Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-r...Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-related mortality combined （1）. About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed （2）. Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality （3）. More recently,展开更多
Obesity is included in the definition of metabolic syndrome. However, there are many controversies surrounding the evaluation of obesity such as body mass index (BMI) and waist circumference (WC) in the definition of ...Obesity is included in the definition of metabolic syndrome. However, there are many controversies surrounding the evaluation of obesity such as body mass index (BMI) and waist circumference (WC) in the definition of metabolic syndrome among various populations. To understand precisely how various anthropometric indices of obesity influence metabolic parameters, we studied the correlations of BMI, WC (Japanese criteria), WC (IDF criteria), visceral fat area (VFA), subcutaneous fat area (SFA) and the VFA/SFA ratio with metabolic parameters in patients with type 2 diabetes. The influences of BMI and WC on diastolic blood pressure and HDL-cholesterol were larger than VFA, whereas the influences of visceral fat area on triglyceride, very low-density lipoprotein-cholesterol, C-peptide and high-sensitivity C-reactive protein were larger than BMI and WC. WC (IDF) was the strongest determinant of adiponectin among anthropometric indices. Present study showed significant different associations of BMI, Japan- and IDF-defined WC, VFA, SFA and the VFA/SFA ratio with blood pressure, glucose and lipid metabolism, and adipocytokines in Japanese patients with type 2 diabetes.展开更多
<strong>Background: </strong>Type 2 diabetes mellitus, beyond its well-known cardiovascular and neurological complications, is now increasingly recognized as having deleterious effects on bone tissue. It’...<strong>Background: </strong>Type 2 diabetes mellitus, beyond its well-known cardiovascular and neurological complications, is now increasingly recognized as having deleterious effects on bone tissue. It’s thus presented as an independent risk factor for bone fragility with a considerable fracture risk relating to many more or less intricate parameters. The general objective of our study is to assess bone mass during type 2 diabetes in Senegalese women. <strong>Methodology:</strong> We had carried out a cross-sectional and descriptive study. Socio-demographic characteristics were collected on the basis of a questionnaire. Then each of the subjects had undergone a complete clinical examination followed by a blood sample for a biological assessment of certain cardiovascular risk factors. Bone mass was measured using a bio-impedancemeter. <strong>Results:</strong> We recruited 88 women with type 2 diabetes and 83 healthy control women. The mean age of diabetic subjects was 52.7 years ± 6.8 (with extremes of 39 and 74 years). In control, the mean age was 51.0 ± 8.5 years (with extremes of 35 and 72 years). Among the diabetic subjects, 22 subjects or 25% practiced a regular walk against 27 (32.5%) in the control. Forty-three among the diabetic subjects (48.8%) were known hypertensive and followed. According to the body mass index, 71 patients (80.7%) were overweight compared to 59 (71.1%) controls. According to the waist size, 80 (90.9%) diabetic subjects had an elevated waist size compared to 69 control women (83.1%). Among diabetic subjects, 41 patients (46.5%) were hyperglycemic imbalance according to