BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnorm...BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnormalities and fallopian tube highgrade serous carcinoma(HGSC)in a young woman.CASE SUMMARY A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion.Upon arrival at the emergency room,her abdomen appeared ovoid and distended with palpable shifting dullness.Ascites were identified through abdominal ultrasound,and computed tomography revealed an omentum cake and an enlarged bilateral adnexa.Blood tests showed elevated CA-125 levels.Paracentesis was conducted,and immunohistochemistry indicated that the cancer cells favored an ovarian origin,making us suspect ovarian cancer.The patient underwent debulking surgery,which led to a diagnosis of stage IIIC HGSC of the fallopian tube.Subsequently,the patient received adjuvant chemotherapy with carboplatin and paclitaxel,resulting in stable current condition.CONCLUSION This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC.UBE2D3 may affect crucial cancer-related pathways,including P53,BRCA,cyclin D,and tyrosine kinase receptors,thereby possibly contributing to cancer development.In addition,ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses.展开更多
Paleomagnetism of the Neoproterozoic Xiaofeng dykes exposed in the Three Gorges region of Hubei Province bear important implications for the paleogeography of the South China block(SCB).New high-precision U-Pb
AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and ...AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales.METHODS Prospective study of consecutive patients attending outpatient services.Both tests were administered by the same researcher on the same day in random order.RESULTS The total sample(n = 135) was randomly divided into two groups.One to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was tested.The agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is modest.The conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations.展开更多
Objective: Mental health literacy affects treatment seeking. We compare literacy levels of psychiatric outpatients and a control group of outpatients seeking treatment for non-psychiatric disorders in the same hospita...Objective: Mental health literacy affects treatment seeking. We compare literacy levels of psychiatric outpatients and a control group of outpatients seeking treatment for non-psychiatric disorders in the same hospital. We hypothesized higher levels of mental health literacy among psychiatric patients than controls, with younger age and higher educational levels associated with better literacy. We also hypothesized that there would be an inverse relationship between educational level and the belief in the supernatural causality of mental disorders. Methods: Literacy was estimated by showing psychiatric outpatients and a control group of non-psychiatric patients vignettes depicting a case of major depression and a case of generalised anxiety disorder. Their opinions regarding diagnosis, etiology, treatment, and attitudes towards mental health services were ascertained by structured questionnaires. Results: Psychiatric patients did not demonstrate superior mental health literacy compared to controls, with the exception of knowing where to obtain a psychiatric referral. Lower age and higher education levels of psychiatric patients were associated with better literacy. The higher the education level is, the less likely to attribute the causality of mental disorders to supernatural elements. Conclusion: This study highlights the need for a program of psycho-education targeting patients, their relatives, and the public.展开更多
Aim: This study aims to estimate the age of an individual using buccal cells by calculating the average cell size and comparing with pulp/tooth area ratio on mandibular canine and linear measurements related to mental...Aim: This study aims to estimate the age of an individual using buccal cells by calculating the average cell size and comparing with pulp/tooth area ratio on mandibular canine and linear measurements related to mental foramen using panoramic radiography (PR). Materials and Methods: One hundred healthy individuals undergoing PR for various dental procedures were included in this study after obtaining consent. Pulp/tooth ratio using Cameriere et al. method on mandibular canine and linear measurements related to mental foramen, i.e., the distance between the superior and inferior border of the mandible (S-I) and the mandible’s superior border to the superior margin of the mental foramen (S-sM) were estimated using Adobe Photoshop image editing software. Later, buccal smears obtained from the same individual were fixed with 95% alcohol and stained with Papanicolaou’s stain for cytomorphometric analysis. The age was calculated using the regression analysis and correlated with chronological age. Results: Statistical significance and better correlation were obtained pulp/ tooth area ratio, the distance of S-I of all age groups. However, the distance of S-sM proved to be more effective in Group 4 (51-60 years) and buccal cell size was found to be comparable to the chronological age particularly in Group 5 (above 60 years). Conclusion: In the present study, the accuracy of estimated age compared to the chronological age was more promising for pulp/tooth area ratio, followed by S-I, S-sM, and cell size.展开更多
