Nearly all real-world networks are complex networks and usually are in danger of collapse.Therefore,it is crucial to exploit and understand the mechanisms of network attacks and provide better protection for network f...Nearly all real-world networks are complex networks and usually are in danger of collapse.Therefore,it is crucial to exploit and understand the mechanisms of network attacks and provide better protection for network functionalities.Network dismantling aims to find the smallest set of nodes such that after their removal the network is broken into connected components of sub-extensive size.To overcome the limitations and drawbacks of existing network dismantling methods,this paper focuses on network dismantling problem and proposes a neighbor-loop structure based centrality metric,NL,which achieves a balance between computational efficiency and evaluation accuracy.In addition,we design a novel method combining NL-based nodes-removing,greedy tree-breaking and reinsertion.Moreover,we compare five baseline methods with our algorithm on ten widely used real-world networks and three types of model networks including Erd€os-Renyi random networks,Watts-Strogatz smallworld networks and Barabasi-Albert scale-free networks with different network generation parameters.Experimental results demonstrate that our proposed method outperforms most peer methods by obtaining a minimal set of targeted attack nodes.Furthermore,the insights gained from this study may be of assistance to future practical research into real-world networks.展开更多
A new centrality measure for complex networks, called resource flow centrality, is pro- posed in this paper. This centrality measure is based on the concept of the resource flow in net- works. It not only can be appli...A new centrality measure for complex networks, called resource flow centrality, is pro- posed in this paper. This centrality measure is based on the concept of the resource flow in net- works. It not only can be applied to the connected networks, but also the disconnected networks. Moreover, it overcomes some disadvantages of several common centrality measures. The perform- ance of the proposed measure is compared with some standard centrality measures using a classic dataset and the results indicate the proposed measure performs more reasonably. The statistical dis- tribution of the proposed centrality is investigated by experiments on large scale computer generated graphs and two networks from the real world.展开更多
Studying the carrying capacity of resources and environment of city clusters in the central China has important practical guidance significance for promoting the healthy, sustainable and stable development of this reg...Studying the carrying capacity of resources and environment of city clusters in the central China has important practical guidance significance for promoting the healthy, sustainable and stable development of this region. According to their influencing factors and reciprocity mechanism, using system dynamics approaches, this paper built a SD model for measuring the carrying capacity of resources and environment of the city clusters in the central China, and through setting different development models, the comprehensive measurement analysis on the carrying capacity was carried out. The results show that the model of promoting socio-economic development under the protection of resources and environment is the optimal model for promoting the harmony development of resources, environment, society and economy in the city clusters. According to this model, the optimum population scale of the city clusters in 2020 is 42.80×106 persons, and the moderate economic development scale is 22.055×1012 yuan (RMB). In 1996-2020, the carrying capacity of resources and environment in the city clusters took on obvious phase-change characteristics. During the studied period, it is basically at the initial development stage, and will come through the development process from slow development to speedup development.展开更多
AIM:To evaluate the central corneal thickness(CCT)measurements of premature infantsMETHODS:The premature infants who were born between 25-34wk of gestational age(GA)were retrieved for the study.All CCT measurements we...AIM:To evaluate the central corneal thickness(CCT)measurements of premature infantsMETHODS:The premature infants who were born between 25-34wk of gestational age(GA)were retrieved for the study.All CCT measurements were performed within the first 2d of their life under topical anesthesia by using an ultrasonic pachymeter.RESULTS:The mean CCT of 200 eyes was 647.79±63.94μm.The mean CCT of the right and left eyes were similar(647.30±64.72μm and 648.29±63.47μm consecutively).The mean CCT of the girls was 642.08±54.89μm and the boys was 653.07±71.14μm,with no statistically significant difference(P】0.05).But there was a negative correlation of the CCT with GA and birth weight(BW)(P【0.01).CONCLUSION:The CCT values of premature babies were negatively correlated with GA and BW.展开更多
A new method for reconstructing the geological history of hydrocarbon accumulation is developed, which are constrained by U-Pb isotope age and clumped isotope((35)47) temperature of host minerals of hydrocarbon-bearin...A new method for reconstructing the geological history of hydrocarbon accumulation is developed, which are constrained by U-Pb isotope age and clumped isotope((35)47) temperature of host minerals of hydrocarbon-bearing inclusions. For constraining the time and depth of hydrocarbon accumulation by the laser in-situ U-Pb isotope age and clumped isotope temperature, there are two key steps:(1) Investigating feature, abundance and distribution patterns of liquid and gaseous hydrocarbon inclusions with optical microscopes.(2) Dating laser in-situ U-Pb isotope age and measuring clumped isotope temperature of the host minerals of hydrocarbon inclusions. These technologies have been applied for studying the stages of hydrocarbon accumulation in the Sinian Dengying gas reservoir in the paleo-uplift of the central Sichuan Basin. By dating the U-Pb isotope age and measuring the temperature of clumped isotope((35)47) of the host minerals of hydrocarbon inclusions in dolomite, three stages of hydrocarbon accumulation were identified:(1) Late Silurian: the first stage of oil accumulation at(416±23) Ma.(2) Late Permian to Early Triassic: the second stage of oil accumulation between(248±27) Ma and(246.3±1.5) Ma.(3) Yanshan to Himalayan period: gas accumulation between(115±69) Ma and(41±10) Ma. The reconstructed hydrocarbon accumulation history of the Dengying gas reservoir in the paleo-uplift of the central Sichuan Basin is highly consistent with the tectonic-burial history, basin thermal history and hydrocarbon generation history, indicating that the new method is a reliable way for reconstructing the hydrocarbon accumulation history.展开更多
