Maxwell’s equations for a mechano-driven media system(MEs-f-MDMS)have been used to characterize the electromagnetism of multislow-moving media that may be accelerated with complex trajectories.Such an approach starts...Maxwell’s equations for a mechano-driven media system(MEs-f-MDMS)have been used to characterize the electromagnetism of multislow-moving media that may be accelerated with complex trajectories.Such an approach starts from the integral forms of the four physics laws and is different from the classical approach of using the Lorentz transformation for correlating the electromagnetic phenomena observed in two inertial reference frames with relative motion.The governing equations inside the moving object/medium are the MEs-f-MDMS,and those in vacuum are the classical Maxwell’s equations;the full solutions of both reconcile at the medium surface/interface and satisfy the boundary conditions.This paper reviews the background,physical principle,and mathematical derivations for formulating the MEs-f-MDMS.Strategies are also presented for mathematically solving the MEs-f-MDMS.The unique advances made by the MEs-f-MDMS have been systematically summarized,as are their potential applications in engineering.We found that the Lorentz transformation is perfect for treating the electromagnetic phenomena of moving point charges in vacuum;however,for moving objects,the covariance of Maxwell’s equations may not hold,and use of the MEs-f-MDMS may be required if the velocity is low.Finally,recent advances for treating the boundary conditions at the nanoscale without assuming an abrupt boundary are also reviewed.展开更多
Plastic instability,including both the discontinuous yielding and stress serrations,has been frequently observed during the tensile deformation of medium-Mn steels(MMnS)and has been intensively studied in recent years...Plastic instability,including both the discontinuous yielding and stress serrations,has been frequently observed during the tensile deformation of medium-Mn steels(MMnS)and has been intensively studied in recent years.Unfortunately,research results are controversial,and no consensus has been achieved regarding the topic.Here,we first summarize all the possible factors that affect the yielding and flow stress serrations in MMnS,including the morphology and stability of austenite,the feature of the phase interface,and the deformation parameters.Then,we propose a universal mechanism to explain the conflicting experimental results.We conclude that the discontinuous yielding can be attributed to the lack of mobile dislocation before deformation and the rapid dislocation multiplication at the beginning of plastic deformation.Meanwhile,the results show that the stress serrations are formed due to the pinning and depinning between dislocations and interstitial atoms in austenite.Strain-induced martensitic transformation,influenced by the mechanical stability of austenite grain and deformation parameters,should not be the intrinsic cause of plastic instability.However,it can intensify or weaken the discontinuous yielding and the stress serrations by affecting the mobility and density of dislocations,as well as the interaction between the interstitial atoms and dislocations in austenite grains.展开更多
A complete road-soft ground model is established in this paper to study the dynamic responses caused by vehicle loads and/or daily temperature variation.A dynamic thermo-elastic model is applied to capturing the behav...A complete road-soft ground model is established in this paper to study the dynamic responses caused by vehicle loads and/or daily temperature variation.A dynamic thermo-elastic model is applied to capturing the behavior of the rigid pavement,the base course,and the subgrade,while the soft ground is characterized using a dynamic thermo-poroelastic model.Solutions to the road-soft ground system are derived in the Laplace-Hankel transform domain.The time domain solutions are obtained using an integration approach.The temperature,thermal stress,pore water pressure,and displacement responses caused by the vehicle load and the daily temperature variation are presented.Results show that obvious temperature change mainly exists within 0.3 m of the road when subjected to the daily temperature variation,whereas the stress responses can still be found in deeper places because of the thermal swelling/shrinkage deformation within the upper road structures.Moreover,it is important to consider the coupling effects of the vehicle load and the daily temperature variation when calculating the dynamic responses inside the road-soft ground system.展开更多
Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord injury.However,whether the human dental pulp stem cell secretome can contribute to functional recovery...Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord injury.However,whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains unclear.In the present study,we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally injected the rats with conditioned medium from human dental pulp stem cells.We found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury,decreased expression of the microglial pyroptosis markers NLRP3,GSDMD,caspase-1,and interleukin-1β,promoted axonal and myelin regeneration,and inhibited the formation of glial scars.In addition,in a lipopolysaccharide-induced BV2 microglia model,conditioned medium from human dental pulp stem cells protected cells from pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway.These results indicate that conditioned medium from human dental pulp stem cells can reduce microglial pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway,thereby promoting the recovery of neurological function after spinal cord injury.Therefore,conditioned medium from human dental pulp stem cells may become an alternative therapy for spinal cord injury.展开更多
We consider the interior transmission eigenvalue problem corresponding to the scattering for an anisotropic medium of the scalar Helmholtz equation in the case where the boundary?Ωis split into two disjoint parts and...We consider the interior transmission eigenvalue problem corresponding to the scattering for an anisotropic medium of the scalar Helmholtz equation in the case where the boundary?Ωis split into two disjoint parts and possesses different transmission conditions.Using the variational method,we obtain the well posedness of the interior transmission problem,which plays an important role in the proof of the discreteness of eigenvalues.Then we achieve the existence of an infinite discrete set of transmission eigenvalues provided that n≡1,where a fourth order differential operator is applied.In the case of n■1,we show the discreteness of the transmission eigenvalues under restrictive assumptions by the analytic Fredholm theory and the T-coercive method.展开更多
