An Intelligent Manufacturing Platform of Polymers:Polymeric Material Genome Engineering

Polymeric materials with excellent performance are the foundation for developing high-level technology and advanced manufacturing.Polymeric material genome engineering(PMGE)is becoming a vital platform for the intelligent manufacturing of polymeric materials.However,the development of PMGE is still in its infancy,and many issues remain to be addressed.In this perspective,we elaborate on the PMGE concepts,summarize the state-of-the-art research and achievements,and highlight the challenges and prospects in this field.In particular,we focus on property estimation approaches,including property proxy prediction and machine learning prediction of polymer properties.The potential engineering applications of PMGE are discussed,including the fields of advanced composites,polymeric materials for communications,and integrated circuits.

Targeting cancer cytoskeleton: the mechanical properties of natural anticancerdrugs

Anticancer drugs are one of the most direct means of cancer therapy.However,the various cancer progressions hamper the development and discovery of anticancer drugs.In fact,the mechanical properties of the tumor cytoskeleton are extremely vital for any phase of cancer,especially in tumor invasion and metastasis.However,in the current category of anticancer drugs,the cytoskeleton-targeting drugs are limited and their role in tumor progression is unclear.Here,we present the mechanical characteristics of tumor stiffness that are tightly regulated by the cancer cytoskeleton,including actin filaments and microtubules during tumor initiation,growth and metastasis,and review the natural drugs that target the cancer cytoskeleton.We define cytoskeleton dynamics as target mechanisms for anticancer drugs and summarize the plant,microbial and marine sources of natural products.Furthermore,this paper also provides a material pathway to study active tumor mechanics,and introduces the unique advantages and future application potential of tumor cytoskeleton-targeting drugs in clinical use.The material approaches to active cancer mechanics are supplied in this review.We aim to promote the development of anticancer drugs that target tumor mechanics by using those material approaches and finding their pharmacological application.

Analytical study of the interface in fibre-reinforced 2D composite material

Imperfect bonding between the constitutive components can greatly affect the properties of the composite structures.An asymptotic analysis of different types of imperfect interfaces arising in the problem of 2D fibrereinforced composite materials are proposed.The performed study is based on the asymptotic reduction of the governing biharmonic problem into two harmonic problems.All solutions are obtained in a closed analytical form.The obtained results can be used for the calculation of pull-out and pushout tests,as well as for the investigation of the fracture of composite materials.

Three-dimensional Analysis of Functionally Graded Piezoelectric Plate with Arbitrarily Distributed Material Properties

An orthotropic functionally graded piezoelectric rectangular plate with arbitrarily distributed material properties was studied, which is simply supported and grounded（electrically） on its four lateral edges. The state equations of the functionally graded piezoelectric material were obtained using the state-space approach, and a Peano-Baker series solution was obtained for the coupled electroelastic fi elds of the functionally graded piezoelectric plate subjected to mechanical and electric loading on its upper and lower surfaces. The influence of different distributions of material properties on the structural response of the plate was studied using the obtained solutions.

Preparation of optical active single-handed helical barium titanate nanotubes and characterization of dielectric properties

Left and right-handed helical barium titanate nanotubes are prepared with the impregnation of Ba（OH）2 into single-handed helical titania nanotubes.Wide angle X-ray diffraction pattern and transmission electron microscopy image indicate that they are constructed by nanoparticles with a partially crystalline structure.The diffuse reflertance circular dichroism spectra indicate that they exhibit optical activity which was proposed to originate from chiral defects on the inner surfaces of the nanotubes.Both the dielectric constant and tanδ decrease with increasing the frequency.At 10 and 100 Hz,one dielectric constant peak at 9.6℃ and one tanδ peak at 5.0℃ are observed at -120℃ to 180℃.