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Comparison of agronomic performance between inter-sub-specific hybrid and inbred japonica rice under different mechanical transplanting methods 被引量:4
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作者 HU Ya-jie WU Pei +7 位作者 ZHANG Hong-cheng DAI Qi-gen HUO Zhong-yang XU Ke GAO Hui WEI Hai-yan GUO Bao-wei CUI Pei-yuan 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2018年第4期806-816,共11页
Mechanical transplanting has been applied to rice cultivation to save labor costs and ease labor shortages in Asian countries, especially in China. However, little information is available related to the characteristi... Mechanical transplanting has been applied to rice cultivation to save labor costs and ease labor shortages in Asian countries, especially in China. However, little information is available related to the characteristics of agronomic performance when comparing inter-sub-specific hybrid rice(IHR) and inbred japonica rice(IJR) under mechanical transplanting method. In 2013 and 2014, field experiments were conducted using IHR(Yongyou 2640) and IJR(Wuyunjing 24) under two cultivation patterns, that is, pot seedlings mechanically transplanted(PS) and carpet seedlings mechanically transplanted(CS). Grain yield, yield components, leaf area index(LAI), leaf area duration(LAD), aboveground biomass, crop growth rate(CGR), nitrogen(N) uptake, and N accumulation were investigated. When compared with CS, PS displayed significantly increased grain yield for both varieties because the larger sink size allowed higher N accumulation from panicle initiation to maturity. Moreover, total aboveground biomass under PS increased significantly compared with that under CS; that is, higher photosynthetic productivity resulted from a greater LAI and higher LAD during the grain filling stage. Higher N absorption capacity in the middle and late growth periods resulted in significantly enhanced total N uptake under PS. When compared with IJR for both treatments, IHR generated 75.2% more grain yield. However, the characteristics creating high yield of IHR were different from those of IJR. Greater aboveground biomass production as well as higher N uptake and accumulation created higher grain yield in IHR than in IJR. These results suggest higher yield could be achieved using PS with IHR, attributing to exploit both yield superiority and productive potential. 展开更多
关键词 high yield formation inter-sub-specific hybrid rice inbred japonica rice mechanical transplanting method
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The mechanical measuring method of welding heat source efficiency 被引量:1
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作者 张建强 张国栋 +2 位作者 何洁 王承权 陈冰泉 《China Welding》 EI CAS 2007年第4期51-55,共5页
Based on the principle of residual deformation induced by superposition of the welding residual stress and working stress, the welding heat source efficiency has been determined by measuring displacement changes of sp... Based on the principle of residual deformation induced by superposition of the welding residual stress and working stress, the welding heat source efficiency has been determined by measuring displacement changes of specimens under loading and unloading in tensile tests, and combining with calculating welding parameters. Meanwhile, the welding heat source eficiencies obtained are compared with those of the measuring-calculating method. The research results show that the welding heat source efficiencies are almost the same as those obtained by the measuring-calculating method. Therefore, the welding heat source efficiency can be determined accurately by this method, and a new determining method of the heat source efficiency for the welding heat process calculating has been provided. 展开更多
关键词 welding heat source efficiency welding stress welding distortion mechanical measuring-calculating method
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Mechanical quadrature methods and extrapolation for solving nonlinear boundary Helmholtz integral equations
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作者 程攀 黄晋 王柱 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2011年第12期1505-1514,共10页
This paper presents mechanical quadrature methods (MQMs) for solving nonlinear boundary Helmholtz integral equations. The methods have high accuracy of order O(h3) and low computation complexity. Moreover, the mec... This paper presents mechanical quadrature methods (MQMs) for solving nonlinear boundary Helmholtz integral equations. The methods have high accuracy of order O(h3) and low computation complexity. Moreover, the mechanical quadrature methods are simple without computing any singular integration. A nonlinear system is constructed by discretizing the nonlinear boundary integral equations. The stability and convergence of the system are proved based on an asymptotical compact theory and the Stepleman theorem. Using the h3-Richardson extrapolation algorithms (EAs), the accuracy to the order of O(h5) is improved. To slove the nonlinear system, the Newton iteration is discussed extensively by using the Ostrowski fixed point theorem. The efficiency of the algorithms is illustrated by numerical examples. 展开更多
