Non-alcoholic fatty liver disease and type 2 diabetes are common comorbidities or target organ damage,which can lead to adverse metabolism and increased risk of cardiovascular and cerebrovascular diseases.In the manag...Non-alcoholic fatty liver disease and type 2 diabetes are common comorbidities or target organ damage,which can lead to adverse metabolism and increased risk of cardiovascular and cerebrovascular diseases.In the management plan of non-alcoholic fatty liver disease and type 2 diabetes,there is no drug with significant efficacy or both.The dialectical idea of traditional Chinese medicine has a good curative effect and significant advantages in treating metabolic disorders.The author now reviewed a case of non-alcoholic steatohepatitis combined with type 2 diabetes.In this case,the method of invigorating the spleen and eliminating turbidity was effective,which effectively prevented the progression of liver disease in the patient,and T2DM was alleviated by maintaining within the standard range after the use of insulin was stopped.It can be said that“killing two birds with one stone”,more fully reflects the advantages of traditional Chinese medicine in the integrated treatment of metabolic-related diseases.展开更多
对近10年来有关中医辨治胃癌前病变(precancerous lesions of gastric cancer,PLGC)的研究进行综述。PLGC是指在慢性萎缩性胃炎基础上出现的胃黏膜肠上皮化生和异型增生,作为慢性萎缩性胃炎与胃癌的中间阶段,PLGC的病程较缓慢。中医辨治...对近10年来有关中医辨治胃癌前病变(precancerous lesions of gastric cancer,PLGC)的研究进行综述。PLGC是指在慢性萎缩性胃炎基础上出现的胃黏膜肠上皮化生和异型增生,作为慢性萎缩性胃炎与胃癌的中间阶段,PLGC的病程较缓慢。中医辨治PLGC具有一定的优势。PLGC主要可分为脾胃虚弱证、脾胃湿热证、肝胃气滞证、胃络瘀阻证、胃阴不足证5种证型。胃镜技术的普及促进了胃病微观辨证的发展,微观辨证与宏观辨证的结合为PLGC的中医辨证论治提供了更加丰富的理论支持。PLGC根本病机为脾胃虚弱,脾胃气机不畅,兼有湿热、瘀毒、痰湿等病理因素蕴结,日久胃阴亏耗。中药治疗PLGC的临床研究开展较多,治疗主要采用以益气健脾为主,兼以疏肝活血、化湿消瘀、化瘀解毒、养阴益胃,从而防止PLGC向胃癌进一步发展。针灸治疗胃癌前病变的研究开展较少。今后需开展更多严格且规范的多中心、大样本的临床随机对照试验,深入研究针灸治疗胃癌前病变机制,以期为中医辨治PLGC提供更多高级别的循证依据。展开更多
Objective:The objective of this study was to systematically evaluate the clinical efficacy of the integration method of heat-clearing, dampness-excreting,spleen-strengthening, and stasis-removing from traditional Chin...Objective:The objective of this study was to systematically evaluate the clinical efficacy of the integration method of heat-clearing, dampness-excreting,spleen-strengthening, and stasis-removing from traditional Chinese medicine (TCM) combined with Western medicine for the treatment of ulcerative colitis(UC).Materials and Methods:The databases China National Knowledge Infrastructure,China Biology Medicinedisc(CBMdisc),WANFANG, VIP, and PubMed were searched for randomized controlled trials investigating the integration of the TCM methods of clearing heat,draining dampness, invigorating the spleen, and removing stasis, combined with Western medicine to treat UC from January 2009 to March 2019. Two reviewers independently conducted literature searches, screenings, data extractions, and literature bias evaluations. A meta-analysis was conducted using RevMan 5.3 and Stata 13.0 software. Results:In total, 15 studies involving 1289 patients were included. The results of the meta-analysis showed that the total effective rate of treatment in the experimental groups was higher than that of the control groups (relative risk [RR]=1.27, 95%confidence interval [CI]:1.21, 1.35, Z=8.74, P <0.00001). In the subgroup analysis, the total effective rate of oral TCM combined with Western medicine was higher than that of the control groups (RR=1.24, 95%CI:1.15, 1.33, Z=5.88, P <0.00001). The total effective rate of oral TCM with enemas combined with Western medicine was higher than that of the control group (RR=1.30, 95%CI:1.12, 1.50, Z=3.52, P=0.0004).The comparison between Western medicine alone and oral TCM combined with enteroscopy