Background Funnel chest has a negative effect on adolescents and it has a strong effect on adolescents＇ psychological and behavior. This study aimed to investigate the psychological characteristics and factors that a...Background Funnel chest has a negative effect on adolescents and it has a strong effect on adolescents＇ psychological and behavior. This study aimed to investigate the psychological characteristics and factors that affect adolescents with funnel chest and to evaluate the relationship between the patients＇ age and their physiological and psychological health. We aimed to establish an age model for maximum surgery benefits for funnel chest patients to provide an objective basis for choosing surgery. Methods The study adopted a general evaluation approach to assess the risk and benefits of minimally invasive surgery for funnel chest. The funnel chest index, the Symptom Checklist-90, and the Eysenck Personality Questionnaire were used as assessment tools to observe physiological and psychological features in funnel chest patients. A sample of 234 adolescents with funnel chest was selected from a third-grade class-A hospital in Beijing. Age groups were adopted as an independent variable, and other factors in funnel chest patients were dependent variables. Results There was a significant difference in the relapse rate for funnel chest in the different age groups （X2=11.883, P=-O.008）. There was a higher relapse rate in patients of 〈10 or 〉-19 years old than in patients of 11-18 years old. There was a significant difference in the SCL-90 total score in the different age groups （F=12.538, P=-0.0001）, the patients older than 13 years had a higher score than those younger than 13 years in the SCL-90. There was a significant difference in the standard score of E （introversion/extraversion） in the different age groups （F=10.06, P=0.0001）. There was also a significance in the funnel chest index before surgery in the different psychological scales （P〈0.01）, with a higher funnel chest index score associated with more obvious psychological trauma. Age and the number of variables, including the relapse rate, SCL-90 score, standard score of E, and standard score of N in the EPQ were significantly correlated （correlation indices were 0.402, 0.623, -0.505, and 0.473, respectively, P〈0.01）. Conclusions There are higher complication rates after surgery and relapse rates when funne{ chest patients are too young or too old. There is more obvious psychological trauma in patients with a high funnel chest index. Our results indicate that the best age for surgery for funnel chest is 14-16 years.展开更多
<strong>Background:</strong> Frailty is a geriatric syndrome, and a common negative consequence of aging, which shares some obvious characteristics as cognitive impairment. Preventing and relieving frailty...<strong>Background:</strong> Frailty is a geriatric syndrome, and a common negative consequence of aging, which shares some obvious characteristics as cognitive impairment. Preventing and relieving frailty may reduce the possibility of developing cognitive impairment. <strong>Objective: </strong>This study aimed to investigate frailty prevalence and its correlation with cognitive function in elderly surgical inpatients. <strong>Methods: </strong>We enrolled a random sample of elderly surgical inpatients from Jingzhou from June 2020 to August 2020. We used a self-made registration sheet to collect their demographic data (gender, age, nationality, educational level and monthly income), and used the FRAIL Scale to assess the prevalence of frailty, and used the Mini-Mental State Examination (MMSE) to assess cognitive function. We used multiple linear regression analysis to explore the correlation between frailty level and demographic data, then Pearson correlation analysis was performed to analyze the correlation between frailty and cognitive function. <strong>Results: </strong>In the 143 elderly surgical inpatients, prevalence of frail was seen in 29 (20.3%), and pre-frail state was found in 64 (44.8%). Only 50 (34.9%) were in healthy state. Cognitive impairment was seen in 28 (19.5%). Pearson correlation analysis showed that the frail scoring was correlated with cognitive function in elderly surgical inpatients (r = -0.378, P < 0.05). <strong>Conclusion:</strong> The prevalence of frailty is high in elderly surgical inpatients, which is closely related to age and gender. Elderly surgical inpatients have high cognitive impairment, and frailty appears strongly associated with cognitive status. The findings suggest that attention should be paid to the frailty and cognitive function in the elderly surgical inpatients by pro-vision of effective interventions.展开更多
Background:The distance from the inferior border of mental foramen(MF)to lower border of mandible remains constant throughout the life.Considering this fact the present study was carried out to determine role of MF in...Background:The distance from the inferior border of mental foramen(MF)to lower border of mandible remains constant throughout the life.Considering this fact the present study was carried out to determine role of MF in age and gender estimation and also its importance in planning various treatments.Aims and Objective:(1)To determine the most common type and shape of MF 2)To measure the height of the mandibular body(H),the distance between the superior margin of the MF to the alveolar crest(SM-AC),the distance between the superior margin of the MF to the inferior border of the mandible(SM-IB),the distance between the inferior margin of the MF to the inferior border(IM-IB)on the right side and left side.(3)To compare the above measurements for age and gender determination.(4)To determine effect of various factors on above measurements(5)to evaluate whether any significant difference in measurement occurs on right and left side.