关键词 Helmholtz equation mechanical quadrature method Newton iteration nonlinear boundary condition
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A COMPARATIVE STUDY OF THE OPENING AND CLOSING PROCESS OF TWO TYPES OF MECHANICAL HEART VALVES USING ALE FINITE ELEMENT METHOD
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作者 陈大鹏 张建海 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1996年第4期299-308,共10页
Using arbitrary Lagrangian-Eulerian(ALE)finite element method,this paper made a comparative study of the opening and closing behaviour of a downstream directional valve(DDM)and a St.Jude medical valve(SJM)through a tw... Using arbitrary Lagrangian-Eulerian(ALE)finite element method,this paper made a comparative study of the opening and closing behaviour of a downstream directional valve(DDM)and a St.Jude medical valve(SJM)through a two dimensional model of mechanical valve-blood interaction in which the valve is considered as a rigid body rotating around a fixed point,and the blood is simplified as viscous incompressible fluid It's concluded that:(1)Compared with SJM valve, DDM valve opens faster and closes the more gently.(2)The peak badk-flow-flow of DDM is smaller than that of SJM.The present investigation shows that being a better analogue of natural valve,DDM has a brighter potential on its durability than SJM. 展开更多
关键词 artificial mechanical valve ALE finite element method fluidsolid interaction
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Mechanical responses and acoustic emission behaviors of coal under compressive differential cyclic loading(DCL):a numerical study via 3D heterogeneous particle model
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作者 Zhengyang Song Yunfeng Wu +2 位作者 Yong Zhang Yi Yang Zhen Yang 《International Journal of Coal Science & Technology》 EI CAS CSCD 2023年第3期136-154,共19页
The stability of coal walls(pillars)can be seriously undermined by diverse in-situ dynamic disturbances.Based on a 3D par-ticle model,this work strives to numerically replicate the major mechanical responses and acous... The stability of coal walls(pillars)can be seriously undermined by diverse in-situ dynamic disturbances.Based on a 3D par-ticle model,this work strives to numerically replicate the major mechanical responses and acoustic emission(AE)behaviors of coal samples under multi-stage compressive cyclic loading with different loading and unloading rates,which is termed differential cyclic loading(DCL).A Weibull-distribution-based model with heterogeneous bond strengths is constructed by both considering the stress-strain relations and AE parameters.Six previously loaded samples were respectively grouped to indicate two DCL regimes,the damage mechanisms for the two groups are explicitly characterized via the time-stress-dependent variation of bond size multiplier,and it is found the two regimes correlate with distinct damage patterns,which involves the competition between stiffness hardening and softening.The numerical b-value is calculated based on the mag-nitudes of AE energy,the results show that both stress level and bond radius multiplier can impact the numerical b-value.The proposed numerical model succeeds in replicating the stress-strain relations of lab data as well as the elastic-after effect in DCL tests.The effect of damping on energy dissipation and phase shift in numerical model is summarized. 展开更多
关键词 Differential cyclic loading(DCL) Particle model Acoustic emission(AE) Discrete element method(DEM)Damage mechanism
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Comparison of yield traits in rice among three mechanized planting methods in a rice-wheat rotation system 被引量:6
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作者 XING Zhi-peng HU Ya-jie +8 位作者 QIAN Hai-jun CAO Wei-wei GUO Bao-wei WEI Hai-yan XU Ke HUO Zhong-yang ZHOU Gui-sheng DAI Qi-gen ZHANG Hong-cheng 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2017年第7期1451-1466,共16页
