This study investigates full liquid phase sintering as a process of fabrication parts from WE43(Mg-4wt.%Y-3wt.%RE-0.7wt.%Zr)alloy using binder jetting additive manufacturing(BJAM).This fabrication process is being dev...This study investigates full liquid phase sintering as a process of fabrication parts from WE43(Mg-4wt.%Y-3wt.%RE-0.7wt.%Zr)alloy using binder jetting additive manufacturing(BJAM).This fabrication process is being developed for use in producing structural or biomedical devices.Specifically,this study focused on achieving a near-dense microstructure with WE43 Mg alloy while substantially reducing the duration of sintering post-processing after BJAM part rendering.The optimal process resulted in microstructure with 2.5%porosity and significantly reduced sintering time.The improved sintering can be explained by the presence of Y_(2)O_(3)and Nd_(2)O_(3)oxide layers,which form spontaneously on the surface of WE43 powder used in BJAM.These layers appear to be crucial in preventing shape distortion of the resulting samples and in enabling the development of sintering necks,particularly under sintering conditions exceeding the liquidus temperature of WE43 alloy.Sintered WE43 specimens rendered by BJAM achieved significant improvement in both corrosion resistance and mechanical properties through reduced porosity levels related to the sintering time.展开更多
Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering applications.However,most synthetic semicrystalline polymers do not possess the intrinsi...Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering applications.However,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell fate.Grafting of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface density.Here,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different ratios.Stable porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL 5k.As a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was assessed.After two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated peptide.In addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface density.Taken together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material interface.Moreover,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(modified)polymers.Furthermore,the use of alkyne-azide“click”chemistry enables spatial control over bioconjugation of many tissue-specific moieties,making this approach a versatile strategy for tissue engineering applications.展开更多
China removed fertilizer manufacturing subsidies from 2015 to 2018 to bolster market-oriented reforms and foster environmentally sustainable practices.However,the impact of this policy reform on food security and the ...China removed fertilizer manufacturing subsidies from 2015 to 2018 to bolster market-oriented reforms and foster environmentally sustainable practices.However,the impact of this policy reform on food security and the environment remains inadequately evaluated.Moreover,although green and low-carbon technologies offer environmental advantages,their widespread adoption is hindered by prohibitively high costs.This study analyzes the impact of removing fertilizer manufacturing subsidies and explores the potential feasibility of redirecting fertilizer manufacturing subsidies to invest in the diffusion of these technologies.Utilizing the China Agricultural University Agri-food Systems model,we analyzed the potential for achieving mutually beneficial outcomes regarding food security and environmental sustainability.The findings indicate that removing fertilizer manufacturing subsidies has reduced greenhouse gas(GHG)emissions from agricultural activities by 3.88 million metric tons,with minimal impact on food production.Redirecting fertilizer manufacturing subsidies to invest in green and low-carbon technologies,including slow and controlled-release fertilizer,organic-inorganic compound fertilizers,and machine deep placement of fertilizer,emerges as a strategy to concurrently curtail GHG emissions,ensure food security,and secure robust economic returns.Finally,we propose a comprehensive set of government interventions,including subsidies,field guidance,and improved extension systems,to promote the widespread adoption of these technologies.展开更多
研究了基于CIM(City Information Modeling,城市信息模型)的城市规划辅助决策系统实现的关键技术,包括模型轻量化、场景优化与加速绘制及基于空间的规划分析算法技术;介绍了系统的总体架构,以及一种适应规划业务需求的数据库设计。在系...研究了基于CIM(City Information Modeling,城市信息模型)的城市规划辅助决策系统实现的关键技术,包括模型轻量化、场景优化与加速绘制及基于空间的规划分析算法技术;介绍了系统的总体架构,以及一种适应规划业务需求的数据库设计。在系统实现方面,介绍了场景组织浏览、景观视线分析、规划方案评审及规划辅助分析等模块的实现。实践表明,该系统在城市规划决策中具有较高的可行性和实用性。展开更多
城市信息模型(City Information Modeling,CIM)的兴起和广泛应用为城市高质量发展和智慧城市建设提供了重要支撑。本文面向智慧城市规建管需求,构建基于CIM的集“规划—投资—设计—建设—管理—运营—双碳—元宇宙”八大功能于一体的...城市信息模型(City Information Modeling,CIM)的兴起和广泛应用为城市高质量发展和智慧城市建设提供了重要支撑。本文面向智慧城市规建管需求,构建基于CIM的集“规划—投资—设计—建设—管理—运营—双碳—元宇宙”八大功能于一体的产城管理平台,实现线下物理城市与线上数字城市的深度融合,助力产城科学规划、高效建设和优质运营。在此基础上解析CIM平台的自我学习过程,提出数据迭代-模型迭代-服务迭代的多层次未来城市场景迭代框架,并分析其场景应用与反馈机制,助力产城全场景穿透,提高政府管理软实力。展开更多
Over the course of millions of years,nature has evolved to ensure survival and presents us with a myriad of functional surfaces and structures that can boast high efficiency,multifunctionality,and sustainability.What ...Over the course of millions of years,nature has evolved to ensure survival and presents us with a myriad of functional surfaces and structures that can boast high efficiency,multifunctionality,and sustainability.What makes these surfaces particularly practical and effective is the intricate micropatterning that enables selective interactions with microstructures.Most of these structures have been realized in the laboratory environment using numerous fabrication techniques by tailoring specific surface properties.Of the available manufacturing methods,additive manufacturing(AM)has created opportunities for fabricating these structures as the complex architectures of the naturally occurring microstructures far exceed the traditional ways.This paper presents a concise overview of the fundamentals of such patterned microstructured surfaces,their fabrication techniques,and diverse applications.A comprehensive evaluation of micro fabrication methods is conducted,delving into their respective strengths and limitations.Greater emphasis is placed on AM processes like inkjet printing and micro digital light projection printing due to the intrinsic advantages of these processes to additively fabricate high resolution structures with high fidelity and precision.The paper explores the various advancements in these processes in relation to their use in microfabrication and also presents the recent trends in applications like the fabrication of microlens arrays,microneedles,and tissue scaffolds.展开更多
文摘This study investigates full liquid phase sintering as a process of fabrication parts from WE43(Mg-4wt.%Y-3wt.%RE-0.7wt.%Zr)alloy using binder jetting additive manufacturing(BJAM).This fabrication process is being developed for use in producing structural or biomedical devices.Specifically,this study focused on achieving a near-dense microstructure with WE43 Mg alloy while substantially reducing the duration of sintering post-processing after BJAM part rendering.The optimal process resulted in microstructure with 2.5%porosity and significantly reduced sintering time.The improved sintering can be explained by the presence of Y_(2)O_(3)and Nd_(2)O_(3)oxide layers,which form spontaneously on the surface of WE43 powder used in BJAM.These layers appear to be crucial in preventing shape distortion of the resulting samples and in enabling the development of sintering necks,particularly under sintering conditions exceeding the liquidus temperature of WE43 alloy.Sintered WE43 specimens rendered by BJAM achieved significant improvement in both corrosion resistance and mechanical properties through reduced porosity levels related to the sintering time.