Unmanned Aerial Vehicle(UAV)ad hoc network has achieved significant growth for its flexibility,extensibility,and high deployability in recent years.The application of clustering scheme for UAV ad hoc network is impera...Unmanned Aerial Vehicle(UAV)ad hoc network has achieved significant growth for its flexibility,extensibility,and high deployability in recent years.The application of clustering scheme for UAV ad hoc network is imperative to enhance the performance of throughput and energy efficiency.In conventional clustering scheme,a single cluster head(CH)is always assigned in each cluster.However,this method has some weaknesses such as overload and premature death of CH when the number of UAVs increased.In order to solve this problem,we propose a dual-cluster-head based medium access control(DCHMAC)scheme for large-scale UAV networks.In DCHMAC,two CHs are elected to manage resource allocation and data forwarding cooperatively.Specifically,two CHs work on different channels.One of CH is used for intra-cluster communication and the other one is for inter-cluster communication.A Markov chain model is developed to analyse the throughput of the network.Simulation result shows that compared with FM-MAC(flying ad hoc networks multi-channel MAC,FM-MAC),DCHMAC improves the throughput by approximately 20%~50%and prolongs the network lifetime by approximately 40%.展开更多
During brain ischemia,excitotoxicity and peri-infarct depolarization injuries occur and cause cerebral tissue damage.Indeed,anoxic depolarization,consisting of massive neuronal depolarization due to the loss of membra...During brain ischemia,excitotoxicity and peri-infarct depolarization injuries occur and cause cerebral tissue damage.Indeed,anoxic depolarization,consisting of massive neuronal depolarization due to the loss of membrane ion gradients,occurs in vivo or in vitro during an energy failure.The neuromodulator adenosine is released in huge amounts during cerebral ischemia and exerts its effects by activating specific metabotropic receptors,namely:A_(1),A_(2A),A_(2B),and A_(3).The A_(2A)receptor subtype is highly expressed in striatal medium spiny neurons,which are particularly susceptible to ischemic damage.Evidence indicates that the A2Areceptors are upregulated in the rat striatum after stroke and the selective antagonist SCH58261 protects from exaggerated glutamate release within the first 4 hours from the insult and alleviates neurological impairment and histological injury in the following 24 hours.We recently added new knowledge to the mechanisms by which the adenosine A2Areceptor subtype participates in ischemia-induced neuronal death by performing patch-clamp recordings from medium spiny neurons in rat striatal brain slices exposed to oxygen and glucose deprivation.We demonstrated that the selective block of A2Areceptors by SCH58261 significantly reduced ionic imbalance and delayed the anoxic depolarization in medium spiny neurons during oxygen and glucose deprivation and that the mechanism involves voltage-gated K+channel modulation and a presynaptic inhibition of glutamate release by the A2Areceptor antagonist.The present review summarizes the latest findings in the literature about the possibility of developing selective ligands of A2Areceptors as advantageous therapeutic tools that may contribute to counteracting neurodegeneration after brain ischemia.展开更多
Simultaneously manipulating multiple physical fields plays an important role in the increasingly complex integrated systems,aerospace equipment,biochemical productions,etc.For on-chip systems with high integration lev...Simultaneously manipulating multiple physical fields plays an important role in the increasingly complex integrated systems,aerospace equipment,biochemical productions,etc.For on-chip systems with high integration level,the precise and efficient control of the propagation of electromagnetic waves and heat fluxes simultaneously is particularly important.In this study,we propose a graphical designing method(i.e.,thermal-electromagnetic surface transformation)based on thermal-electromagnetic null medium to simultaneously control the propagation of electromagnetic waves and thermal fields according to the pre-designed paths.A thermal-electromagnetic cloak,which can create a cloaking effect on both electromagnetic waves and thermal fields simultaneously,is designed by thermal-electromagnetic surface transformation and verified by both numerical simulations and experimental measurements.The thermal-electromagnetic surface transformation proposed in this study provides a new methodology for simultaneous controlling on electromagnetic and temperature fields,and may have significant applications in improving thermal-electromagnetic compatibility problem,protecting of thermal-electromagnetic sensitive components,and improving efficiency of energy usage for complex onchip systems.展开更多
Based on the temperature situation during the rolling process of 4200 mm/3500 mm medium and thick plates at Baosteel,this article analyzes the influencing factors of temperature changes during the rolling process from...Based on the temperature situation during the rolling process of 4200 mm/3500 mm medium and thick plates at Baosteel,this article analyzes the influencing factors of temperature changes during the rolling process from the perspective of heat transfer theory and the temperature change law during the rolling process.The temperature loss during the four rolling processes is tracked on site,and the temperature drop model parameters during the rolling process of 4200mm/3500mm medium and thick plates at Baosteel are quantitatively provided.It is applied to actual rolling production and has achieved good results.展开更多
Power line communication(PLC)provides intelligent electrical functions such as power quality measurement,fault surveys,and remote control of electrical network.Most of research works have been done in low voltage(LV)s...Power line communication(PLC)provides intelligent electrical functions such as power quality measurement,fault surveys,and remote control of electrical network.Most of research works have been done in low voltage(LV)scenario due to the fast development of in-home PLC.The aim of this paper is to evaluate the link-level performance of a medium voltage(MV)MIMO-OFDM communication system based on transmission link under underground power line channel.The MIMO channel is modeled as a modified multipath model in the presence of impulsive noise and background noise.We first perform a measurement on the practical MV MIMO channel parameters for a section of buried cable of 1 km long in Ganzhou city,Jiangxi province,China.Based on the measured channel,we design the frame structure based on an IEEE standard for broadband over power line networks[1]to support MV MIMO-OFDM transmission.According to designed frame structure,we design an encoder and a decoder for a dual binary tail-biting turbo code and optimize some key decoder parameters for low bit error rate performance.Finally,the link-level performance for both spatial multiplexing and spatial diversity are evaluated.Numeral results show that MV MIMO-OFDM is a promising approach to provide both high data rate and link reliability for PLC.展开更多