Understanding the differences in yield traits of rice among pothole seedling of mechanical transplanting (PSMT), carpet seedling of mechanical transplanting (CSMT) and mechanical direct seeding (MDS) is of great... Understanding the differences in yield traits of rice among pothole seedling of mechanical transplanting (PSMT), carpet seedling of mechanical transplanting (CSMT) and mechanical direct seeding (MDS) is of great importance not only for rice scientists but also for rice farmers to develop a high-yield production system under mechanical conditions in a rice-wheat rotation system. However, such traits are yet to be studied among rice varieties ofjaponica-indica hybrid rice (JIHR),japonica conventional rice (JCR) and indica hybrid rice (IHR). Field experiments were conducted in 2014 and 2015, where six cultivars of the three rice types JIHR, JCR and IHR were grown individually with PSMT, CSMT and MDS methods, under respective managements for each method to achieve the maximum attainable yield. Results showed that (i) the PSMT significantly increased grain yield of JIHR by 22.0 and 7.1%, of JCR by 15.6 and 3.7% and of I HR by 22.5 and 7.4%, compared to MDS and CSMT on average across the two years, respectively. The highest yield was produced by the combination of JIHR and PSMT; (ii) high yield under PSMT was mainly attributed to large sink capacity and high-efficient dry matter accumulation. With sufficient panicles per hectare, the increase of spikelet number per panicle, especially the increase in spikelet number of the secondary rachis-branches was determined to be the optimal approach for developing a large sink capacity for rice under PSMT. The optimal tillers development, large leaf area index at heading stage, and high leaf area duration, crop growth rate and net assimilation rate during grain-filling phase could be the cause of sufficient dry matter accumulation for rice under PSMT; (iii) moreover, the PSMT favored plant growth as well as enriched the stems plus sheaths during grain-filling phase, as compared with CSMT and MDS. These results suggest that PSMT may be an alternative approach to increasing grain yield in a rice-wheat rotation system in the lower reaches of the Yangtze River in China. 展开更多
关键词 RICE grain yield mechanized planting method pothole seedling of mechanical transplanting
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A review of welding residual stress test methods 被引量:7
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作者 甘世明 刘华荥 +1 位作者 翟之平 韩永全 《China Welding》 CAS 2022年第2期45-55,共11页
Due to local uneven heating during the welding process,the residual stress of the structure after welding affects the reliability of it.In order to ensure the reliability,it is of great significance to test the residu... Due to local uneven heating during the welding process,the residual stress of the structure after welding affects the reliability of it.In order to ensure the reliability,it is of great significance to test the residual stress distribution of the welded joint.It has always been the focus to find a simple and feasible method for residual stress testing to quickly and accurately obtain the residual stress distribution of welded joints.The mechanical measurement method has high measurement accuracy,convenient and easy operation,but it will cause certain damage to the components.Physical measurement method can avoid damage to components,but its test cost is usually high,and its measurement accuracy can also be affected by the material microstructure characteristics of welded components.Based on the advantages and disadvantages of these two residual stress test methods,a modal test method is proposed.This method is a non-destructive measurement method.Based on the mathematical relationship between the residual stress of the welded structure and the natural frequency(mathematical model),the natural frequency is measured through the modal test to calculate the residual stress quickly.However,it is difficult to establish a mathematical model with this method,and it is not suitable for realization. 展开更多
关键词 welding residual stress mechanical measurement method physical measurement method modal test method
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Temperature and solar radiation utilization of rice for yield formation with different mechanized planting methods in the lower reaches of the Yangtze River,China 被引量:3
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作者 XING Zhi-peng WU Pei +8 位作者 ZHU Ming QIAN Hai-jun HU Ya-jie GUO Bao-wei WEI Hai-yan XU Ke HUO Zhong-yang DAI Qi-gen ZHANG Hong-cheng 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2017年第9期1923-1935,共13页
Several studies have demonstrated the effect of planting methods on rice yield, but information on the climate resources is limited. This study aims to reveal the effects of planting methods on climate resources assoc... Several studies have demonstrated the effect of planting methods on rice yield, but information on the climate resources is limited. This study aims to reveal the effects of planting methods on climate resources associated with rice yield in a rice-wheat rotation system in the lower reaches of the Yangtze River, China. Field experiments were conducted in 2014 and 2015 with two japonica, two indica hybrid, and two japonica-indica hybrid varieties grown under three mechanized planting methods: carpet seedling of mechanical transplanting(CT), mechanical direct seeding(DS), and pot-hole seedling of mechanical transplanting(PT). The