基金the European Research Council starting grant “Cell Hybridge” for financial support under the Horizon2020 framework program (Grant#637308)the Province of Limburg for support and funding
文摘Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering applications.However,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell fate.Grafting of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface density.Here,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different ratios.Stable porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL 5k.As a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was assessed.After two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated peptide.In addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface density.Taken together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material interface.Moreover,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(modified)polymers.Furthermore,the use of alkyne-azide“click”chemistry enables spatial control over bioconjugation of many tissue-specific moieties,making this approach a versatile strategy for tissue engineering applications.
基金The authors acknowledge the financial support received from the National Natural Science Foundation of China(72061147002).
文摘China removed fertilizer manufacturing subsidies from 2015 to 2018 to bolster market-oriented reforms and foster environmentally sustainable practices.However,the impact of this policy reform on food security and the environment remains inadequately evaluated.Moreover,although green and low-carbon technologies offer environmental advantages,their widespread adoption is hindered by prohibitively high costs.This study analyzes the impact of removing fertilizer manufacturing subsidies and explores the potential feasibility of redirecting fertilizer manufacturing subsidies to invest in the diffusion of these technologies.Utilizing the China Agricultural University Agri-food Systems model,we analyzed the potential for achieving mutually beneficial outcomes regarding food security and environmental sustainability.The findings indicate that removing fertilizer manufacturing subsidies has reduced greenhouse gas(GHG)emissions from agricultural activities by 3.88 million metric tons,with minimal impact on food production.Redirecting fertilizer manufacturing subsidies to invest in green and low-carbon technologies,including slow and controlled-release fertilizer,organic-inorganic compound fertilizers,and machine deep placement of fertilizer,emerges as a strategy to concurrently curtail GHG emissions,ensure food security,and secure robust economic returns.Finally,we propose a comprehensive set of government interventions,including subsidies,field guidance,and improved extension systems,to promote the widespread adoption of these technologies.
文摘研究了基于CIM(City Information Modeling,城市信息模型)的城市规划辅助决策系统实现的关键技术,包括模型轻量化、场景优化与加速绘制及基于空间的规划分析算法技术;介绍了系统的总体架构,以及一种适应规划业务需求的数据库设计。在系统实现方面,介绍了场景组织浏览、景观视线分析、规划方案评审及规划辅助分析等模块的实现。实践表明,该系统在城市规划决策中具有较高的可行性和实用性。
文摘城市信息模型(City Information Modeling,CIM)的兴起和广泛应用为城市高质量发展和智慧城市建设提供了重要支撑。本文面向智慧城市规建管需求,构建基于CIM的集“规划—投资—设计—建设—管理—运营—双碳—元宇宙”八大功能于一体的产城管理平台,实现线下物理城市与线上数字城市的深度融合,助力产城科学规划、高效建设和优质运营。在此基础上解析CIM平台的自我学习过程,提出数据迭代-模型迭代-服务迭代的多层次未来城市场景迭代框架,并分析其场景应用与反馈机制,助力产城全场景穿透,提高政府管理软实力。
基金The National Science Foundation(NSF)through Grants ECCS-2111056 and CMMI-1846863.
文摘Over the course of millions of years,nature has evolved to ensure survival and presents us with a myriad of functional surfaces and structures that can boast high efficiency,multifunctionality,and sustainability.What makes these surfaces particularly practical and effective is the intricate micropatterning that enables selective interactions with microstructures.Most of these structures have been realized in the laboratory environment using numerous fabrication techniques by tailoring specific surface properties.Of the available manufacturing methods,additive manufacturing(AM)has created opportunities for fabricating these structures as the complex architectures of the naturally occurring microstructures far exceed the traditional ways.This paper presents a concise overview of the fundamentals of such patterned microstructured surfaces,their fabrication techniques,and diverse applications.A comprehensive evaluation of micro fabrication methods is conducted,delving into their respective strengths and limitations.Greater emphasis is placed on AM processes like inkjet printing and micro digital light projection printing due to the intrinsic advantages of these processes to additively fabricate high resolution structures with high fidelity and precision.The paper explores the various advancements in these processes in relation to their use in microfabrication and also presents the recent trends in applications like the fabrication of microlens arrays,microneedles,and tissue scaffolds.