Development of the medium and low voltage DC distribution system is of great significance to a regional transmission of electric energy,increasing a penetration rate of new energy,and enhancing a safety of the operati...Development of the medium and low voltage DC distribution system is of great significance to a regional transmission of electric energy,increasing a penetration rate of new energy,and enhancing a safety of the operation of the AC/DC interconnected grid.This paper first summarizes the medium and low voltage DC distribution system schemes and plans put forward by many countries,and then elaborate status of under-construction medium and low voltage DC distribution system project cases in China.Based on these project cases,this paper analyzes key issues involved in the medium and low voltage DC distribution system topologies,equipment,operation control technologies and DC fault protections,in order to provide theoretical and technical reference for future medium and low voltage DC distribution system-related projects.Finally,this paper combines a current China research status to summarize and give a prediction about the future research direction of medium and low voltage DC distribution system,which can provide reference for the research of medium and low voltage DC distribution system.展开更多
The Hamiltonian of coupled three-level atoms interacting with light field in the cavity filled with Kerr-like medium is derived. A simplified analytic solution to the Schrodinger equation of the system is obtained. Th...The Hamiltonian of coupled three-level atoms interacting with light field in the cavity filled with Kerr-like medium is derived. A simplified analytic solution to the Schrodinger equation of the system is obtained. The case of A type atom with degenerate lower levels is discussed in detail. It is shown that the coupling strength between atoms and Kerr coefficient affect the system's dynamic behaviors, especially the modulation period and oscillation frequency of the squeezing parameters of the field and the collective dipole moment. Dynamic behaviors of the system are sensitive to the initial state of atoms.展开更多
The paper develops and employs analytical-numerical solution method for the study of the time-harmonic dynamic stress field in the system consisting of the hollow cylinder and surrounding elastic medium under the non-...The paper develops and employs analytical-numerical solution method for the study of the time-harmonic dynamic stress field in the system consisting of the hollow cylinder and surrounding elastic medium under the non-axisymmetric forced vibration of this system.It is assumed that in the interior of the hollow cylinder the point-located with respect to the cylinder axis,non-axisymmetric with respect to the circumferential direction and uniformly distributed time-harmonic forces act.Corresponding boundary value problem is solved by employing of the exponential Fourier transformation with respect to the axial coordinate and by employing of the Fourier series expansion of these transformations.Numerical results on the frequency response of the interface normal stresses are presented and discussed.展开更多
The steel turnout is one of the key components in the medium–low-speed maglev line system.However,the vehicle under active control is prone to vehicle–turnout coupled vibration,and thus,it is necessary to identify t...The steel turnout is one of the key components in the medium–low-speed maglev line system.However,the vehicle under active control is prone to vehicle–turnout coupled vibration,and thus,it is necessary to identify the vibration characteristics of this coupled system through field tests.To this end,dynamic performance tests were conducted on a vehicle–turnout coupled system in a medium–low-speed maglev test line.Firstly,the dynamic response data of the coupled system under various operating conditions were obtained.Then,the natural vibration characteristics of the turnout were analysed using the free attenuation method and the finite element method,indicating a good agreement between the simulation results and the measured results;the acceleration response characteristics of the coupled system were analysed in detail,and the ride quality of the vehicle was assessed by Sperling index.Finally,the frequency distribution characteristics of the coupled system were discussed.All these test results could provide references for model validation and optimized design of medium–low-speed maglev transport systems.展开更多
The plane medium and point charge are regarded as an integral system. The static field's distribution situation of the point charge is studied in the medium structure of plane division layers by using mirror image me...The plane medium and point charge are regarded as an integral system. The static field's distribution situation of the point charge is studied in the medium structure of plane division layers by using mirror image method, drawing the point charge's calculation expression of the electric potential in every medium space. The mathematics model of passive electrostatic detecting people through the medium (regular distance between the goal point charge and the medium) is established, using MATLAB software to carry out emulation of the model and analysing the result, establishing the theoretical foundation for studying the technology of the passive static detecting people through the wall.展开更多
