A dynamic soil freezing characteristic curve model for frozen soil

The soil freezing characteristic curve(SFCC)plays a fundamental role in comprehending thermohydraulic behavior and numerical simulation of frozen soil.This study proposes a dynamic model to uniformly express SFCCs amidst varying total water contents throughout the freezing-thawing process.Firstly,a general model is proposed,wherein the unfrozen water content at arbitrary temperature is determined as the lesser of the current total water content and the reference value derived from saturated SFCC.The dynamic performance of this model is verified through test data.Subsequently,in accordance with electric double layer(EDL)theory,the theoretical residual and minimum temperatures in SFCC are calculated to be-14.5℃to-20℃for clay particles and-260℃,respectively.To ensure that the SFCC curve ends at minimum temperature,a correction function is introduced into the general model.Furthermore,a simplified dynamic model is proposed and investigated,necessitating only three parameters inherited from the general model.Additionally,both general and simplified models are evaluated based on a test database and proven to fit the test data exactly across the entire temperature range.Typical recommended parameter values for various types of soils are summarized.Overall,this study provides not only a theoretical basis for most empirical equations but also proposes a new and more general equation to describe the SFCC.

Train Students to Solve the Practical Problem by Building Mathematics Models

It focuses on that students must be developed the ability to solve the practical problem by building the mathematics models and the ability to combine the theory with the practice. It also states that students must be improved the learning interests and practical experience.

Research on the Applications of Advanced Mathematics on Mathematical Modeling and the Inner Connections with Linear Algebra and Probability Statistics

In this paper, we conduct research on the applications of advanced mathematics on the mathematical modeling and the inner connections with linear algebra and the probability statistics. Aiming at model in mathematical modeling and solving and model of evaluation and promotion of the two links, put forward the ＂bystander＂ and ＂the authorities＂ this two characters, and points out that excellent mathematical modeling participants should have ＂from a bystander to the authorities＂ and ＂from the authorities to return to bystanders＂ two-way role transformation ability. Great situation in mathematics teaching, by means of the mathematical modeling formed in the development of the teachers, as well as the teaching thought, teaching experience and achievements, the onward march of mathematical experiment should be faster than mathematical modeling. Our research provides the new paradigm for the math development which will be meaningful.

Analysis of Mathematical Modeling Thought in College Mathematics Teaching

The mathematical analysis enters the higher mathematics as the mathematics specialized student from the general elementary mathematics the initiation curriculum, its content and middle school mathematics still exist relate very much, while it during the expansion knowledge as also has many transformations. Under this basis, this paper proposes the analysis of the mathematical modeling thought in college mathematics teaching. Mathematics modelling teaching uses the open style teaching method also to wait for consummates regards the concrete course content the main point, the function as carries on each kind of variant to the open style mathematics educational model enable this kind of pattern to have pointed. We propose the novel paradigm for the education that will then be essential for the further development of the systems, in the future, we will then apply more of the methodologies to enhance the current proposed model.

Model informed precision medicine of Chinese herbal medicines formulas-A multi-scale mechanistic intelligent model

Recent trends suggest that Chinese herbal medicine formulas(CHM formulas)are promising treatments for complex diseases.To characterize the precise syndromes,precise diseases and precise targets of the precise targets between complex diseases and CHM formulas,we developed an artificial intelligence-based quantitative predictive algorithm(DeepTCM).DeepTCM has gone through multilevel model calibration and validation against a comprehensive set of herb and disease data so that it accurately captures the complex cellular signaling,molecular and theoretical levels of traditional Chinese medicine(TCM).As an example,our model simulated the optimal CHM formulas for the treatment of coronary heart disease(CHD)with depression,and through model sensitivity analysis,we calculated the balanced scoring of the formulas.Furthermore,we constructed a biological knowledge graph representing interactions by associating herb-target and gene-disease interactions.Finally,we experimentally confirmed the therapeutic effect and pharmacological mechanism of a novel model-predicted intervention in humans and mice.This novel multiscale model opened up a new avenue to combine“disease syndrome”and“macro micro”system modeling to facilitate translational research in CHM formulas.

MATHEMATICAL MODELING AND BIFURCATION ANALYSIS FOR A BIOLOGICAL MECHANISM OF CANCER DRUG RESISTANCE

Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.It has also been demonstrated to be related to cancer heterogeneity,which promotes the emergence of treatment-refractory cancer cell populations.Focusing on how cancer cells develop resistance during the encounter with targeted drugs and the immune system,we propose a mathematical model for studying the dynamics of drug resistance in a conjoint heterogeneous tumor-immune setting.We analyze the local geometric properties of the equilibria of the model.Numerical simulations show that the selectively targeted removal of sensitive cancer cells may cause the initially heterogeneous population to become a more resistant population.Moreover,the decline of immune recruitment is a stronger determinant of cancer escape from immune surveillance or targeted therapy than the decay in immune predation strength.Sensitivity analysis of model parameters provides insight into the roles of the immune system combined with targeted therapy in determining treatment outcomes.

