patients with bullous epidermolysis type of drug eruption over the last 8 years were studied,including 5 males and 11 females,aged 1 to 75 years old,Among them,there were 10 patients aged 20 to 30 years old,The main c...patients with bullous epidermolysis type of drug eruption over the last 8 years were studied,including 5 males and 11 females,aged 1 to 75 years old,Among them,there were 10 patients aged 20 to 30 years old,The main causative drugs included antibiotics,antipyretics,sulfonamides and hydrosulfides,All patients presented middle to high fever,loose bullae on skin,dermolysis and tenderness.More than 90% body surface were involved in 13 cases(81 25%),and mucosae were affected in 14 cases(87 5%).There were 10 patients(62 5%)converted from other types of drug eruption,and 4 combined with basal renal diseases,3 cases died at last.The reason of conversion,the key points of treatment and prognosis of thos disease were discussed.展开更多
Nicolau syndrome(NS) is a rare cutaneous adverse reaction after intra-muscular or intra-articular injection. Clinical features of NS are presented by three typical phases(initial, acute and necrotic phases). The cause...Nicolau syndrome(NS) is a rare cutaneous adverse reaction after intra-muscular or intra-articular injection. Clinical features of NS are presented by three typical phases(initial, acute and necrotic phases). The cause of NS is acute vasospasm, inflammation of arteries and thromboembolic occlusion of arteriole related various drugs. Many results of laboratory test, imaging studiesand histopathology are reported and are associated with disease status. Three phase treatment is recommended for the patients with NS. Initially pain control and rule out differential diagnosis and in acute phase steroid therapy, heparin and pentoxifylline are useful. In necrotic phase, surgical treatment is needed depending on size of the affected site. NS is not well understood so far, however three phase treatment could lead to good result on basis of literature review.展开更多
文摘patients with bullous epidermolysis type of drug eruption over the last 8 years were studied,including 5 males and 11 females,aged 1 to 75 years old,Among them,there were 10 patients aged 20 to 30 years old,The main causative drugs included antibiotics,antipyretics,sulfonamides and hydrosulfides,All patients presented middle to high fever,loose bullae on skin,dermolysis and tenderness.More than 90% body surface were involved in 13 cases(81 25%),and mucosae were affected in 14 cases(87 5%).There were 10 patients(62 5%)converted from other types of drug eruption,and 4 combined with basal renal diseases,3 cases died at last.The reason of conversion,the key points of treatment and prognosis of thos disease were discussed.
文摘Nicolau syndrome(NS) is a rare cutaneous adverse reaction after intra-muscular or intra-articular injection. Clinical features of NS are presented by three typical phases(initial, acute and necrotic phases). The cause of NS is acute vasospasm, inflammation of arteries and thromboembolic occlusion of arteriole related various drugs. Many results of laboratory test, imaging studiesand histopathology are reported and are associated with disease status. Three phase treatment is recommended for the patients with NS. Initially pain control and rule out differential diagnosis and in acute phase steroid therapy, heparin and pentoxifylline are useful. In necrotic phase, surgical treatment is needed depending on size of the affected site. NS is not well understood so far, however three phase treatment could lead to good result on basis of literature review.