Dose in radiation therapy has been reported as the water-equivalent dose using conventional dose calculation algorithms. The Monte Carlo (MC) algorithm employs characterization of human tissues by elemental compositio...Dose in radiation therapy has been reported as the water-equivalent dose using conventional dose calculation algorithms. The Monte Carlo (MC) algorithm employs characterization of human tissues by elemental composition and mass density. It enables more accurate dose calculation for radiation therapy treatment planning and typically reports absorbed dose to medium. Whether one should use dose to medium or tissue (Dm) in place of dose to water (Dw) for MC treatment planning remains the subject of debate. The aim of the current study is to evaluate the differences between dose-volume indices for Dm and Dw MC-calculated IMRT plans. Thirty-seven spine patients were selected for this study. The IMRT optimization and MC calculations were performed using the iPlan RT DoseTM ver 4.1.2 (Brainlab, Munich, Germany) treatment planning system (TPS) with an X-ray Voxel Monte Carlo (XVMC) dose calculation engine. Dw and Dm results for target and critical structures were evaluated using the dose-volume-based indices. Systematic differences between dose-volume indices computed with Dw and Dm were up to 5.2%, 4.2%, and 4.5% for D2, D50 and D98 indices of the clinical target volume (CTV), respectively and up to 1% for the critical structure dose indices. Our study demonstrates that employing Dm in place of Dw in MC-calculated IMRT treatment plans introduces a significant systematic difference in target DVHs. We recommend that for diffused target structures (such as spine tumors), dose to water is a better quantity for dose prescription in photon beam treatment planning using existing MC TPS. While for critical structures, it would be reasonable to report Dm always. However in future with the availability of finer spatial resolution, Dm will be the most suitable variable for both target and critical structures’ dose prescription and reporting in MC treatment planning.展开更多
The performance of three wireless local-area network(WLAN) media access control(MAC) protocols is investigated and compared in the context of simulcast radioover-fiber-based distributed antenna systems(RoF-DASs) where...The performance of three wireless local-area network(WLAN) media access control(MAC) protocols is investigated and compared in the context of simulcast radioover-fiber-based distributed antenna systems(RoF-DASs) where multiple remote antenna units(RAUs) are connected to one access point(AP) with different-length fiber links.The three WLAN MAC protocols under investigation are distributed coordination function(DCF) in basic access mode,DCF in request/clear to send(RTS/CTS) exchange mode,and point coordination function(PCF).In the analysis,the inter-RAU hidden nodes problems and fiber-length difference effect are both taken into account.Results show that adaptive PCF mechanism has better throughput performances than the other two DCF modes,especially when the inserted fiber length is short.展开更多
Combined bodies of rock-like material and rock are widely encountered in geotechnical engineering,such as tunnels and mines.The existing theoretical models describing the stress-strain relationship of a combined body ...Combined bodies of rock-like material and rock are widely encountered in geotechnical engineering,such as tunnels and mines.The existing theoretical models describing the stress-strain relationship of a combined body lack a binary feature.Based on effective medium theory,this paper presents the governing equation of the“elastic modulus”for combined and single bodies under triaxial compressive tests.A binary effective medium model is then established.Based on the compressive experiment of concretegranite combined bodies,the feasibility of determining the stress threshold based on crack axial strain is discussed,and the model is verified.The model is further extended to coal-rock combined bodies of more diverse types,and the variation laws of the compressive mechanical parameters are then discussed.The results show that the fitting accuracy of the model with the experimental curves of the concretegranite combined bodies and various types of coal-rock combined bodies are over 95%.The crack axial strain method can replace the crack volumetric strain method,which clarifies the physical meanings of the model parameters.The variation laws of matrix parameters and crack parameters are discussed in depth and are expected to be more widely used in geotechnical engineering.展开更多
The paper deals with the study of the influence of the non-homogeneous prestresses in the system consisting of the hollow cylinder and surrounding elastic medium on the frequency response of this system caused by the ...The paper deals with the study of the influence of the non-homogeneous prestresses in the system consisting of the hollow cylinder and surrounding elastic medium on the frequency response of this system caused by the time-harmonic ring load acting in the interior of the cylinder.The axisymmetric problem is considered and it is assumed that in the initial state,the system is compressed in the radial direction with homogeneously distributed static forces as a result of which,non-homogeneous pre-stresses(or initial stresses)appear in that.It is also assumed that after these pre-stresses appear in the interior of the cylinder,the point-located(with respect to the axial coordinate directed along the cylinder’s central axis)additional time-harmonic ring load acts.Thus,it is required to determine how the pre-stresses influence the frequency response of the system to the noted additional time-harmonic loading.This influence,which is the non-linear effect,is studied within the scope of the so-called three-dimensional linearized equations and relations of the theory of elastic waves in pre-stressed bodies.The solution to the corresponding boundary value problems is found by employing the discrete analytical solution method and numerical results on the influence of the pre-stresses on the frequency response of the interface stresses which appear as a result of the action of the additional time-harmonic forces,are presented and discussed.In particular,it is established that the pre-stresses mentioned above cause to decrease the magnitude of the interface dynamic stresses appearing as a result of the additional time-harmonic loading.展开更多
In this paper, an explicit finite element method to analyze the dynamic responses of three-medium coupled systems with any terrain is developed on the basis of the numerical simulation of the continuous conditions on ...In this paper, an explicit finite element method to analyze the dynamic responses of three-medium coupled systems with any terrain is developed on the basis of the numerical simulation of the continuous conditions on the bounda-ries among fluid saturated porous medium, elastic single-phase medium and ideal fluid medium. This method is a very effective one with the characteristic of high calculating speed and small memory needed because the formulae for this explicit finite element method have the characteristic of decoupling, and which does not need to solve sys-tem of linear equations. The method is applied to analyze the dynamic response of a reservoir with considering the dynamic interactions among water, dam, sediment and basement rock. The vertical displacement at the top point of the dam is calculated and some conclusions are given.展开更多
