Prognostic Value of Semi-Quantitative 18F-FDG PET/CT Parameters in Hodgkin’s Lymphoma

Objective:To assess the prognostic value of maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),and total lesion glycolysis(TLG)determined by 18F-fluorodeoxyglucose positron emission tomography-computed tomography(18F-FDG PET/CT)imaging in Hodgkin’s lymphoma patients.Methods:A total of 148 Hodgkin’s lymphoma patients diagnosed with lymph node biopsy from October 2014 to October 2015 were retrospectively analyzed followed by categorizing into good(125 cases)and poor(23 cases)prognosis groups.The chi-squared test was used to analyze the clinicopathological characteristics of Hodgkin’s lymphoma patients with the semi-quantitative 18F-FDG PET/CT parameters;the Spearman method was used to analyze the correlation between the semi-quantitative parameters and clinicopathological features of Hodgkin’s lymphoma;receiver operating characteristic curve was used to analyze the predictive value of the semi-quantitative parameters for poor prognosis of Hodgkin’s lymphoma patients.Results:Mean SUVmax,MTV,and TLG of the 148 cases of Hodgkin’s lymphoma were 7.26±2.38,12.46±3.14 cm3,and 76.83±18.56 g,respectively.Significant variations in the Ann Arbor stage and clinical classification were observed with different levels of semi-quantitative parameters(P<0.05).The semi-quantitative parameters were not correlated with age and gender(P>0.05)but positively correlated with Ann Arbor stage and clinical classification(P<0.05).These parameters in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The area under the curve(AUC)of SUVmax,MTV,and TLG in predicting the poor prognosis group was 0.881,0.875,and 0.838,with cut-off values of 7.264,12.898 cm3,and 74.580g,as well as specificity of 88.8%,84.0%,and 78.4%,and sensitivity of 87.0%,87.0%,and 78.3%,respectively;the AUC of the combined prediction was 0.986,with a specificity of 97.6%and sensitivity of 86.3%.Conclusion:The semi-quantitative 18F-FDG PET/CT parameters provide valuable insights for Hodgkin’s lymphoma prognosis assessment.

遵义市2010年7月8～13日暴雨洪涝特征及影响评估(英文)

A strong rainfall during June 8-13,2010 in Zunyi City is comprehensively analyzed by several diagnosis methods,including space location,maximum value,history comparison,maximum value assumption and disaster influence analysis.Results show that this time the successive heavy precipitation fall in the northeastern area of Zunyi City,which are Zheng’an,Daozheng and Wuchuan etc..There are in total of 4 times of heavy rainstorms,8 times of rainstorms and 8 times of heavy rains in 14 meteorological observatories of the entire city.In the whole 215 towns,the daily precipitation in 162 stations reaches rainstorm scale,of which 45 stations reaches heavy rainstorm scale.The 24 hours rainfall of the heavy rain in Wuchuan Maotian town reaches 288.6 mm and the maximum rainfall intensity is 90.2 mm.The total precipitation from 22:00 on 7th to 05:00 on 10th in Fenshui,Wuchuan reaches 423.0 mm.The 1 h maximum precipitation,daily maximum precipitation and the maximum precipitation in any 3 days all surpasses the rainstorm which occurs once in a hundred years.The heavy precipitation results in large range of water-logging and flooding;the water level of several rivers passes the dangerous or warning line.The damages and impacts of the disaster are also put forward in this paper.

Estimation of dynamic stress spectrum distribution in structural fatigue test

The determination of structural dynamic stress spectrum distribution is of great signifi- cance in the structural fatigue strength evaluation as well as reliability design. In previous empirical data processing methods, the data grouping and distribution fitting were excessively coarse and contained distinctive defects. This paper proposed an effective approach to statistically group actual measured dynamic stress data and validly extrapolate the combined distribution to fit the dynamic stress spectrum distribution. This approach has been verified its effectiveness through chi-square test, stress spectrum extrapolation and damage calculation in dynamic stress study.

Dynamic Evolution of NDVI in Qinling Mountains from 2000 to 2019

[Objectives]To investigate the dynamic evolution of vegetation index in Qinling Mountains from 2000 to 2019.[Methods]Based on MODIS13 NDVI data,the regularity of dynamics of vegetation index in Qinling Mountains from 2000 to 2019 was analyzed using maximum value composite method and trend analysis method.[Results]The NDVI in Qinling Mountains was in the range of 0.799-0.863 during 2000-2019.It showed a slow upward trend overall,and the growth rate was 0.033/(10 a).The area with declined NDVI accounted for 4.111%of the study area.It was distributed in the surrounding areas of cities,and was manly affected by the process of urbanization.The improved area accounted for 36.224%of the study area.It was widely distributed in Qinling Mountains,and was mainly affected by natural factors and national policies.[Conclusions]This study provides a basis for the protection of ecological environment and the sustainable development and utilization of resources in Qinling Mountains.

