Carbon dioxide geological sequestration is an effective method to reduce the content of greenhouse gases in the atmosphere of our planet.This process can also be used to improve the production of oil reservoirs by mix...Carbon dioxide geological sequestration is an effective method to reduce the content of greenhouse gases in the atmosphere of our planet.This process can also be used to improve the production of oil reservoirs by mixing carbon dioxide and crude oil.In the present study,a differential separation experiment(DL)based on actual crude oil components is used to simulate such a process.The results show that after mixing,the viscosity and density of reservoir fluid decrease and the volume coefficient increase,indicating that the pre buried gas induces fluid expansion and an improvement of the fluid rheological properties.These effects are interpreted using a pore scale model based on real scanning electron microscopy(SEM).The results show that increasing the pressure and reducing the viscosity are beneficial to increasing the micro oil displacement efficiency.Moreover,these effects can improve the production in the target area and slow down the decline of the formation pressure.Furthermore,in the case of fracture development in the reservoir(due to CO_(2)injection before exploitation),the risk of gas channelling,induced by the displacement pressure difference between injection and production wells,is avoided.展开更多
In this paper, the accuracy of estimating stained non-wetting phase saturation using digital image processing is examined, and a novel post-processing approach for calculating threshold is presented. In order to remov...In this paper, the accuracy of estimating stained non-wetting phase saturation using digital image processing is examined, and a novel post-processing approach for calculating threshold is presented. In order to remove the effect of the background noise of images and to enhance the high-frequency component of the original image, image smoothing and image sharpening methods are introduced. Depending on the correct threshold, the image binarization processing is particularly useful for estimating stained non-wetting phase saturation. Calculated saturation data are compared with the measured saturation data during the two-phase flow experiment in an artificial steel planar porous media model. The results show that the calculated saturation data agree with the measured ones. With the help of an artificial steel planar porous media model, digital image processing is an accurate and simple method for obtaining the stained non-wetting phase saturation.展开更多
This paper validates the effectiveness of a comprehensive mixed media model for effective advertising designed to bring customers into auto dealerships by use of their AIDA (attention, interest, desire, action) mode...This paper validates the effectiveness of a comprehensive mixed media model for effective advertising designed to bring customers into auto dealerships by use of their AIDA (attention, interest, desire, action) model and statistical science to quantitatively assess the effectiveness of various advertising methods using television, newspapers, flyers, direct mail, public transportation, and the internet. This model is applied to a dealership representing a well-known automaker, where its effectiveness is verified.展开更多
The ability to capture permeability of fractured porous media plays a significant role in several engineering applications, including reservoir, mining, petroleum and geotechnical engineering. In order to solve fluid ...The ability to capture permeability of fractured porous media plays a significant role in several engineering applications, including reservoir, mining, petroleum and geotechnical engineering. In order to solve fluid flow and coupled flow-deformation problems encountered in these engineering applications,both empirical and theoretical models had been proposed in the past few decades. Some of them are simple but still work in certain circumstances; others are complex but also need some modifications to be applicable. Thus, the understanding of state-of-the-art permeability evolution model would help researchers and engineers solve engineering problems through an appropriate approach. This paper summarizes permeability evolution models proposed by earlier and recent researchers with emphasis on their characteristics and limitations.展开更多
An alternate yet general form of the classical effective thermal conductivity model (Maxwell model) for two-phase porous materials is presented, serving an explicit thermo-physicM basis. It is demonstrated that the ...An alternate yet general form of the classical effective thermal conductivity model (Maxwell model) for two-phase porous materials is presented, serving an explicit thermo-physicM basis. It is demonstrated that the reduced effective thermal conductivity of the porous media due to non-conducting pore inclusions is caused by the mechanism of thermal stretching, which is a combi- nation of reduced effective heat flow area and elongated heat transfer distance (thermal tortuosity).展开更多
