supervised learning techniques like Logistic Regression(LR),Support Vector Machine(SVM),Random Forest(RF),Naïve Bayes(NB),and Extreme Gradient Boosting(XGBoost).The proposed framework has been evaluated by deploying the identified ML algorithm on a Jupyter notebook in Kubeflow to simulate Kubernetes for validation purposes.RF classifier has shown better outcomes(99.90%accuracy)than other classifiers in detecting anomalies/intrusions in the containerized environment.

Classification of plant functional types based on the nutrition traits： a case study on alpine meadow community in the Zoigê Plateau

The ecological concept of Plant Functional Types（PFTs）, which refers to the assemblage of plants with certain functional traits, has been introduced for the study of plant responses to the environment change and human disturbance. Taking the alpine meadow community in the Zoigê Plateau as a study case, this paper classified PFTs in terms of plant nutrition traits. The sequential results are as follows.（1） The main herbages in the Zoigê Plateau included 16 species in 5 families. Among the five families, Cyperaceae vegetation accounted for 81.37%of herbage area in total, while the remaining 4families occupied less than 20%. As for the species,Kobresia setchwanensis Hand.-Maizz. was dominant,accounting for 48.74% of the total area; while the remaining 51.26% was comprised of Polygonum viviparum L., Anaphalis fiavescens Hand.-Mazz.,Stipa aliena Keng and other species.（2） By using the Principal Component Analysis（PCA）, the assessment of herbages nutrition was carried out based on the comprehensive multi-index evaluation model.Polygonum viviparum L. had the highest nutritional value score（1.43）, and Stipa aliena Keng had the lowest（-1.40）. Nutritional value of herbage species had a significantly positive correlation with altitude（P＆lt;0.01） in the Zoigê Plateau.（3） Based on the nutritional values, herbages in the Zoigê Plateau could be grouped into 3 nutrition PFTs（high, medium and low） by using the Natural Breaks（Jenks） method.

医疗卫生应急演练规范化管理的设计和政策建议

目的开展上海市医疗卫生应急演练工作规范化管理的设计,统筹全市医疗卫生应急演练的组织,指导医疗卫生单位应急演练项目的实施。方法2023年4—5月,对上海市应急管理和医疗卫生相关21名专家进行半结构化访谈,从计划、组织、指挥、协调、控制五大管理职能维度进行分析。结果医疗卫生应急演练规范化管理的设计基于“医疗卫生应急演练的规划”和“医疗卫生应急演练项目的组织实施”两个层面开展。工作计划要将目标分解到时间和资源上以形成执行方案,组织安排要在既定的目标下进行任务梳理和职责分解,指挥活动要按照规定或工作流程进行程序化决策,不断地沟通和调整来协调成员单位一致行动,通过检查考核等手段来评价演练工作是否达到预期目标。结论建议进一步开展示范性案例回顾,解析医疗卫生应急演练规范化管理的关键要素;从管理职能出发明确医疗卫生应急演练管理的适用范围、参与主体和工作原则,基于演练进一步完善医疗卫生应急预案;通过长期系统性规范管理,推动医疗卫生应急演练工作高质量发展。

The Separation of Powers from Functions and the Establishment of a New Structure of Management and Operation of State-owned Assets

The development of the socialist market economy demands the furtherintensification of the reform of the management operating system (MOS)of the state-owned assets, the strengthening of the efficiency in the man-agement of state-owned assets,and the improvement of the operating bene-

Dynamic changes of cellular immune function and individualized adjustments of immunosup-pressant for the management of severe infection after liver transplantation

Objective To explore the dynamic changes of the cellular immune function in severe infection after liver transplantation,and to guide the individualized immunology adjustment. Methods 378 cases of liver transplantation were analyzed retrospectively. Seventy - four cases ( infection group) suffered serious infection,including 54 cases cured ( cure group) ,20 cases died (

Evolution of Air Traffic Management Concept of Operations and Its Impact on the System Architecture