文摘Maxwell’s equations for a mechano-driven media system(MEs-f-MDMS)have been used to characterize the electromagnetism of multislow-moving media that may be accelerated with complex trajectories.Such an approach starts from the integral forms of the four physics laws and is different from the classical approach of using the Lorentz transformation for correlating the electromagnetic phenomena observed in two inertial reference frames with relative motion.The governing equations inside the moving object/medium are the MEs-f-MDMS,and those in vacuum are the classical Maxwell’s equations;the full solutions of both reconcile at the medium surface/interface and satisfy the boundary conditions.This paper reviews the background,physical principle,and mathematical derivations for formulating the MEs-f-MDMS.Strategies are also presented for mathematically solving the MEs-f-MDMS.The unique advances made by the MEs-f-MDMS have been systematically summarized,as are their potential applications in engineering.We found that the Lorentz transformation is perfect for treating the electromagnetic phenomena of moving point charges in vacuum;however,for moving objects,the covariance of Maxwell’s equations may not hold,and use of the MEs-f-MDMS may be required if the velocity is low.Finally,recent advances for treating the boundary conditions at the nanoscale without assuming an abrupt boundary are also reviewed.
基金support from the National Natural Science Foundation of China(Nos.51831002,51904028,and 52233018)the Beijing Municipal Natural Science Foundation(No.2242048)the Fundamental Research Funds for the Central Universities,China(No.FRF-EYIT-23-08).
文摘Plastic instability,including both the discontinuous yielding and stress serrations,has been frequently observed during the tensile deformation of medium-Mn steels(MMnS)and has been intensively studied in recent years.Unfortunately,research results are controversial,and no consensus has been achieved regarding the topic.Here,we first summarize all the possible factors that affect the yielding and flow stress serrations in MMnS,including the morphology and stability of austenite,the feature of the phase interface,and the deformation parameters.Then,we propose a universal mechanism to explain the conflicting experimental results.We conclude that the discontinuous yielding can be attributed to the lack of mobile dislocation before deformation and the rapid dislocation multiplication at the beginning of plastic deformation.Meanwhile,the results show that the stress serrations are formed due to the pinning and depinning between dislocations and interstitial atoms in austenite.Strain-induced martensitic transformation,influenced by the mechanical stability of austenite grain and deformation parameters,should not be the intrinsic cause of plastic instability.However,it can intensify or weaken the discontinuous yielding and the stress serrations by affecting the mobility and density of dislocations,as well as the interaction between the interstitial atoms and dislocations in austenite grains.
基金funding support from the National Natural Science Foundation of China(Grant Nos.42077262 and 42077261).
文摘A complete road-soft ground model is established in this paper to study the dynamic responses caused by vehicle loads and/or daily temperature variation.A dynamic thermo-elastic model is applied to capturing the behavior of the rigid pavement,the base course,and the subgrade,while the soft ground is characterized using a dynamic thermo-poroelastic model.Solutions to the road-soft ground system are derived in the Laplace-Hankel transform domain.The time domain solutions are obtained using an integration approach.The temperature,thermal stress,pore water pressure,and displacement responses caused by the vehicle load and the daily temperature variation are presented.Results show that obvious temperature change mainly exists within 0.3 m of the road when subjected to the daily temperature variation,whereas the stress responses can still be found in deeper places because of the thermal swelling/shrinkage deformation within the upper road structures.Moreover,it is important to consider the coupling effects of the vehicle load and the daily temperature variation when calculating the dynamic responses inside the road-soft ground system.
基金supported by the Research Foundation of Technology Committee of Tongzhou District,No.KJ2019CX001(to SX).
文摘Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord injury.However,whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains unclear.In the present study,we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally injected the rats with conditioned medium from human dental pulp stem cells.We found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury,decreased expression of the microglial pyroptosis markers NLRP3,GSDMD,caspase-1,and interleukin-1β,promoted axonal and myelin regeneration,and inhibited the formation of glial scars.In addition,in a lipopolysaccharide-induced BV2 microglia model,conditioned medium from human dental pulp stem cells protected cells from pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway.These results indicate that conditioned medium from human dental pulp stem cells can reduce microglial pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway,thereby promoting the recovery of neurological function after spinal cord injury.Therefore,conditioned medium from human dental pulp stem cells may become an alternative therapy for spinal cord injury.
基金supported by the National Natural Science Foundation of China(11571132,12301542)the Natural Science Foundation of Hubei(2022CFB725)the Natural Science Foundation of Yichang(A23-2-027)。
文摘We consider the interior transmission eigenvalue problem corresponding to the scattering for an anisotropic medium of the scalar Helmholtz equation in the case where the boundary?Ωis split into two disjoint parts and possesses different transmission conditions.Using the variational method,we obtain the well posedness of the interior transmission problem,which plays an important role in the proof of the discreteness of eigenvalues.Then we achieve the existence of an infinite discrete set of transmission eigenvalues provided that n≡1,where a fourth order differential operator is applied.In the case of n■1,we show the discreteness of the transmission eigenvalues under restrictive assumptions by the analytic Fredholm theory and the T-coercive method.
