Introduction: During the application of non-invasive positive pressure ventilation (NPPV) therapy in home mechanical ventilation (HMV), leaks in the NPPV mask may occur owing to the position of the mask due to conditi...Introduction: During the application of non-invasive positive pressure ventilation (NPPV) therapy in home mechanical ventilation (HMV), leaks in the NPPV mask may occur owing to the position of the mask due to conditions such as skin disorders. Methods: To investigate whether such a leak affects FiO2 supplied to the alveoli, we simulated a patient with chronic obstructive pulmonary disorder during NPPV in HMV. In addition, FiO2 was measured in the portion assumed to be the mouth and lungs while setting the flow of the oxygen concentrator and leak amount based on a previous study. Results: FiO2 supplied to the lungs increased statistically significantly upon increasing the amount of leak (P Conclusions: We observed that FiO2 supplied to alveoli can be reduced by a leak in the NPPV mask. Because our results differ from those previously reported, we believe that further studies should reassess the selection of respirators and oxygen concentrators.展开更多
目的探讨鼻氧管、氧气面罩和氧袋面罩三种吸氧方法治疗重型病毒性肺炎患者的临床效果。方法113例重型病毒性肺炎患者为研究对象,其中,32例接受鼻氧管吸氧氧疗(鼻氧管组),40例接受氧气面罩吸氧氧疗(氧气面罩组),41例接受氧袋面罩吸氧氧疗...目的探讨鼻氧管、氧气面罩和氧袋面罩三种吸氧方法治疗重型病毒性肺炎患者的临床效果。方法113例重型病毒性肺炎患者为研究对象,其中,32例接受鼻氧管吸氧氧疗(鼻氧管组),40例接受氧气面罩吸氧氧疗(氧气面罩组),41例接受氧袋面罩吸氧氧疗(氧袋面罩组)。对比三组患者吸氧治疗前后的血气分析监测结果[pH值、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、氧合指数(OI)、血氧饱和度(SpO_(2))],OI<300 mm Hg(1 mm Hg=0.133 kPa)持续时间、治疗有效率及气管插管率。结果治疗前,三组患者的pH值、PaO_(2)、PaCO_(2)、OI、SpO_(2)对比,差异无统计学意义(P>0.05)。氧袋面罩组治疗48 h后的pH值高于本组治疗前,差异具有统计学意义(P<0.05);氧袋面罩组治疗24、48 h后的PaO_(2)高于本组治疗前,且高于氧气面罩组及鼻氧管组同时点,差异具有统计学意义(P<0.05);氧袋面罩组治疗24、48 h后的OI高于氧气面罩组及鼻氧管组同时点,差异具有统计学意义(P<0.05);三组患者治疗24、48 h后的SpO_(2)均高于本组治疗前,差异具有统计学意义(P<0.05)。氧袋面罩组患者的OI<300 mm Hg持续时间为(8.32±3.82)d、治疗有效率为70.7%、气管插管率为19.5%;氧气面罩组患者的OI<300 mm Hg持续时间为(9.34±4.36)d、治疗有效率为67.5%、气管插管率为22.5%;鼻氧管组患者的OI<300 mm Hg持续时间为(12.35±4.64)d、治疗有效率为56.3%、气管插管率为31.3%。氧袋面罩组及氧气面罩组患者的OI<300 mm Hg持续时间均短于鼻氧管组,差异具有统计学意义(P<0.05);氧袋面罩组及氧气面罩组患者的OI<300 mm Hg持续时间对比,差异无统计学意义(P>0.05);三组患者的治疗有效率及气管插管率两两对比,差异无统计学意义(P>0.05)。结论氧气面罩、氧袋面罩吸氧氧疗应用于重型病毒性肺炎患者较鼻氧管吸氧氧疗可更明显改善患者的血气指标,具有较高的安全性。展开更多
文摘Introduction: During the application of non-invasive positive pressure ventilation (NPPV) therapy in home mechanical ventilation (HMV), leaks in the NPPV mask may occur owing to the position of the mask due to conditions such as skin disorders. Methods: To investigate whether such a leak affects FiO2 supplied to the alveoli, we simulated a patient with chronic obstructive pulmonary disorder during NPPV in HMV. In addition, FiO2 was measured in the portion assumed to be the mouth and lungs while setting the flow of the oxygen concentrator and leak amount based on a previous study. Results: FiO2 supplied to the lungs increased statistically significantly upon increasing the amount of leak (P Conclusions: We observed that FiO2 supplied to alveoli can be reduced by a leak in the NPPV mask. Because our results differ from those previously reported, we believe that further studies should reassess the selection of respirators and oxygen concentrators.
文摘目的探讨鼻氧管、氧气面罩和氧袋面罩三种吸氧方法治疗重型病毒性肺炎患者的临床效果。方法113例重型病毒性肺炎患者为研究对象,其中,32例接受鼻氧管吸氧氧疗(鼻氧管组),40例接受氧气面罩吸氧氧疗(氧气面罩组),41例接受氧袋面罩吸氧氧疗(氧袋面罩组)。对比三组患者吸氧治疗前后的血气分析监测结果[pH值、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、氧合指数(OI)、血氧饱和度(SpO_(2))],OI<300 mm Hg(1 mm Hg=0.133 kPa)持续时间、治疗有效率及气管插管率。结果治疗前,三组患者的pH值、PaO_(2)、PaCO_(2)、OI、SpO_(2)对比,差异无统计学意义(P>0.05)。氧袋面罩组治疗48 h后的pH值高于本组治疗前,差异具有统计学意义(P<0.05);氧袋面罩组治疗24、48 h后的PaO_(2)高于本组治疗前,且高于氧气面罩组及鼻氧管组同时点,差异具有统计学意义(P<0.05);氧袋面罩组治疗24、48 h后的OI高于氧气面罩组及鼻氧管组同时点,差异具有统计学意义(P<0.05);三组患者治疗24、48 h后的SpO_(2)均高于本组治疗前,差异具有统计学意义(P<0.05)。氧袋面罩组患者的OI<300 mm Hg持续时间为(8.32±3.82)d、治疗有效率为70.7%、气管插管率为19.5%;氧气面罩组患者的OI<300 mm Hg持续时间为(9.34±4.36)d、治疗有效率为67.5%、气管插管率为22.5%;鼻氧管组患者的OI<300 mm Hg持续时间为(12.35±4.64)d、治疗有效率为56.3%、气管插管率为31.3%。氧袋面罩组及氧气面罩组患者的OI<300 mm Hg持续时间均短于鼻氧管组,差异具有统计学意义(P<0.05);氧袋面罩组及氧气面罩组患者的OI<300 mm Hg持续时间对比,差异无统计学意义(P>0.05);三组患者的治疗有效率及气管插管率两两对比,差异无统计学意义(P>0.05)。结论氧气面罩、氧袋面罩吸氧氧疗应用于重型病毒性肺炎患者较鼻氧管吸氧氧疗可更明显改善患者的血气指标,具有较高的安全性。