Network is considered naturally as a wide range of different contexts, such as biological systems, social relationships as well as various technological scenarios. Investigation of the dynamic phenomena taking place i...Network is considered naturally as a wide range of different contexts, such as biological systems, social relationships as well as various technological scenarios. Investigation of the dynamic phenomena taking place in the network, determination of the structure of the network and community and description of the interactions between various elements of the network are the key issues in network analysis. One of the huge network structure challenges is the identification of the node(s) with an outstanding structural position within the network. The popular method for doing this is to calculate a measure of centrality. We examine node centrality measures such as degree, closeness, eigenvector, Katz and subgraph centrality for undirected networks. We show how the Katz centrality can be turned into degree and eigenvector centrality by considering limiting cases. Some existing centrality measures are linked to matrix functions. We extend this idea and examine the centrality measures based on general matrix functions and in particular, the logarithmic, cosine, sine, and hyperbolic functions. We also explore the concept of generalised Katz centrality. Various experiments are conducted for different networks generated by using random graph models. The results show that the logarithmic function in particular has potential as a centrality measure. Similar results were obtained for real-world networks.展开更多
In Central China, the obvious climate change has happened along with global warming. Based on the observational analysis, the climate change has significant effects, both positive and negative, in every field within t...In Central China, the obvious climate change has happened along with global warming. Based on the observational analysis, the climate change has significant effects, both positive and negative, in every field within the study area, and with the harmful effects far more prevalent. Under the A1B scenario, it is reported that temperature, precipitation, days of heat waves, and extreme precipitation intensity will increase at respective rates of 0.38℃ per decade, 12.6 mm per decade, 6.4 d and 47 mm per decade in the 21st century. It is widely believed that these climate changes in the future will result in some apparent impacts on agro-ecosystems, water resources, wetland ecosystem, forest ecosystem, human health, energy sectors and other sensitive fields in Central China. Due to the limited scientific knowledge and researches, there are still some shortages in the climate change assessment methodologies and many uncertainties in the climate prediction results. Therefore, it is urgent and essential to increase the studies of the regional climate change adaptation, extend the research fields, and enhance the studies in the extreme weather and climate events to reduce the uncertainties of the climate change assessments.展开更多
The number of botnet malware attacks on Internet devices has grown at an equivalent rate to the number of Internet devices that are connected to the Internet.Bot detection using machine learning(ML)with flow-based fea...The number of botnet malware attacks on Internet devices has grown at an equivalent rate to the number of Internet devices that are connected to the Internet.Bot detection using machine learning(ML)with flow-based features has been extensively studied in the literature.Existing flow-based detection methods involve significant computational overhead that does not completely capture network communication patterns that might reveal other features ofmalicious hosts.Recently,Graph-Based Bot Detection methods using ML have gained attention to overcome these limitations,as graphs provide a real representation of network communications.The purpose of this study is to build a botnet malware detection system utilizing centrality measures for graph-based botnet detection and ML.We propose BotSward,a graph-based bot detection system that is based on ML.We apply the efficient centrality measures,which are Closeness Centrality(CC),Degree Centrality(CC),and PageRank(PR),and compare them with others used in the state-of-the-art.The efficiency of the proposed method is verified on the available Czech Technical University 13 dataset(CTU-13).The CTU-13 dataset contains 13 real botnet traffic scenarios that are connected to a command-and-control(C&C)channel and that cause malicious actions such as phishing,distributed denial-of-service(DDoS)attacks,spam attacks,etc.BotSward is robust to zero-day attacks,suitable for large-scale datasets,and is intended to produce better accuracy than state-of-the-art techniques.The proposed BotSward solution achieved 99%accuracy in botnet attack detection with a false positive rate as low as 0.0001%.展开更多
The satellite-based water vapor stable isotope measurements have been widely used in modern hydrological and atmospheric studies.Their use is important for arid areas where the precipitation events are limited,and bel...The satellite-based water vapor stable isotope measurements have been widely used in modern hydrological and atmospheric studies.Their use is important for arid areas where the precipitation events are limited,and below-cloud evaporation is strong.This study presents the spatial and temporal characteristics of water vapor isotopologue across the Tianshan Mountains in arid central Asia using the NASAAura Tropospheric Emission Spectrometer(TES).The near-surface water vapor stable isotopes are enriched in summer and depleted in winter,consistent with the seasonality of precipitation isotopes.From the surface to 200 hPa,the isotope values in water vapor show a decreasing trend as the atmospheric pressure decreases and elevation rises.The vapor isotope values in the lower atmosphere in the southern basin of the Tianshan Mountains are usually higher than that in the northern basin,and the seasonal difference in vapor isotopes is slightly more significant in the southern basin.In addition,bottom vapor isotopologue in summer shows a depletion trend from west to east,consistent with the rainout effect of the westerly moisture path in central Asia.The isotopic signature provided by the TES is helpful to understand the moisture transport and below-cloud processes influencing stable water isotopes in meteoric water.展开更多
Aim of this paper is to characterize different risk measures in portfolio construction on seven Central and South-East European stock markets;Slovenia, Croatia, Hungary, Poland, Chez Republic, Bulgaria and Romania. Se...Aim of this paper is to characterize different risk measures in portfolio construction on seven Central and South-East European stock markets;Slovenia, Croatia, Hungary, Poland, Chez Republic, Bulgaria and Romania. Selected countries are members of EU, except Croatia and Turkey which have candidate status. Empirical part of this paper consists of three stages;at first descriptive statistic on stock returns was performed, afterwards different risk measures were employed in portfolio construction and in the last part, portfolios were tested in the out-of-sample period. Results indicate presence of extreme kurtosis and skewness in stock return series. Resulting portfolios incorporate stocks with extremely high kurtosis and stocks with negative skewness. Portfolio construction based only on risk and return results in major exposure to extreme returns and unsatisfactory portfolio out of sample results.展开更多