Background Chronic otitis media(COM) is a significant clinical problem.Understanding the mechanisms of COM is critical for its control and treatment.However,little is known of the processes leading to COM as a result ...Background Chronic otitis media(COM) is a significant clinical problem.Understanding the mechanisms of COM is critical for its control and treatment.However,little is known of the processes leading to COM as a result of lack of animal models of N-ethyl-N-nitrosourea(ENU) induced mutations in otitis media with effusion(OME).Methods Otoscopy and auditory brain response(ABR) evaluation were carried out under sedation in Nmf391nmf/nmf mice of 2,4,6 and 8 months of age.The mice were killed for study of middle and inner ear pathology.Results Tympanic membrane visualization and ABR thresholds in 1-to 8-month-old Nmf391nmf/nmf mice showed spontaneous OME and inner ear diseases in approximately 100% of the animals.The significant elevation of ABR thresholds suggested a sensorineural component in hearing loss in addition to the conductive loss.Middle and inner ear histology showed various degrees of outer hair cells loss and middle ear inflammation in all the mice,but no inflammation cells in the inner ear.The ABR threshold at 32 kHz was significantly elevated.Conclusions This study shows histopathologic changes in the Nmf391nmf/nmf mouse model of COM with effusion that have not been reported in human COM.This ENU induced mutation model of COM will be valuable for the characterization of middle ear inflammation and inner ear disease processes that are induced by middle ear infections.We propose that COM with effusion in this ENU induced mutation model is the cause of the cochlea hair cells damage.展开更多
This paper presents a cross-media semantic mining model (CSMM) based on object semantic. This model obtains object-level semantic information in terms of maximum probability principle. Then semantic templates are tr...This paper presents a cross-media semantic mining model (CSMM) based on object semantic. This model obtains object-level semantic information in terms of maximum probability principle. Then semantic templates are trained and constructed with STTS (Semantic Template Training System), which are taken as the bridge to realize the transition from various low-level media feature to object semantic. Furthermore, we put forward a kind of double layers metadata structure to efficaciously store and manage mined low-level feature and high-level semantic. This model has broad application in lots of domains such as intelligent retrieval engine, medical diagnoses, multimedia design and so on.展开更多
The permeability in the methane hydrate reservoir is one of the key parameters in estimating the gas production performance and the flow behavior of gas and water during dissociation.In this paper,a three-dimensional ...The permeability in the methane hydrate reservoir is one of the key parameters in estimating the gas production performance and the flow behavior of gas and water during dissociation.In this paper,a three-dimensional cubic pore-network model based on invasion percolation is developed to study the effect of hydrate particle formation and growth habit on the permeability.The variation of permeability in porous media with different hydrate saturation is studied by solving the network problem.The simulation results are well consistent with the experimental data.The proposed model predicts that the permeability will reduce exponentially with the increase of hydrate saturation,which is crucial in developing a deeper understanding of the mechanism of hydrate formation and dissociation in porous media.展开更多
Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations...Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations for media managers to promote health communication via social media. Methods: Our custom model was derived from literature review, empirical research was tested by the use of questionnaire investigation, and then the collected data were analyzed by structural equation model tool SmartPLS. Finally, the custom model was modified according to the experimental results of SmartPLS. Results: A total of 239 (66.39%) of the respondents were female and 121 (33.61%) were male. The maximum of two stages of age were 18 - 29 (70.56%), 30 - 39 (13.89%). Wechat (60.28%), QQ Zone (55.22%), Micro-blog (48.89%) were the most commonly used social media to obtain health information. About 44.72% of respondents used social media to obtain health information multiple times a day. The whole numerical values of AVE, cronbach’s alpha, CR and square roots of AVE were above the benchmarks of themselves and showed great reliability and validity. All the 11 hypotheses had obvious statistical significance, the P-value of eight path coefficients exhibited <0.001, one path coefficient exhibited <0.01 and two path coefficients exhibited <0.05. Conclusions: A suitable model of consumer health information seeking behavior via social media was created and some inner relationships were found. Namely, gratification of health information and its platform had a positive effect on attitudes toward health information seeking behavior. Health information literacy and health status were proved to have a significant influence on attitudes toward health information seeking behavior, subject norms and perceived behavioral control respectively. In addition, attitudes toward the health information seeking behavior, subject norms and perceived behavioral control were proved to positively associate with health information seeking behavior intention.展开更多
