Influence of reservoir heterogeneity on immiscible water-alternating-CO_(2)flooding:A case study

Currently,limited studies of immiscible water-alternating-CO_(2)(imWACO_(2))flooding focus on the impact of reservoir heterogeneity on reservoir development outcomes.Given this,using the heterogeneous reservoirs in the Gao 89-1 block as a case study,this study conducted slab core flooding experiments and numerical simulations to assess the impact of reservoir heterogeneity on imWACO_(2)flooding efficiency.It can be concluded that imWACO_(2)flooding can enhance the sweep volume and oil recovery compared to continuous CO_(2)flooding.As the permeability difference increases,the difference in the swept volume between zones/layers with relatively high and low permeability increases.To optimize the exploitation of reservoirs in the Gao 89-1 block,the optimal timing and CO_(2)injection rate for imWACO_(2)flooding are determined at water cut of 40%and 10000 m^(3)/d,respectively.A short injection-production semi-period,combined with multiple cycles of water and CO_(2)injection alternations,is beneficial for enhanced oil recovery from imWACO_(2)flooding.

Optimization design of wide face water slots for medium-thick slab casting mold

A three-dimensional finite-element model has been established to investigate the thermal behavior of the medium-thick slab copper casting mold with different cooling water slot designs. The mold wall temperatures measured using thermocouples buried in different positions of the mold with the original designed cooling system were analyzed to determine the corresponding heat flux profile. This profile was then used for simulation to predict the temperature distribution and the thermal stress distribution of the molds. The predicted temperatures during operation matched the plant measurements. The results showed that the maximum temperature, about 635 K in the wide hot surface, was found about 60 mm below the meniscus and 226 mm from the center of the mold. For the mold with the type I modified design, there was an insignificant decrease in temperature of about 5 K, and for the mold with the type II modified design, the maximum temperature was decreased by about 15 K and the temperature of the hot surface was distributed more uniformly along the length of the mold. The corresponding maximum thermal stress at the hot surface of the mold was reduced from 408 MPa to 386 MPa with the type II modified design. The results indicated that the modified design II is beneficial to the increase of mold life and the quality of casting slabs.

FREQUENCY-DOMAIN METHOD FOR RECONSTRUCTION OF THE PARAMETERS OF DIELECTRIC SLABS

The complex parameters of dielectric slabs can be reconstructed according to thescattered field data if the slabs are illuminated by a harmonic electromagnetic wave and thescattered field is measured.This paper describes a method for reconstruction of the parametersof single or double inhomogeneous lossy dielectric slabs.The numerical results are demonstrated.

EXACT SOLUTION FOR RECTANGULAR SLAB WITH THREE EDGES SIMPLY-SUPPORTED AND OTHER FREE

In this paper,we give all-sided pastic analysis of the rectangular slab with three edges simply-supported and other free.Here we discuss the following four cases:(1)The uniformly distributedload over the area a slab.(2).A concentrated load act at midpoint of free edges slab.(3)A concen-trated load act at the center a slab.(4)The line load act along free edge of slab.

Neural stem cell-conditioned medium upregulated the PCMT1 expression and inhibited the phosphorylation of MST1 in SHSY5Y cells induced by Aβ_(25-35)

A progressive neurodegenerative disease,Alzheimer’s disease(AD).Studies suggest that highly expressed protein isoaspartate methyltransferase 1(PCMT1)in brain tissue.In the current study,we explored the effects of neural stem cell-conditioned medium(NSC-CDM)on the PCMT1/MST1 pathway to alleviate Aβ_(25-35)-induced damage in SH-SY5Y cells.Our data suggested that Aβ_(25-35) markedly inhibited cell viability.NSC-CDM or Neural stem cell-complete medium(NSC-CPM)had a suppression effect on toxicity when treatment with Aβ_(25-35),with a greater effect observed with NSC-CDM.Aβ_(25-35)+NSC-CDM group exhibited an increase in PCMT1 expression.sh-PCMT1 markedly decreased cell proliferation and suppressed the protective role of NSC-CDM through the induction of apoptosis and improved p-MST1 expression.Overexpression of PCMT1 reversed the Aβ_(25-35)-induced decrease in cell proliferation and apoptosis.In summary,our findings suggest that NSC-CDM corrects the Aβ_(25-35)-induced damage to cells by improving PCMT1 expressions,which in turn reduces phosphorylation of MST1.

