Osteoporosis is one of the common orthopaedic diseases,characterised by increased bone fragility due to reduced bone mass and microstructural degeneration,posing a great threat to patients’quality of life and safety....Osteoporosis is one of the common orthopaedic diseases,characterised by increased bone fragility due to reduced bone mass and microstructural degeneration,posing a great threat to patients’quality of life and safety.In recent years,Chinese medicine(natural)has had a unique advantage in the treatment of osteoporosis and has shown good efficacy.Autophagy is an inherent cellular survival mechanism for the removal and recycling of damaged proteins and organelles and plays an important role in maintaining the stability of the intracellular environment and organ function.Therefore,this article aims to provide a comprehensive review of these Chinese medicines(natural)for the treatment of osteoporosis through autophagy.They have been intensively studied and reported to have effects such as promoting osteogenesis and anti-bone resorption.The Chinese medicines include plants such as Cistanche deserticola,Epimedium,Curculigo orchioides Gaertn,Achyranthes bidentata Blume,Leonurus japonicus Houtt,Ginseng,Chuanxiong Rhizome,Eucommia ulmoides,Morindae Officinalis Radix,Curcuma longa,Polygoni Cuspidati Rhizoma et Radix,Anemarrhena asphodeloides Bunge,Salvia miltiorrhiza Bge and Pueraria Lobata,thus providing evidence for the use of alternative herbal therapies for the effective treatment of osteoporosis.展开更多
Primary osteoporosis （POP） is one of the most common diseases in the elderly people resulting in high risk of fracture and poor quality of life. In addition to the pathological changes in bone mass, most of the POP ...Primary osteoporosis （POP） is one of the most common diseases in the elderly people resulting in high risk of fracture and poor quality of life. In addition to the pathological changes in bone mass, most of the POP patients also suffer from Chinese medicine （CM） syndromes of Shen （Kidney） essence deficiency. Shen essences are highly related to bone. Shen essence deficiency plays an important part in the development of POP and a better diagnosis of POP could be made by combining CM syndromes with Western medicine risk factors. Treatments of POP should aim at both increasing the bone mass and relieving the syndromes of Shen essence deficiency. Clinical study confirmed that treating POP patients with Shen-tonifying herbs could increase the bone mass and relieve the CM syndromes of POP patients. Basic researches clarified the mechanism by which Shen-tonifying herbs increased bone mass in animal models. The mechanisms by which Shentonifying herbs relieve the CM syndromes are still in investigation.展开更多
Objective： To investigate menopause-related symptoms, traditional Chinese Medicine （TCM）-diagnosis and hormone status of two comparable urban samples of menopausal women, one in Essen （Germany） and the other in S...Objective： To investigate menopause-related symptoms, traditional Chinese Medicine （TCM）-diagnosis and hormone status of two comparable urban samples of menopausal women, one in Essen （Germany） and the other in Shanghai （China）. Methods： Patients suffering from menopausesyndrome were recruited from the TCM-outpatient clinic of the University of Duisburg-Essen in Germany （35 subjects） and from the Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine in China （35 subjects）. The Kupperman-lndex for tracing menopausal symptoms was applied. The complete TCM-diagnosis was carried out by the same investigator in China as well as in Germany. Testosterone and estrogen blood samples were collected once from every woman. Results： There were significant differences in specific symptoms of the Kupperman-lndex, such as a higher prevalence of formication and depression in German menopausal women; whereas Chinese menopausal women suffered significantly more from vertigo, headache and paraesthesia symptoms. Concerning TCM- diagnosis, Shen （肾）-yang deficiency was diagnosed in 51.43% of the German women in contrast to 5.71 % of the Chinese women; 17.14 % of the German women were diagnosed as having Shen-yin deficiency compared to 74.29 % of the Chinese women. The German women showed significantly lower mean hormone levels for testosterone compared to the Chinese women （P≤0.0005）. Conclusions： German and Chinese menopausal women do not show different prevalence but have different patterns of menopausal symptoms. Furthermore, from a TCM point of view, German women suffer more from Shen-yang deficiency whereas Chinese women suffer more from Shen-yin deficiency syndrome. These results are supported by significantly lower levels of testosterone in German women compared to Chinese women, which, in TCM, is a characteristic of yang deficiency.展开更多
Objective: To observe the effect of Kidney tonic, the Migu Tablet (密骨片,MGT) on bone and endocrine of osteoporosis rats. Methods: Two stages were divided, stage 1: Using ovariectomy to establish the osteoporosis rat...Objective: To observe the effect of Kidney tonic, the Migu Tablet (密骨片,MGT) on bone and endocrine of osteoporosis rats. Methods: Two stages were divided, stage 1: Using ovariectomy to establish the osteoporosis rat model; stage 2: Treating the model; Results: After 3 months treatment with MGT, which can prevent the lowering of femur bone density, tibia trabecular volume and femur bending resistant strength, but was unable to raise those lowered parameters. Serum corticosterone determination showed that the Kidney tonic could regulate the secretion of estrogen and testosterone, adjust the imbalance of E 2/T ratio. Conclusions: MGT, a Kidney tonic could prevent and treat experimental osteoporosis, its imbalance of E 2/T ratio adjustment is possibly one of the mechanisms to lessen the patient's Kidney deficiency.展开更多
基金the financial support from the Science and Technology Development Program of Jilin Provincial Science and Technology Department,(No.20210101200JC).