and Western medicine showed that the effective rate of enteroscopy (RR=1.18, 95%CI:1.05, 1.33, Z=2.86, P=0.004) and the symptom scores before and after treatment all improved more in the combined treatment groups than in those of the Western medicine group alone, with statistically significant differences (RR=-4.23, 95%CI:-4.93,-3.53, Z=11.84, P <0.00001). Conclusion:The integration of the TCM methods of heat clearing, dampness excreting, spleen strengthening, and stasis removing combined with Western medicine can significantly improve the cure rate of UC, and is an effective method to treat UC.展开更多
Objective: To investigate the effect of Chinese drugs (CD) that invigorate Spleen to remove Dampness and activate the blood circulation to eliminate Turbid for retarding progression of chronic renal failure (CRF).Meth...Objective: To investigate the effect of Chinese drugs (CD) that invigorate Spleen to remove Dampness and activate the blood circulation to eliminate Turbid for retarding progression of chronic renal failure (CRF).Methods: Thirty-nine patients with CRF were divided into two groups at random: the 18 patients in group A (the control group) were treated with low protein diet and controlling blood pressure and 21 patients in group B (the treatment group) were treated similarly with that of the control group and additional CD. Levels of serous creatinine (SCr), blood urea nitrogen (BUN), blood albumin (Alb), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and hemoglobin (Hb) were checked every two months and the rate of progression of CRF was estimated by slope of the creatinine reciprocal (1/SCr) with time (months).Results: Levels of SCr and BUn in group B were lower and HDL higher than those in group A significantly,P < 0.05. Mean slopes of the creatinine reciprocal with time in the two groups were markedly different,P < 0.01.Conclusion: Additional CD treatment based upon the low protein diet and controlling blood pressure could retard the rate of progression of CRF evidently.展开更多
目的观察肥胖型多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)患者应用健脾化痰祛湿法联合针刺周期疗法的临床疗效。方法选取2019年6月—2021年6月期间在南阳市第二人民医院中医妇科就诊的肥胖型PCOS患者100例,采用简单随机化法分...目的观察肥胖型多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)患者应用健脾化痰祛湿法联合针刺周期疗法的临床疗效。方法选取2019年6月—2021年6月期间在南阳市第二人民医院中医妇科就诊的肥胖型PCOS患者100例,采用简单随机化法分对照组和试验组,每组各50例。对照组采用常规治疗,试验组常规治疗+健脾化痰祛湿法联合针刺周期疗法。治疗3个月后,观察比较两组患者临床疗效,治疗前后体质量指数(Body mass index,BMI)、腰臀比(Waist hip ratio,WHR)、子宫内膜容受性[子宫内膜厚度、子宫动脉血流搏动指数(Pulsatility index,PI)和子宫动脉阻力指数(Resistance index,RI)]和糖代谢指标[糖化血红蛋白(HbAlc)、空腹胰岛素(Fasting insulin,FINS)和胰岛素抵抗指数(Homeostasis model assessment-insulin resistance,HOMA-IR)]、脂肪代谢因子[脂联素(Adiponectin,APN)、廋素(Leptin,LEP)]水平。结果治疗后试验组总有效率为90.00%(45/50)明显高于对照组74.00%(37/50),差异有统计学意义(P<0.05)。治疗后两组患者BMI指数及WHR比值均较治疗前降低,差异有统计学意义(P<0.05);且试验组BMI指数及WHR比值均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者子宫内膜厚度均较治疗前增厚、RI指数均较治疗前降低,差异有统计学意义(P<0.05);且试验组子宫内膜厚度较对照组增厚、RI指数较对照组降低,差异有统计学意义(P<0.05)。治疗后两组患者HbAlc、FINS及HOMA-IR水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组HbAlc、FINS及HOMA-IR水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者APN、LEP水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组APN、LEP水平均较对照组降低,差异有统计学意义(P<0.05)。结论应用健脾化痰祛湿法联合针刺周期疗法治疗肥胖型PCOS可提高疗效,并能改善患者子宫内膜容受性和糖脂代谢因子。展开更多
基金The fifth batch of national training programs for clinical talents of traditional Chinese medicine(No.1[2022]of Chinese Medicine People’s Education Letter)Shaanxi Natural Science Basic Research Plan(2022JM-454)+1 种基金Scientific research project of Shaanxi Provincial Administration of Traditional Chinese Medicine(2021-PY-001)Science and Technology Project of Ankang Science and Technology Bureau(AK2020-SF-06,AK2021-SFZC-06).
