The unique cellular microstructure of Fe-rich Sm_(2)Co_(17)-type permanent magnets is closely associated with the structure of the solid solution precursor.We investigate the phase structure,magnetic properties,and me...The unique cellular microstructure of Fe-rich Sm_(2)Co_(17)-type permanent magnets is closely associated with the structure of the solid solution precursor.We investigate the phase structure,magnetic properties,and mechanical behavior of B-doped Sm_(2)Co_(17)-type magnets with high Fe content.The doped B atoms can diffuse into the interstitial vacancy,resulting in lattice expansion and promote the homogenization of the phase organizational structure during the solid solution treatment in theory.However,the resulting second phase plays a dominant role to result in more microtwin structures and highly ordered 2:17R phases in the solid solution stage,which inhibits the ordering transformation of 1:7H phase during aging and affects the generation of the cellular structure,and to result in a decrease in magnetic properties,yet the interface formed between it and the matrix phase hinders the movement of dislocations and enhances the mechanical properties.Hence,the precipitation of high flexural strain grain boundary phase induced by B element doping is also a new and effective way to improve the flexural strain of Sm_(2)Co_(17)-type magnets.Our study provides a new understanding of the phase structure evolution and its effect on the magnetic and mechanical properties of Sm_(2)Co_(17)-type magnets with high Fe content.展开更多
Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neur...Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients incapacitated.Repetitive transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological conditions.Over the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and connectivity.It has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological insult.However,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of studies.This study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated mechanisms.This review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s disease.Apoptotic mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also highlighted.Finally,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.展开更多
Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significan...Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase evolution.Herein,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation process.The results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial polarization.Moreover,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic diffraction.Specifically,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon matrix.This design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.展开更多
Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid compositi...Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these forces.Intrinsic and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse formation.In the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called plasticity.Synaptic plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).展开更多
Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental disorders.The utilization of neuroimaging or biomarkers to...Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental disorders.The utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant goal.There have been several studies that examine brain imaging in psychiatric disorders,but more work is needed to elucidate the complexities of the human brain.In this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and depression.Xu et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as biomarkers.Stoyanov et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and depression.These two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.展开更多
The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully ci...The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),respectively.With the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire deposits.Microstructure characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α phases.The mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and discussed.The mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat treatment.No fracture occurred within the interfacial area,further suggesting the robust interface.The findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.展开更多
Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusi...Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed slightly.The dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)increased.With the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical<2111>-<1123>rare-earth(RE)textures.The alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening contributions.These results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.展开更多
Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental disability.Detailed asse...Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental disability.Detailed assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and electroencephalography.At present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic encephalopathy.This review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent articles.This review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic accuracy.Many challenges limit the timing consistency,particularly the need for intensive care and clinical monitoring.Conversely,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after birth.This suggests that in the future it will be important to explore a wider range of times after hypoxic-ischemic encephalopathy to fully understand the optimal timing for predicting long-term outcomes.展开更多
Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 gene.Attentiondeficit/hyperactivity disorder(ADHD)is considered a neurodevelopme...Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 gene.Attentiondeficit/hyperactivity disorder(ADHD)is considered a neurodevelopment and psychiatric disorder in childhood.Genetic characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and ADHD.Magnetic resonance imaging(MRI)has been used to assess medical images in Sotos syndrome and ADHD.The images process is considered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more complete information in single image in this editorial.In the future,genetic mechanisms and artificial intelligence related to medical images could be used in the clinical diagnosis of Sotos syndrome and ADHD.展开更多
The modeling and self-excited vibration mechanism in the magnetic levitation-collision interface coupling system are investigated.The effects of the control and interface parameters on the system's stability are a...The modeling and self-excited vibration mechanism in the magnetic levitation-collision interface coupling system are investigated.The effects of the control and interface parameters on the system's stability are analyzed.The frequency range of self-excited vibrations is investigated from the energy point of view.The phenomenon of self-excited vibrations is elaborated with the phase trajectory.The corresponding control strategies are briefly analyzed with respect to the vibration mechanism.The results show that when the levitation objects collide with the mechanical interface,the system's vibration frequency becomes larger with the decrease in the collision gap;when the vibration frequency exceeds the critical frequency,the electromagnetic system continues to provide energy to the system,and the collision interface continuously dissipates energy so that the system enters the self-excited vibration state.展开更多
The longitudinal wave term within Faraday’s law of electromagnetic induction (Faraday’s law) underwent recovery to ensure its suitability for theoretical derivation of the equation governing longitudinal electromagn...The longitudinal wave term within Faraday’s law of electromagnetic induction (Faraday’s law) underwent recovery to ensure its suitability for theoretical derivation of the equation governing longitudinal electromagnetic (LEM) waves. The revised Maxwell’s equations include the crucial parameters being the attenuation time constants of magnetic vortex potential and electric vortex potential generated by external electromagnetic field within the propagation medium. Specific expressions for them are obtained through theoretical analysis. Subsequently, a model for propagating magnetic P-wave generated by the superposition of a left-handed photo and a right-handed photon in a vacuum is formulated based on reevaluated total current law and revised Faraday’s law, covering wave equations, energy equation, as well as propagation mode involving mutual induction and conversion between scalar magnetic field and vortex electric field. Furthermore, through theoretical derivations centered around magnetic P-wave, evidence was presented regarding its ability to absorb huge free energy through the entangled interaction between zero-point vacuum energy field and the torsion field produced by the vortex electric field.展开更多
The flexibility of nanoparticle films is a topic of rapidly growing interest in both scientific and engineering researches due to their numerous potential applications in a broad range of wearable electronics and biom...The flexibility of nanoparticle films is a topic of rapidly growing interest in both scientific and engineering researches due to their numerous potential applications in a broad range of wearable electronics and biomedical devices.This article presents the elucidation of the properties of nanoparticle films.Here,a flexible film is fabricated based on polyethylene terephthalate(PET)and magnetic iron oxide at the nanoscale using layer-by-layer technology.The 2D thin flexible film material can be bent at different angles from 0°to 360°.With an increase in elastic deformation angles,the magnetocaloric effect of the film gradually increases in the alternating magnetic field.The test results from a vibrating sample magnetometer and a low-frequency impedance analyzer demonstrate that the film has a good magnetic response and anisotropy.The magnetocaloric effect and magnetic induction effect are controlled by deformation,providing a new idea for the application of elastic films.It combines the flexibility of the nanoparticle PET substrate and,in the future,it may be used for skin adhesion for administration and magnetic stimulation control.展开更多