AIM:To compare the RTVue spectral optical coherence tomography(SD-OCT),Sirius Scheimpflug-Placido topographer,Lenstar optical low coherence reflectometry(OLCR)and ultrasound pachymetry(USP)devices in terms of their ag...AIM:To compare the RTVue spectral optical coherence tomography(SD-OCT),Sirius Scheimpflug-Placido topographer,Lenstar optical low coherence reflectometry(OLCR)and ultrasound pachymetry(USP)devices in terms of their agreement and repeatability of measuring central corneal thickness(CCT).METHODS:In this prospective study,50 eyes of 50patients were included.Three repeated measures were obtained using SD-OCT,Scheimpflug-Placido topographer and USP and five measurements were determined with the OLCR.Bland-Altman plots were used to assess agreement among the instruments,and 95%limits of agreement(LoA)for each comparison were calculated.Intra-examiner repeatability was assessed using intraclass correlation coefficients(ICCs).RESULTS:The mean CCT by SD-OCT,ScheimpflugPlacido topographer,OLCR,and USP were 525.90±34.08μm,525.92±34.10μm,530.30±35.62μm,and543.50±37.11μm respectively.All 4 modalities of CCT measurements correlated closely with each other,with Pearson correlation coefficients ranging from 0.977 to0.995.The mean differences(and upper/lower LoA)for CCT measurements were-0.05±6.77μm(13.3/-13.3)between SD-OCT and Scheimpflug-Placido topographer,4.38±3.79μm(11.8/-3.1)between OLCR and SD-OCT,4.38±6.03μm(16.2/-7.5)between OLCR and ScheimpflugPlacido topographer,13.20±6.46μm(25.9/0.5)between USP and OLCR,17.59±6.76μm(30.8/4.3)between USP and SD-OCT,and 17.58±8.13μm(33.5/1.6)between USP and Scheimpflug-Placido topographer.Intra-examiner repeatability was excellent for all devices with ICCs】0.98.CONCLUSION:For most practical purposes,CCT measurements with the RTVue,Sirius and Lenstar can be used interchangeably.Although highly correlated,CCTmeasurement differences between USP and these 3optical instruments can be significant depending on the clinical situation.展开更多
In this work we propose a centrality measure for networks, which we refer to as Laplacian centrality, that provides a general framework for the centrality of a vertex based on the idea that the importance (or centrali...In this work we propose a centrality measure for networks, which we refer to as Laplacian centrality, that provides a general framework for the centrality of a vertex based on the idea that the importance (or centrality) of a vertex is related to the ability of the network to respond to the deactivation or removal of that vertex from the network. In particular, the Laplacian centrality of a vertex is defined as the relative drop of Laplacian energy caused by the deactivation of this vertex. The Laplacian energy of network G with?n?vertices is defined as , where ?is the eigenvalue of the Laplacian matrix of G. Other dynamics based measures such as that of Masuda and Kori and PageRank compute the importance of a node by analyzing the way paths pass through a node while our measure captures this information as well as the way these paths are “redistributed” when the node is deleted. The validity and robustness of this new measure are illustrated on two different terrorist social network data sets and 84 networks in James Moody’s Add Health in school friendship nomination data, and is compared with other standard centrality measures.展开更多
Adequate intravenous fluid therapy is essential in renal transplant recipients to ensure a good allograft perfusion. Central venous pressure(CVP) has been cons-idered the corners-tone to guide the fluid therapy for de...Adequate intravenous fluid therapy is essential in renal transplant recipients to ensure a good allograft perfusion. Central venous pressure(CVP) has been cons-idered the corners-tone to guide the fluid therapy for decades; it was the only available simple tool worldwide. However, the revolutionary advances in assessing the dynamic preload variables together with the availability of new equipment to precisely measure the effect of intravenous fluids on the cardiac output had created a question mark on the future role of CVP. Des-pite the critical role of fluid therapy in the field of tra-nsplantation. There are only a few clinical studies that compared the CVP guided fluid therapy with the other modern techniques and their relation to the outcome in renal transplantation. Our work sheds some light on the available published data in renal transplantation, together with data from other disciplines evaluating the utility of central venous pressure measurement. Although lager well-designed studies are still required to consolidate the role of new techniques in the field of renal transplantation, we can confidently declare that the new techniques have the advantages of providing more accurate haemodynamic assessment, which results in a better patient outcome.展开更多
AIM:To observe choroidal thickness changes in the choroidal hyperpermeability area(CHA)in patients with central serous chorioretinopathy(CSC)after photodynamic therapy(PDT)using indocyanine green angiography(ICGA)comb...AIM:To observe choroidal thickness changes in the choroidal hyperpermeability area(CHA)in patients with central serous chorioretinopathy(CSC)after photodynamic therapy(PDT)using indocyanine green angiography(ICGA)combined with optical coherence tomography(OCT).METHODS:This was a cohort study of 17 eyes(17 patients)with CSC.In all patients,the range of CHA was determined by ICGA.The patients were divided into two groups based on CHA covered the fovea(group A)or not(group B).All patients received half-dose verteporfin PDT over CHA in ICGA.Choroidal thickness was measured by OCT before,1,and 3 mo after treatment.The choroidal thickness values of the fovea and CHAs were obtained for each measurement.Secondary outcomes were changes in the best-corrected visual acuity(BCVA)and amount of subretinal fluid(SRF).RESULTS:The differences in center choroidal thickness at baseline and at 1 and 3 mo post-PDT were statistically significant in group A and all patients(both P<0.001).There was no significant difference in group B(P=0.059).The differences of thickness of CHA and BCVA at baseline and1 and 3 mo post-PDT were statistically significant in group A,group B,and all patients(all P<0.01).All patients showed complete SRF absorption at 3 mo post-PDT.CONCLUSION:Center choroidal thickness does not accurately reflect changes in CHA of patients whose CHA does not covered the fovea center.Using CHA as the observation target can make up for this limitation,expand the scope of application,and reduce bias.展开更多
AIMTo measure central corneal thickness (CCT) and pre-corneal tear film thickness using the Galilei dual-Scheimpflug analyzer (GSA) in New Zealand white rabbits.