Aggravation of Cancer,Heart Diseases and Diabetes Subsequent to COVID-19 Lockdown via Mathematical Modeling

The global populationhas beenandwill continue to be severely impacted by theCOVID-19 epidemic.The primary objective of this research is to demonstrate the future impact of COVID-19 on those who suffer from other fatal conditions such as cancer,heart disease,and diabetes.Here,using ordinary differential equations(ODEs),two mathematical models are developed to explain the association between COVID-19 and cancer and between COVID-19 and diabetes and heart disease.After that,we highlight the stability assessments that can be applied to these models.Sensitivity analysis is used to examine how changes in certain factors impact different aspects of disease.The sensitivity analysis showed that many people are still nervous about seeing a doctor due to COVID-19,which could result in a dramatic increase in the diagnosis of various ailments in the years to come.The correlation between diabetes and cardiovascular illness is also illustrated graphically.The effects of smoking and obesity are also found to be significant in disease compartments.Model fitting is also provided for interpreting the relationship between real data and the results of thiswork.Diabetic people,in particular,need tomonitor their health conditions closely and practice heart health maintenance.People with heart diseases should undergo regular checks so that they can protect themselves from diabetes and take some precautions including suitable diets.The main purpose of this study is to emphasize the importance of regular checks,to warn people about the effects of COVID-19(including avoiding healthcare centers and doctors because of the spread of infectious diseases)and to indicate the importance of family history of cancer,heart diseases and diabetes.The provision of the recommendations requires an increase in public consciousness.

Residual subsidence time series model in mountain area caused by underground mining based on GNSS online monitoring

The residual subsidence caused by underground mining in mountain area has a long subsidence duration time and great potential harm,which seriously threatens the safety of people's production and life in the mining area.Therefore,it is necessary to use appropriate monitoring methods and mathematical models to effectively monitor and predict the residual subsidence caused by underground mining.Compared with traditional level survey and InSAR(Interferometric Synthetic Aperture Radar)technology,GNSS(Global Navigation Satellite System)online monitoring technology has the advantages of long-term monitoring,high precision and more flexible monitoring methods.The empirical equation method of residual subsidence in mining subsidence is effectively combined with the rock creep equation,which can not only describe the residual subsidence process from the mechanism,but also predict the residual subsidence.Therefore,based on GNSS online monitoring technology,combined with the mining subsidence model of mountain area and adding the correlation coefficient of the compaction degree of caving broken rock and the Kelvin model of rock mechanics,this paper constructs the residual subsidence time series model of arbitrary point on the ground in mountain area.Through the example,the predicted results of the model in the inversion parameter phase and the dynamic prediction phase are compared with the measured data sequence.The results show that the model can carry out effective numerical calculation according to the GNSS monitoring data of any point on the ground,and the model prediction effect is good,which provides a new method for the prediction of residual subsidence in mountain mining.

Mathematical Modeling of Cell Polarity Establishment of Budding Yeast

The budding yeast Saccharomyces cerevisiae is a powerful model system for studying the cell polarity establishment.The cell polarization process is regulated by signaling molecules,which are initially distributed in the cytoplasm and then recruited to a proper location on the cell membrane in response to spatial cues or spontaneously.Polarization of these signaling molecules involves complex regulation,so the mathematical models become a useful tool to investigate the mechanism behind the process.In this review,we discuss how mathematical modeling has shed light on different regulations in the cell polarization.We also propose future applications for the mathematical modeling of cell polarization and morphogenesis.

A Vertex Network Model of Arabidopsis Leaf Growth

Biology provides many examples of complex systems whose properties allow organisms to develop in a highly reproducible,or robust,manner.One such system is the growth and development of flat leaves in Arabidopsis thaliana.This mechanistically challenging process results from multiple inputs including gene interactions,cellular geometry,growth rates,and coordinated cell divisions.To better understand how this complex genetic and cellular information controls leaf growth,we developed a mathematical model of flat leaf production.This two-dimensional model describes the gene interactions in a vertex network of cells which grow and divide according to physical forces and genetic information.Interestingly,the model predicts the presence of an unknown additional factor required for the formation of biologically realistic gene expression domains and iterative cell division.This two-dimensional model will form the basis for future studies into robustness of adaxial-abaxial patterning.

