基于ECM模型的智能健身镜用户持续使用意愿研究

目的通过ECM模型剖析智能健身镜用户持续使用意愿的要素,探究用户感知有用性、期望确认度与用户满意度之间的关系。方法借助ECM模型解构其关键要素,深层分析各要素的影响因子,结合SPSS和Amos数据分析工具进行实证研究,检验各要素中的变量回归关系。结果感知有用性与用户满意度以及持续使用意愿之间存在明显的正向关联,期望确认度对用户满意度和感知有用性产生显著影响,而用户满意度虽对持续使用意愿具有一定的影响,但统计学上并未达到显著水平。结论智能健身镜用户行为具有一定的复杂性,感知有用性和期望确认度在用户持续使用意愿的形成过程中起关键作用。通过验证ECM模型的适用性,明确此类产品的优化关键在于优化产品性能和提供个性化附加价值,进而提高用户的使用体验。

基于AR-ECM平均差异模型的串联电池组SOC、容量多尺度联合估计方法

考虑电池单体老化差异所致的电池组不一致性,针对串联电池组荷电状态(state of charge,SOC)、容量估计问题,提出一种基于自回归等效电路模型(autoregression equivalent circuit model,AR-ECM)的平均差异模型(mean-difference model,MDM)。基于此模型,提出串联电池组SOC、容量多尺度联合估计算法。该算法由2个部分组成,一是基于AR-ECM的MDM及差异化模型参数辨识策略:条件辨识策略和定频分组辨识策略;二是基于多时间尺度H无穷滤波(multi-timescale H infinity filter,Mts-HIF)的电池组SOC、容量联合估计算法。通过将所提出MDM中的自回归平均模型(autoregression mean model,AR-MM)与传统MDM中的n阶RC平均模型(nRC mean model,nRC-MM)比较,结果表明所提出的AR-MM在复杂运行工况下具有更优的动态跟随性能。依据最小化信息量准则(akaike information criterion,AIC),AR-MM具有更优的复杂度与精度的权衡。通过与基于多时间尺度扩展卡尔曼滤波(multi-timescale extended Kalman filter,Mts-EKF)联合状态估计算法比较,结果表明所提出的Mts-HIF状态估计算法具有更优的鲁棒性、精度和收敛速度。

基于VMD-Transformer-ECM模型的空气中有害气体浓度预测

空气中有害气体的浓度序列具有较强的复杂性、非线性及波动性,为气体浓度的准确预测带来了很大挑战。针对该问题,提出了一种基于变分模态分解(VMD)和误差补偿(ECM)的Transformer预测模型(VMD-Transformer-ECM)。首先通过VMD将气体浓度时间序列分解成不同频率的本征模态函数(IMF),以降低预测模型输入的复杂性和非平稳性;然后通过Transformer模型对分解所得的各模态分量进行预测,并对预测结果进行重构以得到初步预测值;最后通过ECM模型对误差序列进行预测,并使用误差预测值来补偿初步预测值,以进一步提高模型的预测精度。在不同数据集中对所提模型进行了验证,结果显示,与其他模型相比,VMD-Transformer-ECM模型对CO_(2)及其他有害气体浓度预测的平均绝对百分比误差(MAPE)和均方根误差(RMSE)最小,决定系数(R^(2))最大,其中在预测步长为3 h时,本模型对CO_(2)浓度预测的MAPE为4.38%,RMSE为35.44×10^(-6),R^(2)为0.94,表明所提模型的预测精度较高,预测性能较好。

真皮ECM黏弹性通过激活Hmmr促进毛囊再生

目的毛囊真皮微环境对毛囊再生具有非常重要的作用,而ECM的力学环境对毛囊再生的影响机制尚不清晰。本研究旨在探究ECM力学微环境对毛囊再生的影响机制。方法单细胞数据分析静止期毛囊和早期生长期毛囊筛选与ECM相关差异基因,通过生信分析、免疫荧光、q RT-PCR等手段验证差异基因的表达和ECM黏弹性的变化,功能干扰及类器官功能实验验证ECM黏弹性对毛囊再生的功能。结果通过单细胞数据分析发现早期生长期毛囊具有一群独特的真皮细胞亚群,该亚群特异性高表达透明质酸介导的运动受体(Hmmr);富集分析发现Hmmr阳性细胞和细胞与基质间的黏附相关,进一步生信分析和免疫荧光验证了早期生长期Elastin蛋白的表达降低,说明早期生长期毛囊的ECM黏弹性低于静止期。同时通过增加Elastin蛋白的表达发现Hmmr表达降低,说明早期生长期Hmmr的表达增加与ECM黏弹性降低有关。最终通过功能干扰和类器官功能实验验证了黏弹性降低激活Hmmr表达,促进毛囊再生。进一步通过Cellchat分析发现Hmmr阳性细胞亚群还与毛乳头细胞(DP)亚群通过Ncam1-Fgfr1信号通路进行相互作用,促进毛囊的再生。结论在毛囊再生过程中,毛囊ECM黏弹性降低,激活Hmmr表达,进而通过DP细胞的Fgfr1信号促进毛囊的再生,这一发现为研究ECM力学环境对毛囊再生提供了新的思路。