Medium J^(1/2)-clean环和Medium J^(1/2)-∗-clean环

作为Medium*-clean环的推广,本文引入了Medium J^(1/2)-clean环和Medium J^(1/2)-∗-clean环的概念,研究了这两类环的基本性质和扩张性质,并考虑它们与一些特殊环之间的联系。

Constitutive Laws for Visco-plastic Porous Medium Shaped by Regularly Distributed Circular Particles

A numerical study is presented,using a homogenization technique to consider the plain strain problem of visco-plastic porous medium shaped by regularly distributed circular particles. Based on a rigid plastic material,the paper derives the macroscopic constitutive laws for homogenous equivalent medium. By changing the shape parameter of circular particles,the effect of pore shape on macroscopic constitutive laws is explored. Yield surfaces with different pore shapes are obtained. About voids,a two-scale conception is introduced,which regards main void as macroscopic scale and secondary cavities as microscopic scale. The macroscopic potential involving main and secondary voids is achieved. The proposed macroscopic constitutive law taking microscopic features as influence factors is helpful for exploring the macroscopic mechanical properties of porous medium when numerical simulation is required.

North slope transition zone of Songnan-Baodao sag in Qiongdongnan Basin and its control on medium and large gas fields,South China Sea

Based on analysis of newly collected 3D seismic and drilled well data,the geological structure and fault system of Baodao sag have been systematically examined to figure out characteristics of the transition fault terrace belt and its control on the formation of natural gas reservoirs.The research results show that the Baodao sag has the northern fault terrace belt,central depression belt and southern slope belt developed,among them,the northern fault terrace belt consists of multiple transition fault terrace belts such as Baodao B,A and C from west to east which control the source rocks,traps,reservoirs,oil and gas migration and hydrocarbon enrichment in the Baodao sag.The activity of the main fault of the transition belt in the sedimentary period of Yacheng Formation in the Early Oligocene controlled the hydrocarbon generation kitchen and hydrocarbon generation potential.From west to east,getting closer to the provenance,the transition belt increased in activity strength,thickness of source rock and scale of delta,and had multiple hydrocarbon generation depressions developed.The main fault had local compression under the background of tension and torsion,giving rise to composite traps under the background of large nose structure,and the Baodao A and Baodao C traps to the east are larger than Baodao B trap.Multiple fault terraces controlled the material source input from the uplift area to form large delta sand bodies,and the synthetic transition belt of the west and middle sections and the gentle slope of the east section of the F12 fault in the Baodao A transition belt controlled the input of two major material sources,giving rise to a number of delta lobes in the west and east branches.The large structural ridge formed under the control of the main fault close to the hydrocarbon generation center allows efficient migration and accumulation of oil and gas.The combination mode and active time of the main faults matched well with the natural gas charging period,resulting in the hydrocarbon gas enrichment.Baodao A transition belt is adjacent to Baodao 27,25 and 21 lows,where large braided river delta deposits supplied by Shenhu uplift provenance develop,and it is characterized by large structural ridges allowing high efficient hydrocarbon accumulation,parallel combination of main faults and early cessation of faulting activity,so it is a favorable area for hydrocarbon gas accumulation.Thick high-quality gas reservoirs have been revealed through drilling,leading to the discovery of the first large-scale gas field in Baodo 21-1 of Baodao sag.This discovery also confirms that the north transition zone of Songnan-Baodao sag has good reservoir forming conditions,and the transition fault terrace belt has great exploration potential eastward.

Development Strategies of E-commerce for Small and Medium - sized Enterprises

In the economic structure of our country, small and medium-sized enterprises （SMEs） are the most important part of the backbone, with the continuous popularization of the Internet, e-commerce has gradually become a business model that the current small and medium enterprises must face and accept, The development of enterprises is of great signifi cance. In this context, the article first introduced the importance of the development of e-commerce SMEs, and then based on the actual operation of the community put forward and analyzed the current e-commerce development under the existing problems, and finally based on the actual lack of effective Development Strategy of E - commerce for Small and Medium - sized Enterprises.

0.47C-0.36Si-0.67Mn钢连铸板坯低温轧制过程变形抗力模型

用Gleeble-3500热模拟试验机对0.47C-0.36Si-0.67Mn中碳钢150 mm连铸板坯在650～920℃、变形量0.1～0.6、变形速率10～20 s^(-1)单道次轴向压缩时的变形抗力进行试验和研究,并建立了实验钢在低温下的变形抗力数学模型。结果表明,随温度降低,变形速率和变形量增加,试验钢变形抗力增加:在700℃以下变形时,由于发生动态铁素体相变,当加工硬化同动态相变软化达到平衡时曲线出现变形抗力极值,而后随形变诱导铁素体量的增加,变形抗力下降预报值与实测值相符,变形抗力的预报精度为±13.76 MPa。

三元混晶板中的电子-声子作用

本文发展了三元混晶板中电子-声子作用的量子理论,给出了该系统声子的本征频率以及电子-声子作用的哈密顿算符.这一理论建立在无序位移独立位移(REI)模型和连续模型的基础上.