fasting blood glucose and 59 patients (67%) according to glycated hemoglobin level. Thirty-seven diabetics (42%), had both high fasting blood glucose and elevated glycated hemoglobin. The mean duration of diabetes was 8.68 ± 7.18 years. We found significantly higher bone mass in type 2 diabetic subjects (p = 0.03). Among diabetics, 27.3% had low bone mass compared to 36.1% of control. It’s noted that the subjects of the “low bone mass” group among the control subjects also have a significant drop in other anthropometric parameters (weight, body mass index, waist size, muscle mass). It should also be noted that the fat mass is significantly higher in diabetic subjects with normal or even high bone mass. In control subjects, bone mass was positively correlated with weight (r = 0.36;p = 0.001), muscle mass (r = 0.93;p < 0.0001) and fasting blood glucose (r = 0.26;p = 0.02);and negatively correlate with age (r = 0.22;p = 0.04). On the other hand, in type 2 diabetic subjects, bone mass is positively correlated with age (r = 0.22;p = 0.04), muscle mass (r = 0.89;p < 0.0001) and the diabetes duration (r = 0.44;p = 0.001). <strong>Conclusion: </strong>Bone mass is higher in type 2 diabetics compared to healthy controls. Chronic hyperglycemia and the diabetes duration are believed to be responsible for the increase in bone mass. In addition, an increase in muscle mass would lead to an increase in bone mass.展开更多
为研究桥梁抗风型调谐质量阻尼器(tuned mass damper, TMD)对车辆荷载引起结构振动的减振效果,并揭示车载作用下的TMD激振机理,提出了基于模态动能演化的多自由度结构TMD控制方法,确定了安装TMD的最优设计参数和布设位置;考虑桥梁有限...为研究桥梁抗风型调谐质量阻尼器(tuned mass damper, TMD)对车辆荷载引起结构振动的减振效果,并揭示车载作用下的TMD激振机理,提出了基于模态动能演化的多自由度结构TMD控制方法,确定了安装TMD的最优设计参数和布设位置;考虑桥梁有限元模型动力求解的通用性,基于桥梁三维动力分析系统BDANS软件建立了车-桥-TMD动力耦合分析系统;以经典单自由度移动弹簧质量过简支梁模型为研究对象,分析了车-桥-TMD系统振动特性,结合某深水区非通航桥梁抗风型TMD工程实例分析了TMD对车致振动的减振效果和机理。研究结果表明:TMD行程幅值与减振效果呈现正相关特点,即行程幅值越大对车-桥动力效应引起的振动减振效果越好;安装TMD可以显著提高结构的等效阻尼比,满足等效阻尼比>1%的工程需求,提高桥梁结构振动的稳定性;TMD在一定条件下可以减小车辆通过时引发桥梁竖向位移冲击效应,最大可减少3%左右;TMD对车-桥2个子系统的加速度瞬态峰值均起到了一定的抑制效果,尤其对桥梁结构竖向振动加速度作用效果明显,安装TMD后的桥梁跨中竖向振动加速度RMS值减少约20%;对大跨钢箱桥梁而言,相比较小的车辆荷载冲击效应,一阶竖弯呈邻跨反对称特性的桥梁结构在车辆通行过程中更容易激起TMD,使桥梁结构获得更佳的减振效果。展开更多
文摘Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-related mortality combined （1）. About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed （2）. Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality （3）. More recently,
文摘Obesity is included in the definition of metabolic syndrome. However, there are many controversies surrounding the evaluation of obesity such as body mass index (BMI) and waist circumference (WC) in the definition of metabolic syndrome among various populations. To understand precisely how various anthropometric indices of obesity influence metabolic parameters, we studied the correlations of BMI, WC (Japanese criteria), WC (IDF criteria), visceral fat area (VFA), subcutaneous fat area (SFA) and the VFA/SFA ratio with metabolic parameters in patients with type 2 diabetes. The influences of BMI and WC on diastolic blood pressure and HDL-cholesterol were larger than VFA, whereas the influences of visceral fat area on triglyceride, very low-density lipoprotein-cholesterol, C-peptide and high-sensitivity C-reactive protein were larger than BMI and WC. WC (IDF) was the strongest determinant of adiponectin among anthropometric indices. Present study showed significant different associations of BMI, Japan- and IDF-defined WC, VFA, SFA and the VFA/SFA ratio with blood pressure, glucose and lipid metabolism, and adipocytokines in Japanese patients with type 2 diabetes.
