The erapeutic effect of triamcinolone acetonide with pingyangmycin on lymphatic malformations in oral and maxillofacial regions

Objective To investigate therapeutic effect of tri- amcinolone acetonide and pingyangmycin on lymphatic malformations in oral and maxillofacial regions. Methods 29 patients with lymphatic malformations in oral and maxillofacial regions were divided into two groups to re-

Observation on the Effect of Electroacupuncture in Treating Maxillofacial Hemangioma

Objective: To investigate the cl inical effect of electro￣acupuncture (EA) in treating maxillofacial hemangiom a (MFH). Methods:Platinum needles (electrode) were inserted into t he MFH in 405 patients, the locations of which were found with the guidance of B￣ultrasonography or CT, and the number of needles was decided by the size of the MFH, the distance between needles was about 1.5cm, and the peri￣lesional health tissues were protected with plastic insulating canulae. The electrodes, i.e. the cathodes and anodes, were linked to the EA apparatus for EA treatment, and the usually applied voltage was 5.0-7.0V, the current 60-80mA and the quanti ty about 100 coulombs/cm of MFH's diameter. B￣ultrasonography was used for mo nitoring during EA, and the treatment was finished when B￣ultrasonography sho wed disappearance of blood flow in the MFH. Results: Evaluation ac cording to WHO's standard for therapeutic efficacy evaluation of tumor showed th at, after treatment, 345 patients (85.2%) were completely remitted (CR), 39 (9.6 %) partially remitted (PR), 12 (3.0%) improved pathologically, and 9 (2.2%) show ing no improvement, the effective rate (CR+PR) being 94.8%. Conclusion: EA, as a creative technique for treatment of MFH, has made a breakthrough in clinical practice,showing high efficacy. It also has such superiorities as be ing simple, causing less injury, and enabling the patients to recover quickly, w ith no scar left and easily to popularize, and therefore, it provides an effecti ve method for curing MFH.

Wet-adhesive materials of oral and maxillofacial region:From design to application

Oral and maxillofacial diseases are a group of high-incidence disorders that affect people’s life quality to a great extent,while the wet and highly movable environment of the related regions brings challenges to traditional therapies.Faced with the obstacles of insufficient adhesive strength and ensuing short drug retention time,conventional oral therapeutic agents often have difficulty in achieving their desired efficacy.Oral and maxillofacial wet-adhesive materials have the advantages of excellent wet environment retention,internal stability,plasticity,and clinical potential,thus have become a significant research direction in the field of oral related disorders healing.In the past decade,the development of oral adhesive materials with good wet adhesion has accelerated based on the chemical molecular interaction,physical interlocking,and biological adhesion mechanisms,including biomimetic-inspired materials,naturally derived polymer–based materials and adhesive electrospun fiber films.These fancy wet-adhesive materials can be used for oral mucosal drug delivery,oral vaccination,wound healing,and bone defects treatments.Despite their numerous novel applications,wet-adhesive materials in stomatology still face unresolved challenges from material and biological aspects.Here,advances in designs of oral and maxillofacial wetadhesive materials are reviewed in terms of design backgrounds,attachment mechanisms,and common classifications.Recent demonstrations of wet-adhesive materials for oral and maxillofacial region medical applications from drug delivery to multifunctional tissue treatments are presented.To conclude,current challenges and prospects on potential applications of oral and maxillofacial wet-adhesive materials are also briefly discussed.