Correlations between the Maximum Standard Uptake Value of Positron Emission Tomography/Computed Tomography and Laboratory Parameters before and after Treatment in Patients with Lymphoma

Background： After the first examination of patients with lymphoma diagnosis, important laboratory tests such as complete blood count; albumin, kidney and liver function tests; uric acid; 132-microglobulin; C-reactive protein （CRP）; erythrocyte sedimentation rate （ESR）; and lactate dehydrogenase （LDH） examinations are recommended. In this study, our aim was to find the relationship between laboratory parameters and the maximum standard uptake value （SUVmax） of positron emission tomography/computed tomography （PET/CT） in patients with lymphoma at the diagnosis and after treatment. Methods： Thirty-tbur lymphoma patients treated at Mustafa Kemal University Internal Medicine Clinic between 2014 and 2017 were included in this retrospective study. Results ofCRP, ESR, LDH, albumin, and white blood cell （WBC） count were recorded betbre each PET scan test, and each parameter was analyzed for correlation with SUV measurements. Results： Spearman＇s correlation test showed that the after-treatment SUV values were significantly correlated with the alter-treatment LDH, ESR, and CRP values （for LDH, ESR, and CRP, R2： 0.453, 0.426, and 0.351; P = 0.007, 0.012, and 0.042, respectively）. On the other hand, albumin and WBC count did not show a significant correlation with the after-treatment SUVmax values （all P 〉 0.05）. Conclusions： CRP, ESR, and LDH values may also be good predictors in patients for whom PET/CT imaging cannot be performed.

Prevention and Control of Chlorella for C30 Concrete Surface with Coral Aggregate

C30 coral aggregate concrete with chlorella control effect was prepared by adding nano-TiO_(2) and hydrophobic material,and the effects of nano-TiO_(2) and hydrophobic material on the basic properties of C30 coral aggregate concrete and chlorella control effect under different experimental conditions were compared.The experimental results show that nano-TiO_(2) and hydrophobic materials have a certain degree of influence on the basic properties of concrete,but the influence is not significant.Under long-term immersion,nano-TiO_(2) and hydrophobic materials can inhibit the growth of Chlorella vulgaris.The maximum fluorescence value of concrete is decreased by 53.6% after adding TiO_(2),and the maximum fluorescence value of concrete is prolonged by 20%(1 day).The maximum fluorescence value of concrete is decreased by 67.7% after adding hydrophobic materials,and the maximum fluorescence value of concrete is also prolonged by 20%(1 day);Under the condition of simulated tidal water,the inhibition effect of Nano-TiO_(2) on the growth degree and growth rate of Chlorella vulgaris is weakened,at this time the maximum fluorescence value of concrete mixed with nano-TiO_(2) is decreased by 50.5%,and the maximum fluorescence value is only prolonged by 14.3%;while the inhibition of hydrophobic materials on the growth degree and growth rate of Chlorella vulgaris is enhanced significantly,and the maximum fluorescence value of concrete with hydrophobic materials is decreased by 80.3%;the maximum fluorescence time is prolonged by 114.3%.

Preoperative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after curative intent surgical resection

Background: Postoperative early recurrence(ER) in patients with pancreatic ductal adenocarcinoma(PDAC) is frequently encountered after curative intent surgery. Nonetheless, clinical significance and risk factors of ER after surgery for PDAC have not been extensively investigated. The aim of this study was to determine preoperative risk predictors for ER in patients with PDAC after upfront surgery. Methods: Eighty-one consecutive patients with PDAC who underwent curative intent surgical resection at Kangbuk Samsung Hospital between January 2004 and May 2015 were enrolled. ER was defined as tumor relapse within 6 months after surgery. Results: ER occurred in 26 patients(32.1%), whereas 49 patients(60.5%) had late recurrence( ≥ 6 months after surgery), and 6 patients had no recurrence(7.4%). Univariate analysis showed that C-reactive protein(CRP) > 3.0 mg/dL, modified Glasgow prognostic score(mGPS) = 2, decrease of total lymphocyte count by > 50% of baseline value in the preoperative period, prognostic nutritional index(PNI) < 45, neutrophilto-lymphocyte ratio(NLR) ≥ 3, and preoperative maximum standardized uptake value(SUVmax) were significantly associated with ER. Multivariate logistic regression analysis revealed that CRP > 3.0 mg/dL, decrease of total lymphocyte count by > 50% of baseline value, and preoperative SUVmax were significant and independent contributors of ER in patients with resectable PDAC who underwent curative intent surgery. Conclusions: Postoperative ER for resectable PDAC was frequent with poor prognosis after curative intent upfront surgery. It is reasonable to suggest that there is a subgroup of resectable PDAC patients at highrisk of ER and neoadjuvant therapy should be considered in these patients in a clinical trial setting.

