The agglomeration of moist fine coal and the mechanism of aperture blinding in screening were analyzed. The theoretical analysis and a pilot test on that the elastic screen mesh can overcome the aperture blinding prob...The agglomeration of moist fine coal and the mechanism of aperture blinding in screening were analyzed. The theoretical analysis and a pilot test on that the elastic screen mesh can overcome the aperture blinding problem were presented.展开更多
Based on economic theories,the paper studies the personnel selection at the asymmetric job market using signaling and screening model.The authors hold the opinion that an organization can screen the candidates'sig...Based on economic theories,the paper studies the personnel selection at the asymmetric job market using signaling and screening model.The authors hold the opinion that an organization can screen the candidates'signaling based on the self-selection principle by providing an apropriate compensation choice.A pay-based screening mechanism is qualified applicants and retain the excellent applicants.展开更多
Discrete element method(DEM)is an effective approach for studying the screening process of flip-flow screens.However,there have been few studies focusing on the thick layer of sticky-wet particles on flip-flow screens...Discrete element method(DEM)is an effective approach for studying the screening process of flip-flow screens.However,there have been few studies focusing on the thick layer of sticky-wet particles on flip-flow screens.To achieve accurate simulations of the thick layer of sticky-wet particles on a flip-flow screen,firstly,the movement law of particle flow was studied,and a multi-regime combination cali-bration method based on characteristics of particle flow regimes was proposed.Based on the Plackett-Burman experiment,the curse of dimensionality caused by multi-state and multi-contact parameters was overcome.Subsequently,the lifting cylinder,rotating drum,and trampoline tests were carried out to obtain macroscopic reference values under various granular flow regimes.The calibration results were then determined using the response surface method and climbing algorithm.Finally,the calibration results were tested at both macroscopic and mesoscopic scales and compared with a commonly used calibration method.The results demonstrate that the calibration method,which considers the multi-state characteristics,improves simulation accuracy by 2%-10%and reduces the simulation error to less than 10%,thus meeting the requirements for engineering optimization of flip-flow screens.展开更多
基于多靶点虚拟筛选、网络药理学分析和体外实验,探讨强肝胶囊(QGC)治疗非酒精性脂肪性肝病(NAFLD)的潜在作用机制。利用基于PPARα/γ、FXR及sEH的多靶点虚拟筛选选出QGC中具有治疗NAFLD的活性成分,运用网络药理学预测活性成分靶点、...基于多靶点虚拟筛选、网络药理学分析和体外实验,探讨强肝胶囊(QGC)治疗非酒精性脂肪性肝病(NAFLD)的潜在作用机制。利用基于PPARα/γ、FXR及sEH的多靶点虚拟筛选选出QGC中具有治疗NAFLD的活性成分,运用网络药理学预测活性成分靶点、疾病相关靶点,筛选调控疾病的关键靶点,通过Discovery Studio 2020软件和Gromacs软件对关键活性成分和关键靶点进行分子对接和分子动力学模拟分析。最后,通过实验验证QGC中的关键活性成分对肝细胞脂肪变性的改善作用。多靶点虚拟筛选得到235个QGC活性成分,网络药理学分析得到320个成分-疾病共同靶点。分子对接结果表明,芹菜素、异鼠李素、迷迭香酸、大黄素甲醚、木犀草素与关键靶点PTPN1、PPARα、PPARγ、AR具有良好的结合能力。分子动力学模拟进一步验证了迷迭香酸、大黄素甲醚等化合物与关键靶点具有良好的结合稳定性。体外实验结果显示,5个关键活性成分均能改善HepG2细胞的脂肪变性,其中异鼠李素、迷迭香酸、大黄素甲醚改善细胞脂肪变性模型的效果最佳。本研究通过多层面探讨,为QGC在NAFLD治疗中的开发和应用提供理论依据。展开更多
文摘The agglomeration of moist fine coal and the mechanism of aperture blinding in screening were analyzed. The theoretical analysis and a pilot test on that the elastic screen mesh can overcome the aperture blinding problem were presented.
文摘Based on economic theories,the paper studies the personnel selection at the asymmetric job market using signaling and screening model.The authors hold the opinion that an organization can screen the candidates'signaling based on the self-selection principle by providing an apropriate compensation choice.A pay-based screening mechanism is qualified applicants and retain the excellent applicants.
基金supported by the Anhui Province Major Science and Technology Achievements Engineering Research and Development Special Project(grant No.202103c08020007)the Fundamental Research Funds for the Central Universities(grant No.2022YJSHH15).
文摘Discrete element method(DEM)is an effective approach for studying the screening process of flip-flow screens.However,there have been few studies focusing on the thick layer of sticky-wet particles on flip-flow screens.To achieve accurate simulations of the thick layer of sticky-wet particles on a flip-flow screen,firstly,the movement law of particle flow was studied,and a multi-regime combination cali-bration method based on characteristics of particle flow regimes was proposed.Based on the Plackett-Burman experiment,the curse of dimensionality caused by multi-state and multi-contact parameters was overcome.Subsequently,the lifting cylinder,rotating drum,and trampoline tests were carried out to obtain macroscopic reference values under various granular flow regimes.The calibration results were then determined using the response surface method and climbing algorithm.Finally,the calibration results were tested at both macroscopic and mesoscopic scales and compared with a commonly used calibration method.The results demonstrate that the calibration method,which considers the multi-state characteristics,improves simulation accuracy by 2%-10%and reduces the simulation error to less than 10%,thus meeting the requirements for engineering optimization of flip-flow screens.
文摘基于多靶点虚拟筛选、网络药理学分析和体外实验,探讨强肝胶囊(QGC)治疗非酒精性脂肪性肝病(NAFLD)的潜在作用机制。利用基于PPARα/γ、FXR及sEH的多靶点虚拟筛选选出QGC中具有治疗NAFLD的活性成分,运用网络药理学预测活性成分靶点、疾病相关靶点,筛选调控疾病的关键靶点,通过Discovery Studio 2020软件和Gromacs软件对关键活性成分和关键靶点进行分子对接和分子动力学模拟分析。最后,通过实验验证QGC中的关键活性成分对肝细胞脂肪变性的改善作用。多靶点虚拟筛选得到235个QGC活性成分,网络药理学分析得到320个成分-疾病共同靶点。分子对接结果表明,芹菜素、异鼠李素、迷迭香酸、大黄素甲醚、木犀草素与关键靶点PTPN1、PPARα、PPARγ、AR具有良好的结合能力。分子动力学模拟进一步验证了迷迭香酸、大黄素甲醚等化合物与关键靶点具有良好的结合稳定性。体外实验结果显示,5个关键活性成分均能改善HepG2细胞的脂肪变性,其中异鼠李素、迷迭香酸、大黄素甲醚改善细胞脂肪变性模型的效果最佳。本研究通过多层面探讨,为QGC在NAFLD治疗中的开发和应用提供理论依据。