The lack of soft magnetic composites with high power density in MHz frequency range has become an obstacle in the efficient operation of the electrical and electronic equipments.Here,a promising method to increase the...The lack of soft magnetic composites with high power density in MHz frequency range has become an obstacle in the efficient operation of the electrical and electronic equipments.Here,a promising method to increase the cut-off frequency of iron-based soft magnetic composites to hundreds of MHz is reported.The cut-off frequency is increased from 10 MHz to 1 GHz by modulating the height of the ring,the distribution of particles,and the particle size.The mechanism of cut-off frequency and permeability is the coherent rotation of domain modulated by inhomogeneous field due to the eddy current effect.An empirical formula for the cut-off frequency in a magnetic ring composed of iron-based particles is established from experimental data.This work provides an effective approach to fabricate soft magnetic composites with a cut-off frequency in hundreds of MHz.展开更多
High entropy alloys with the composition of FeCoNiA10.2Si0.2 were prepared by arc melting and induction melting, denoted by A1 and A2, respectively. The samples prepared by these two techniques have a face-centered cu...High entropy alloys with the composition of FeCoNiA10.2Si0.2 were prepared by arc melting and induction melting, denoted by A1 and A2, respectively. The samples prepared by these two techniques have a face-centered cubic (FCC) phase structure and a typical dendrite morphology. The tensile yield strength and maximum strength of A2 samples are about 280 and 632 MPa, respectively. Moreover~ the elongation can reach 41.7%. These two alloys prepared by the different methods possess the similar magnetic properties. The saturation magnetization and coercivity can reach 1.151 T and 1400 A/m for A1 samples and 1.015 T and 1431 A/m for A2 samples, respectively. Phases in A2 samples do not change, which are heat treated at different temperatures, then quenched in water. Only the sample, which is heat treated at 600~C for 3 h and then furnace cooled, has a new phase precipitated. Besides, the coercivity decreases obviously at this temperature. Cold rolling and the subsequent heat treatment cannot improve the magnetic properties effectively. However, cold rolling plays an important role in improving the strength.展开更多
Magnetic properties of Fe84Zr2Nb4B10 sample were investigated. The sample was produced from nanocrystalline powders made by the mechanical alloying (MA) and consolidation using the spark plasma sintering (SPS) techniq...Magnetic properties of Fe84Zr2Nb4B10 sample were investigated. The sample was produced from nanocrystalline powders made by the mechanical alloying (MA) and consolidation using the spark plasma sintering (SPS) technique. Effects of milling time on phase transformation, structural characteristics, and magnetic properties of powders were examined by X-ray diffraction (XRD), scanning electron microscopy (SEM), and physical property measure system (PPMS), respectively. Results show that nanostructured α-Fe supersaturated solid solution is obtained in the final MAed products. The saturation magnetization (Ms) increased with increasing milling time and became constant at 130 h, but the coercivity (Hc) increased firstly and then decreased. The consolidated bulk sample exhibited a high density of 6.893 g·cm-3, there was no phase change during SPS process, and the saturation magnetization and susceptibility of the SPSed bulk sample improved in comparison with the milled powders. The variation of magnetic parameters can be explained by nano-scale effect and Herzer model.展开更多
AIM:To explore the brain mechanism of acupuncture for children with anisometropic amblyopia using the voxelmirror homotopic connectivity(VMHC)analysis method of resting functional magnetic resonance imaging(rs-fMRI)te...AIM:To explore the brain mechanism of acupuncture for children with anisometropic amblyopia using the voxelmirror homotopic connectivity(VMHC)analysis method of resting functional magnetic resonance imaging(rs-fMRI)technology based on clinical effectiveness.METHODS:Eighty children with anisometropic monocular amblyopia were randomly divided into two groups:control(40 cases,1 case of shedding)and acupuncture(40 cases,1 case of shedding)groups.The control group was treated with glasses,red flash,grating,and visual stimulations,with each procedure conducted for 5min per time.Based on routine treatment,the acupuncture group underwent acupuncture of“regulating qi and unblocking meridians to bright eyes”,Jingming(BL1),Cuanzhu(BL2),Guangming(GB37),Fengchi(GB20)acupoints were taken on both sides,with the needle kept for 30min each time.Both groups were treated once every other day,three times per week,for a total of 4wk.After the treatment,the overall curative effect of the two groups and the latency and amplitude changes of P100 wave of pattern visual-evoked potential were counted.At the same time,nine children with left eye amblyopia were randomly selected from the two groups and were scanned with rsfMRI before and after treatment.The differences in the brain regions between the two groups were compared and analyzed with VMHC.RESULTS:Chi-square test showed a notable difference in the total