In examining potential host rocks for such purposes as the disposal of high-level radioactive wastes,it is important to understand the coupled thermo-hydro-mechanical(THM) behavior of a porous medium.A rigorous and ...In examining potential host rocks for such purposes as the disposal of high-level radioactive wastes,it is important to understand the coupled thermo-hydro-mechanical(THM) behavior of a porous medium.A rigorous and fully unified coupled thermo-hydro-mechanical model for unsaturated porous media is required to simulate the complex coupling mechanisms involved.Based on modified Darcy's and Fourier's laws,equations of mechanical equilibrium,mass conservation and energy conservation are derived by introducing void ratio and volumetric liquid water content into the model.The newly derived model takes into account the effects of temperature on the dynamic viscosity of liquid water and void ratio,the influence of liquid flow on temperature gradient(thermo-osmosis),the influence on mass and heat conservation equations,and the influence of heat flow on water pressure gradient and thermal convection.The new coupled THM constitutive model is constructed by a finite element program and is used to simulate the coupled behavior of a tunnel during excavation,ventilation and concrete lining stages.Oil and gas engineering,underground disposal of nuclear waste and tunnel engineering may be benefited from the development of the new model.展开更多
The filtration coefficient before filtration (λ-0)is intro-duced and a mathematical model for the leukocyte filtra-tion process, which relates to the filtration efficieney,capacity and leukoeyte concentration, filter...The filtration coefficient before filtration (λ-0)is intro-duced and a mathematical model for the leukocyte filtra-tion process, which relates to the filtration efficieney,capacity and leukoeyte concentration, filter thickness and fliter surface area, is established according to the mass balance for particles in a filter and the particle concen-tration decrease per unit of filter depth. The model can be uded to calculate the filtration efficiency or capacity.It is found that the filtration performance observed dur-ing the experiments could be explained well by the mod-el.The established model can be applied to the design and optimization of ungrafted and grafted melt blown nonwoven filtration materials.展开更多
Single or multi-layer infiltration rate models describe water penetration into soil porous zone at a variety of comparable complexity levels. Commonly, those models are indicating a route leading from general to more ...Single or multi-layer infiltration rate models describe water penetration into soil porous zone at a variety of comparable complexity levels. Commonly, those models are indicating a route leading from general to more specific case depending on the mathematical structure and the simulated ongoing phenomenon. For the purpose of wastewater flow quantification through porous media, an algorithmic procedure was developed which includes certain interconnected activity stages and decision nodes. Furthermore, a schematic cross shaped representation of the infiltration rate models’ ontology is presented within a route, leading from general to more specific models and evaluation criteria are introduced to determine highest ranking and thus the best model amid those placed on the horizontal axis of the cross shaped scheme, via a simple Multi-Criteria Analysis Decision Making.展开更多
A mathematical model based on Darcy's law and electroosmosis equation in porous media is developed and two parameters named electroosmosis coefficient K, and relative electroosmosis coefficient Kre are used to cal...A mathematical model based on Darcy's law and electroosmosis equation in porous media is developed and two parameters named electroosmosis coefficient K, and relative electroosmosis coefficient Kre are used to calculate the curves of Ke and Krevs. water saturation whick are employed to estimate the effect of electroosmosis on water displacing oil process in sandstone cores. Under the conditions of constant injection rate displacement and constant electrical potential gradient, the method to calculate parameters K. and K. at different water saturation is developed and unsteadystate displacement experin.ental data under the effect of electroosmosis are used to determine the Parameter values. The results show that K, and K, are increased firstly with increasing water saturation and then decreased. This trend shows the inter-relationship between electroosmosis and the water displacing oil process. Finally, application of the model to ECMP mechauics studies and ac-tual reservoirs is analyzed in this peper.展开更多
In this paper, we are interested by the dissolution of NAPL (Non-Aqueous Phase Liquid) contaminants in heterogeneous soils or aquifers. The volume averaging technique is applied to 2D systems with Darcy-scale heteroge...In this paper, we are interested by the dissolution of NAPL (Non-Aqueous Phase Liquid) contaminants in heterogeneous soils or aquifers. The volume averaging technique is applied to 2D systems with Darcy-scale heterogeneities. A large-scale model is derived from a Darcy-scale dissolution model in the case of small and large Damkholer numbers, i.e., for smooth or sharp dissolution fronts. The resulting models in both cases have the mathematical structure of a non-equilibrium dissolution model. It is shown how to calculate the resulting mass exchange and relative permeability terms from the Darcy-scale heterogeneities and other fluid properties. One of the important finding is that the obtained values have a very different behavior compared to the Darcy-scale usual correlations. The large scale correlations are also very different between the two limit cases. The resulting large-scale models are compared favorably to Darcy-scale direct simulations.展开更多
基金Thanks for the support of a major national special project during the 13th Five-Year Plan period,“Chemical Flooding Technology for Offshore Oil Fields”(No.2016ZX05025-003)“Heavy Oil Chemical Flooding Mechanism and Simulation Technology Research”(No.2019-YXKJ-008)Research on Source Sink Matching Technology and Scheme of Regional CCUs Project(2021-ZYZL-XNY-01),etc.
