Research on Polymer Materials in Bio Medical and Its Application

Intelligent hydrogels is as drug carrier, and it has a good application prospect. There are some changes factors in the human environment, such as temperature, pH. Therefore, the temperature sensitive hydrogels and pH sensitive hydrogels can release system for drugs in the body. So the paper detailed descript a novel MWCNTs good dispersion of PMAA/MWCNTs nano hybrid hydrogels. The introduction of MWCNTs significantly increased the hydrogel pH response and mechanical strength, and depends on the MWCNTs component ratio, particle size and concentration of cross-linking agent. The study found, swelling rate of hybrid hydrogels was faster than the pure PMAA hydrogel, and the swelling behavior were explained. The compression stress-strain experiments should be found, MWCNTs load transfer plays an important role in improving the mechanical properties of the hybrid hydrogels network compression.

Synthesis and Structure of Tetraphenylglycolide

The title compound (C28H20O4, Mr = 420.44) has been prepared and its crystal structure was determined by X-ray diffraction method. The crystal of the com- pound belongs to monoclinic, space group C2/c with a = 23.988(2), b = 9.015(1), c = 22.558(1) ?, β = 116.47(1)o, V = 4366.5(7) ?3, Z = 8, Dx = 1.279 g/cm3, μ = 0.085 mm-1, F(000) = 1760 and R = 0.0616 for 2138 observed reflections (I > 2σ(I)). The glycolide heterocycle moiety displays a twisted boat conformation. Centroid distance of 3.863(2) ? between the nearly parallel benzene rings shows the existence of aromatic stacking in the crystal.

Cytotoxicity,Degradation and Release Behavior of Alginate Fibers Loaded with Chlorhexidine Gluconate and Its Docking Simulation

To investigate the feasibility and safety of alginate fibers loaded with chlorhexidine gluconate(CHG)for biomedical applications,vitro cytotoxic test and drug release pattern were studied.Discovery Studio(DS),a computer aided software,was utilized to briefly investigate the energy state and solvation at the molecular level.Alginate fiber loaded with CHG presented different drug release patterns in PBS and A solution.Cytotoxicity results indicated that CHG-loaded alginate fibers can promote the growth of L-929 mouse fibroblast cells with better biocompatibility.Through the simulation,the lowest energy conformation of three representative molecular bond regions was optimized with stronger stability.As the torsional energy increased,the bond energy of the target regions decreased.Besides,the transition energy of the target regions was greatly reduced by solvation.In a word,alginate fibers loaded with CHG expressed better biocompatibility and drug sustained-release ability,which indicates that CHG-loaded alginate fibers has a broad application prospect in medical dressing.

Using Gamma-Radiation for Drug Releasing from MWNT Vehicle

A drug delivery system via multi-walled carbon nanotube （MWNT） vehicle was synthesized in aqueous solution. MWNTs were first noncovalently functionalized with chitosan oligomers （CS） with a molecule weight of 4000-6000, making MWNTs water-soluble, and then a cancer ancillary drug tea polyphenols （TP） was conjugated mainly via the hydrogen bond between CS and TP molecules, making MWNTs efficient vehicle for drug delivering. The release of drug molecules can be realized by pH variation and γ-radiation, leading to new methods for controlling drug release from carbon nanotubes carrier. Due to the high penetrability of γ-rays, γ-radiation shows up new opportunities in controlled drug release, possibly facilitating the future cancer treatment in vivo.