The air traffic management system(ATM)has the task of ensuring safe,orderly and expeditious flow of air traffic.The ATM system architecture is very much dependent on the concept of operations(ConOps).Over the years the evolution in ConOps has resulted in changes in the ATM′s physical architecture,improving its physical infrastructure,increasing the levels of automation and making operational changes to improve air traffic flow,to cope with increasing demand for air travel.However,what is less clear is the impact of such changes in ConOps on the ATM′s functional architecture.This is vital for ensuring optimality in the implementation of the physical architecture components to support the ATM functions.This paper reviews the changes in the ConOps over the years,proposes a temporally invariant ATM functional model,and discusses some of the main key technologies expected to make significant improvements to the ATM system.

Technical efficiency and its determinants of the various cropping systems in the purple-soiled,hilly region of southwestern China

This study examines the technical efficiency(TE) differences among typical cropping systems of smallholder farmers in the purple-soiled hilly region of southwestern China.Household-,plot-,and crop-level data and community surveys were conducted to explore TE levels and determinants of typical cropping systems by using a translog stochastic frontier production function.Results indicate significant difference in TE and its determinants among cropping systems.The mean TEs of the rice cropping system(R),the rice-rape cropping system(RR),the rice-rape-potato cropping system(RRP),and the oil cropping system(O) are0.86,0.90,0.84,and 0.85,respectively,which are over 1.17 times higher than those of the maize-sweet potato-other crop cropping system(MSO) and the maize-sweet potato-wheat cropping system(MSW) at0.78 and 0.69,respectively.Moreover,Technical inefficiency(TIE) of different cropping systems is significantly affected by characteristics of the household as well as plot.However,the impact of land quality,mechanical cultivation conditions,crop structure,farming system,farm radius,household type,cultivated land area per capita,and annual household income per capitalon TIE vary by cropping system.Additionally,output elasticity of land,labor,and capital,as a group,is greater than the one of agricultural machinery and irrigation.Finally,when household-owned effective agricultural labor is at full farming capacity,optimal plot sizes for the R,RR,RRP,MSO,MSW,and 0 cropping systems are 1.12hm^2,0.35 hm^2,0.25 hm^2,2.82 hm^2,1.87 hm^2,and 1.17hm^2,respectively.

Specific Elements of the Public Internal Control in Countries of the European Union

The concern for greater efficiency in the public sector has determined the application in countries of the European Union of the public internal control systems, stemm from the desire of management of national funds in economic conditions. This paper addresses such issues relating to highlighting elements reflecting the importance of the control function in the management process; and identifying the characteristics of the elements constituting the control systems in countries belonging to the European Union, which were grouped into two categories depending on the date of accession to the union, using public internal control related data provided by the European Commission. Particular attention is given to highlight the characteristics of the control system applied in Romania compared to other states. Research has revealed a greater number of similarities in the characteristics of the control systems of internal public in countries that joined the Union after 1990, compared with those who became members before this year, concerning the financing of the sector public, the accounting system applied, the coordination of such a system, who bears responsibility for financial management, or the limits of managerial responsibility.

Administrative Decisions/Practices that Make the School Effective

The purpose of this work is to develop a model of effective educational administration and leadership through the conceptual definition of educational administration and the understanding of the concept of leadership in school.In particular,the educational administration will be identified and demarcated and its basic functions that are vital for the smooth operation,development and efficiency of educational organizations will be identified.Then,the concept of leadership will be analyzed,the modern models and forms in which it can be practiced in schools will be presented and the basic differences between leadership and administration will be captured.Finally,the concept of school effectiveness will be analyzed and effective ways of administration and leadership at school level will be listed,emphasizing the skills that an effective principal of a modern school unit must have.