基于改进遗传算法的锂离子电池ECM模型参数辨识

可靠的动力电池等效电路(Equivalent Circuit Model, ECM)模型是电动汽车电池管理系统重要的技术支撑,而等效电路模型的精确性很大程度上取决于参数辨识精度。以容量3.5 A·h的三元锂离子电池为研究对象,采用双极化ECM模型构建锂离子电池模型,在此基础上提出一种基于改进遗传算法的参数识别方法,对模型中的参数进行辨识;基于所辨识的参数建立电池仿真模型,分别采用变流和恒流工况验证所构建的电池模型。结果表明,误差均控制在±0.02 V以内,所提出的改进遗传算法参数辨识方法具有较高的精度。

Deep tectonics and seismogenic mechanisms of the seismic source zone of the Jishishan M_(s)6.2 earthquake on December 18,2023,at the northeast margin of the Tibetan Plateau

On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China Block.In this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and anisotropy.We discovered that the location of the earthquake was related to changes in the crustal structure.The results showed that the Jishishan M_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave velocity.The epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity region.Additionally,the source area is flanked by two high-velocity anomalies from the east and west.The principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this region.In some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal anisotropy.These features underscore the relationship between the occurrence of the Jishishan M_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic characteristics.The NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension process.The presence of this weak layer makes it easier for strong earthquakes to occur through the release of overlying rigid crustal stresses.However,it is unlikely that an earthquake of comparable or larger magnitude would occur in the short term(e.g.,in one year)at the Jishishan east margin fault.

Marginal zone lymphoma with severe rashes: A case report

BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.

The largest CPIES array in the marginal sea:abundant dynamics in the northeast South China Sea

The South China Sea(SCS)is a marginal sea connecting the Pacific and Indian oceans and has gained much attention in recent decades.The dynamics in the northeast SCS are considerably influenced by topography,monsoons,tropical cyclones,the Kuroshio intrusion,and water exchange through the Luzon Strait(LS).

中国煤炭消费对碳排放的影响研究——基于ECM模型的分析

中国是全球最大的煤炭生产国和消费国,控制煤炭消费对中国实现“双碳”目标至关重要。与此同时,中国也是世界主要的石油和天然气消费国,2023年中国碳排放量占全球碳排放总量的30.93%。采用单位根检验、协整检验、ECM(Error Correction Model,误差修正模型)检验和Granger因果关系检验,实证分析了中国煤炭消费量与碳排放量之间的短期动态和长期均衡关系。研究结果表明,中国煤炭消费量和碳排放量之间存在双向Granger因果关系,即煤炭消费量的变化会引起碳排放量的变化,同时碳排放量的变化会反向影响煤炭消费量。协整分析进一步揭示了两者之间存在稳定的长期均衡关系。基于ECM进行分析,还发现短期内煤炭消费量的变化会对碳排放量产生显著影响。

Distal margin distance in radical resection of locally advanced rectal cancer after neoadjuvant therapy

Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced rectal cancer, with the common goal of improving oncological outcomes while preserving function. The controversy regarding the circumferential resection margin distance in rectal cancer surgery has been resolved. With the promotion of neoadjuvant therapy concepts and advancements in technology, treatment strategies have become more diverse.Following tumor downstaging, there is an increasing trend towards extending the safe distance of distal rectal margin. This provides more opportunities for patients with low rectal cancer to preserve their anal function.However, there is currently no consensus on the specific distance of distal resection margin.

Bendamustine and rituximab as frontline therapy in extranodal marginal zone lymphoma:a single-institution experience

Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone lymphoma.Frontline bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s lymphomas.Only one trial has evaluated frontline BR prospectively in EMZL.This retrospective study reports outcomes among EMZL patients receiving frontline BR.Twenty-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ disease.The median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)individuals.Overall response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not reached.The estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to BR.BR is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature.

Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan Basin, SW China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration

Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain lateral comparison profile and seismic reflection structures in the 2D seismic section, which can provide references for future worldwide exploration. Microbial mounds with larger buildups and thicker vertical reservoirs are typically targeted on the windward margin, while small-sized microbial mounds and flats with better lateral connections are typically focused on the leeward margin.