Longitudinal surface cracks of thin slabs

Based on the production practice of medium carbon thin slabs in the CSP plant,the reasons and influencing factors for the formation of longitudinal cracks were investigated,and some industrial measures were taken to eliminate the cracks.The results show that the efficient solutions to reduce longitudinal cracks are improving the performance of the mold powder,stabilizing the mold heat flux,and maintaining a proper taper of the mold during casting.Proper pouring temperature and secondary cooling also play important roles in preventing longitudinal surface cracks.

Experimental study of temperature gradient in track slab under outdoor conditions in Chengdu area

Temperature is one of the important loads for designing slab track. The characteristic of slab track tem- perature varies greatly with different regional climates. In this work, a bi-block slab track model was built under outdoor conditions in Chengdu area; the statistical characteristic of temperature gradient in track slab and the relationship between temperature gradient and surface air temperature were tested and analyzed. The results show that the track slab temperature gradient will vary periodically according to the surface air temperature, and show a clear nonlinearity along the height direction. The temperature gradient distribution is extremely uneven： the temperature gradient in the top part of the track slab is larger than that in the bottom part; the most frequently occurring temperature gradient of the track slab is around -3.5 ℃/m and more than 75 % locates in the level -10 to 10 ℃/m; concrete with a relatively good heat exchange condition with the surrounding air has a narrower band distribution. In addition, the frequency distribution histogram should exclude the time zone from 00：00 to 06：00 because there is almost no traffic in this period. The amplitude of track slab temperature variation is obviously lower than that of the air temperature variation, and the former is approximately linear with the latter.

浸没环境对自负折射率薄膜表面反射光的Goos-Hnchen位移的影响

计算了光从真空-负折射率薄膜-真空,真空-负折射率薄膜-金属,正折射率介质-负折射率薄膜-真空以及真空-负折射率薄膜-正折射率介质四种复合结构中的负折射率薄膜表面反射的等效反射系数和GH位移.着重比较分析了在正折射率介质-负折射率薄膜-真空,真空-负折射率薄膜-正折射率介质两种结构中正折射率材料的吸收效应对不同入射极化波的GH位移的影响.

中薄板坯角部纵向边裂的原因与措施

分析了中薄板坯角部纵向边裂的影响因素,采取优化结晶器振动台控制系统和同步精度,优化结晶器锥度,提高结晶器整备精度,适当减小结晶器冷却水量,提高扇形段辊缝和接弧精度标准等措施后,中薄板坯角部纵向边裂发生率由3.5%降至1.0%,保证了中薄板坯产品的质量。

Separation density prediction of geldart A^(-)dense medium in gas-solid fluidized bed coal beneficiators

Gas-solid Fluidized Bed Coal Beneficiator(GFBCB)process is a crucial dry coal beneficiation fluidization technology.The work employs the GFBCB process alongside a novel Geldart A^(-)dense medium,consisting of Geldart A magnetite particles and Geldart C ultrafine coal,to separate small-size separated objects in the GFBCB.The effects of various operational conditions,including the volume fraction of ultrafine coal,the gas velocity,the separated objects size,and the separation time,were investigated on the GFBCB's separation performance.The results indicated that the probable error for 6∼3 mm separated objects could be controlled within 0.10 g/cm^(3).Compared to the traditional Geldart B/D dense medium,the Geldart A/A^(-)dense medium exhibited better size-dependent separation performance with an overall probable error 0.04∼0.12 g/cm^(3).Moreover,it achieved a similar separation accuracy to the Geldart B/D dense medium fluidized bed with different external energy for the small-size object beneficiation.The work furthermore validated a separation density prediction model based on theoretical derivation,available for both Geldart B/D dense medium and Geldart A/A^(-)dense medium at different operational conditions.

A Deprojection Analysis of Abell 1650 with XMM-Newton

We revisit the XMM-Newton observation of the galaxy cluster Abell 1650 with a deprojection technique. We find that the radial deprojected spectra of Abell 1650 can be marginally fitted by a single-temperature model. In order to study the properties of the central gas, we fit the spectra of the central two regions with a two- temperature model. The fits then become significantly better and the cool gas about 1～2 keV can be connected with the gas cooling. Fitting the central spectrum （r≤1′） by using a cooling flow model with an isothermal component yields a small mass deposition rate of 10-7^＋11 M. yr^-1, while the standard cooling flow model can not fit this spectrum satisfactorily except that there exists a cut-off temperature having a level of about 3 keV. From the isothermal model we derive the deprojected electron density profile ne（r）, and then together with the deprojected temperature profile the total mass and gas mass fraction of cluster are also determined. We compare the properties of Abell 1650 with those of Abell 1835 （a large cooling flow cluster） and some other clusters, to explore the difference in properties between large and small cooling flow cluster, and what causes the difference in the cooling flow of different clusters. It has been shown that Abell 1835 has a steeper potential well and thus a higher electron density and a lower temperature in its center, indicating that the shape of the gravitational potential well in central region determines the cooling flow rates of clusters. We calculate the potential, internal and radiated energies of these two clusters, and find that the gas energies in both clusters are conserved during the collapsing stage.