Inventory Management and Demand Forecasting Improvement of a Forecasting Model Based on Artificial Neural Networks

Forecasting is predicting or estimating a future event or trend.Supply chains have been constantly growing in most countries ever since the industrial revolution of the 18th century.As the competitiveness between supply chains intensifies day by day,companies are shifting their focus to predictive analytics techniques to minimize costs and boost productivity and profits.Excessive inventory(overstock)and stock outs are very significant issues for suppliers.Excessive inventory levels can lead to loss of revenue because the company's capital is tied up in excess inventory.Excess inventory can also lead to increased storage,insurance costs and labor as well as lower and degraded quality based on the nature of the product.Shortages or out of stock can lead to lost sales and a decline in customer contentment and loyalty to the store.If clients are unable to find the right products on the shelves,they may switch to another vendor or purchase alternative items.Demand forecasting is valuable for planning,scheduling and improving the coordination of all supply chain activities.This paper discusses the use of neural networks for seasonal time series forecasting.Our objective is to evaluate the contribution of the correct choice of the transfer function by proposing a new form of the transfer function to improve the quality of the forecast.

Research on Effective Access for Strengthening and Improving the Management and Benefit use of Large Instruments

The purchasement and development as well as the benefit of utilization for the large equipment in universities of China are analyzed in this paper, the paper in dicates that in utilization of large equipment the contradictions such as urgency and necessity for the purchasement and development of large equipment and serious waste in resources since inadequacy of annual utilization rate of large equipment are existed, it also raises that the key step of giving full play to the benefit of large equipment is to strengthen management and development after the equipment are purchased, the paper regards through stressing standardized management and maintenance、opening the laboratory、improving the functions of equipment、renovating technology、fully examining and scientifically deciding before purchasement, the investment benefit for the large equipment can be raised effectively.

Investigating the influence of segmentation in estimating safety performance functions for roadway sections

Safety performance functions（SPFs） are crucial to science-based road safety management.Success in developing and applying SPFs, apart data quality and availability, depends fundamentally on two key factors： the validity of the statistical inferences for the available data and on how well the data can be organized into distinct homogeneous entities. The latter aspect plays a key role in the identification and treatment of road sections or corridors with problems related to safety. Indeed, the segmentation of a road network could be especially critical in the development of SPFs that could be used in safety management for roadway types, such as motorways（freeways in North America）, which have a large number of variables that could result in very short segments if these are desired to be homogeneous. This consequence, from an analytical point of view, can be a problem when the location of crashes is not precise and when there is an overabundance of segments with zero crashes. Lengthening the segments for developing and applying SPFs can mitigate this problem, but at a sacrifice of homogeneity. This paper seeks to address this dilemma by investigating four approaches for segmentation for motorways, using sample data from Italy. The best results were obtained for the segmentation based on two curves and two tangents within a segment and with fixed length segments. The segmentation characterized by a constant value of all original variables inside each segment was the poorest approach by all measures.

Facilitating Change: The Role and Function of Private Foundations in Innovation Management

1. The focus is on private foundations, which are engaged in advancing science, technology, and the humanities. In this context the Volkswagen Foundationis a prominent example for Germany. 2. Accordingly, the paper does not look at the management within firms , but at the systemic level of innovation management. Though innovation has a broadermeaning, including also economic, social, and political aspects. research and higher education are central arenas and factors of change. 3. Contemporary research and higher education are confronted with new challenges, which require new responses and new forms of innovation management: science and technology has become an integral part of the knowledge- based society; the boundaries between basic and applied research are vanishing, problem --oriented research is increasing, as a consequence the demand for inter

A Novel Analysis of Delay and Power Consumption for Polling Schemes in the IoT

In the Internet of Things（IoT）, various battery-powered wireless devices are connected to collect and exchange data, and typical traffic is periodic and heterogeneous. Polling with power management is a very promising technique that can be used for communication among these devices in the IoT. In this paper, we propose a novel and scalable model to study the delay and the power consumption performance for polling schemes with power management under heterogeneous settings（particularly the heterogeneous sleeping interval）. In our model,by introducing the concept of virtual polling interval, we successfully convert the considered energy-efficient polling scheme into an equivalent purely-limited vacation system. Thus, we can easily evaluate the mean and variance of the delay and the power consumption by applying existing queueing formulae, without developing a new theoretical model as required in previous works. Extensive simulations show that our analytical results are very accurate for both homogeneous and heterogeneous settings.