Primary maxillary chondrosarcoma: A case report

BACKGROUND Sarcomas of the head and neck region are rare tumors,constituting less than 1%of malignant neoplasms in this area,of which few cases(20%)originate from bone or cartilage.Chondrosarcoma is a malignant neoplasm that develops in bone,with a predilection for the pelvis,chest wall,and scapula,and is uncommon in the maxilla and jaw.Although this type of lesion has locally aggressive behavior,destroying the affected bone,it can metastasize when it is not diagnosed early and compromise the patient's life.CASE SUMMARY On intraoral examination of a 32-year-old female with a tumor in the middle third of the face,a well-defined rise in volume of approximately 3 cm in diameter was observed.Computed tomography with 3-dimensional reconstruction was performed,and we observed that the osteolytic lesion affected the vestibular cortex as the palatal bone.Hematoxylin and eosin staining revealed an appearance that was similar to mature hyaline cartilage,hypercellularity,nuclear and cellular pleomorphism,and multinucleated cells,with significant vacuolization.CONCLUSION Determination of the clinical and histopathological characteristics of rare neoplasms in the maxillofacial region,such as chondrosarcomas,allows the pathologist and surgeon to make the appropriate therapeutic decisions,optimizing the patient’s prognosis.

Research status of biodegradable metals designed for oral and maxillofacial applications:A review

The oral and maxillofacial regions have complex anatomical structures and different tissue types,which have vital health and aesthetic functions.Biodegradable metals(BMs)is a promising bioactive materials to treat oral and maxillofacial diseases.This review summarizes the research status and future research directions of BMs for oral and maxillofacial applications.Mg-based BMs and Zn-based BMs for bone fracture fixation systems,and guided bone regeneration(GBR)membranes,are discussed in detail.Zn-based BMs with a moderate degradation rate and superior mechanical properties for GBR membranes show great potential for clinical translation.Fe-based BMs have a relatively low degradation rate and insoluble degradation products,which greatly limit their application and clinical translation.Furthermore,we proposed potential future research directions for BMs in the oral and maxillofacial regions,including 3D printed BM bone scaffolds,surface modification for BMs GBR membranes,and BMs containing hydrogels for cartilage regeneration,soft tissue regeneration,and nerve regeneration.Taken together,the progress made in the development of BMs in oral and maxillofacial regions has laid a foundation for further clinical translation.

Craniofacial resection of advanced oral and maxillofacial malignant tumors

Objective To evaluate the clinical outcome of craniofacial resection for advanced malignant tumors in oral and maxillofacial regions.Methods Forty-six patients who underwent craniofacial resection for malignancies involving the anterior and middle cranial fossa over a 20-year period between June 1978 and December 1997 at our department were evaluated. Twenty patients received radiation therapy and an adjuvant therapy after the operation. Eleven patients received chemotherapy of various types as an adjuvant therapy.Results The 3- and 5-year survival rates were 48.8% (20/41) and 35.1% (13/37), respectively, while the 10-year survival rate was 20% (4/20).Conclusions Our results revealed good prospects of using craniofacial resection on patients with advanced malignancies in the oral and maxillofacial regions.

Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Clinical imperatives for the reconstruction of jaw bone defects or resorbed alveolar ridge require new therapies or procedures instead of autologous/allogeneic bone grafts.Regenerative medicine,based on stem cell science and tissue engineering technology,is considered as an ideal alternative strategy for bone regeneration.In this paper,we review the current choices of cell source and strategies on directing the osteogenic differentiation of stem cells.The preclinical animal models for bone regeneration and the key translational points to clinical success in oral and maxillofacial region are also discussed.We propose comprehensive strategies based on stem cell and tissue engineering researches,allowing for clinical application in oral and maxillofacial region.

Biomaterial scaffolds in maxillofacial bone tissue engineering:A review of recent advances

Maxillofacial bone defects caused by congenital malformations,trauma,tumors,and inflammation can severely affect functions and aesthetics of maxillofacial region.Despite certain successful clinical applications of biomaterial scaffolds,ideal bone regeneration remains a challenge in maxillofacial region due to its irregular shape,complex structure,and unique biological functions.Scaffolds that address multiple needs of maxillofacial bone regeneration are under development to optimize bone regeneration capacity,costs,operational convenience.etc.In this review,we first highlight the special considerations of bone regeneration in maxillofacial region and provide an overview of the biomaterial scaffolds for maxillofacial bone regeneration under clinical examination and their efficacy,which provide basis and directions for future scaffold design.Latest advances of these scaffolds are then discussed,as well as future perspectives and challenges.Deepening our understanding of these scaffolds will help foster better innovations to improve the outcome of maxillofacial bone tissue engineering.