rice yield and total dry matter under PT were greater than those under CT and DS methods. Besides, the entire growth duration and daily production showed significant positive relations with rice yield. Compared with CT and DS, the effective accumulated temperature and cumulative solar radiation of rice under PT were higher in phenological phases. In addition, the dry matter/effective accumulated temperature and solar energy utilization of rice under CT and DS were higher during vegetative phase and lower during reproductive and grain filling phases in contrast to PT. The mean daily temperature and mean daily solar radiation in the entire growth duration showed significant positive correlation with rice yield, total dry matter, and harvest index. This study demonstrated that when the mean daily temperature is 〈25.1°C in vegetative phase and 〉20.1°C in grain filling phase, rice yield could be increased by selecting mechanized planting methods. Most varieties under PT method exhibited high yield and climate resources use efficiency compared with CT and DS. In conclusion, the PT method could be a better cultivation measure for high rice yield, accompanied with high temperature and solar radiation use efficiency in a rice-wheat rotation system in the lower reaches of the Yangtze River, China. 展开更多
关键词 rice mechanized planting methods temperature solar radiation
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Novel electromagnetism-like mechanism method for multiobjective optimization problems 被引量:1
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作者 Lixia Han Shujuan Jiang Shaojiang Lan 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2015年第1期182-189,共8页
As a new-style stochastic algorithm, the electromagnetism-like mechanism(EM) method gains more and more attention from many researchers in recent years. A novel model based on EM(NMEM) for multiobjective optimizat... As a new-style stochastic algorithm, the electromagnetism-like mechanism(EM) method gains more and more attention from many researchers in recent years. A novel model based on EM(NMEM) for multiobjective optimization problems is proposed, which regards the charge of all particles as the constraints in the current population and the measure of the uniformity of non-dominated solutions as the objective function. The charge of the particle is evaluated based on the dominated concept, and its magnitude determines the direction of a force between two particles. Numerical studies are carried out on six complex test functions and the experimental results demonstrate that the proposed NMEM algorithm is a very robust method for solving the multiobjective optimization problems. 展开更多
关键词 electromagnetism-like mechanism(EM) method multi-objective optimization problem PARTICLE Pareto optimal solutions
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Solving ground eigenvalue and eigenfunction of spheroidal wave equation at low frequency by supersymmetric quantum mechanics method 被引量:2
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作者 唐文林 田贵花 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第1期121-127,共7页
The spheroidal wave functions are found to have extensive applications in many branches of physics and mathematics. We use the perturbation method in supersymmetric quantum mechanics to obtain the analytic ground eige... The spheroidal wave functions are found to have extensive applications in many branches of physics and mathematics. We use the perturbation method in supersymmetric quantum mechanics to obtain the analytic ground eigenvalue and the ground eigenfunction of the angular spheroidal wave equation at low frequency in a series form. Using this approach, the numerical determinations of the ground eigenvalue and the ground eigenfunction for small complex frequencies are also obtained. 展开更多
关键词 spheroidal wave equation the perturbation method in supersymmetric quantum mechanics super-potential eigenvalue and eigenfunction
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Clinical Observation on Treatment of 78 Patients of B-Thalassemla with Bushen Ylsul (补肾益髓) Method and Study on Its Molecular Mechanism 被引量:6
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作者 吴志奎 蔡辉国 +7 位作者 方素萍 张新华 王蕾 陈玉英 吕鑫霞 黄有文 王荣新 陈佩珍 《Chinese Journal of Integrated Traditional and Western Medicine》 2003年第2期141-141,共1页