(6)To derive a regression equation for age estimation.Materials and Methods:A total of 300 Orthopantomogram were studied.Measurements such as H,SM-AC,SM-IB and IM-IB were carried out on both sides on type II MF in males and females in all the six age groups.Statistical analysis was carried using IBM SPSS version 24 to determine differences in measurements and linear regression analysis was carried out to determine age of individuals.Result:The most common appearance of MF was type II and shape was oval.Statistically significant differences occurred in measurements using which regressive equation for age estimation was derived for males&females.Conclusion:MF,being a stable landmark in mandible,serves as a good indicator for the determination of age and gender.Hence,using certain measurements related to MF,it can help in determining the age of the individual.Further,its position and distance from the alveolar crest serve as a guide for orthognathic surgeries,implant placement,and pre-prosthetic surgery.展开更多
文摘BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnormalities and fallopian tube highgrade serous carcinoma(HGSC)in a young woman.CASE SUMMARY A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion.Upon arrival at the emergency room,her abdomen appeared ovoid and distended with palpable shifting dullness.Ascites were identified through abdominal ultrasound,and computed tomography revealed an omentum cake and an enlarged bilateral adnexa.Blood tests showed elevated CA-125 levels.Paracentesis was conducted,and immunohistochemistry indicated that the cancer cells favored an ovarian origin,making us suspect ovarian cancer.The patient underwent debulking surgery,which led to a diagnosis of stage IIIC HGSC of the fallopian tube.Subsequently,the patient received adjuvant chemotherapy with carboplatin and paclitaxel,resulting in stable current condition.CONCLUSION This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC.UBE2D3 may affect crucial cancer-related pathways,including P53,BRCA,cyclin D,and tyrosine kinase receptors,thereby possibly contributing to cancer development.In addition,ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses.
文摘Paleomagnetism of the Neoproterozoic Xiaofeng dykes exposed in the Three Gorges region of Hubei Province bear important implications for the paleogeography of the South China block(SCB).New high-precision U-Pb
文摘AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales.METHODS Prospective study of consecutive patients attending outpatient services.Both tests were administered by the same researcher on the same day in random order.RESULTS The total sample(n = 135) was randomly divided into two groups.One to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was tested.The agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is modest.The conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations.
文摘Objective: Mental health literacy affects treatment seeking. We compare literacy levels of psychiatric outpatients and a control group of outpatients seeking treatment for non-psychiatric disorders in the same hospital. We hypothesized higher levels of mental health literacy among psychiatric patients than controls, with younger age and higher educational levels associated with better literacy. We also hypothesized that there would be an inverse relationship between educational level and the belief in the supernatural causality of mental disorders. Methods: Literacy was estimated by showing psychiatric outpatients and a control group of non-psychiatric patients vignettes depicting a case of major depression and a case of generalised anxiety disorder. Their opinions regarding diagnosis, etiology, treatment, and attitudes towards mental health services were ascertained by structured questionnaires. Results: Psychiatric patients did not demonstrate superior mental health literacy compared to controls, with the exception of knowing where to obtain a psychiatric referral. Lower age and higher education levels of psychiatric patients were associated with better literacy. The higher the education level is, the less likely to attribute the causality of mental disorders to supernatural elements. Conclusion: This study highlights the need for a program of psycho-education targeting patients, their relatives, and the public.
文摘Aim: This study aims to estimate the age of an individual using buccal cells by calculating the average cell size and comparing with pulp/tooth area ratio on mandibular canine and linear measurements related to mental foramen using panoramic radiography (PR). Materials and Methods: One hundred healthy individuals undergoing PR for various dental procedures were included in this study after obtaining consent. Pulp/tooth ratio using Cameriere et al. method on mandibular canine and linear measurements related to mental foramen, i.e., the distance between the superior and inferior border of the mandible (S-I) and the mandible’s superior border to the superior margin of the mental foramen (S-sM) were estimated using Adobe Photoshop image editing software. Later, buccal smears obtained from the same individual were fixed with 95% alcohol and stained with Papanicolaou’s stain for cytomorphometric analysis. The age was calculated using the regression analysis and correlated with chronological age. Results: Statistical significance and better correlation were obtained pulp/ tooth area ratio, the distance of S-I of all age groups. However, the distance of S-sM proved to be more effective in Group 4 (51-60 years) and buccal cell size was found to be comparable to the chronological age particularly in Group 5 (above 60 years). Conclusion: In the present study, the accuracy of estimated age compared to the chronological age was more promising for pulp/tooth area ratio, followed by S-I, S-sM, and cell size.
