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CT灌注成像Tmax参数对急性前循环缺血性脑卒中患者预后的预测价值 被引量:3
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作者 张佳慧 徐运 《中国实用神经疾病杂志》 2023年第7期798-803,共6页
目的探讨急性前循环缺血性脑卒中患者CT灌注参数与临床预后的关系,以及Tmax参数是否可用于急性脑卒中患者良好预后的预测。方法回顾性纳入26例于2014-03—2020-09就诊于南京鼓楼医院的急性前循环缺血性脑卒中患者。所有患者均接受阿替... 目的探讨急性前循环缺血性脑卒中患者CT灌注参数与临床预后的关系,以及Tmax参数是否可用于急性脑卒中患者良好预后的预测。方法回顾性纳入26例于2014-03—2020-09就诊于南京鼓楼医院的急性前循环缺血性脑卒中患者。所有患者均接受阿替普酶静脉溶栓治疗,患者发病后48 h内完成全脑CT灌注成像扫描,头颅磁共振弥散加权成像呈侧脑室旁单一病灶。通过病例系统筛选患者的临床资料,由2名影像科主治医师分别处理CT灌注原始图像。使用美国GE公司的CT Kinetics软件系统在原始灌注图像上勾画感兴趣区,软件在各个灌注参数的彩色函数图上叠加相应的区域并运算每个灌注参数。计算并记录Tmax与发病至灌注成像扫描间隔时间的比值(定义为Tmax-time index)。根据90 d mRS评分将患者分为m RS≤1组和mRS>1组,采用非参数检验对2组患者不同灌注参数和Tmax-time index参数进行分析,斯皮尔曼等级相关分析对Tmax参数及Tmax-time index与mRS≤1进行分析,通过COX回归分析对混杂因素进行校正,受试者工作特征曲线用于分析参数的预测价值并计算出最佳预测界值。结果2组患者入院时NIHSS评分有统计学差异(P=0.029),余基线资料差异均无统计学意义(P>0.05)。灌注参数仅Tmax存在组间差异,Tmax参数及Tmax-time index参数与m RS≤1(定义为良好预后)呈显著性相关(P值:0.016比0.006;ρ值:0.468比0.526)。校正入院NIHSS评分、扫描间隔时间、心房颤动等混杂因素后,Tmax参数是急性脑卒中患者预后良好的独立预测因子(P=0.042)。校正心房颤动、入院NIHSS评分因素后,Tmax-time index可独立预测急性脑卒中患者的良好预后(P=0.041)。受试者工作特征曲线提示Tmax<1.25 s是急性脑卒中患者良好预后的最佳预测界值(P=0.019,AUC=0.805,95%CI 0.618~0.991,特异性57.1%,敏感性94.7%),Tmax-time index<1.08是急性脑卒中患者良好预后的最佳预测界值(P=0.009,AUC=0.842,95%CI 0.661~1.000,特异性85.7%,敏感性89.7%)。上述两个参数在预测效力上无统计学差异(P>0.05)。结论CT灌注成像的Tmax参数及Tmax-time index参数可用于预测急性脑卒中患者的临床预后。 展开更多
关键词 急性缺血性脑卒中 最大达峰时间 tmax tmax-time index 静脉溶栓 缺血半暗带 CT灌注成像 预后
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扬子板块北缘马元铅锌矿床中的沥青反射率特征及其意义 被引量:2
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作者 黄小东 陈翠华 +5 位作者 黎洪秩 宋志娇 尹力 赵昌松 牛育天 林旭 《科学技术与工程》 北大核心 2016年第24期110-115,共6页
马元铅锌矿床是扬子板块周缘发现的大型铅锌矿床之一,该矿床类型为密西西比河谷型(MVT)铅锌矿床。角砾状白云岩为主要的富矿岩系,可见脉状、透镜体状矿脉,矿体中富含大量的固体或者焦沥青,沥青为灰黑色,呈球颗状、细(网)脉状、液滴... 马元铅锌矿床是扬子板块周缘发现的大型铅锌矿床之一,该矿床类型为密西西比河谷型(MVT)铅锌矿床。角砾状白云岩为主要的富矿岩系,可见脉状、透镜体状矿脉,矿体中富含大量的固体或者焦沥青,沥青为灰黑色,呈球颗状、细(网)脉状、液滴状或不规则状,与铅锌矿石密切共生/伴生在一起。沥青来源为上伏地层下寒武统郭家坝组黑色炭质板岩,构造活动对有机质运移产生重要作用。不同高程和不同形态沥青的反射率大致相同,沥青反射率3.10%4.71%,平均值为3.93%,有机质达到过成熟阶段,最大古地温(Tmax)261311℃,平均值288℃。 展开更多
关键词 马元铅锌矿床 角砾状构造 沥青特征 反射率特征 最大古地温(tmax)
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The Short-term Effects of Temperature on Infectious Diarrhea among Children under 5 Years Old in Jiangsu,China:A Time-series Study(2015-2019) 被引量:3
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作者 Nan-nan HUANG Hao ZHENG +4 位作者 Bin LI Gao-qiang FEI Zhen DING Jia-jia WANG Xiao-bo LI 《Current Medical Science》 SCIE CAS 2021年第2期211-218,共8页
The association between meteorological factors and infectious diarrhea has been widely studied in many countries.However,investigation among children under 5 years old in Jiangsu,China remains quite limited.Data inclu... The association between meteorological factors and infectious diarrhea has been widely studied in many countries.However,investigation among children under 5 years old in Jiangsu,China remains quite limited.Data including infectious diarrhea cases among children under five years old and daily meteorological indexes in Jiangsu,China from 2015 to 2019 were collected.The lag-effects up to 21 days of daily maximum temperature(Tmax)on infectious diarrhea were explored using a quasi-Poisson regression with a distributed lag non-linear model(DLNM)approach.The cases number of infectious diarrhea was significantly associated with seasonal variation of meteorological factors,and the burden of disease mainly occurred among children aged 0-2 years old.Moreover,when the reference value was set at 16.7°C,Tmax had a significant lag-effect on cases of infectious diarrhea among children under 5 years old in Jiangsu Province,which was increased remarkably in cold weather with the highest risk at 8℃.The results of DLNM analysis implicated that the lag-effect of Tmax varied among the 13 cities in Jiangsu and had significant differences in 8 cities.The highest risk of Tmax was presented at 5 lag days in Huaian with a maximum RR of 1.18(95% CI:1.09,1.29).Suzhou which had the highest number of diarrhea cases(15830 cases),had a maximum RR of 1.04(95%CI:1.03,1.05)on lag 15 days.Tmax is a considerable indicator to predict the epidemic of infectious diarrhea among 13 cities in Jiangsu,which reminds us that in cold seasons,more preventive strategies and measures should be done to prevent infectious diarrhea. 展开更多
关键词 infectious diarrhea INCIDENCE meteorological factors maximum temperature(tmax) lag-effect
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