Objective: To study the treatment of B-Thalas-semia (ThE) with Chinese herbal medicine for Bushen Yisui (BSYS), its theoretical base and molecular mechanism. Methods: Seventy-eight patients with ThE were treated with ... Objective: To study the treatment of B-Thalas-semia (ThE) with Chinese herbal medicine for Bushen Yisui (BSYS), its theoretical base and molecular mechanism. Methods: Seventy-eight patients with ThE were treated with BSYS recipe (consisted of 11 Chinese herbal drugs as Dogwood fruit, Fleeceflower root, prepared Rehmannia root and turtle shell, etc.) orally taken, 3 times per day, 10 g/time, 3 months as one therapeutic course. Hemoglobin (Hb), red blood cell (RBC), reticulocyte (Ret) and hemoglobin F (HbF) were checked every month. At the same time, PAGE, PVR, PCR-SSCP, RT-PCR, DNA series analysis, mRNA gene expression analysis techniques were used to conduct the systematic gene analysis in patients to study the molecular mechanism of TCM treatment from aspects of gene mutation, gene expression and control-regulation. Results: All the blood criteria in patients after BSYS treatment were improved significantly with clinical symptoms 展开更多
关键词 of in gene method and Study on Its Molecular Mechanism Clinical Observation on Treatment of 78 Patients of B-Thalassemla with Bushen Ylsul HbF on with
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Effect of nitrogen introduction methods on the microstructure and properties of gradient cemented carbides 被引量:1
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作者 Tian-en Yang Ji Xiong Lan Sun Zhi-xing Guo Ding Cao 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2011年第6期709-716,共8页
关键词 gradient cemented carbide gradient methods nitrogen microstructure mechanical properties sintering
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Synthesis of Low-cost LiFePO_4 from Li_2CO_3 by a Novel Hydrothermal Method and Investigation on the Reaction Mechanism 被引量:2
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作者 李向锋 HU Yunlong +1 位作者 LIU Fang 张昭 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2015年第2期223-230,共8页
Phspho-olivine Li Fe PO4 was synthesized from the relatively insoluble lithium source Li2CO3, proper iron and phosphorus sources(n(Li):n(Fe):n(P)=1:1:1) by a novel hydrothermal method. Afterwards, the opti... Phspho-olivine Li Fe PO4 was synthesized from the relatively insoluble lithium source Li2CO3, proper iron and phosphorus sources(n(Li):n(Fe):n(P)=1:1:1) by a novel hydrothermal method. Afterwards, the optimal sample was mixed with glucose and two-step calcinated(500 ℃ and 750 ℃) under high-purity N2 to obtain the Li Fe PO4/C composite. The resultant samples were characterized by X-ray diffraction(XRD), atomic absorption spectrometry(AAS), scanning electron microscops(SEM), transmission electron microscopy(TEM), energy dispersive spectrometry(EDS), elementary analysis(EA) and electrochemical tests. The results show that the optimal reaction condition is to set the reactant concentration at 0.5 mol·L^-1, the reaction temperature at 180 ℃ for 16 h duration. During the reaction course, an intermediate product NH4 Fe PO4·H2O was first synthesized, and then it reacted with Li+ to form Li Fe PO4. The optimized Li Fe PO4 sample with an average particle size(300 to 500 nm) and regular morphology exhibits a relatively high discharge capacity of 84.95 m Ah· g^-1 at the first charge-discharge cycle(0.1C, 1C=170 m A·g^-1). Moreover, the prepared Li Fe PO4/C composite shows a high discharge capacity of 154.3 m Ah·g^-1 at 0.1C and 128.2 m Ah·g^-1 even at 5C. Besides it has good reversibility and stability in CV test. 展开更多
关键词 Li-ion battery LiFePO4 hydrothermal method Li2CO3 reaction mechanism
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NUMERICAL RESOLVENT METHODS FOR CONSTRAINED PROBLEMS IN MECHANICS
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作者 Gonzalo Alduncin 《Analysis in Theory and Applications》 1996年第4期1-25,共25页
Resolvent methods are presented for generating systematically iterative numerical algorithms for constrained problems in mechanics.The abstract framework corresponds to a general mixed finite element subdif-ferential ... Resolvent methods are presented for generating systematically iterative numerical algorithms for constrained problems in mechanics.The abstract framework corresponds to a general mixed finite element subdif-ferential model,with dual and primal evolution versions,which is shown to apply to problems of fluid dynamics,transport phenomena and solid mechanics,among others.In this manner,Uzawa's type methods and penalization-duality schemes,as well as macro-hybrid formulations,are generalized to non necessarily potential nanlinear mechanical problems. 展开更多
关键词 PRO this NUMERICAL RESOLVENT methodS FOR CONSTRAINED PROBLEMS IN MECHANICS
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KINETO-ELASTODYNAMIC ANALYSIS USED BY THE MATRIX-TRANSIT METHOD
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作者 Tong Zhou Zou HujunShanghai Jiaotong University 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 1995年第2期149-154,共6页
An element based on the harmonic functions for Performing vibration analysis oflinkages was developed to propose the matrix-transit equations and the kineto-elastrodynamics(KED) different equations. Method and the KED... An element based on the harmonic functions for Performing vibration analysis oflinkages was developed to propose the matrix-transit equations and the kineto-elastrodynamics(KED) different equations. Method and the KED equations was continllous undertaken by themodal superposition approach. The results from those equations include the quasistatic parts andthe dynamic parts. The dynamic parts equaled to the developing parts of the computationaccurations. 展开更多