基金supported in part by the Beijing Natural Science Foundation under Grant L192031the National Key Research and Development Program under Grant 2020YFA0711303。
文摘Unmanned Aerial Vehicle(UAV)ad hoc network has achieved significant growth for its flexibility,extensibility,and high deployability in recent years.The application of clustering scheme for UAV ad hoc network is imperative to enhance the performance of throughput and energy efficiency.In conventional clustering scheme,a single cluster head(CH)is always assigned in each cluster.However,this method has some weaknesses such as overload and premature death of CH when the number of UAVs increased.In order to solve this problem,we propose a dual-cluster-head based medium access control(DCHMAC)scheme for large-scale UAV networks.In DCHMAC,two CHs are elected to manage resource allocation and data forwarding cooperatively.Specifically,two CHs work on different channels.One of CH is used for intra-cluster communication and the other one is for inter-cluster communication.A Markov chain model is developed to analyse the throughput of the network.Simulation result shows that compared with FM-MAC(flying ad hoc networks multi-channel MAC,FM-MAC),DCHMAC improves the throughput by approximately 20%~50%and prolongs the network lifetime by approximately 40%.
基金supported by University of Florence RICATEN 2023 to EC.Grant/Award Numbers 58514_InternazionalizzazioneUniversity of Florence,to EC.Parkinson’s UK,Grant/Award Number:H-0902 to AJGWellcome Trust,Grant/Award Number:0926/Z/10/Z to AJG。
文摘During brain ischemia,excitotoxicity and peri-infarct depolarization injuries occur and cause cerebral tissue damage.Indeed,anoxic depolarization,consisting of massive neuronal depolarization due to the loss of membrane ion gradients,occurs in vivo or in vitro during an energy failure.The neuromodulator adenosine is released in huge amounts during cerebral ischemia and exerts its effects by activating specific metabotropic receptors,namely:A_(1),A_(2A),A_(2B),and A_(3).The A_(2A)receptor subtype is highly expressed in striatal medium spiny neurons,which are particularly susceptible to ischemic damage.Evidence indicates that the A2Areceptors are upregulated in the rat striatum after stroke and the selective antagonist SCH58261 protects from exaggerated glutamate release within the first 4 hours from the insult and alleviates neurological impairment and histological injury in the following 24 hours.We recently added new knowledge to the mechanisms by which the adenosine A2Areceptor subtype participates in ischemia-induced neuronal death by performing patch-clamp recordings from medium spiny neurons in rat striatal brain slices exposed to oxygen and glucose deprivation.We demonstrated that the selective block of A2Areceptors by SCH58261 significantly reduced ionic imbalance and delayed the anoxic depolarization in medium spiny neurons during oxygen and glucose deprivation and that the mechanism involves voltage-gated K+channel modulation and a presynaptic inhibition of glutamate release by the A2Areceptor antagonist.The present review summarizes the latest findings in the literature about the possibility of developing selective ligands of A2Areceptors as advantageous therapeutic tools that may contribute to counteracting neurodegeneration after brain ischemia.
基金supported by the National Natural Science Foundation of China (Nos. 61971300, 12274317, 12374277, 61905208)Open Foundation of China-Belarus Belt and Road Joint Laboratory on Electromagnetic Environment Effect (No. ZBKF2022031202)+1 种基金Scientific and Technological Innovation Programs (STIP) of Higher Education Institutions in Shanxi (Nos. 2019L0159 and 2019L0146)2022 University Outstanding Youth Foundation of Taiyuan University of Technology
文摘Simultaneously manipulating multiple physical fields plays an important role in the increasingly complex integrated systems,aerospace equipment,biochemical productions,etc.For on-chip systems with high integration level,the precise and efficient control of the propagation of electromagnetic waves and heat fluxes simultaneously is particularly important.In this study,we propose a graphical designing method(i.e.,thermal-electromagnetic surface transformation)based on thermal-electromagnetic null medium to simultaneously control the propagation of electromagnetic waves and thermal fields according to the pre-designed paths.A thermal-electromagnetic cloak,which can create a cloaking effect on both electromagnetic waves and thermal fields simultaneously,is designed by thermal-electromagnetic surface transformation and verified by both numerical simulations and experimental measurements.The thermal-electromagnetic surface transformation proposed in this study provides a new methodology for simultaneous controlling on electromagnetic and temperature fields,and may have significant applications in improving thermal-electromagnetic compatibility problem,protecting of thermal-electromagnetic sensitive components,and improving efficiency of energy usage for complex onchip systems.
文摘Based on the temperature situation during the rolling process of 4200 mm/3500 mm medium and thick plates at Baosteel,this article analyzes the influencing factors of temperature changes during the rolling process from the perspective of heat transfer theory and the temperature change law during the rolling process.The temperature loss during the four rolling processes is tracked on site,and the temperature drop model parameters during the rolling process of 4200mm/3500mm medium and thick plates at Baosteel are quantitatively provided.It is applied to actual rolling production and has achieved good results.