The Maximum Surplus before Ruin and Related Problems in a Jump-Diffusion Renewal Risk Process

In this paper, we investigate a Sparre Andersen risk model perturbed by diffusion with phase-type inter-claim times. We mainly study the distribution of maximum surplus prior to ruin. A matrix form of integro-differential equation for this quantity is derived, and its solution can be expressed as a linear combination of particular solutions of the corresponding homogeneous integro-differential equations. By using the divided differences technique and nonnegative real part roots of Lundberg＇s equation, the explicit Laplace transforms of particular solutions are obtained. Specially, we can deduce closed-form results as long as the individual claim size is rationally distributed. We also give a concise matrix expression for the expected discounted dividend payments under a barrier dividend strategy. Finally, we give some examples to present our main results.

Optimal L_∞ Estimates for Galerkin Methods for Nonlinear Singular Two-point Boundary Value Problems

In this paper, we apply the symmetric Galerkin methods to the numerical solutions of a kind of singular linear two-point boundary value problems. We estimate the error in the maximum norm. For the sake of obtaining full superconvergence uniformly at all nodal points, we introduce local mesh refinements. Then we extend these results to a class of nonlinear problems. Finally, we present some numerical results which confirm our theoretical conclusions.

Minimum Time Extrema Estimation for Large-Scale Radio-Frequency Identification Systems

We consider the extrema estimation problem in large-scale radio-frequency identification(RFID)systems,where there are thousands of tags and each tag contains a finite value.The objective is to design an extrema estimation protocol with the minimum execution time.Because the standard binary search protocol wastes much time due to inter-frame overhead,we propose a parameterized protocol and treat the number of slots in a frame as an unknown parameter.We formulate the problem and show how to find the best parameter to minimize the worst-case execution time.Finally,we propose two rules to further reduce the execution time.The first is to find and remove redundant frames.The second is to concatenate a frame from minimum value estimation with a frame from maximum value estimation to reduce the total number of frames.Simulations show that,in a typical scenario,the proposed protocol reduces execution time by 79%compared with the standard binary search protocol.

3-D CFD simulation of transients in multiple pump system with some pumps being stopped

The computational fluid dynamics(CFD)approach can be used to obtain both internal and external characteristics of centrifugal pumps,and the variations of the hydrodynamic force,the pressure and the torque on the blades acquired by the CFD are highly associated with the safety of the pumping system.Based on the CFD simulations,this paper investigates the stopping characteristics of multiple pumps with some pumps being stopped.The 3-D geometric model is built,including all 6 pumps,the valves,the pipes,the tanks and other components,and using the Realizable k-ε turbulence model.The CFD results for the operating points agree well with the results from the theoretical analysis.With some pumps being stopped,the key parameters of the operating pumps would not be stable,with a larger fluctuation;the direction of the hydrodynamic force might be opposite with more than 3 stopped pumps.For the stopped pumps,the maximum reverse values of the discharge and the rotational speed would be larger when fewer pumps are stopped,and could be more than 120%of the rated values,which is dangerous for the pumping system.The CFD results could help understanding the stopping process of multiple pump systems with some pumps being stopped.

A Dynamic Input- Output Model Solution

In this paper we research the homogeneous input output model of forward delay that lag is one production cycle. It is conformed that the necessary and sufficient conditions of economic balanced development are that the output vector GENG Xian\|min Xinjiang Petroleum Institute, Urumqi 830000, ChinaAbstract:\ In this paper we research the homogeneous input output model of forward delay that lag is one production cycle. It is conformed that the necessary and sufficient conditions of economic balanced development are that the output vector X(t) is the right positive characteristic vector of (I-A) -1 (A+B), and the input vector is AX(t). We also constitute the workable economic subset S-,when the output vector of the first production cycle is X(1), the economy will surely collapse.

A New DGM(1,1)Model with a Grey Parameter and Its Application

In the DGM(1, 1) model modeling process, the influencing factors are uncertain. But the solution of DGM(1, 1) model with uncertain information is unique, which conflicts with the nonuniqueness principle of solution in grey theory. In view of this situation, this paper makes an in-depth analysis of the meaning of grey action quantity β_(2) in DGM(1, 1) model and regards β_(2) as an interval grey number. The maximum possibility whitenization value is given to estimate the kernel of grey number,and the typical possibility function is constructed to describe the possibility of grey number taking different values. A new DGM(1, 1) model with a grey parameter is then proposed, whose simulation results are interval grey numbers. The proposed model is compatible with the DGM(1, 1) model in model structure and simulation results. Finally, the practical example results show the applicability and effectiveness of the proposed model.