The mechanical properties and constitutive behaviors of as-cast AA7050 in both the solid and semi-solid states were determined using the on-cooling and in situ solidification approaches, respectively. The results show...The mechanical properties and constitutive behaviors of as-cast AA7050 in both the solid and semi-solid states were determined using the on-cooling and in situ solidification approaches, respectively. The results show that the strength in the solid state tends to increase with decreasing temperature. The strain rate plays an important role in the stress–strain behaviors at higher temperatures, whereas the influence becomes less pronounced and irregular when the temperature is less than 250°C. The experimental data were fitted to the extended Ludwik equation, which is suitable to describe the mechanical behavior of the materials in the as-cast state. In the semi-solid state, both the strength and ductility of the alloy are high near the solidus temperature and decrease drastically with decreasing solid fraction. As the solid fraction is less than 0.97, the maximum strength only slightly decreases, whereas the post-peak ductility begins to increase. The experimental data were fitted to the modified creep law, which is used to describe the mechanical behavior of semi-solid materials, to determine the equivalent parameter fGBWL, i.e., the fraction of grain boundaries covered by liquid phase.展开更多
Fluoxetine hydrochloride,better known for its commercial name Prozac,is one of the most widely prescribed antidepressant drugs all over the world.This drug was considered a"breakthrough drug"for the treatment of dep...Fluoxetine hydrochloride,better known for its commercial name Prozac,is one of the most widely prescribed antidepressant drugs all over the world.This drug was considered a"breakthrough drug"for the treatment of depression because of its very high selectivity as a serotonin reuptake inhibitor and because it presented a lower side-effectprofile than previous drugs (Wong et al., 2005).展开更多
The mechanism of the breakup of supercontinent is a scientific frontier in the field of supercontinent study.The rifting and breakup of supercontinent has long been considered to be related to mantle plume.Paleo-
Damaged eggshells result in losses of eggs.The genetic mechanism of variable eggshell strength is still unclear.The current study was conducted to verify whether the eggshell calcification related genes,CALB1,SPP1,DMP...Damaged eggshells result in losses of eggs.The genetic mechanism of variable eggshell strength is still unclear.The current study was conducted to verify whether the eggshell calcification related genes,CALB1,SPP1,DMP4,BMP2 and SLIT2,were associated with eggshell mechanical property.For this purpose quantitative PCR(q-PCR) analysis was performed to detect gene expression between two groups of hens laying strong and weak eggs.The hens were selected from 360 White Leghorn layers at 60 wk to ensure that the strong and weak eggs differed significantly in breaking strength but not in eggshell thickness and weight.Using this special strong/weak eggshell model,we found that the expression of CALB1 in the uterus of strong shell group was about 3-fold higher(P〈0.05) than that in weak shell group.The DMP4 expression was significantly higher(2-fold,P〈0.05) in the uterus of weak shell group than that in strong shell group.However,no difference was observed for genes of SPP1,SLIT2 and BMP2 between these two groups.The current study provides a new insight to investigate the association of candidate genes with eggshell mechanical property.展开更多
Objective To study the role and mechanism of sphingosine-phosphate(S1P)/sphingosine-1-phosphate receptor 1(S1P1)signal pathway during post conditioning of hypertrophic cardiomyocytes.Methods Neonatal rat cardiomyocyte...Objective To study the role and mechanism of sphingosine-phosphate(S1P)/sphingosine-1-phosphate receptor 1(S1P1)signal pathway during post conditioning of hypertrophic cardiomyocytes.Methods Neonatal rat cardiomyocytes were isolated and cultured,then stimulated by norepinephrine(NE)to induce cardiomyocytes hypertrophy.Using tri-gas incubator to create展开更多
基金supported by the Fundamental Research Funds for the Central Universities of China(No.FRF-BR-15-078A)Beijing Laboratory of Metallic Materials and Processing for Modern Transportation,Specialized Research Fund for the Doctoral Program of Higher Education(No.20120006110019)the Opening Research Fund of the State Key Laboratory for Advanced Metals and Materials(Nos.2012Z-13,2014ZD-02,and 2015-ZD08)
文摘The mechanical properties and constitutive behaviors of as-cast AA7050 in both the solid and semi-solid states were determined using the on-cooling and in situ solidification approaches, respectively. The results show that the strength in the solid state tends to increase with decreasing temperature. The strain rate plays an important role in the stress–strain behaviors at higher temperatures, whereas the influence becomes less pronounced and irregular when the temperature is less than 250°C. The experimental data were fitted to the extended Ludwik equation, which is suitable to describe the mechanical behavior of the materials in the as-cast state. In the semi-solid state, both the strength and ductility of the alloy are high near the solidus temperature and decrease drastically with decreasing solid fraction. As the solid fraction is less than 0.97, the maximum strength only slightly decreases, whereas the post-peak ductility begins to increase. The experimental data were fitted to the modified creep law, which is used to describe the mechanical behavior of semi-solid materials, to determine the equivalent parameter fGBWL, i.e., the fraction of grain boundaries covered by liquid phase.
基金Agencia Nacional de Investigación e Innovación (ANII,Fondo Clemente Estable,FCE_6834 to FMR)Programa de Desarollo de las Ciencias Basicas,Pedeciba,Uruguay
文摘Fluoxetine hydrochloride,better known for its commercial name Prozac,is one of the most widely prescribed antidepressant drugs all over the world.This drug was considered a"breakthrough drug"for the treatment of depression because of its very high selectivity as a serotonin reuptake inhibitor and because it presented a lower side-effectprofile than previous drugs (Wong et al., 2005).
文摘The mechanism of the breakup of supercontinent is a scientific frontier in the field of supercontinent study.The rifting and breakup of supercontinent has long been considered to be related to mantle plume.Paleo-
基金funded by the National Natural Science Foundation of China(31472084)the National High Technology Research and Development Program of China(2013AA102501)+2 种基金the National Key Technology R&D Program of China(2011BAD28B03)the Programs for Changjiang Scholars and Innovative Research in University,China(IRT1191)the China Agriculture Research Systems(CARS-41)
文摘Damaged eggshells result in losses of eggs.The genetic mechanism of variable eggshell strength is still unclear.The current study was conducted to verify whether the eggshell calcification related genes,CALB1,SPP1,DMP4,BMP2 and SLIT2,were associated with eggshell mechanical property.For this purpose quantitative PCR(q-PCR) analysis was performed to detect gene expression between two groups of hens laying strong and weak eggs.The hens were selected from 360 White Leghorn layers at 60 wk to ensure that the strong and weak eggs differed significantly in breaking strength but not in eggshell thickness and weight.Using this special strong/weak eggshell model,we found that the expression of CALB1 in the uterus of strong shell group was about 3-fold higher(P〈0.05) than that in weak shell group.The DMP4 expression was significantly higher(2-fold,P〈0.05) in the uterus of weak shell group than that in strong shell group.However,no difference was observed for genes of SPP1,SLIT2 and BMP2 between these two groups.The current study provides a new insight to investigate the association of candidate genes with eggshell mechanical property.
文摘Objective To study the role and mechanism of sphingosine-phosphate(S1P)/sphingosine-1-phosphate receptor 1(S1P1)signal pathway during post conditioning of hypertrophic cardiomyocytes.Methods Neonatal rat cardiomyocytes were isolated and cultured,then stimulated by norepinephrine(NE)to induce cardiomyocytes hypertrophy.Using tri-gas incubator to create