AIM: To assess central corneal thickness (CCT) changes measured with Scheimpflug device following instillation of 2% fluorescein in normal subjects. ~ METHODS: This was a prospective randomized study of 60 hospita...AIM: To assess central corneal thickness (CCT) changes measured with Scheimpflug device following instillation of 2% fluorescein in normal subjects. ~ METHODS: This was a prospective randomized study of 60 hospital volunteers. After baseline CCT measurements of both eyes of 40 subjects were obtained using Scheimpflug system, a drop of preservative-free 2% fluorescein, was instilled in one eye and in other eye, one drop of normal saline (control). Measurements were repeated after 1, 2, 5, 10, 20, 30, 40, 50 and 60min (continuous assessment group). Twenty subjects had baseline CCT taken, then fluorescein was instilled in one eye and measurements were taken at lmin. Ten eyes had saline rinse after lmin and 10 other eyes did not, measurements were repeated at 2min (eye rinse group). RESULTS: The mean baseline CCT for continuous assessment group was 546.2±32.1um (range, 489.0-606.0), control eyes was 546.6~±30.7 um (range, 489.0-602.0). At lmin after fluorescein instillation, CCT significantly increased by 37.0±34.0um (P〈0.001), then decreased gradually, reaching baseline at 60min. CCT variations were not significant in control group (P〉0.05). For eye rinse group, CCT mean differences between baseline and 2min were 18.2um (95 % Ch -54.7 to 18.3) with rinse and 26.5um (95% CI: -62.9 to 9.9) without rinse; paired sample tests were not significant (P〉0.05). CONCLUSION: The presence of fluorescein increased CCT value to a clinically relevant level of 6.8%. Eye rinse did not significantly reduce the effect at 2min post fluorescein timepoint.展开更多
This study was designed to measure the performance of county health systems in central and western China utilizing routine healthcare data.Drawing on a literature review and expert consultation,the study established a...This study was designed to measure the performance of county health systems in central and western China utilizing routine healthcare data.Drawing on a literature review and expert consultation,the study established a theoretical framework and an indicator system for performance review.Questionnaires were designed and disseminated to collect empirical data on health system performance in four counties of two central and western provinces.Quantitative data were subjected to descriptive statistical analysis through SPSS12.0.Three dimensions were introduced in the performance review framework—health outcomes,financial risk protection and consumer and provider satisfaction.Health outcomes were assessed from four secondary indicators:infant mortality rate;maternal mortality rate;under-5 child mortality rate;and the incidence of Class A and Class B notifiable diseases.Financial risk was assessed using two secondary indicators:the proportion of the cost of inpatient care that was reimbursed under the New Cooperative Medical System(NCMS) insurance scheme,and the rate of NCMS funds utilization.The assessment of satisfaction was made using two secondary indicators:the overall satisfaction of local residents with healthcare services,and the satisfaction of health practitioners at the township and village level.The study indicated better health system performance in the two counties in Chongqing than those in Shanxi.It was concluded that outcome framework scores can fairly reveal performance differences among county health systems in central and western China,and can provide practical evidence for optimizing the operation and inputs of county health systems.Caution needs to be exercised in generalizing such performance outcomes as many factors such as spending and organization that contribute to county health system performance were not included in the study.展开更多
Agricultural area in central China is a densely populated area with a lot of agricultural population,relatively developed agriculture and relatively backward non-agriculture. Its development status affects the process...Agricultural area in central China is a densely populated area with a lot of agricultural population,relatively developed agriculture and relatively backward non-agriculture. Its development status affects the process of rising strategy in central region,restricts the construction of a well-off society and a harmonious society in the central region and even China. Based on this,major problems in the development of agricultural area of central China are analyzed,such as large population of farmers,great development pressure on agricultural area,serious shortage of agricultural inputs,relatively low education level,backward infrastructure in agricultural area,and relatively backward non-agricultural development. In order to accelerate the rising of central area and to promote the rapid development of central agriculture,corresponding countermeasures are put forward,including increasing the financial support for the construction of agricultural areas,vigorously setting up multi-level rural education,strengthening the infrastructure construction of agricultural areas,consolidating the construction of rural organizations,reinforcing the management function of government,and increasing the research and extension of agricultural science and technology.展开更多
This paper introduced first a conceptual framework of 'information literacy training of farmers' based on the widely recognized understanding of the term 'information literacy(IL).' It then followed wi...This paper introduced first a conceptual framework of 'information literacy training of farmers' based on the widely recognized understanding of the term 'information literacy(IL).' It then followed with a discussion based on these three authors' field investigation regarding to Hubei peasants' current information literacy training in such perspectives as information consciousness,information ability and ways and means of information access.It concluded by pointing out some of the more apparent factors that had adverse impacts on the farmers' information literacy training in central China and suggested a few possible remedial measures to guide the course for those who are involved in such undertakings.展开更多
基金the National Natural Science Foundation of China under Grants 61871209 and 61901210,in part by Artificial Intelligence and Intelligent Transportation Joint Technical Center of HUST and Hubei Chutian Intelligent Transportation Co.,LTD under project”Intelligent Transportation Operation Monitoring Network and System”.