Formation of E-cyanomethamine in a nitrile rich environment

Recently a new molecule, cyanomethamine, has been detected towards Sagittarius B2（N） （Sgr B2（N））. Studying the formation mechanisms of complex interstellar molecules is difficult. Hence, a theoretical quantum chemical approach for analyzing the reaction mechanism describing the forma- tion of interstellar cyanomethamine through detected interstellar molecules and radicals （NCCN＋H） is discussed in the present work. Calculations are performed by using quantum chemical techniques, such as Density Functional Theory （DFT） and Mφ11er-Plesset perturbation （MP2） theory with a 6-311G（d,p） basis set, both in the gas phase and in icy grains. The proposed reaction path （NCCN＋H＋H） has exother- micity with no barrier which indicates the possibility of cyanomethamine formation in the interstellar medium.

The adjustment of γ-aminobutyric acid_A tonic subunits in Huntington＇s disease：from transcription to translation to synaptic levels into the neostriatum

γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6,β3,δ,or ρ1-3 subunits,they are located at perisynaptic and/or in extrasynaptic regions.The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation.On this basis,GABAA tonic inhibition has been proposed as a potential target for therapeutic intervention of Huntington＇s disease.Huntington＇s disease is a neurodegenerative disorder caused by a genetic mutation of the huntingtin protein.For experimental studies of Huntington＇s disease mouse models have been developed,such as R6/1,R6/2,Hdh Q92,Hdh Q150,as well as YAC128.In all of them,some key experimental reports are focused on neostriatum.The neostriatum is considered as the most important connection between cerebral cortex and basal ganglia structures,its cytology display two pathways called direct and indirect constituted by medium sized spiny neurons expressing dopamine D1 and D2 receptors respectively,they display strong expression of many types of GABAA receptors,including tonic subunits.The studies about of GABAA tonic subunits and Huntington＇s disease into the neostriatum are rising in recent years,suggesting interesting changes in their expression and localization which can be used as a strategy to delay the cellular damage caused by the imbalance between excitation and inhibition,a hallmark of Huntington＇s disease.

Downregulated lncRNA DRAIC enhances the radiotherapy sensitivity of human HCC cell line HepG2 by targeting miR-223-3p

Objective This study aims to investigate the effects of the long noncoding RNA(lncRNA)DRAIC on the proliferation,apoptosis,and radiosensitivity of hepatocellular carcinoma(HCC)cells and the molecular mechanisms involved.Methods Cancer tissues and their corresponding adjacent tissues from 30 patients with HCC were collected,and the expression levels of DRAIC and miR-223-3p were detected via RT-q PCR.DRAIC interference and miR-223-3p overexpression vectors were transfected into HepG2 cells.In addition,DRAIC and miR-223-3p interference vectors were co-transfected into HepG2 cells.The constructed cells were irradiated at 4 Gy.Cell colony formation assay,MTT assay,and flow cytometry were performed to detect the radiosensitivity,proliferation inhibition rate,and apoptosis rate of HepG2 cells,respectively.Dual luciferase reporter gene assay was performed to detect the targeted regulation of DRAIC on miR-223-3p expression.Results The expression level of DRAIC in HCC tissues was higher than that in paracancer tissues,whereas the expression level of miR-223-3p was lower in HCC tissues than that in paracancer tissues(P<0.05).Inhibition of DRAIC expression or overexpression of miR-223-3p increased the proliferation inhibition and apoptosis rates of HepG2 cells(P<0.05).After irradiation,cell survival fraction decreased and cell proliferation inhibition and apoptosis rates increased(P<0.05).DRAIC targeted the regulation of miR-223-3p expression,and interference of miR-223-3p expression reversed the effects of inhibiting DRAIC expression on the proliferation,apoptosis,and radiosensitivity of HepG2 cells.Conclusion Inhibition of DRAIC expression can inhibit the proliferation of HepG2 cells,promote cell apoptosis,and enhance the radiosensitivity of cells via upregulation of miR-223-3p.