文摘Carbon dioxide geological sequestration is an effective method to reduce the content of greenhouse gases in the atmosphere of our planet.This process can also be used to improve the production of oil reservoirs by mixing carbon dioxide and crude oil.In the present study,a differential separation experiment(DL)based on actual crude oil components is used to simulate such a process.The results show that after mixing,the viscosity and density of reservoir fluid decrease and the volume coefficient increase,indicating that the pre buried gas induces fluid expansion and an improvement of the fluid rheological properties.These effects are interpreted using a pore scale model based on real scanning electron microscopy(SEM).The results show that increasing the pressure and reducing the viscosity are beneficial to increasing the micro oil displacement efficiency.Moreover,these effects can improve the production in the target area and slow down the decline of the formation pressure.Furthermore,in the case of fracture development in the reservoir(due to CO_(2)injection before exploitation),the risk of gas channelling,induced by the displacement pressure difference between injection and production wells,is avoided.
基金supported by the National Natural Science Foundation of China(Grant No51079043)the Special Fund for Public Welfare Industry of Ministry of Water Resources of China(Grants No200901064 and 201001020)the Research Innovation Program for College Graduates of Jiangsu Province(Grant No CXZZ11_0450)
文摘In this paper, the accuracy of estimating stained non-wetting phase saturation using digital image processing is examined, and a novel post-processing approach for calculating threshold is presented. In order to remove the effect of the background noise of images and to enhance the high-frequency component of the original image, image smoothing and image sharpening methods are introduced. Depending on the correct threshold, the image binarization processing is particularly useful for estimating stained non-wetting phase saturation. Calculated saturation data are compared with the measured saturation data during the two-phase flow experiment in an artificial steel planar porous media model. The results show that the calculated saturation data agree with the measured ones. With the help of an artificial steel planar porous media model, digital image processing is an accurate and simple method for obtaining the stained non-wetting phase saturation.
文摘This paper validates the effectiveness of a comprehensive mixed media model for effective advertising designed to bring customers into auto dealerships by use of their AIDA (attention, interest, desire, action) model and statistical science to quantitatively assess the effectiveness of various advertising methods using television, newspapers, flyers, direct mail, public transportation, and the internet. This model is applied to a dealership representing a well-known automaker, where its effectiveness is verified.
基金supported by the National Nature Science Foundation of China(No.51278383,No.51238009 and No.51025827)Key Scientific and Technological Innovation Team of Zhejiang Province(No.2011R50020)Key Scientific and Technological Innovation Team of Wenzhou(No.C20120006)
文摘The ability to capture permeability of fractured porous media plays a significant role in several engineering applications, including reservoir, mining, petroleum and geotechnical engineering. In order to solve fluid flow and coupled flow-deformation problems encountered in these engineering applications,both empirical and theoretical models had been proposed in the past few decades. Some of them are simple but still work in certain circumstances; others are complex but also need some modifications to be applicable. Thus, the understanding of state-of-the-art permeability evolution model would help researchers and engineers solve engineering problems through an appropriate approach. This paper summarizes permeability evolution models proposed by earlier and recent researchers with emphasis on their characteristics and limitations.
基金supported by the National 111 Project of China (B06024)the National Basic Research Program of China (2011CB610305)+1 种基金the Major International Joint Research Program of China (11120101002)the National Natural Science Foundation of China (51206128)
文摘An alternate yet general form of the classical effective thermal conductivity model (Maxwell model) for two-phase porous materials is presented, serving an explicit thermo-physicM basis. It is demonstrated that the reduced effective thermal conductivity of the porous media due to non-conducting pore inclusions is caused by the mechanism of thermal stretching, which is a combi- nation of reduced effective heat flow area and elongated heat transfer distance (thermal tortuosity).