文摘Osteoporosis is one of the common orthopaedic diseases,characterised by increased bone fragility due to reduced bone mass and microstructural degeneration,posing a great threat to patients’quality of life and safety.In recent years,Chinese medicine(natural)has had a unique advantage in the treatment of osteoporosis and has shown good efficacy.Autophagy is an inherent cellular survival mechanism for the removal and recycling of damaged proteins and organelles and plays an important role in maintaining the stability of the intracellular environment and organ function.Therefore,this article aims to provide a comprehensive review of these Chinese medicines(natural)for the treatment of osteoporosis through autophagy.They have been intensively studied and reported to have effects such as promoting osteogenesis and anti-bone resorption.The Chinese medicines include plants such as Cistanche deserticola,Epimedium,Curculigo orchioides Gaertn,Achyranthes bidentata Blume,Leonurus japonicus Houtt,Ginseng,Chuanxiong Rhizome,Eucommia ulmoides,Morindae Officinalis Radix,Curcuma longa,Polygoni Cuspidati Rhizoma et Radix,Anemarrhena asphodeloides Bunge,Salvia miltiorrhiza Bge and Pueraria Lobata,thus providing evidence for the use of alternative herbal therapies for the effective treatment of osteoporosis.
基金Supported by the National Basic Research Program of China(973 Program,No.2010CB530400)Program for Innovative Research Team in University(No,IRT1270),National Natural Science Foundation of China(No.81403239)+1 种基金Shanghai Natural Science Foundation(No.12ZR1450400)085 Project of Shanghai University of Traditional Chinese Medicine(No.085ZY1204)
文摘Primary osteoporosis （POP） is one of the most common diseases in the elderly people resulting in high risk of fracture and poor quality of life. In addition to the pathological changes in bone mass, most of the POP patients also suffer from Chinese medicine （CM） syndromes of Shen （Kidney） essence deficiency. Shen essences are highly related to bone. Shen essence deficiency plays an important part in the development of POP and a better diagnosis of POP could be made by combining CM syndromes with Western medicine risk factors. Treatments of POP should aim at both increasing the bone mass and relieving the syndromes of Shen essence deficiency. Clinical study confirmed that treating POP patients with Shen-tonifying herbs could increase the bone mass and relieve the CM syndromes of POP patients. Basic researches clarified the mechanism by which Shen-tonifying herbs increased bone mass in animal models. The mechanisms by which Shentonifying herbs relieve the CM syndromes are still in investigation.
基金the German Academic Exchange Service(Deutscher Akademischer Austauschdienst,DAAD,No.A/06/00013)
文摘Objective： To investigate menopause-related symptoms, traditional Chinese Medicine （TCM）-diagnosis and hormone status of two comparable urban samples of menopausal women, one in Essen （Germany） and the other in Shanghai （China）. Methods： Patients suffering from menopausesyndrome were recruited from the TCM-outpatient clinic of the University of Duisburg-Essen in Germany （35 subjects） and from the Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine in China （35 subjects）. The Kupperman-lndex for tracing menopausal symptoms was applied. The complete TCM-diagnosis was carried out by the same investigator in China as well as in Germany. Testosterone and estrogen blood samples were collected once from every woman. Results： There were significant differences in specific symptoms of the Kupperman-lndex, such as a higher prevalence of formication and depression in German menopausal women; whereas Chinese menopausal women suffered significantly more from vertigo, headache and paraesthesia symptoms. Concerning TCM- diagnosis, Shen （肾）-yang deficiency was diagnosed in 51.43% of the German women in contrast to 5.71 % of the Chinese women; 17.14 % of the German women were diagnosed as having Shen-yin deficiency compared to 74.29 % of the Chinese women. The German women showed significantly lower mean hormone levels for testosterone compared to the Chinese women （P≤0.0005）. Conclusions： German and Chinese menopausal women do not show different prevalence but have different patterns of menopausal symptoms. Furthermore, from a TCM point of view, German women suffer more from Shen-yang deficiency whereas Chinese women suffer more from Shen-yin deficiency syndrome. These results are supported by significantly lower levels of testosterone in German women compared to Chinese women, which, in TCM, is a characteristic of yang deficiency.
文摘Objective: To observe the effect of Kidney tonic, the Migu Tablet (密骨片,MGT) on bone and endocrine of osteoporosis rats. Methods: Two stages were divided, stage 1: Using ovariectomy to establish the osteoporosis rat model; stage 2: Treating the model; Results: After 3 months treatment with MGT, which can prevent the lowering of femur bone density, tibia trabecular volume and femur bending resistant strength, but was unable to raise those lowered parameters. Serum corticosterone determination showed that the Kidney tonic could regulate the secretion of estrogen and testosterone, adjust the imbalance of E 2/T ratio. Conclusions: MGT, a Kidney tonic could prevent and treat experimental osteoporosis, its imbalance of E 2/T ratio adjustment is possibly one of the mechanisms to lessen the patient's Kidney deficiency.