文摘Nearly all real-world networks are complex networks and usually are in danger of collapse.Therefore,it is crucial to exploit and understand the mechanisms of network attacks and provide better protection for network functionalities.Network dismantling aims to find the smallest set of nodes such that after their removal the network is broken into connected components of sub-extensive size.To overcome the limitations and drawbacks of existing network dismantling methods,this paper focuses on network dismantling problem and proposes a neighbor-loop structure based centrality metric,NL,which achieves a balance between computational efficiency and evaluation accuracy.In addition,we design a novel method combining NL-based nodes-removing,greedy tree-breaking and reinsertion.Moreover,we compare five baseline methods with our algorithm on ten widely used real-world networks and three types of model networks including Erd€os-Renyi random networks,Watts-Strogatz smallworld networks and Barabasi-Albert scale-free networks with different network generation parameters.Experimental results demonstrate that our proposed method outperforms most peer methods by obtaining a minimal set of targeted attack nodes.Furthermore,the insights gained from this study may be of assistance to future practical research into real-world networks.
基金Supported by the National Natural Science Foundation of China(61272119,61203372)
文摘A new centrality measure for complex networks, called resource flow centrality, is pro- posed in this paper. This centrality measure is based on the concept of the resource flow in net- works. It not only can be applied to the connected networks, but also the disconnected networks. Moreover, it overcomes some disadvantages of several common centrality measures. The perform- ance of the proposed measure is compared with some standard centrality measures using a classic dataset and the results indicate the proposed measure performs more reasonably. The statistical dis- tribution of the proposed centrality is investigated by experiments on large scale computer generated graphs and two networks from the real world.
基金Under the auspices of National Natural Science Foundation of China (No. 40971101)Major Project of 11th Five-Year Scientific and Technological Support Plan of China (No. 2006BAJ14B03)
文摘Studying the carrying capacity of resources and environment of city clusters in the central China has important practical guidance significance for promoting the healthy, sustainable and stable development of this region. According to their influencing factors and reciprocity mechanism, using system dynamics approaches, this paper built a SD model for measuring the carrying capacity of resources and environment of the city clusters in the central China, and through setting different development models, the comprehensive measurement analysis on the carrying capacity was carried out. The results show that the model of promoting socio-economic development under the protection of resources and environment is the optimal model for promoting the harmony development of resources, environment, society and economy in the city clusters. According to this model, the optimum population scale of the city clusters in 2020 is 42.80×106 persons, and the moderate economic development scale is 22.055×1012 yuan (RMB). In 1996-2020, the carrying capacity of resources and environment in the city clusters took on obvious phase-change characteristics. During the studied period, it is basically at the initial development stage, and will come through the development process from slow development to speedup development.
文摘AIM:To evaluate the central corneal thickness(CCT)measurements of premature infantsMETHODS:The premature infants who were born between 25-34wk of gestational age(GA)were retrieved for the study.All CCT measurements were performed within the first 2d of their life under topical anesthesia by using an ultrasonic pachymeter.RESULTS:The mean CCT of 200 eyes was 647.79±63.94μm.The mean CCT of the right and left eyes were similar(647.30±64.72μm and 648.29±63.47μm consecutively).The mean CCT of the girls was 642.08±54.89μm and the boys was 653.07±71.14μm,with no statistically significant difference(P】0.05).But there was a negative correlation of the CCT with GA and birth weight(BW)(P【0.01).CONCLUSION:The CCT values of premature babies were negatively correlated with GA and BW.