A framework for dynamic modelling of railway track switches considering the switch blades,actuators and control systems

The main contribution of this paper is the development and demonstration of a novel methodology that can be followed to develop a simulation twin of a railway track switch system to test the functionality in a digital environment.This is important because,globally,railway track switches are used to allow trains to change routes;they are a key part of all railway networks.However,because track switches are single points of failure and safety-critical,their inability to operate correctly can cause significant delays and concomitant costs.In order to better understand the dynamic behaviour of switches during operation,this paper has developed a full simulation twin of a complete track switch system.The approach fuses finite element for the rail bending and motion,with physics-based models of the electromechanical actuator system and the control system.Hence,it provides researchers and engineers the opportunity to explore and understand the design space around the dynamic operation of new switches and switch machines before they are built.This is useful for looking at the modification or monitoring of existing switches,and it becomes even more important when new switch concepts are being considered and evaluated.The simulation is capable of running in real time or faster meaning designs can be iterated and checked interactively.The paper describes the modelling approach,demonstrates the methodology by developing the system model for a novel“REPOINT”switch system,and evaluates the system level performance against the dynamic performance requirements for the switch.In the context of that case study,it is found that the proposed new actuation system as designed can meet(and exceed)the system performance requirements,and that the fault tolerance built into the actuation ensures continued operation after a single actuator failure.

Practical Use of the Subjective Mathematical Model of Bayes and Its External Validation in Dental Medicine & Dentistry

Objective: Our study aims to validate the subjective Bayes mathematical model using the mathematical model of logistic regression. Expert systems are being utilized increasingly in medical fields for the purposes of assisting diagnosis and treatment planning in Dentistry. Existing systems used few symptoms for dental diagnosis. In Dentistry, few symptoms are not enough for diagnosis. In this research, a conditional probability model (Bayes rule) was developed with increased number of symptoms associated with a disease for diagnosis. A test set of recurrent cases was then used to test the diagnostic capacity of the system. The generated diagnosis matched that of the human experts. The system was also tested for its capacity to handle uncommon dental diseases and the system portrayed useful potential. Method: The study used the Subjective Mathematical Bayes Model (SBM) approach and employed Logistic Regression Mathematical Model (LMR) techniques. The external validation of the subjective mathematical Bayes model (MSB) concerns the real cases of 625 patients who developed alveolar osteitis (OA). We propose strategies for reproducibility and reporting standards, outlining an updated WAMBS (when to Worry and how to Avoid the Misuse of Bayesian Statistics) checklist. Finally, we outline the impact of Bayesian analysis Logistic Regression Mathematical Model (LMR) techniques and on artificial intelligence, a major goal in the next decade. Results: The internal validation had identified seven (7) etiological factors of OA, which will be compared to the cases of MRL, for the external validation which retained six (6) etiological factors of OA. The experts in the internal validation of the MSB had generated 40 cases of OA and a COP of (0.5), which will be compared to the MRL that collected 625 real cases of OA to produce a Cop of (0.6) in the external validation, which discriminates between healthy patients (Se) and sick patients (Sp). Compared to real cases and the logistic regression model, the Bayesian model is efficient and its validity is established.

Mathematical Modeling of the Co-Infection Dynamics of HIV and Tuberculosis Incorporating Inconsistency in HIV Treatment

A non-linear HIV-TB co-infection has been formulated and analyzed. The positivity and invariant region has been established. The disease free equilibrium and its stability has been determined. The local stability was determined and found to be stable under given conditions. The basic reproduction number was obtained and according to findings, co-infection diminishes when this number is less than unity, and persists when the number is greater than unity. The global stability of the endemic equilibrium was calculated. The impact of HIV on TB was established as well as the impact of TB on HIV. Numerical solution was also done and the findings indicate that when the rate of HIV treatment increases the latent TB increases while the co-infected population decreases. When the rate of HIV treatment decreases the latent TB population decreases and the co-infected population increases. Encouraging communities to prioritize the consistent treatment of HIV infected individuals must be emphasized in order to reduce the scourge of HIV-TB co-infection.

