Background:To evaluate the acute toxicity of the experienced prescription Lucao Wenban granules on mice and provide a theoretical basis for clinical medication safety.Methods:The mice were not deprived of water for 16...Background:To evaluate the acute toxicity of the experienced prescription Lucao Wenban granules on mice and provide a theoretical basis for clinical medication safety.Methods:The mice were not deprived of water for 16 h after fasting,and were intragastrically given the experienced prescription Lucao Wenban granules at the maximum mass concentration(0.55 g/mL)and the maximum volume(0.04 mL/g body weight)2 times within 24 hours.The toxicity was observed and recorded within 14 days after administration.At the end of the experiment,the biochemical indexes of mice were detected.The liver,heart,spleen,lung,and kidney were dissected and observed after executing mice to weigh the wet weight and calculate the coefficient of viscera.Results:There was no death after the mice were given 342.32 g/kg of crude medicine of the experienced prescription Lucao Wenban granules.No significant differences were detected in body weight,biochemical indexes,visceral index between the experiment group and the control group.Conclusion:There is no acute toxicity in mice.The maximum tolerable dose is 342.32 g/kg,which is 144 times of clinical dose.展开更多
基金Integrating Traditional Chinese and Western medicine(ZDBZ-ZXY-201601).
文摘Background:To evaluate the acute toxicity of the experienced prescription Lucao Wenban granules on mice and provide a theoretical basis for clinical medication safety.Methods:The mice were not deprived of water for 16 h after fasting,and were intragastrically given the experienced prescription Lucao Wenban granules at the maximum mass concentration(0.55 g/mL)and the maximum volume(0.04 mL/g body weight)2 times within 24 hours.The toxicity was observed and recorded within 14 days after administration.At the end of the experiment,the biochemical indexes of mice were detected.The liver,heart,spleen,lung,and kidney were dissected and observed after executing mice to weigh the wet weight and calculate the coefficient of viscera.Results:There was no death after the mice were given 342.32 g/kg of crude medicine of the experienced prescription Lucao Wenban granules.No significant differences were detected in body weight,biochemical indexes,visceral index between the experiment group and the control group.Conclusion:There is no acute toxicity in mice.The maximum tolerable dose is 342.32 g/kg,which is 144 times of clinical dose.
