A Re-understanding on the Safety Matters of Chinese Herbal Medicine

Traditional Chinese medicine (TCM) plays a very important role in Chinese people ’ s health-keeping, enjoying an position of the same significance with Western medicine and drugs. Entering into the 21 century, and due to the swift and drastic development in economy and elevation in living quality, the public have come to pay much more

A Brief Discussion on the Safety of Famous Region Herb

With the vigorous development of the Chinese herbal medicine market in China,the production of high-quality authentic medicinal materials must not only ensure its unique authentic properties,but also ensure its quality and safety.This article elaborates the challenges faced by the authentic Chinese medicinal materials and gives suggestions to improve the quality system of Chinese medicinal materials.

To Establish A Body of Evidence on Safety for Postmarketing Chinese Medicine：A New Research Paradigm

The issue of safety evaluation on postmarketing Chinese medicines has become a hot topic in China’s mainland recently. Researchers and decision-makers can obtain a variety of evidence resources about safety in order to evaluate the safety profile for postmarketing Chinese medicines. A registry study on ten Chinese medicine injections for postmarketing surveillance has come to the end. From such a study observing more than 300,000 patients for more than 4 years, a theoretical research question emerges, that is, how to identify and evaluate safety evidence systematically. We put forward a brand new research paradigm on the theory level, which is to establish a body of evidence on safety evaluation for postmarketing Chinese medicine. Therefore, multiple information sources were explored and extracted from preclinical experiments for toxicity, postmarketing clinical trials for efficacy and safety evaluation, registry study for surveillance, retrospective data analysis from hospital information system and spontaneous response system, and case reports and systematic review from literature. Greater efforts for this idea and cooperation with experts in this field both in China and abroad are urgently needed.

Scientific understanding of toxicity and safety of Chinese medicines

Traditional Chinese medicine is a treasure of traditional culture and medicine which should be inherited and developed. How to cor- rectly understand the toxicity of Chinese materia medica （CMM） is an important guarantee for safe drug use. The history of the applica- tion and research of the toxicity of CMM has been long, and the Chi- nese medicine community ,has never stopped exploring the issues related to the safety of CMM.

Disease-based Toxicology on Safety Assessment Strategy and Application for Herbal and Traditional Medicines

The safety issue on herbal and traditional medicines(H&TM) is one of the most challenging problems and serious concern worldwide. With scientific endeavor and further exploration, we came to realize that there are great differences between H&TM and synthetic drugs in many aspects, such as medical theory, medication experience, compatibility, processing, toxicological characteristics, and safety evaluating requirements. In the current preclinical models for synthetic drugs, the safety assessment results of some conventional deemed 'nontoxic' H&TM were not well consistent with clinical situations, which resulted in major difficulties to understand the mechanisms and guide the safe and rational uses of these H&TM. Thus, based on the traditional Chinese medicine toxicity theory called You Gu Wu Yun, this paper introduces a novel safety assessment strategy for H&TM, named as disease-based toxicology. It aims to cognize the relativity and susceptibility of the toxicity of H&TM, and then to enhance controllability in new drug development and clinical applications. It also provides a theoretical practice for the traditional Chinese medicine toxicity theory and a methodological promotion for the future development of the precision toxicology for H&TM.

IN VITRO AND IN VIVO EVALUATION OF THE SAFETY OF SOME BENINESE PLANTS USED IN TRADITIONAL MEDICINE

About 80%of population in developing countries use traditional remedies in their usual health care and plants used in traditional medicine are an interesting alternative to expensive and hardly available modern medicines,mainly in rural areas.Moreover,they are a promising source of new drugs structurally innovative.Therefore it is important to investigate their biological properties and we focused on5 beninese plants:Byrsocarpus coccineus Schumach.&Thonn(Connaraceae),Carpolobia lutea G.Don(Polygalaceae),