Three-dimensional constrained gravity inversion of Moho depth and crustal structural characteristics at Mozambique continental margin

Mozambique's continental margin in East Africa was formed during the break-off stage of the east and west Gondwana lands. Studying the geological structure and division of continent-ocean boundary(COB) in Mozambique's continental margin is considered of great significance to rebuild Gondwana land and understand its movement mode. Along these lines, in this work, the initial Moho was fit using the known Moho depth from reflection seismic profiles, and a 3D multi-point constrained gravity inversion was carried out. Thus, highaccuracy Moho depth and crustal thickness in the study area were acquired. According to the crustal structure distribution based on the inversion results, the continental crust at the narrowest position of the Mozambique Channel was detected. According to the analysis of the crustal thickness, the Mozambique ridge is generally oceanic crust and the COB of the whole Mozambique continental margin is divided.

Linkage between precipitation isotopes and water vapor sources in the monsoon margin:Evidence from arid areas of Northwest China

The isotope composition in precipitation has been widely considered as a tracer of monsoon activity.Compared with the coastal region,the monsoon margin usually has limited precipitation with large fluctuation and is usually sensitive to climate change.The water resource management in the monsoon margin should be better planned by understanding the composition of precipitation isotope and its influencing factors.In this study,the precipitation samples were collected at five sampling sites(Baiyin City,Kongtong District,Maqu County,Wudu District,and Yinchuan City)of the monsoon margin in the northwest of China in 2022 to analyze the characteristics of stable hydrogen(δD)and oxygen(δ18O)isotopes.We analyzed the impact of meteorological factors(temperature,precipitation,and relative humidity)on the composition of precipitation isotope at daily level by regression analysis,utilized the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)-based backward trajectory model to simulate the air mass trajectory of precipitation events,and adopted the potential source contribution function(PSCF)and concentration weighted trajectory(CWT)to analyze the water vapor sources.The results showed that compared with the global meteoric water line(GMWL),the slope of the local meteoric water line(LMWL;δD=7.34δ^(18)O-1.16)was lower,indicating the existence of strong regional evaporation in the study area.Temperature significantly contributed toδ18O value,while relative humidity had a significant negative effect onδ18O value.Through the backward trajectory analysis,we found eight primary locations that were responsible for the water vapor sources of precipitation in the study area,of which moisture from the Indian Ocean to South China Sea(ITSC)and the western continental(CW)had the greatest influence on precipitation in the study area.The hydrogen and oxygen isotopes in precipitation are significantly influenced by the sources and transportation paths of air mass.In addition,the results of PSCF and CWT analysis showed that the water vapor source areas were primarily distributed in the south and northwest direction of the study area.

Influences of burial process on diagenesis and high-quality reservoir development of deep-ultra-deep clastic rocks:A case study of Lower Cretaceous Qingshuihe Formation in southern margin of Junggar Basin,NW China

Taking the Lower Cretaceous Qingshuihe Formation in the southern margin of Junggar Basin as an example,the influences of the burial process in a foreland basin on the diagenesis and the development of high-quality reservoirs of deep and ultra-deep clastic rocks were investigated using thin section,scanning electron microscope,electron probe,stable isotopic composition and fluid inclusion data.The Qingshuihe Formation went through four burial stages of slow shallow burial,tectonic uplift,progressive deep burial and rapid deep burial successively.The stages of slow shallow burial and tectonic uplift not only can alleviate the mechanical compaction of grains,but also can maintain an open diagenetic system in the reservoirs for a long time,which promotes the dissolution of soluble components by meteoric freshwater and inhibits the precipitation of dissolution products in the reservoirs.The late rapid deep burial process contributed to the development of fluid overpressure,which effectively inhibits the destruction of primary pores by compaction and cementation.The fluid overpressure promotes the development of microfractures in the reservoir,which enhances the dissolution effect of organic acids.Based on the quantitative reconstruction of porosity evolution history,it is found that the long-term slow shallow burial and tectonic uplift processes make the greatest contribution to the development of deep-ultra-deep high-quality clastic rock reservoirs,followed by the late rapid deep burial process,and the progressive deep burial process has little contribution.