基金Supported by the China National Science and Technology Major Project(2016ZX05004-002)Basic Research and Strategic Reserve Technology Research Fund of Institutes Directly Under CNPC(2018D-5008-03)PetroChina Science and Technology Project(2019D-5009-16)。
文摘A new method for reconstructing the geological history of hydrocarbon accumulation is developed, which are constrained by U-Pb isotope age and clumped isotope((35)47) temperature of host minerals of hydrocarbon-bearing inclusions. For constraining the time and depth of hydrocarbon accumulation by the laser in-situ U-Pb isotope age and clumped isotope temperature, there are two key steps:(1) Investigating feature, abundance and distribution patterns of liquid and gaseous hydrocarbon inclusions with optical microscopes.(2) Dating laser in-situ U-Pb isotope age and measuring clumped isotope temperature of the host minerals of hydrocarbon inclusions. These technologies have been applied for studying the stages of hydrocarbon accumulation in the Sinian Dengying gas reservoir in the paleo-uplift of the central Sichuan Basin. By dating the U-Pb isotope age and measuring the temperature of clumped isotope((35)47) of the host minerals of hydrocarbon inclusions in dolomite, three stages of hydrocarbon accumulation were identified:(1) Late Silurian: the first stage of oil accumulation at(416±23) Ma.(2) Late Permian to Early Triassic: the second stage of oil accumulation between(248±27) Ma and(246.3±1.5) Ma.(3) Yanshan to Himalayan period: gas accumulation between(115±69) Ma and(41±10) Ma. The reconstructed hydrocarbon accumulation history of the Dengying gas reservoir in the paleo-uplift of the central Sichuan Basin is highly consistent with the tectonic-burial history, basin thermal history and hydrocarbon generation history, indicating that the new method is a reliable way for reconstructing the hydrocarbon accumulation history.
文摘Network is considered naturally as a wide range of different contexts, such as biological systems, social relationships as well as various technological scenarios. Investigation of the dynamic phenomena taking place in the network, determination of the structure of the network and community and description of the interactions between various elements of the network are the key issues in network analysis. One of the huge network structure challenges is the identification of the node(s) with an outstanding structural position within the network. The popular method for doing this is to calculate a measure of centrality. We examine node centrality measures such as degree, closeness, eigenvector, Katz and subgraph centrality for undirected networks. We show how the Katz centrality can be turned into degree and eigenvector centrality by considering limiting cases. Some existing centrality measures are linked to matrix functions. We extend this idea and examine the centrality measures based on general matrix functions and in particular, the logarithmic, cosine, sine, and hyperbolic functions. We also explore the concept of generalised Katz centrality. Various experiments are conducted for different networks generated by using random graph models. The results show that the logarithmic function in particular has potential as a centrality measure. Similar results were obtained for real-world networks.
基金supported by the Special Climate Change Research Program of China Meteorological Administration(No.CCSF-2010-04)
文摘In Central China, the obvious climate change has happened along with global warming. Based on the observational analysis, the climate change has significant effects, both positive and negative, in every field within the study area, and with the harmful effects far more prevalent. Under the A1B scenario, it is reported that temperature, precipitation, days of heat waves, and extreme precipitation intensity will increase at respective rates of 0.38℃ per decade, 12.6 mm per decade, 6.4 d and 47 mm per decade in the 21st century. It is widely believed that these climate changes in the future will result in some apparent impacts on agro-ecosystems, water resources, wetland ecosystem, forest ecosystem, human health, energy sectors and other sensitive fields in Central China. Due to the limited scientific knowledge and researches, there are still some shortages in the climate change assessment methodologies and many uncertainties in the climate prediction results. Therefore, it is urgent and essential to increase the studies of the regional climate change adaptation, extend the research fields, and enhance the studies in the extreme weather and climate events to reduce the uncertainties of the climate change assessments.
文摘The number of botnet malware attacks on Internet devices has grown at an equivalent rate to the number of Internet devices that are connected to the Internet.Bot detection using machine learning(ML)with flow-based features has been extensively studied in the literature.Existing flow-based detection methods involve significant computational overhead that does not completely capture network communication patterns that might reveal other features ofmalicious hosts.Recently,Graph-Based Bot Detection methods using ML have gained attention to overcome these limitations,as graphs provide a real representation of network communications.The purpose of this study is to build a botnet malware detection system utilizing centrality measures for graph-based botnet detection and ML.We propose BotSward,a graph-based bot detection system that is based on ML.We apply the efficient centrality measures,which are Closeness Centrality(CC),Degree Centrality(CC),and PageRank(PR),and compare them with others used in the state-of-the-art.The efficiency of the proposed method is verified on the available Czech Technical University 13 dataset(CTU-13).The CTU-13 dataset contains 13 real botnet traffic scenarios that are connected to a command-and-control(C&C)channel and that cause malicious actions such as phishing,distributed denial-of-service(DDoS)attacks,spam attacks,etc.BotSward is robust to zero-day attacks,suitable for large-scale datasets,and is intended to produce better accuracy than state-of-the-art techniques.The proposed BotSward solution achieved 99%accuracy in botnet attack detection with a false positive rate as low as 0.0001%.
基金This research was supported by the National Natural Science Foundation of China(Nos.41971034 and 41701028)the Foundation for Distinguished Young Scholars of Gansu Province(No.20JR10RA112)the Northwest Normal University(No.NWNU LKZD2021-04)。
文摘The satellite-based water vapor stable isotope measurements have been widely used in modern hydrological and atmospheric studies.Their use is important for arid areas where the precipitation events are limited,and below-cloud evaporation is strong.This study presents the spatial and temporal characteristics of water vapor isotopologue across the Tianshan Mountains in arid central Asia using the NASAAura Tropospheric Emission Spectrometer(TES).The near-surface water vapor stable isotopes are enriched in summer and depleted in winter,consistent with the seasonality of precipitation isotopes.From the surface to 200 hPa,the isotope values in water vapor show a decreasing trend as the atmospheric pressure decreases and elevation rises.The vapor isotope values in the lower atmosphere in the southern basin of the Tianshan Mountains are usually higher than that in the northern basin,and the seasonal difference in vapor isotopes is slightly more significant in the southern basin.In addition,bottom vapor isotopologue in summer shows a depletion trend from west to east,consistent with the rainout effect of the westerly moisture path in central Asia.The isotopic signature provided by the TES is helpful to understand the moisture transport and below-cloud processes influencing stable water isotopes in meteoric water.