关键词 Kineto-elastrodynamics (KED) Matrix-transit methods Laser experimentPlaner elastric link mechanism Space elastric link mechanics
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Mechanical Analysis Methods of Cantilever Gearbox Housing
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作者 王珏 李朋 宋诗瑶 《Journal of Shanghai Jiaotong university(Science)》 EI 2023年第2期233-242,共10页
The mechanical state of cantilever gearbox housing is different from ordinary ones due to the long arm of force caused by cantilever structure.Conventional mechanical analysis methods either took cantilever gearbox ho... The mechanical state of cantilever gearbox housing is different from ordinary ones due to the long arm of force caused by cantilever structure.Conventional mechanical analysis methods either took cantilever gearbox housing as ordinary ones or cantilever beam.Few published papers have specially focused on mechanical analysis method for cantilever gearbox housing.This paper takes a longwall shearer cutting unit gearbox(SCUG)as an example and the mechanical analysis method is investigated according to the causes of fatigue for SCUG.Force analysis model is established for finding out regions of static fatigue caused by low-frequency loads,and local resonance analysis is used for finding out regions of vibration fatigue caused by high-frequency loads.Not only bending moment but also torque caused by gear meshing forces is taken into account in the force analysis model.Vibration response is obtained from cutting experiment,and dominant frequencies of local resonance are obtained by frequency domain analysis.Finite element model of SCUG is established,and natural frequencies and strain modes are analyzed for obtaining the main vibration modes corresponding to dominant frequencies.Hence,large stress regions caused by low and high frequency loads are obtained.Results show that the worst working condition is oblique cutting,and the stress of B-B in 600 mm cutting depth can reach 166 MPa.Obviously,950 Hz,1250 Hz,and 1400 Hz are dominant frequencies of SCUG(23rd,25th and 27th natural frequencies).Generally,this paper proposes some principles for mechanical analysis method of cantilever gearbox housing. 展开更多
关键词 cantilever gearbox housing mechanical analysis method static fatigue vibration fatigue dynamic characteristics cutting experiment
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Exploring unbinding mechanism of drugs from SERT via molecular dynamics simulation and its implication in antidepressants
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作者 谭新官 刘雪峰 +2 位作者 庞铭慧 王雨晴 赵蕴杰 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第8期510-519,共10页
The human serotonin transporter(SERT)terminates neurotransmission by removing serotonin from the synaptic cleft,which is an essential process that plays an important role in depression.In addition to natural substrate... The human serotonin transporter(SERT)terminates neurotransmission by removing serotonin from the synaptic cleft,which is an essential process that plays an important role in depression.In addition to natural substrate serotonin,SERT is also the target of the abused drug cocaine and,clinically used antidepressants,escitalopram,and paroxetine.To date,few studies have attempted to investigate the unbinding mechanism underlying the orthosteric and allosteric modulation of SERT.In this article,the conserved property of the orthosteric and allosteric sites(S1 and S2)of SERT was revealed by combining the high resolutions of x-ray crystal structures and molecular dynamics(MD)simulations.The residues Tyr95 and Ser438 located within the S1 site,and Arg104 located within the S2 site in SERT illustrate conserved interactions(hydrogen bonds and hydrophobic interactions),as responses to selective serotonin reuptake inhibitors.Van der Waals interactions were keys to designing effective drugs inhibiting SERT and further,electrostatic interactions highlighted escitalopram as a potent antidepressant.We found that cocaine,escitalopram,and paroxetine,whether the S1 site or the S2 site,were more competitive.According to this potential of mean force(PMF)simulations,the new insights reveal the principles of competitive inhibitors that lengths of trails from central SERT to an opening were~18A for serotonin and~22 A for the above-mentioned three drugs.Furthermore,the distance between the natural substrate serotonin and cocaine(or escitalopram)at the allosteric site was~3A.Thus,it can be inferred that the potent antidepressants tended to bind at deeper positions of the S1 or the S2 site of SERT in comparison to the substrate.Continuing exploring the processes of unbinding four ligands against the two target pockets of SERT,this study observed a broad pathway in which serotonin,cocaine,escitalopram(at the S1 site),and paroxetine all were pulled out to an opening between MT1b and MT6a,which may be helpful to understand the dissociation mechanism of antidepressants. 展开更多