文摘Background Funnel chest has a negative effect on adolescents and it has a strong effect on adolescents＇ psychological and behavior. This study aimed to investigate the psychological characteristics and factors that affect adolescents with funnel chest and to evaluate the relationship between the patients＇ age and their physiological and psychological health. We aimed to establish an age model for maximum surgery benefits for funnel chest patients to provide an objective basis for choosing surgery. Methods The study adopted a general evaluation approach to assess the risk and benefits of minimally invasive surgery for funnel chest. The funnel chest index, the Symptom Checklist-90, and the Eysenck Personality Questionnaire were used as assessment tools to observe physiological and psychological features in funnel chest patients. A sample of 234 adolescents with funnel chest was selected from a third-grade class-A hospital in Beijing. Age groups were adopted as an independent variable, and other factors in funnel chest patients were dependent variables. Results There was a significant difference in the relapse rate for funnel chest in the different age groups （X2=11.883, P=-O.008）. There was a higher relapse rate in patients of 〈10 or 〉-19 years old than in patients of 11-18 years old. There was a significant difference in the SCL-90 total score in the different age groups （F=12.538, P=-0.0001）, the patients older than 13 years had a higher score than those younger than 13 years in the SCL-90. There was a significant difference in the standard score of E （introversion/extraversion） in the different age groups （F=10.06, P=0.0001）. There was also a significance in the funnel chest index before surgery in the different psychological scales （P〈0.01）, with a higher funnel chest index score associated with more obvious psychological trauma. Age and the number of variables, including the relapse rate, SCL-90 score, standard score of E, and standard score of N in the EPQ were significantly correlated （correlation indices were 0.402, 0.623, -0.505, and 0.473, respectively, P〈0.01）. Conclusions There are higher complication rates after surgery and relapse rates when funne{ chest patients are too young or too old. There is more obvious psychological trauma in patients with a high funnel chest index. Our results indicate that the best age for surgery for funnel chest is 14-16 years.
文摘<strong>Background:</strong> Frailty is a geriatric syndrome, and a common negative consequence of aging, which shares some obvious characteristics as cognitive impairment. Preventing and relieving frailty may reduce the possibility of developing cognitive impairment. <strong>Objective: </strong>This study aimed to investigate frailty prevalence and its correlation with cognitive function in elderly surgical inpatients. <strong>Methods: </strong>We enrolled a random sample of elderly surgical inpatients from Jingzhou from June 2020 to August 2020. We used a self-made registration sheet to collect their demographic data (gender, age, nationality, educational level and monthly income), and used the FRAIL Scale to assess the prevalence of frailty, and used the Mini-Mental State Examination (MMSE) to assess cognitive function. We used multiple linear regression analysis to explore the correlation between frailty level and demographic data, then Pearson correlation analysis was performed to analyze the correlation between frailty and cognitive function. <strong>Results: </strong>In the 143 elderly surgical inpatients, prevalence of frail was seen in 29 (20.3%), and pre-frail state was found in 64 (44.8%). Only 50 (34.9%) were in healthy state. Cognitive impairment was seen in 28 (19.5%). Pearson correlation analysis showed that the frail scoring was correlated with cognitive function in elderly surgical inpatients (r = -0.378, P < 0.05). <strong>Conclusion:</strong> The prevalence of frailty is high in elderly surgical inpatients, which is closely related to age and gender. Elderly surgical inpatients have high cognitive impairment, and frailty appears strongly associated with cognitive status. The findings suggest that attention should be paid to the frailty and cognitive function in the elderly surgical inpatients by pro-vision of effective interventions.
文摘Background:The distance from the inferior border of mental foramen(MF)to lower border of mandible remains constant throughout the life.Considering this fact the present study was carried out to determine role of MF in age and gender estimation and also its importance in planning various treatments.Aims and Objective:(1)To determine the most common type and shape of MF 2)To measure the height of the mandibular body(H),the distance between the superior margin of the MF to the alveolar crest(SM-AC),the distance between the superior margin of the MF to the inferior border of the mandible(SM-IB),the distance between the inferior margin of the MF to the inferior border(IM-IB)on the right side and left side.(3)To compare the above measurements for age and gender determination.(4)To determine effect of various factors on above measurements(5)to evaluate whether any significant difference in measurement occurs on right and left side.(6)To derive a regression equation for age estimation.Materials and Methods:A total of 300 Orthopantomogram were studied.Measurements such as H,SM-AC,SM-IB and IM-IB were carried out on both sides on type II MF in males and females in all the six age groups.Statistical analysis was carried using IBM SPSS version 24 to determine differences in measurements and linear regression analysis was carried out to determine age of individuals.Result:The most common appearance of MF was type II and shape was oval.Statistically significant differences occurred in measurements using which regressive equation for age estimation was derived for males&females.Conclusion:MF,being a stable landmark in mandible,serves as a good indicator for the determination of age and gender.Hence,using certain measurements related to MF,it can help in determining the age of the individual.Further,its position and distance from the alveolar crest serve as a guide for orthognathic surgeries,implant placement,and pre-prosthetic surgery.