文摘Power line communication(PLC)provides intelligent electrical functions such as power quality measurement,fault surveys,and remote control of electrical network.Most of research works have been done in low voltage(LV)scenario due to the fast development of in-home PLC.The aim of this paper is to evaluate the link-level performance of a medium voltage(MV)MIMO-OFDM communication system based on transmission link under underground power line channel.The MIMO channel is modeled as a modified multipath model in the presence of impulsive noise and background noise.We first perform a measurement on the practical MV MIMO channel parameters for a section of buried cable of 1 km long in Ganzhou city,Jiangxi province,China.Based on the measured channel,we design the frame structure based on an IEEE standard for broadband over power line networks[1]to support MV MIMO-OFDM transmission.According to designed frame structure,we design an encoder and a decoder for a dual binary tail-biting turbo code and optimize some key decoder parameters for low bit error rate performance.Finally,the link-level performance for both spatial multiplexing and spatial diversity are evaluated.Numeral results show that MV MIMO-OFDM is a promising approach to provide both high data rate and link reliability for PLC.
基金supported by the National Key Rese arch and Development Program of China(2018YFB0904100)Science and Technology Project of State Grid(SGHB0000KXJS1800685)
文摘Development of the medium and low voltage DC distribution system is of great significance to a regional transmission of electric energy,increasing a penetration rate of new energy,and enhancing a safety of the operation of the AC/DC interconnected grid.This paper first summarizes the medium and low voltage DC distribution system schemes and plans put forward by many countries,and then elaborate status of under-construction medium and low voltage DC distribution system project cases in China.Based on these project cases,this paper analyzes key issues involved in the medium and low voltage DC distribution system topologies,equipment,operation control technologies and DC fault protections,in order to provide theoretical and technical reference for future medium and low voltage DC distribution system-related projects.Finally,this paper combines a current China research status to summarize and give a prediction about the future research direction of medium and low voltage DC distribution system,which can provide reference for the research of medium and low voltage DC distribution system.
文摘The Hamiltonian of coupled three-level atoms interacting with light field in the cavity filled with Kerr-like medium is derived. A simplified analytic solution to the Schrodinger equation of the system is obtained. The case of A type atom with degenerate lower levels is discussed in detail. It is shown that the coupling strength between atoms and Kerr coefficient affect the system's dynamic behaviors, especially the modulation period and oscillation frequency of the squeezing parameters of the field and the collective dipole moment. Dynamic behaviors of the system are sensitive to the initial state of atoms.
文摘The paper develops and employs analytical-numerical solution method for the study of the time-harmonic dynamic stress field in the system consisting of the hollow cylinder and surrounding elastic medium under the non-axisymmetric forced vibration of this system.It is assumed that in the interior of the hollow cylinder the point-located with respect to the cylinder axis,non-axisymmetric with respect to the circumferential direction and uniformly distributed time-harmonic forces act.Corresponding boundary value problem is solved by employing of the exponential Fourier transformation with respect to the axial coordinate and by employing of the Fourier series expansion of these transformations.Numerical results on the frequency response of the interface normal stresses are presented and discussed.
基金This work was supported by the National Natural Science Foundation of China(Grant No.51875483)the Independently Funded Research Project of State Key Laboratory of Traction Power(Grant Nos.2020TPL-T01 and 2020TPL-T04).
文摘The steel turnout is one of the key components in the medium–low-speed maglev line system.However,the vehicle under active control is prone to vehicle–turnout coupled vibration,and thus,it is necessary to identify the vibration characteristics of this coupled system through field tests.To this end,dynamic performance tests were conducted on a vehicle–turnout coupled system in a medium–low-speed maglev test line.Firstly,the dynamic response data of the coupled system under various operating conditions were obtained.Then,the natural vibration characteristics of the turnout were analysed using the free attenuation method and the finite element method,indicating a good agreement between the simulation results and the measured results;the acceleration response characteristics of the coupled system were analysed in detail,and the ride quality of the vehicle was assessed by Sperling index.Finally,the frequency distribution characteristics of the coupled system were discussed.All these test results could provide references for model validation and optimized design of medium–low-speed maglev transport systems.
文摘The plane medium and point charge are regarded as an integral system. The static field's distribution situation of the point charge is studied in the medium structure of plane division layers by using mirror image method, drawing the point charge's calculation expression of the electric potential in every medium space. The mathematics model of passive electrostatic detecting people through the medium (regular distance between the goal point charge and the medium) is established, using MATLAB software to carry out emulation of the model and analysing the result, establishing the theoretical foundation for studying the technology of the passive static detecting people through the wall.