文摘<strong>Background: </strong>Type 2 diabetes mellitus, beyond its well-known cardiovascular and neurological complications, is now increasingly recognized as having deleterious effects on bone tissue. It’s thus presented as an independent risk factor for bone fragility with a considerable fracture risk relating to many more or less intricate parameters. The general objective of our study is to assess bone mass during type 2 diabetes in Senegalese women. <strong>Methodology:</strong> We had carried out a cross-sectional and descriptive study. Socio-demographic characteristics were collected on the basis of a questionnaire. Then each of the subjects had undergone a complete clinical examination followed by a blood sample for a biological assessment of certain cardiovascular risk factors. Bone mass was measured using a bio-impedancemeter. <strong>Results:</strong> We recruited 88 women with type 2 diabetes and 83 healthy control women. The mean age of diabetic subjects was 52.7 years ± 6.8 (with extremes of 39 and 74 years). In control, the mean age was 51.0 ± 8.5 years (with extremes of 35 and 72 years). Among the diabetic subjects, 22 subjects or 25% practiced a regular walk against 27 (32.5%) in the control. Forty-three among the diabetic subjects (48.8%) were known hypertensive and followed. According to the body mass index, 71 patients (80.7%) were overweight compared to 59 (71.1%) controls. According to the waist size, 80 (90.9%) diabetic subjects had an elevated waist size compared to 69 control women (83.1%). Among diabetic subjects, 41 patients (46.5%) were hyperglycemic imbalance according to fasting blood glucose and 59 patients (67%) according to glycated hemoglobin level. Thirty-seven diabetics (42%), had both high fasting blood glucose and elevated glycated hemoglobin. The mean duration of diabetes was 8.68 ± 7.18 years. We found significantly higher bone mass in type 2 diabetic subjects (p = 0.03). Among diabetics, 27.3% had low bone mass compared to 36.1% of control. It’s noted that the subjects of the “low bone mass” group among the control subjects also have a significant drop in other anthropometric parameters (weight, body mass index, waist size, muscle mass). It should also be noted that the fat mass is significantly higher in diabetic subjects with normal or even high bone mass. In control subjects, bone mass was positively correlated with weight (r = 0.36;p = 0.001), muscle mass (r = 0.93;p < 0.0001) and fasting blood glucose (r = 0.26;p = 0.02);and negatively correlate with age (r = 0.22;p = 0.04). On the other hand, in type 2 diabetic subjects, bone mass is positively correlated with age (r = 0.22;p = 0.04), muscle mass (r = 0.89;p < 0.0001) and the diabetes duration (r = 0.44;p = 0.001). <strong>Conclusion: </strong>Bone mass is higher in type 2 diabetics compared to healthy controls. Chronic hyperglycemia and the diabetes duration are believed to be responsible for the increase in bone mass. In addition, an increase in muscle mass would lead to an increase in bone mass.
文摘为研究桥梁抗风型调谐质量阻尼器(tuned mass damper, TMD)对车辆荷载引起结构振动的减振效果,并揭示车载作用下的TMD激振机理,提出了基于模态动能演化的多自由度结构TMD控制方法,确定了安装TMD的最优设计参数和布设位置;考虑桥梁有限元模型动力求解的通用性,基于桥梁三维动力分析系统BDANS软件建立了车-桥-TMD动力耦合分析系统;以经典单自由度移动弹簧质量过简支梁模型为研究对象,分析了车-桥-TMD系统振动特性,结合某深水区非通航桥梁抗风型TMD工程实例分析了TMD对车致振动的减振效果和机理。研究结果表明:TMD行程幅值与减振效果呈现正相关特点,即行程幅值越大对车-桥动力效应引起的振动减振效果越好;安装TMD可以显著提高结构的等效阻尼比,满足等效阻尼比>1%的工程需求,提高桥梁结构振动的稳定性;TMD在一定条件下可以减小车辆通过时引发桥梁竖向位移冲击效应,最大可减少3%左右;TMD对车-桥2个子系统的加速度瞬态峰值均起到了一定的抑制效果,尤其对桥梁结构竖向振动加速度作用效果明显,安装TMD后的桥梁跨中竖向振动加速度RMS值减少约20%;对大跨钢箱桥梁而言,相比较小的车辆荷载冲击效应,一阶竖弯呈邻跨反对称特性的桥梁结构在车辆通行过程中更容易激起TMD,使桥梁结构获得更佳的减振效果。