文摘Non-alcoholic fatty liver disease and type 2 diabetes are common comorbidities or target organ damage,which can lead to adverse metabolism and increased risk of cardiovascular and cerebrovascular diseases.In the management plan of non-alcoholic fatty liver disease and type 2 diabetes,there is no drug with significant efficacy or both.The dialectical idea of traditional Chinese medicine has a good curative effect and significant advantages in treating metabolic disorders.The author now reviewed a case of non-alcoholic steatohepatitis combined with type 2 diabetes.In this case,the method of invigorating the spleen and eliminating turbidity was effective,which effectively prevented the progression of liver disease in the patient,and T2DM was alleviated by maintaining within the standard range after the use of insulin was stopped.It can be said that“killing two birds with one stone”,more fully reflects the advantages of traditional Chinese medicine in the integrated treatment of metabolic-related diseases.
文摘对近10年来有关中医辨治胃癌前病变(precancerous lesions of gastric cancer,PLGC)的研究进行综述。PLGC是指在慢性萎缩性胃炎基础上出现的胃黏膜肠上皮化生和异型增生,作为慢性萎缩性胃炎与胃癌的中间阶段,PLGC的病程较缓慢。中医辨治PLGC具有一定的优势。PLGC主要可分为脾胃虚弱证、脾胃湿热证、肝胃气滞证、胃络瘀阻证、胃阴不足证5种证型。胃镜技术的普及促进了胃病微观辨证的发展,微观辨证与宏观辨证的结合为PLGC的中医辨证论治提供了更加丰富的理论支持。PLGC根本病机为脾胃虚弱,脾胃气机不畅,兼有湿热、瘀毒、痰湿等病理因素蕴结,日久胃阴亏耗。中药治疗PLGC的临床研究开展较多,治疗主要采用以益气健脾为主,兼以疏肝活血、化湿消瘀、化瘀解毒、养阴益胃,从而防止PLGC向胃癌进一步发展。针灸治疗胃癌前病变的研究开展较少。今后需开展更多严格且规范的多中心、大样本的临床随机对照试验,深入研究针灸治疗胃癌前病变机制,以期为中医辨治PLGC提供更多高级别的循证依据。
基金financially supported by Project of China-Japanese Friendship Hospital,the study on the pathogenesis of UC with syndrome of retention of dampness heat in large intestine based on relevant pathways of “bacteria–intestine–brain axis”(2019-JYB-JS-020)。
文摘Objective:The objective of this study was to systematically evaluate the clinical efficacy of the integration method of heat-clearing, dampness-excreting,spleen-strengthening, and stasis-removing from traditional Chinese medicine (TCM) combined with Western medicine for the treatment of ulcerative colitis(UC).Materials and Methods:The databases China National Knowledge Infrastructure,China Biology Medicinedisc(CBMdisc),WANFANG, VIP, and PubMed were searched for randomized controlled trials investigating the integration of the TCM methods of clearing heat,draining dampness, invigorating the spleen, and removing stasis, combined with Western medicine to treat UC from January 2009 to March 2019. Two reviewers independently conducted literature searches, screenings, data extractions, and literature bias evaluations. A meta-analysis was conducted using RevMan 5.3 and Stata 13.0 software. Results:In total, 15 studies involving 1289 patients were included. The results of the meta-analysis showed that the total effective rate of treatment in the experimental groups was higher than that of the control groups (relative risk [RR]=1.27, 95%confidence interval [CI]:1.21, 1.35, Z=8.74, P <0.00001). In the subgroup analysis, the total effective rate of oral TCM combined with Western medicine was higher than that of the control groups (RR=1.24, 95%CI:1.15, 1.33, Z=5.88, P <0.00001). The total effective rate of oral TCM with enemas combined with Western medicine was higher than that of the control group (RR=1.30, 95%CI:1.12, 1.50, Z=3.52, P=0.0004).The comparison between Western medicine alone and oral TCM combined with enteroscopy and Western medicine showed that the effective rate of enteroscopy (RR=1.18, 95%CI:1.05, 1.33, Z=2.86, P=0.004) and the symptom scores before and after treatment all improved more in the combined treatment groups than in those of the Western medicine group alone, with statistically significant differences (RR=-4.23, 95%CI:-4.93,-3.53, Z=11.84, P <0.00001). Conclusion:The integration of the TCM methods of heat clearing, dampness excreting, spleen strengthening, and stasis removing combined with Western medicine can significantly improve the cure rate of UC, and is an effective method to treat UC.