关键词 human serotonin transporter(SERT) comprehensive molecular dynamics(MD)simulation drug design molecular mechanics/generalized Born surface area(MM/GBSA)method
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Effectiveness and Safety of Double-balloon Catheter versus Intra-amniotic Injection of Ethacridine Lactate for Termination of Second Trimester Pregnancy in Patients with Liver Dysfunction 被引量:14
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作者 李娜 吴鹏 +3 位作者 赵捷 冯玲 乔福元 曾万江 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2015年第1期129-134,共6页
Severe liver dysfunction in pregnancy(SLDP) is rare but serious complications with high mortality rate. This study compared the effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ... Severe liver dysfunction in pregnancy(SLDP) is rare but serious complications with high mortality rate. This study compared the effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy in patients with SLD. A total of 55 patients with indications of labor induction were enrolled and analyzed by retrospective control analysis method. Twenty-three cases adopted Cook double balloon dilation as Cook group, and 32 cases received intra-amniotic injection of ethacridine lactate as EL group. The primary outcome was evaluated by successful abortion rate and the difference in the induction-to-abortion interval. Secondary outcomes included liver function recovery and the frequency of adverse events. Both Cook and EL regimens were effective, with successful abortion rate of 87.0% and 93.8%, respectively(P=0.639). The induction-to-delivery interval was similar between Cook group and EL group(38.1±21.5 vs. 41.3±17.4, P=0.543). The liver disease status was more severe in Cook group than in EL group, but it did not show any significant difference after pregnancy termination between the two groups and the improvement rate also did not show any significant difference. Both treatments were safe and there was no significant difference in bleeding and cervical laceration adverse events between the two groups. Our study firstly compared double-balloon catheter and ethacridine lactate for the induction of labor in women with SLD during second trimester pregnancy. 展开更多
关键词 severe liver dysfunction labor induction double-balloon catheter mechanical method ethacridine lactate
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对苯二酚在室温离子液体碳糊电极上电化学行为的半经验量子化学AM1研究 被引量:3
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作者 贾晓光 张玲 朱永春 《沈阳师范大学学报(自然科学版)》 CAS 2008年第3期340-343,共4页
为了从理论上对对苯二酚在[BMIM]BF4室温离子液体及甲基硅油与石墨粉组成的碳糊电极上的电化学行为深入研究,以半经验分子轨道的AM1方法计算对[BMIM]BF4室温离子液体,甲基硅油和对苯二酚及其之间的分子相互作用的热力学参数如生成焓、... 为了从理论上对对苯二酚在[BMIM]BF4室温离子液体及甲基硅油与石墨粉组成的碳糊电极上的电化学行为深入研究,以半经验分子轨道的AM1方法计算对[BMIM]BF4室温离子液体,甲基硅油和对苯二酚及其之间的分子相互作用的热力学参数如生成焓、电离能、分子间距离及能量.[BMIM]BF4室温离子液体与对苯二酚是以BF4-负离子为作用基点,而甲基硅油是以甲基碳作为作用基点,甲基硅油具有降低最高占有轨道能量,催化了对苯二酚的电化学氧化.[BMIM]BF4室温离子液体离子性质增加了极性水分子的渗透性,表现出较大的介电常数,给出了较大的充电电流. 展开更多
关键词 [BMIM]BF4室温离子液体 对苯二酚 AM1半经验量子化学计算方法
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Experiment on diffuse reflection laser ranging to space debris and data analysis 被引量:7
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作者 Hao Sun Hai-Feng Zhang +1 位作者 Zhong-Ping Zhang Bin Wu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2015年第6期909-917,共9页
Space debris poses a serious threat to human space activities and needs to be measured and cataloged. As a new technology for space target surveillance, the measurement accuracy of diffuse reflection laser ranging (D... Space debris poses a serious threat to human space activities and needs to be measured and cataloged. As a new technology for space target surveillance, the measurement accuracy of diffuse reflection laser ranging (DRLR) is much higher than that of microwave radar and optoelectronic measurement. Based on the laser ranging data of space debris from the DRLR system at Shanghai Astronomical Observatory acquired in March-April, 2013, the characteristics and precision of the laser ranging data are analyzed and their applications in orbit determination of space debris are discussed, which is implemented for the first time in China. The experiment indicates that the precision of laser ranging data can reach 39 cm-228 cm. When the data are sufficient enough (four arcs measured over three days), the orbital accuracy of space debris can be up to 50 m. 展开更多
关键词 space vehicles -- astrometry -- celestial mechanics -- methods data analysis
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