efficiency rate between the acupuncture(94.87%)and control groups(79.49%).Regarding the P100 wave latency and amplitude,the acupuncture group had significantly shorter latency and higher amplitude of P100 wave than the control group.Moreover,the VMHC values of the bilateral temporal lobe,superior temporal gyrus,and middle temporal gyrus were notably increased in the acupuncture group after treatment.CONCLUSION:Acupuncture combined with conventional treatment can significantly improve the corrected visual acuity and optic nerve conduction in children with anisometropic amblyopia.Compared with the conventional treatment,the regulation of acupuncture on the functional activities of the relevant brain areas in the anterior cerebellum may be an effective acupuncture mechanism for anisometropic amblyopia.展开更多
1Cr25Ni20Si2 tube blank centrifugally cast in a steady magnetic field was investigated. The results indicated that the solidification structure and the mechanical properties of the blank can be improved remarkably by ...1Cr25Ni20Si2 tube blank centrifugally cast in a steady magnetic field was investigated. The results indicated that the solidification structure and the mechanical properties of the blank can be improved remarkably by electromagnetic stirring, and seamless tube can be manufactured from such blanks.展开更多
The application of mathematical modeling to biological fluids is of utmost importance, as it has diverse applicationsin medicine. The peristaltic mechanism plays a crucial role in understanding numerous biological flo...The application of mathematical modeling to biological fluids is of utmost importance, as it has diverse applicationsin medicine. The peristaltic mechanism plays a crucial role in understanding numerous biological flows. In thispaper, we present a theoretical investigation of the double diffusion convection in the peristaltic transport of aPrandtl nanofluid through an asymmetric tapered channel under the combined action of thermal radiation andan induced magnetic field. The equations for the current flow scenario are developed, incorporating relevantassumptions, and considering the effect of viscous dissipation. The impact of thermal radiation and doublediffusion on public health is of particular interest. For instance, infrared radiation techniques have been used totreat various skin-related diseases and can also be employed as a measure of thermotherapy for some bones toenhance blood circulation, with radiation increasing blood flow by approximately 80%. To solve the governingequations, we employ a numerical method with the aid of symbolic software such as Mathematica and MATLAB.The velocity, magnetic force function, pressure rise, temperature, solute (species) concentration, and nanoparticlevolume fraction profiles are analytically derived and graphically displayed. The results outcomes are compared withthe findings of limiting situations for verification.展开更多
The C15 Laves phase with composition Tb0.2Pr0.8(Fe0.4Co0.6)1.93 was synthesized by mechanical alloying (MA) and subsequent annealing process. The structure and magnetic properties of Tb0.2Pr0.8(Fe0.4Co0.6)1.93 w...The C15 Laves phase with composition Tb0.2Pr0.8(Fe0.4Co0.6)1.93 was synthesized by mechanical alloying (MA) and subsequent annealing process. The structure and magnetic properties of Tb0.2Pr0.8(Fe0.4Co0.6)1.93 were investigated by means of X-ray diffraction (XRD), a vibrating sample magnetometer, and a standard strain technique. The effect of annealing on the structure and magnetic properties was studied. The analysis of XRD shows that the high Pr-content Tb0.2Pr0.8(Fe0.4Co0.6)1.93 alloy with the single phase of MgCu2-type structure can be successfully synthesized by MA method. The sample annealed at 450℃ is found to have a coercivity of 196 kA/m at room temperature. An epoxy/Tb0.2Pr0.8(Fe0.4Co0.6)1.93 composite was produced by a cold isostatic pressing technique. A large magnetostriction of 400 ppm, at an applied magnetic field of 800 kA/m, was found for the composite. The epoxy-bonded Tb0.2Pr0.8(Fe0.4Co0.6)1.93 composite combines a high magnetostriction with a significant coercivitv, which is a oromising magnetostrictive material.展开更多
On the basis of the ideal gas model, the polarization of charges in the mantle was obtained, a physical and mathematical model was constructed, and estimated calculations of the dipole mode of the Earth’s magnetic fi...On the basis of the ideal gas model, the polarization of charges in the mantle was obtained, a physical and mathematical model was constructed, and estimated calculations of the dipole mode of the Earth’s magnetic field were performed, taking into account the speed of its angular rotation, the parameters of density and temperature, the chemical composition, the ionization potential, the dielectric constant and the percentage of the main chemical compounds of the mantle substance.展开更多
基金the NationalKey R&D Program of China (Grant Nos. 2021YFB3503102and 2022YFB3505301)Science and Technology Innovation2025 Major Project of Ningbo (Grant No. 2022Z204)+2 种基金ZhejiangProvincial Natural Science Foundation Youth OriginalProject (Grant No. LDQ24E010001)the Key R&D Programof Shanxi Province (Grant No. 202302050201014)Ningbo Natural Science Foundation (Grant No. 2021J216).