文摘Dose in radiation therapy has been reported as the water-equivalent dose using conventional dose calculation algorithms. The Monte Carlo (MC) algorithm employs characterization of human tissues by elemental composition and mass density. It enables more accurate dose calculation for radiation therapy treatment planning and typically reports absorbed dose to medium. Whether one should use dose to medium or tissue (Dm) in place of dose to water (Dw) for MC treatment planning remains the subject of debate. The aim of the current study is to evaluate the differences between dose-volume indices for Dm and Dw MC-calculated IMRT plans. Thirty-seven spine patients were selected for this study. The IMRT optimization and MC calculations were performed using the iPlan RT DoseTM ver 4.1.2 (Brainlab, Munich, Germany) treatment planning system (TPS) with an X-ray Voxel Monte Carlo (XVMC) dose calculation engine. Dw and Dm results for target and critical structures were evaluated using the dose-volume-based indices. Systematic differences between dose-volume indices computed with Dw and Dm were up to 5.2%, 4.2%, and 4.5% for D2, D50 and D98 indices of the clinical target volume (CTV), respectively and up to 1% for the critical structure dose indices. Our study demonstrates that employing Dm in place of Dw in MC-calculated IMRT treatment plans introduces a significant systematic difference in target DVHs. We recommend that for diffused target structures (such as spine tumors), dose to water is a better quantity for dose prescription in photon beam treatment planning using existing MC TPS. While for critical structures, it would be reasonable to report Dm always. However in future with the availability of finer spatial resolution, Dm will be the most suitable variable for both target and critical structures’ dose prescription and reporting in MC treatment planning.
基金supported in part by National 973 Program(2012CB315705)NSFC Program(61302086,61271042,61107058, 61302016,and 61335002)+2 种基金Specialized Research Fund for the Doctoral Program of Higher Education(20130005120007)Program for New Century Excellent Talents in University(NCET-13-0682)Fundamental Research Funds for the Central Universities
文摘The performance of three wireless local-area network(WLAN) media access control(MAC) protocols is investigated and compared in the context of simulcast radioover-fiber-based distributed antenna systems(RoF-DASs) where multiple remote antenna units(RAUs) are connected to one access point(AP) with different-length fiber links.The three WLAN MAC protocols under investigation are distributed coordination function(DCF) in basic access mode,DCF in request/clear to send(RTS/CTS) exchange mode,and point coordination function(PCF).In the analysis,the inter-RAU hidden nodes problems and fiber-length difference effect are both taken into account.Results show that adaptive PCF mechanism has better throughput performances than the other two DCF modes,especially when the inserted fiber length is short.
基金the Major Program of National Natural Science Foundation of China(No.41941019)Shaanxi Province Innovative Talent Promotion Plan-Science and Technology Innovation Team(No.2021TD-55)Central University Natural Science Innovation Team(No.300102262402)。
文摘Combined bodies of rock-like material and rock are widely encountered in geotechnical engineering,such as tunnels and mines.The existing theoretical models describing the stress-strain relationship of a combined body lack a binary feature.Based on effective medium theory,this paper presents the governing equation of the“elastic modulus”for combined and single bodies under triaxial compressive tests.A binary effective medium model is then established.Based on the compressive experiment of concretegranite combined bodies,the feasibility of determining the stress threshold based on crack axial strain is discussed,and the model is verified.The model is further extended to coal-rock combined bodies of more diverse types,and the variation laws of the compressive mechanical parameters are then discussed.The results show that the fitting accuracy of the model with the experimental curves of the concretegranite combined bodies and various types of coal-rock combined bodies are over 95%.The crack axial strain method can replace the crack volumetric strain method,which clarifies the physical meanings of the model parameters.The variation laws of matrix parameters and crack parameters are discussed in depth and are expected to be more widely used in geotechnical engineering.
文摘The paper deals with the study of the influence of the non-homogeneous prestresses in the system consisting of the hollow cylinder and surrounding elastic medium on the frequency response of this system caused by the time-harmonic ring load acting in the interior of the cylinder.The axisymmetric problem is considered and it is assumed that in the initial state,the system is compressed in the radial direction with homogeneously distributed static forces as a result of which,non-homogeneous pre-stresses(or initial stresses)appear in that.It is also assumed that after these pre-stresses appear in the interior of the cylinder,the point-located(with respect to the axial coordinate directed along the cylinder’s central axis)additional time-harmonic ring load acts.Thus,it is required to determine how the pre-stresses influence the frequency response of the system to the noted additional time-harmonic loading.This influence,which is the non-linear effect,is studied within the scope of the so-called three-dimensional linearized equations and relations of the theory of elastic waves in pre-stressed bodies.The solution to the corresponding boundary value problems is found by employing the discrete analytical solution method and numerical results on the influence of the pre-stresses on the frequency response of the interface stresses which appear as a result of the action of the additional time-harmonic forces,are presented and discussed.In particular,it is established that the pre-stresses mentioned above cause to decrease the magnitude of the interface dynamic stresses appearing as a result of the additional time-harmonic loading.
基金National Natural Scienccs Foundation of China (50178005).
文摘In this paper, an explicit finite element method to analyze the dynamic responses of three-medium coupled systems with any terrain is developed on the basis of the numerical simulation of the continuous conditions on the bounda-ries among fluid saturated porous medium, elastic single-phase medium and ideal fluid medium. This method is a very effective one with the characteristic of high calculating speed and small memory needed because the formulae for this explicit finite element method have the characteristic of decoupling, and which does not need to solve sys-tem of linear equations. The method is applied to analyze the dynamic response of a reservoir with considering the dynamic interactions among water, dam, sediment and basement rock. The vertical displacement at the top point of the dam is calculated and some conclusions are given.