文摘Aim of this paper is to characterize different risk measures in portfolio construction on seven Central and South-East European stock markets;Slovenia, Croatia, Hungary, Poland, Chez Republic, Bulgaria and Romania. Selected countries are members of EU, except Croatia and Turkey which have candidate status. Empirical part of this paper consists of three stages;at first descriptive statistic on stock returns was performed, afterwards different risk measures were employed in portfolio construction and in the last part, portfolios were tested in the out-of-sample period. Results indicate presence of extreme kurtosis and skewness in stock return series. Resulting portfolios incorporate stocks with extremely high kurtosis and stocks with negative skewness. Portfolio construction based only on risk and return results in major exposure to extreme returns and unsatisfactory portfolio out of sample results.
文摘AIM:To compare the RTVue spectral optical coherence tomography(SD-OCT),Sirius Scheimpflug-Placido topographer,Lenstar optical low coherence reflectometry(OLCR)and ultrasound pachymetry(USP)devices in terms of their agreement and repeatability of measuring central corneal thickness(CCT).METHODS:In this prospective study,50 eyes of 50patients were included.Three repeated measures were obtained using SD-OCT,Scheimpflug-Placido topographer and USP and five measurements were determined with the OLCR.Bland-Altman plots were used to assess agreement among the instruments,and 95%limits of agreement(LoA)for each comparison were calculated.Intra-examiner repeatability was assessed using intraclass correlation coefficients(ICCs).RESULTS:The mean CCT by SD-OCT,ScheimpflugPlacido topographer,OLCR,and USP were 525.90±34.08μm,525.92±34.10μm,530.30±35.62μm,and543.50±37.11μm respectively.All 4 modalities of CCT measurements correlated closely with each other,with Pearson correlation coefficients ranging from 0.977 to0.995.The mean differences(and upper/lower LoA)for CCT measurements were-0.05±6.77μm(13.3/-13.3)between SD-OCT and Scheimpflug-Placido topographer,4.38±3.79μm(11.8/-3.1)between OLCR and SD-OCT,4.38±6.03μm(16.2/-7.5)between OLCR and ScheimpflugPlacido topographer,13.20±6.46μm(25.9/0.5)between USP and OLCR,17.59±6.76μm(30.8/4.3)between USP and SD-OCT,and 17.58±8.13μm(33.5/1.6)between USP and Scheimpflug-Placido topographer.Intra-examiner repeatability was excellent for all devices with ICCs】0.98.CONCLUSION:For most practical purposes,CCT measurements with the RTVue,Sirius and Lenstar can be used interchangeably.Although highly correlated,CCTmeasurement differences between USP and these 3optical instruments can be significant depending on the clinical situation.
文摘In this work we propose a centrality measure for networks, which we refer to as Laplacian centrality, that provides a general framework for the centrality of a vertex based on the idea that the importance (or centrality) of a vertex is related to the ability of the network to respond to the deactivation or removal of that vertex from the network. In particular, the Laplacian centrality of a vertex is defined as the relative drop of Laplacian energy caused by the deactivation of this vertex. The Laplacian energy of network G with?n?vertices is defined as , where ?is the eigenvalue of the Laplacian matrix of G. Other dynamics based measures such as that of Masuda and Kori and PageRank compute the importance of a node by analyzing the way paths pass through a node while our measure captures this information as well as the way these paths are “redistributed” when the node is deleted. The validity and robustness of this new measure are illustrated on two different terrorist social network data sets and 84 networks in James Moody’s Add Health in school friendship nomination data, and is compared with other standard centrality measures.
文摘Adequate intravenous fluid therapy is essential in renal transplant recipients to ensure a good allograft perfusion. Central venous pressure(CVP) has been cons-idered the corners-tone to guide the fluid therapy for decades; it was the only available simple tool worldwide. However, the revolutionary advances in assessing the dynamic preload variables together with the availability of new equipment to precisely measure the effect of intravenous fluids on the cardiac output had created a question mark on the future role of CVP. Des-pite the critical role of fluid therapy in the field of tra-nsplantation. There are only a few clinical studies that compared the CVP guided fluid therapy with the other modern techniques and their relation to the outcome in renal transplantation. Our work sheds some light on the available published data in renal transplantation, together with data from other disciplines evaluating the utility of central venous pressure measurement. Although lager well-designed studies are still required to consolidate the role of new techniques in the field of renal transplantation, we can confidently declare that the new techniques have the advantages of providing more accurate haemodynamic assessment, which results in a better patient outcome.