文摘The unique cellular microstructure of Fe-rich Sm_(2)Co_(17)-type permanent magnets is closely associated with the structure of the solid solution precursor.We investigate the phase structure,magnetic properties,and mechanical behavior of B-doped Sm_(2)Co_(17)-type magnets with high Fe content.The doped B atoms can diffuse into the interstitial vacancy,resulting in lattice expansion and promote the homogenization of the phase organizational structure during the solid solution treatment in theory.However,the resulting second phase plays a dominant role to result in more microtwin structures and highly ordered 2:17R phases in the solid solution stage,which inhibits the ordering transformation of 1:7H phase during aging and affects the generation of the cellular structure,and to result in a decrease in magnetic properties,yet the interface formed between it and the matrix phase hinders the movement of dislocations and enhances the mechanical properties.Hence,the precipitation of high flexural strain grain boundary phase induced by B element doping is also a new and effective way to improve the flexural strain of Sm_(2)Co_(17)-type magnets.Our study provides a new understanding of the phase structure evolution and its effect on the magnetic and mechanical properties of Sm_(2)Co_(17)-type magnets with high Fe content.
基金supported by the Hefei Comprehensive National Science Center Hefei Brain Project(to KW)the National Natural Science Foundation of China,Nos.31970979(to KW),82101498(to XW)the STI2030-Major Projects,No.2021ZD0201800(to PH).
文摘Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients incapacitated.Repetitive transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological conditions.Over the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and connectivity.It has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological insult.However,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of studies.This study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated mechanisms.This review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s disease.Apoptotic mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also highlighted.Finally,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.
基金financially supported by the National Natural Science Foundation of China(52373271)Science,Technology and Innovation Commission of Shenzhen Municipality under Grant(KCXFZ20201221173004012)+1 种基金National Key Research and Development Program of Shaanxi Province(No.2023-YBNY-271)Open Testing Foundation of the Analytical&Testing Center of Northwestern Polytechnical University(2023T019).
文摘Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase evolution.Herein,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation process.The results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial polarization.Moreover,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic diffraction.Specifically,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon matrix.This design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.
基金supported by PTDC-01778/2022-NeuroDev3D,iNOVA4Health(UIDB/04462/2020 and UIDP/04462/2020)LS4FUTURE(LA/P/0087/2020)。
文摘Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these forces.Intrinsic and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse formation.In the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called plasticity.Synaptic plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).
文摘Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental disorders.The utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant goal.There have been several studies that examine brain imaging in psychiatric disorders,but more work is needed to elucidate the complexities of the human brain.In this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and depression.Xu et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as biomarkers.Stoyanov et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and depression.These two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.
基金financially supported by the Agency for Science,Technology and Research(A*Star),Republic of Singapore,under the Aerospace Consortium Cycle 12“Characterization of the Effect of Wire and Powder Deposited Materials”(No.A1815a0078)。
文摘The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),respectively.With the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire deposits.Microstructure characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α phases.The mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and discussed.The mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat treatment.No fracture occurred within the interfacial area,further suggesting the robust interface.The findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.
基金supported by the National Science and Technology Major Project,China(No.2019-VI-0004-0118)the National Natural Science Foundation of China(No.51771152)the National Key R&D Program of China(No.2018YFB1106800)。
文摘Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed slightly.The dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)increased.With the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical<2111>-<1123>rare-earth(RE)textures.The alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening contributions.These results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.
基金supported by a grant from the Health Research New Zealand(HRC)22/559(to AJG and LB)。
文摘Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental disability.Detailed assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and electroencephalography.At present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic encephalopathy.This review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent articles.This review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic accuracy.Many challenges limit the timing consistency,particularly the need for intensive care and clinical monitoring.Conversely,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after birth.This suggests that in the future it will be important to explore a wider range of times after hypoxic-ischemic encephalopathy to fully understand the optimal timing for predicting long-term outcomes.
基金Supported by Natural Science Foundation of Shanghai,No.17ZR1431400National Key R and D Program of China,No.2017YFA0103902.