基金supported by National Natural Science Foundation of China(grant no.39970785)International Collaborate Research Foundation of National Natural Science of China(grant no.322200462)National Institutes of Health (grant no.ROIDC007392)
文摘Background Chronic otitis media(COM) is a significant clinical problem.Understanding the mechanisms of COM is critical for its control and treatment.However,little is known of the processes leading to COM as a result of lack of animal models of N-ethyl-N-nitrosourea(ENU) induced mutations in otitis media with effusion(OME).Methods Otoscopy and auditory brain response(ABR) evaluation were carried out under sedation in Nmf391nmf/nmf mice of 2,4,6 and 8 months of age.The mice were killed for study of middle and inner ear pathology.Results Tympanic membrane visualization and ABR thresholds in 1-to 8-month-old Nmf391nmf/nmf mice showed spontaneous OME and inner ear diseases in approximately 100% of the animals.The significant elevation of ABR thresholds suggested a sensorineural component in hearing loss in addition to the conductive loss.Middle and inner ear histology showed various degrees of outer hair cells loss and middle ear inflammation in all the mice,but no inflammation cells in the inner ear.The ABR threshold at 32 kHz was significantly elevated.Conclusions This study shows histopathologic changes in the Nmf391nmf/nmf mouse model of COM with effusion that have not been reported in human COM.This ENU induced mutation model of COM will be valuable for the characterization of middle ear inflammation and inner ear disease processes that are induced by middle ear infections.We propose that COM with effusion in this ENU induced mutation model is the cause of the cochlea hair cells damage.
基金Supported by the National Basic Research Program of China 973 Program (2007CB310801)the Specialized Research Fund for the Doctoral Program of Higer Education of China (20070486064)+1 种基金the Natural Science Foundation of Hubei Province (2007ABA038)the Programme of Introducing Talents of Discipline to Universities (B07037)
文摘This paper presents a cross-media semantic mining model (CSMM) based on object semantic. This model obtains object-level semantic information in terms of maximum probability principle. Then semantic templates are trained and constructed with STTS (Semantic Template Training System), which are taken as the bridge to realize the transition from various low-level media feature to object semantic. Furthermore, we put forward a kind of double layers metadata structure to efficaciously store and manage mined low-level feature and high-level semantic. This model has broad application in lots of domains such as intelligent retrieval engine, medical diagnoses, multimedia design and so on.
基金supported by the National High Technology Research and Development (863) Program of China (Grant Nos.2006AA09A209-5)the National Natural Science Foundation of China (Grant Nos. 90510003)the Major Research Project of the Ministry of Education (Grant Nos. 306005)
文摘The permeability in the methane hydrate reservoir is one of the key parameters in estimating the gas production performance and the flow behavior of gas and water during dissociation.In this paper,a three-dimensional cubic pore-network model based on invasion percolation is developed to study the effect of hydrate particle formation and growth habit on the permeability.The variation of permeability in porous media with different hydrate saturation is studied by solving the network problem.The simulation results are well consistent with the experimental data.The proposed model predicts that the permeability will reduce exponentially with the increase of hydrate saturation,which is crucial in developing a deeper understanding of the mechanism of hydrate formation and dissociation in porous media.
文摘Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations for media managers to promote health communication via social media. Methods: Our custom model was derived from literature review, empirical research was tested by the use of questionnaire investigation, and then the collected data were analyzed by structural equation model tool SmartPLS. Finally, the custom model was modified according to the experimental results of SmartPLS. Results: A total of 239 (66.39%) of the respondents were female and 121 (33.61%) were male. The maximum of two stages of age were 18 - 29 (70.56%), 30 - 39 (13.89%). Wechat (60.28%), QQ Zone (55.22%), Micro-blog (48.89%) were the most commonly used social media to obtain health information. About 44.72% of respondents used social media to obtain health information multiple times a day. The whole numerical values of AVE, cronbach’s alpha, CR and square roots of AVE were above the benchmarks of themselves and showed great reliability and validity. All the 11 hypotheses had obvious statistical significance, the P-value of eight path coefficients exhibited <0.001, one path coefficient exhibited <0.01 and two path coefficients exhibited <0.05. Conclusions: A suitable model of consumer health information seeking behavior via social media was created and some inner relationships were found. Namely, gratification of health information and its platform had a positive effect on attitudes toward health information seeking behavior. Health information literacy and health status were proved to have a significant influence on attitudes toward health information seeking behavior, subject norms and perceived behavioral control respectively. In addition, attitudes toward the health information seeking behavior, subject norms and perceived behavioral control were proved to positively associate with health information seeking behavior intention.