文摘Objective: To investigate the effect of Chinese drugs (CD) that invigorate Spleen to remove Dampness and activate the blood circulation to eliminate Turbid for retarding progression of chronic renal failure (CRF).Methods: Thirty-nine patients with CRF were divided into two groups at random: the 18 patients in group A (the control group) were treated with low protein diet and controlling blood pressure and 21 patients in group B (the treatment group) were treated similarly with that of the control group and additional CD. Levels of serous creatinine (SCr), blood urea nitrogen (BUN), blood albumin (Alb), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and hemoglobin (Hb) were checked every two months and the rate of progression of CRF was estimated by slope of the creatinine reciprocal (1/SCr) with time (months).Results: Levels of SCr and BUn in group B were lower and HDL higher than those in group A significantly,P < 0.05. Mean slopes of the creatinine reciprocal with time in the two groups were markedly different,P < 0.01.Conclusion: Additional CD treatment based upon the low protein diet and controlling blood pressure could retard the rate of progression of CRF evidently.
文摘目的观察肥胖型多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)患者应用健脾化痰祛湿法联合针刺周期疗法的临床疗效。方法选取2019年6月—2021年6月期间在南阳市第二人民医院中医妇科就诊的肥胖型PCOS患者100例,采用简单随机化法分对照组和试验组,每组各50例。对照组采用常规治疗,试验组常规治疗+健脾化痰祛湿法联合针刺周期疗法。治疗3个月后,观察比较两组患者临床疗效,治疗前后体质量指数(Body mass index,BMI)、腰臀比(Waist hip ratio,WHR)、子宫内膜容受性[子宫内膜厚度、子宫动脉血流搏动指数(Pulsatility index,PI)和子宫动脉阻力指数(Resistance index,RI)]和糖代谢指标[糖化血红蛋白(HbAlc)、空腹胰岛素(Fasting insulin,FINS)和胰岛素抵抗指数(Homeostasis model assessment-insulin resistance,HOMA-IR)]、脂肪代谢因子[脂联素(Adiponectin,APN)、廋素(Leptin,LEP)]水平。结果治疗后试验组总有效率为90.00%(45/50)明显高于对照组74.00%(37/50),差异有统计学意义(P<0.05)。治疗后两组患者BMI指数及WHR比值均较治疗前降低,差异有统计学意义(P<0.05);且试验组BMI指数及WHR比值均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者子宫内膜厚度均较治疗前增厚、RI指数均较治疗前降低,差异有统计学意义(P<0.05);且试验组子宫内膜厚度较对照组增厚、RI指数较对照组降低,差异有统计学意义(P<0.05)。治疗后两组患者HbAlc、FINS及HOMA-IR水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组HbAlc、FINS及HOMA-IR水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者APN、LEP水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组APN、LEP水平均较对照组降低,差异有统计学意义(P<0.05)。结论应用健脾化痰祛湿法联合针刺周期疗法治疗肥胖型PCOS可提高疗效,并能改善患者子宫内膜容受性和糖脂代谢因子。