文摘Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 gene.Attentiondeficit/hyperactivity disorder(ADHD)is considered a neurodevelopment and psychiatric disorder in childhood.Genetic characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and ADHD.Magnetic resonance imaging(MRI)has been used to assess medical images in Sotos syndrome and ADHD.The images process is considered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more complete information in single image in this editorial.In the future,genetic mechanisms and artificial intelligence related to medical images could be used in the clinical diagnosis of Sotos syndrome and ADHD.
基金Project supported by the National Natural Science Foundation of China(No.12372005)。
文摘The modeling and self-excited vibration mechanism in the magnetic levitation-collision interface coupling system are investigated.The effects of the control and interface parameters on the system's stability are analyzed.The frequency range of self-excited vibrations is investigated from the energy point of view.The phenomenon of self-excited vibrations is elaborated with the phase trajectory.The corresponding control strategies are briefly analyzed with respect to the vibration mechanism.The results show that when the levitation objects collide with the mechanical interface,the system's vibration frequency becomes larger with the decrease in the collision gap;when the vibration frequency exceeds the critical frequency,the electromagnetic system continues to provide energy to the system,and the collision interface continuously dissipates energy so that the system enters the self-excited vibration state.
文摘The longitudinal wave term within Faraday’s law of electromagnetic induction (Faraday’s law) underwent recovery to ensure its suitability for theoretical derivation of the equation governing longitudinal electromagnetic (LEM) waves. The revised Maxwell’s equations include the crucial parameters being the attenuation time constants of magnetic vortex potential and electric vortex potential generated by external electromagnetic field within the propagation medium. Specific expressions for them are obtained through theoretical analysis. Subsequently, a model for propagating magnetic P-wave generated by the superposition of a left-handed photo and a right-handed photon in a vacuum is formulated based on reevaluated total current law and revised Faraday’s law, covering wave equations, energy equation, as well as propagation mode involving mutual induction and conversion between scalar magnetic field and vortex electric field. Furthermore, through theoretical derivations centered around magnetic P-wave, evidence was presented regarding its ability to absorb huge free energy through the entangled interaction between zero-point vacuum energy field and the torsion field produced by the vortex electric field.
基金Project supported by Scientific Research Funds(Grant No.7001/700199)Henan Provincial Department Scientific Research Project(Grant No.22A430034).
文摘The flexibility of nanoparticle films is a topic of rapidly growing interest in both scientific and engineering researches due to their numerous potential applications in a broad range of wearable electronics and biomedical devices.This article presents the elucidation of the properties of nanoparticle films.Here,a flexible film is fabricated based on polyethylene terephthalate(PET)and magnetic iron oxide at the nanoscale using layer-by-layer technology.The 2D thin flexible film material can be bent at different angles from 0°to 360°.With an increase in elastic deformation angles,the magnetocaloric effect of the film gradually increases in the alternating magnetic field.The test results from a vibrating sample magnetometer and a low-frequency impedance analyzer demonstrate that the film has a good magnetic response and anisotropy.The magnetocaloric effect and magnetic induction effect are controlled by deformation,providing a new idea for the application of elastic films.It combines the flexibility of the nanoparticle PET substrate and,in the future,it may be used for skin adhesion for administration and magnetic stimulation control.
基金the National Natural Science Foun-dation of China(Grant Nos.91963201 and 12174163)the 111 Project(Grant No.B20063).
文摘The lack of soft magnetic composites with high power density in MHz frequency range has become an obstacle in the efficient operation of the electrical and electronic equipments.Here,a promising method to increase the cut-off frequency of iron-based soft magnetic composites to hundreds of MHz is reported.The cut-off frequency is increased from 10 MHz to 1 GHz by modulating the height of the ring,the distribution of particles,and the particle size.The mechanism of cut-off frequency and permeability is the coherent rotation of domain modulated by inhomogeneous field due to the eddy current effect.An empirical formula for the cut-off frequency in a magnetic ring composed of iron-based particles is established from experimental data.This work provides an effective approach to fabricate soft magnetic composites with a cut-off frequency in hundreds of MHz.
