研究表明血管钙化是一个类似成骨的主动、可预防和可逆转的高度可调控的生物学过程。骨形态发生蛋白(bone morphogenetic proteins,BMPs)家族作为转化生长因子β(transforming growth f a c t o r-β,TG F-β)超家族的成员,因具有诱导...研究表明血管钙化是一个类似成骨的主动、可预防和可逆转的高度可调控的生物学过程。骨形态发生蛋白(bone morphogenetic proteins,BMPs)家族作为转化生长因子β(transforming growth f a c t o r-β,TG F-β)超家族的成员,因具有诱导骨形成的特点而得名,到目前为止,已发现3 0余种BMP成员,其中BMP-2是一类唯一能够单独诱导骨组织形成的局部生长因子。目前有关动脉粥样硬化及血管钙化中BMP-2作用机制的研究日益增多。本文就近年BMP-2诱导动脉钙化(arterial calcification,AC)的相关研究进展作一综述。展开更多
Peripheral and central sensitizations are phenomena that occur during migraine. The role of gabapentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was ...Peripheral and central sensitizations are phenomena that occur during migraine. The role of gabapentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the animals were given intragastric gabapentin. Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensiti- zation during migraine. Electrophysiology, liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve, decreases excitatory amino acid content and inhibits the activation of protein kinase C. This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine. Gabapentin inhibits mi- graine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C activation.展开更多
文摘研究表明血管钙化是一个类似成骨的主动、可预防和可逆转的高度可调控的生物学过程。骨形态发生蛋白(bone morphogenetic proteins,BMPs)家族作为转化生长因子β(transforming growth f a c t o r-β,TG F-β)超家族的成员,因具有诱导骨形成的特点而得名,到目前为止,已发现3 0余种BMP成员,其中BMP-2是一类唯一能够单独诱导骨组织形成的局部生长因子。目前有关动脉粥样硬化及血管钙化中BMP-2作用机制的研究日益增多。本文就近年BMP-2诱导动脉钙化(arterial calcification,AC)的相关研究进展作一综述。
基金financially sponsored by the Natural Science Foundation of Shandong Province,No.ZR2012HQ014a grant from the Science and Technology Plan Program of Universities in Shandong Province,No.J10LF14
文摘Peripheral and central sensitizations are phenomena that occur during migraine. The role of gabapentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the animals were given intragastric gabapentin. Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensiti- zation during migraine. Electrophysiology, liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve, decreases excitatory amino acid content and inhibits the activation of protein kinase C. This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine. Gabapentin inhibits mi- graine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C activation.