Mathematical Modeling of HIV Investigating the Effect of Inconsistent Treatment

HIV is a retrovirus that infects and impairs the cells and functions of the immune system. It has caused a great challenge to global public health systems and leads to Acquired Immunodeficiency Syndrome (AIDS), if not attended to in good time. Antiretroviral therapy is used for managing the virus in a patient’s lifetime. Some of the symptoms of the disease include lean body mass and many opportunistic infections. This study has developed a SIAT mathematical model to investigate the impact of inconsistency in treatment of the disease. The arising non-linear differential equations have been obtained and analyzed. The DFE and its stability have been obtained and the study found that it is locally asymptotically stable when the basic reproduction number is less than unity. The endemic equilibrium has been obtained and found to be globally asymptotically stable when the basic reproduction number is greater than unity. Numerical solutions have been obtained and analyzed to give the trends in the spread dynamics. The inconsistency in treatment uptake has been analyzed through the numerical solutions. The study found that when the treatment rate of those infected increases, it leads to an increase in treatment population, which slows down the spread of HIV and vice versa. An increase in the rate of treatment of those with AIDS leads to a decrease in the AIDS population, the reverse happens when this rate decreases. The study recommends that the community involvement in advocating for consistent treatment of HIV to curb the spread of the disease.

MATHEMATICAL MODEL OF ~4He QUANTUM INTERFEROMETER GYROSCOPE

The mathematical model of 4He quantum interferometer gyroscope is presented. The model includes the driven equation, the current equation and the position equation. Therefore, it can sufficiently describe the gyro- scope system. The driven equation shows the thermally driven gyroscope can work for a long time but the pres- sure driven one cannot. From the current equation, the superfluid currents passing through the weak link contain the AC currents which show the rotation flux, and other currents caused by drive. As shown in the position equa- tion, the displacement of diaphragm is the only detectable parameter in the gyroscope system. The model is tested by the simulations based on experimental parameters, and can be used to research performance of the gyroscope and analyse the gyroscope error.

Application of the Sediment Mathematical Modelling on Planned Project of Lingdingyang Bay

Based on the combined hydraulic calculation for the eastern network region at the Pearl River estuary and several outlets to the Lingdingyang Bay, the sediment calculation modelling was introduced in the establishment of the sediment mathematical model for Lingdingyang Bay and the eastern region with one and two dimensional flow calculation. Model adjustment and verification were performed in conjunction with field data. The simulated results coincide well with measured data.In addition the model is applied to predict the shore-line planning scheme of Lingdingyang Bay.The theoretical criterion is provided for the shore line plan in the model.And a new mathematical simulated method is put out to research the planning engineering concerned with one-dimensional net rivers and two-dimensional estuary.

Principle, Modeling and Control of DC-DC Convertors for EV

DC DC convertors can convert the EV's high voltage DC power supply into the low voltage DC power supply. In order to design an excellent convertor one must be guided by theory of automatic control. The principle and the method of design, modeling and control for DC DC convertors of EV are introduced. The method of the system response to a unit step function input and the frequency response method are applied to researching the convertor's mathematics model and control characteristic. Experiments show that the designed DC DC convertor's output voltage precision is high, the antijamming ability is strong and the adjustable performance is fast and smooth.

MATHEMATICAL MODEL OF SELF-REPAIRING FLIGHT CONTROL

The most prospective method for certain structural failures and damages that cannot employ redundancy is self-repairing techniques, to ensure especially the maximum flight safety. Based on the characters of self-repairing aircraft, this paper states some basic assumptions of the self-repairing aircraft, and puts forward some special new conceptions concerning the self-repairing aircraft: control input, operating input, command input, repair input and operating and control factor as well as their relationships. Thus it provides a simple and reliable mathematical model structure for the research on the self-repairing control of the aircraft.

System-Level Modeling and Simulation of Force-Balance MEMS Accelerometers

This paper presents two approaches for system-level simulation of force-balance accelerometers. The derivation of the system-level model is elaborated and simulation results are obtained from the implementation of those strategies on the fabricated silicon force-balance MEMS accelerometer. The mathematical model presented is implemented in VHDL- AMS and SIMULINK TM,respectively. The simulation results from the two approaches are compared and show a slight difference. Using VHDL-AMS is flexible,reusable,and more accurate. But there is not a mature solver developed for the language and this approach takes more time, while the simulation model can be easily built and quickly evaluated using SIMULINK.

Mathematical Models of Tire-Lateral Road Adhesion for Use in Road Vehicle Dynamics Studies

Mathematical models of tire-lateral mad adhesion for use in mad vehicle dynamics studies are set up to express the relations of adhesion coefficients with slip ratio in lateral direction.The models of tire-lateral mad adhesion revolutionize the Pacejka's model in concept and therefore make it possible for applications in vehicle dynamics studies by the expression of lateral adhesion coefficient as a function of wheel slip ratio,instead of the wheel slip angle,taking into account in the mean time the influences of mad surface condition, vehicle velocity,vertical load,tire slip angle,and wheel camber angle.