文摘High entropy alloys with the composition of FeCoNiA10.2Si0.2 were prepared by arc melting and induction melting, denoted by A1 and A2, respectively. The samples prepared by these two techniques have a face-centered cubic (FCC) phase structure and a typical dendrite morphology. The tensile yield strength and maximum strength of A2 samples are about 280 and 632 MPa, respectively. Moreover~ the elongation can reach 41.7%. These two alloys prepared by the different methods possess the similar magnetic properties. The saturation magnetization and coercivity can reach 1.151 T and 1400 A/m for A1 samples and 1.015 T and 1431 A/m for A2 samples, respectively. Phases in A2 samples do not change, which are heat treated at different temperatures, then quenched in water. Only the sample, which is heat treated at 600~C for 3 h and then furnace cooled, has a new phase precipitated. Besides, the coercivity decreases obviously at this temperature. Cold rolling and the subsequent heat treatment cannot improve the magnetic properties effectively. However, cold rolling plays an important role in improving the strength.
基金supported by the National Natural Science Foundation of China (Nos. 50874051 50574041)the New Century Excellent Talents in University (No. NCET-05-0739)
文摘Magnetic properties of Fe84Zr2Nb4B10 sample were investigated. The sample was produced from nanocrystalline powders made by the mechanical alloying (MA) and consolidation using the spark plasma sintering (SPS) technique. Effects of milling time on phase transformation, structural characteristics, and magnetic properties of powders were examined by X-ray diffraction (XRD), scanning electron microscopy (SEM), and physical property measure system (PPMS), respectively. Results show that nanostructured α-Fe supersaturated solid solution is obtained in the final MAed products. The saturation magnetization (Ms) increased with increasing milling time and became constant at 130 h, but the coercivity (Hc) increased firstly and then decreased. The consolidated bulk sample exhibited a high density of 6.893 g·cm-3, there was no phase change during SPS process, and the saturation magnetization and susceptibility of the SPSed bulk sample improved in comparison with the milled powders. The variation of magnetic parameters can be explained by nano-scale effect and Herzer model.
基金Supported by National Natural Science Foundation of China(No.82160935,No.82260965)Traditional Chinese Medicine Discipline“Qi Huang Ying Cai”Tutor Special Fund Doctoral Program(No.ZYXKBD-202208)+4 种基金Higher Education Innovation Fund Project of Gansu Province(No.2021A-087)Natural Science Foundation of Gansu Province(No.22JR5RA583)Traditional Chinese Medicine Discipline“Qi Huang Ying Cai”Tutor Special Fund Master’s Supervisor Program(No.ZYXKSD-202220)Youth Research Fund Project of Gansu University of Chinese Medicine(No.ZQ2017-9)Gansu Province 2023 Provincial Key Talent Project(No.2).
文摘AIM:To explore the brain mechanism of acupuncture for children with anisometropic amblyopia using the voxelmirror homotopic connectivity(VMHC)analysis method of resting functional magnetic resonance imaging(rs-fMRI)technology based on clinical effectiveness.METHODS:Eighty children with anisometropic monocular amblyopia were randomly divided into two groups:control(40 cases,1 case of shedding)and acupuncture(40 cases,1 case of shedding)groups.The control group was treated with glasses,red flash,grating,and visual stimulations,with each procedure conducted for 5min per time.Based on routine treatment,the acupuncture group underwent acupuncture of“regulating qi and unblocking meridians to bright eyes”,Jingming(BL1),Cuanzhu(BL2),Guangming(GB37),Fengchi(GB20)acupoints were taken on both sides,with the needle kept for 30min each time.Both groups were treated once every other day,three times per week,for a total of 4wk.After the treatment,the overall curative effect of the two groups and the latency and amplitude changes of P100 wave of pattern visual-evoked potential were counted.At the same time,nine children with left eye amblyopia were randomly selected from the two groups and were scanned with rsfMRI before and after treatment.The differences in the brain regions between the two groups were compared and analyzed with VMHC.RESULTS:Chi-square test showed a notable difference in the total efficiency rate between the acupuncture(94.87%)and control groups(79.49%).Regarding the P100 wave latency and amplitude,the acupuncture group had significantly shorter latency and higher amplitude of P100 wave than the control group.Moreover,the VMHC values of the bilateral temporal lobe,superior temporal gyrus,and middle temporal gyrus were notably increased in the acupuncture group after treatment.CONCLUSION:Acupuncture combined with conventional treatment can significantly improve the corrected visual acuity and optic nerve conduction in children with anisometropic amblyopia.Compared with the conventional treatment,the regulation of acupuncture on the functional activities of the relevant brain areas in the anterior cerebellum may be an effective acupuncture mechanism for anisometropic amblyopia.