基金Supported by the National Natural Science Foundation of China (50579087,50720135906, 50539050)CAS/SAFEA International Partnership Program for Creative Research Teams
文摘In examining potential host rocks for such purposes as the disposal of high-level radioactive wastes,it is important to understand the coupled thermo-hydro-mechanical(THM) behavior of a porous medium.A rigorous and fully unified coupled thermo-hydro-mechanical model for unsaturated porous media is required to simulate the complex coupling mechanisms involved.Based on modified Darcy's and Fourier's laws,equations of mechanical equilibrium,mass conservation and energy conservation are derived by introducing void ratio and volumetric liquid water content into the model.The newly derived model takes into account the effects of temperature on the dynamic viscosity of liquid water and void ratio,the influence of liquid flow on temperature gradient(thermo-osmosis),the influence on mass and heat conservation equations,and the influence of heat flow on water pressure gradient and thermal convection.The new coupled THM constitutive model is constructed by a finite element program and is used to simulate the coupled behavior of a tunnel during excavation,ventilation and concrete lining stages.Oil and gas engineering,underground disposal of nuclear waste and tunnel engineering may be benefited from the development of the new model.
文摘The filtration coefficient before filtration (λ-0)is intro-duced and a mathematical model for the leukocyte filtra-tion process, which relates to the filtration efficieney,capacity and leukoeyte concentration, filter thickness and fliter surface area, is established according to the mass balance for particles in a filter and the particle concen-tration decrease per unit of filter depth. The model can be uded to calculate the filtration efficiency or capacity.It is found that the filtration performance observed dur-ing the experiments could be explained well by the mod-el.The established model can be applied to the design and optimization of ungrafted and grafted melt blown nonwoven filtration materials.
文摘Single or multi-layer infiltration rate models describe water penetration into soil porous zone at a variety of comparable complexity levels. Commonly, those models are indicating a route leading from general to more specific case depending on the mathematical structure and the simulated ongoing phenomenon. For the purpose of wastewater flow quantification through porous media, an algorithmic procedure was developed which includes certain interconnected activity stages and decision nodes. Furthermore, a schematic cross shaped representation of the infiltration rate models’ ontology is presented within a route, leading from general to more specific models and evaluation criteria are introduced to determine highest ranking and thus the best model amid those placed on the horizontal axis of the cross shaped scheme, via a simple Multi-Criteria Analysis Decision Making.
文摘A mathematical model based on Darcy's law and electroosmosis equation in porous media is developed and two parameters named electroosmosis coefficient K, and relative electroosmosis coefficient Kre are used to calculate the curves of Ke and Krevs. water saturation whick are employed to estimate the effect of electroosmosis on water displacing oil process in sandstone cores. Under the conditions of constant injection rate displacement and constant electrical potential gradient, the method to calculate parameters K. and K. at different water saturation is developed and unsteadystate displacement experin.ental data under the effect of electroosmosis are used to determine the Parameter values. The results show that K, and K, are increased firstly with increasing water saturation and then decreased. This trend shows the inter-relationship between electroosmosis and the water displacing oil process. Finally, application of the model to ECMP mechauics studies and ac-tual reservoirs is analyzed in this peper.
文摘In this paper, we are interested by the dissolution of NAPL (Non-Aqueous Phase Liquid) contaminants in heterogeneous soils or aquifers. The volume averaging technique is applied to 2D systems with Darcy-scale heterogeneities. A large-scale model is derived from a Darcy-scale dissolution model in the case of small and large Damkholer numbers, i.e., for smooth or sharp dissolution fronts. The resulting models in both cases have the mathematical structure of a non-equilibrium dissolution model. It is shown how to calculate the resulting mass exchange and relative permeability terms from the Darcy-scale heterogeneities and other fluid properties. One of the important finding is that the obtained values have a very different behavior compared to the Darcy-scale usual correlations. The large scale correlations are also very different between the two limit cases. The resulting large-scale models are compared favorably to Darcy-scale direct simulations.