基金Supported by the National Natural Science Foundation of China(No.81760174,No.31871261)the Zunyi Science and Technology Project(No.2018-166)the Research Initiation Fund for Masters in Affiliated Hospital of Zunyi Medical College(No.2016-43)。
文摘AIM:To observe choroidal thickness changes in the choroidal hyperpermeability area(CHA)in patients with central serous chorioretinopathy(CSC)after photodynamic therapy(PDT)using indocyanine green angiography(ICGA)combined with optical coherence tomography(OCT).METHODS:This was a cohort study of 17 eyes(17 patients)with CSC.In all patients,the range of CHA was determined by ICGA.The patients were divided into two groups based on CHA covered the fovea(group A)or not(group B).All patients received half-dose verteporfin PDT over CHA in ICGA.Choroidal thickness was measured by OCT before,1,and 3 mo after treatment.The choroidal thickness values of the fovea and CHAs were obtained for each measurement.Secondary outcomes were changes in the best-corrected visual acuity(BCVA)and amount of subretinal fluid(SRF).RESULTS:The differences in center choroidal thickness at baseline and at 1 and 3 mo post-PDT were statistically significant in group A and all patients(both P<0.001).There was no significant difference in group B(P=0.059).The differences of thickness of CHA and BCVA at baseline and1 and 3 mo post-PDT were statistically significant in group A,group B,and all patients(all P<0.01).All patients showed complete SRF absorption at 3 mo post-PDT.CONCLUSION:Center choroidal thickness does not accurately reflect changes in CHA of patients whose CHA does not covered the fovea center.Using CHA as the observation target can make up for this limitation,expand the scope of application,and reduce bias.
文摘AIMTo measure central corneal thickness (CCT) and pre-corneal tear film thickness using the Galilei dual-Scheimpflug analyzer (GSA) in New Zealand white rabbits.
基金Supported by Research Centre, College of Applied Medical Sciencesthe Deanship of Scientific Research at King Saud University
文摘AIM: To assess central corneal thickness (CCT) changes measured with Scheimpflug device following instillation of 2% fluorescein in normal subjects. ~ METHODS: This was a prospective randomized study of 60 hospital volunteers. After baseline CCT measurements of both eyes of 40 subjects were obtained using Scheimpflug system, a drop of preservative-free 2% fluorescein, was instilled in one eye and in other eye, one drop of normal saline (control). Measurements were repeated after 1, 2, 5, 10, 20, 30, 40, 50 and 60min (continuous assessment group). Twenty subjects had baseline CCT taken, then fluorescein was instilled in one eye and measurements were taken at lmin. Ten eyes had saline rinse after lmin and 10 other eyes did not, measurements were repeated at 2min (eye rinse group). RESULTS: The mean baseline CCT for continuous assessment group was 546.2±32.1um (range, 489.0-606.0), control eyes was 546.6~±30.7 um (range, 489.0-602.0). At lmin after fluorescein instillation, CCT significantly increased by 37.0±34.0um (P〈0.001), then decreased gradually, reaching baseline at 60min. CCT variations were not significant in control group (P〉0.05). For eye rinse group, CCT mean differences between baseline and 2min were 18.2um (95 % Ch -54.7 to 18.3) with rinse and 26.5um (95% CI: -62.9 to 9.9) without rinse; paired sample tests were not significant (P〉0.05). CONCLUSION: The presence of fluorescein increased CCT value to a clinically relevant level of 6.8%. Eye rinse did not significantly reduce the effect at 2min post fluorescein timepoint.
文摘This study was designed to measure the performance of county health systems in central and western China utilizing routine healthcare data.Drawing on a literature review and expert consultation,the study established a theoretical framework and an indicator system for performance review.Questionnaires were designed and disseminated to collect empirical data on health system performance in four counties of two central and western provinces.Quantitative data were subjected to descriptive statistical analysis through SPSS12.0.Three dimensions were introduced in the performance review framework—health outcomes,financial risk protection and consumer and provider satisfaction.Health outcomes were assessed from four secondary indicators:infant mortality rate;maternal mortality rate;under-5 child mortality rate;and the incidence of Class A and Class B notifiable diseases.Financial risk was assessed using two secondary indicators:the proportion of the cost of inpatient care that was reimbursed under the New Cooperative Medical System(NCMS) insurance scheme,and the rate of NCMS funds utilization.The assessment of satisfaction was made using two secondary indicators:the overall satisfaction of local residents with healthcare services,and the satisfaction of health practitioners at the township and village level.The study indicated better health system performance in the two counties in Chongqing than those in Shanxi.It was concluded that outcome framework scores can fairly reveal performance differences among county health systems in central and western China,and can provide practical evidence for optimizing the operation and inputs of county health systems.Caution needs to be exercised in generalizing such performance outcomes as many factors such as spending and organization that contribute to county health system performance were not included in the study.
文摘Agricultural area in central China is a densely populated area with a lot of agricultural population,relatively developed agriculture and relatively backward non-agriculture. Its development status affects the process of rising strategy in central region,restricts the construction of a well-off society and a harmonious society in the central region and even China. Based on this,major problems in the development of agricultural area of central China are analyzed,such as large population of farmers,great development pressure on agricultural area,serious shortage of agricultural inputs,relatively low education level,backward infrastructure in agricultural area,and relatively backward non-agricultural development. In order to accelerate the rising of central area and to promote the rapid development of central agriculture,corresponding countermeasures are put forward,including increasing the financial support for the construction of agricultural areas,vigorously setting up multi-level rural education,strengthening the infrastructure construction of agricultural areas,consolidating the construction of rural organizations,reinforcing the management function of government,and increasing the research and extension of agricultural science and technology.
文摘This paper introduced first a conceptual framework of 'information literacy training of farmers' based on the widely recognized understanding of the term 'information literacy(IL).' It then followed with a discussion based on these three authors' field investigation regarding to Hubei peasants' current information literacy training in such perspectives as information consciousness,information ability and ways and means of information access.It concluded by pointing out some of the more apparent factors that had adverse impacts on the farmers' information literacy training in central China and suggested a few possible remedial measures to guide the course for those who are involved in such undertakings.