Transformation of marginal zone lymphoma into high-grade B-cell lymphoma expressing terminal deoxynucleotidyl transferase:A case report

BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and HGBL-not otherwise specific(HGBL-NOS),which are morphologically characteristic of HGBL but lack MYC,BCL-2,or BCL-6 rearrangements.HGBL is partially transformed by follicular lymphoma and other indolent lymphoma,with few cases of marginal zone lymphoma(MZL)transformation.HGBL often has a poor prognosis and intensive therapy is currently mainly advocated,but there is no good treatment for these patients who cannot tolerate chemotherapy.CASE SUMMARY We reported a case of MZL transformed into HGBL-NOS with TP53 mutation and terminal deoxynucleotidyl transferase expression.Gene analysis revealed the gene expression profile was identical in the pre-and post-transformed tissues,suggesting that the two diseases are homologous,not secondary tumors.The chemotherapy was ineffective and the side effect was severe,so we tried combination therapy including venetoclax and obinutuzumab.The patient tolerated treatment well,and reached partial response.The patient had recurrence of hepatocellular carcinoma and died of multifunctional organ failure.He survived for 12 months after diagnosis.CONCLUSION Venetoclax combined with obinutuzumab might improve the survival in some HGBL patients,who are unsuitable for chemotherapy.

基于A-ECMS的增程式电动汽车能量管理策略设计及应用

增程式电动汽车因其电驱效率高、无里程焦虑等优点,在新能源汽车市场备受青睐。为了进一步提升其综合性能,本研究在MATLAB/Simulink环境下构建了增程式电动汽车仿真模型,并利用等效自适应因子以改进燃油消耗最小化算法,形成了基于A-ECMS的能量管理策略。结果表明,在WLTC循环工况测试中,A-ECMS能量管理策略的百公里综合油耗为6.42 L,综合燃油消耗量为0.71 L,均低于其他方法。最终的电池充电状态(SOC)为31.1%,与目标SOC的偏差仅为1.1%。该策略显著提升了燃油经济性和电池使用寿命,为增程式电动汽车性能优化提供了新的参考方法。

应力松弛速率可调的ECM及其对骨髓间充质干细胞成骨分化的影响

目的天然细胞外基质(ECM)通常表现出动态的力学性能,尤其是其黏弹性表现出时间依赖性响应行为,极大地影响了细胞命运。通过仿生构建弹性模量相同而应力松弛速率可调控的复合水凝胶作为ECM,可探究ECM的黏弹性力学线索影响骨髓间充质干细胞(MSCs)成骨分化行为的力学生物学机制。方法本工作通过调节仿生ECM中两种动态共价键,即硼酸酯键与亚胺键的相对比例,即可实现控制该ECM的弹性模量相同而应力松弛速率不同(设置不同ECM的半应力松弛时间在2~200 s),以此为工具来研究水凝胶的应力松弛速率对MSCs成骨分化行为的影响规律及机制。结果具有较快应力松弛速率的ECM,即当ECM的半应力松弛时间为10 s时,更有利于促进MSCs成骨分化行为。结论应力松弛速率可调的ECM,由于动态亚胺键与动态硼酸酯键的能量耗散速率不同,进而影响MSCs的细胞膜表面整合素聚集、肌动蛋白收缩以及细胞体积扩增,TRPV4激活和体积扩增之间的相互反馈控制了RUNX2的核定位,从而实现对MSCs的成骨分化调控。综上所述,本研究为构建基于动态共价键的黏弹性可调ECM提供了一种新策略,对于系统研究ECM物理特性影响干细胞命运的力学生物学机制具有重要的参考价值。

ECM重塑下肿瘤淋巴管生成模型的定性分析与数值模拟

肿瘤转移是肿瘤发展过程中的重要环节,也是导致癌症恶化和治疗失败的主要原因之一。以肿瘤转移为背景,本文研究基于肿瘤与细胞外基质(Extracellular Matrix,ECM)相互作用的肿瘤淋巴管生成模型。首先用数学语言梳理肿瘤淋巴管生成的生物原理,其次做出假设,建立数学模型并进行定性分析。主要通过逼近方法、偏微分方程定性理论和Banach不动点定理证明模型局部解的存在唯一性,以及借助局部解的正则性估计和嵌入不等式证明模型整体解的存在唯一性。最后利用差分数值方法进行数值模拟来说明模型的可靠性与准确性。本文对深入理解肿瘤转移机制、指导癌症治疗以及推动相关研究具有重要意义。

基于ECM-ISC模型的“互联网+政务服务”平台公众持续使用意愿研究

随着数字政府的持续建设,“互联网+政务服务”改革成为优化营商环境和提升政务服务质量的突破口。基于ECM-ISC模型,从“顾客”视角出发探索“互联网+政务服务”平台公众持续使用意愿的决定因素。结果显示:期望确认显著正向影响感知有用性;期望确认显著正向影响满意度;感知有用性显著正向影响公众持续使用意愿;满意度显著正向影响公众持续使用意愿。研究可为数字政府建设及海南省政府数字化转型提供一定参考。