基金ItemSponsored by National Natural Science Foundation of China (59995440)
文摘1Cr25Ni20Si2 tube blank centrifugally cast in a steady magnetic field was investigated. The results indicated that the solidification structure and the mechanical properties of the blank can be improved remarkably by electromagnetic stirring, and seamless tube can be manufactured from such blanks.
基金Institutional Fund Projects under No.(IFP-A-2022-2-5-24)by Ministry of Education and University of Hafr Al Batin,Saudi Arabia.
文摘The application of mathematical modeling to biological fluids is of utmost importance, as it has diverse applicationsin medicine. The peristaltic mechanism plays a crucial role in understanding numerous biological flows. In thispaper, we present a theoretical investigation of the double diffusion convection in the peristaltic transport of aPrandtl nanofluid through an asymmetric tapered channel under the combined action of thermal radiation andan induced magnetic field. The equations for the current flow scenario are developed, incorporating relevantassumptions, and considering the effect of viscous dissipation. The impact of thermal radiation and doublediffusion on public health is of particular interest. For instance, infrared radiation techniques have been used totreat various skin-related diseases and can also be employed as a measure of thermotherapy for some bones toenhance blood circulation, with radiation increasing blood flow by approximately 80%. To solve the governingequations, we employ a numerical method with the aid of symbolic software such as Mathematica and MATLAB.The velocity, magnetic force function, pressure rise, temperature, solute (species) concentration, and nanoparticlevolume fraction profiles are analytically derived and graphically displayed. The results outcomes are compared withthe findings of limiting situations for verification.
基金supported by the National Natural Science Foundation of China (Nos. 50801039 and 50744014)It was also supported by the Natural Science Foundation of Zhejiang Province (Nos. Y406389)Ningbo City (Nos. 2007A610029 and 2005A610022)
文摘The C15 Laves phase with composition Tb0.2Pr0.8(Fe0.4Co0.6)1.93 was synthesized by mechanical alloying (MA) and subsequent annealing process. The structure and magnetic properties of Tb0.2Pr0.8(Fe0.4Co0.6)1.93 were investigated by means of X-ray diffraction (XRD), a vibrating sample magnetometer, and a standard strain technique. The effect of annealing on the structure and magnetic properties was studied. The analysis of XRD shows that the high Pr-content Tb0.2Pr0.8(Fe0.4Co0.6)1.93 alloy with the single phase of MgCu2-type structure can be successfully synthesized by MA method. The sample annealed at 450℃ is found to have a coercivity of 196 kA/m at room temperature. An epoxy/Tb0.2Pr0.8(Fe0.4Co0.6)1.93 composite was produced by a cold isostatic pressing technique. A large magnetostriction of 400 ppm, at an applied magnetic field of 800 kA/m, was found for the composite. The epoxy-bonded Tb0.2Pr0.8(Fe0.4Co0.6)1.93 composite combines a high magnetostriction with a significant coercivitv, which is a oromising magnetostrictive material.
文摘On the basis of the ideal gas model, the polarization of charges in the mantle was obtained, a physical and mathematical model was constructed, and estimated calculations of the dipole mode of the Earth’s magnetic field were performed, taking into account the speed of its angular rotation, the parameters of density and temperature, the chemical composition, the ionization potential, the dielectric constant and the percentage of the main chemical compounds of the mantle substance.