Mentha haplocalyx(Mentha canadensis)is widely used as a medicinal plant in traditional Chinese medicine,and the extracts of its aerial parts are found to signifcantly inhibit the activity ofα-glucosidase with an IC_(...Mentha haplocalyx(Mentha canadensis)is widely used as a medicinal plant in traditional Chinese medicine,and the extracts of its aerial parts are found to signifcantly inhibit the activity ofα-glucosidase with an IC_(50) value of 21.0μg/mL.Bioactivity-guided isolation of the extracts aforded two new compounds(1 and 2),together with 23 known ones(3-25).Their structures were established by extensive spectroscopic analyses(1D and 2D NMR,MS,IR and UV).Compounds 1-17 and 21-25 were evaluated for theirα-glucosidase inhibitory activities.Compound 11 was the most active ones with an IC_(50) values of 83.4μM.These results verify theα-glucosidase inhibitory activity of M.haplocalyx(M.canadensis)and specify its active compounds for the frst time.展开更多
Four chemical compounds,such as diosmin(Ⅰ),5,8,4′-trihydroxy-6,7-dimethoxyflavone(Ⅱ),5,7,3′-trihydroxy-4′-methoxyflavone(Ⅲ),octacosanoic acid(Ⅳ),are isolated from draff of above-ground part of Mentha haplocalyx...Four chemical compounds,such as diosmin(Ⅰ),5,8,4′-trihydroxy-6,7-dimethoxyflavone(Ⅱ),5,7,3′-trihydroxy-4′-methoxyflavone(Ⅲ),octacosanoic acid(Ⅳ),are isolated from draff of above-ground part of Mentha haplocalyx Briq.after extracting volatile oil by silica gel and sephadex LH-20 column chromatography methods,and the structures of these compounds are elucidated by 1H-NMR,13C-NMR and ESI-MS.The compounds of Ⅰ,Ⅱand Ⅲ are firstly isolated from draff of M.haplocalyx.展开更多
基金supported by the CAS Hundred Talents Program,the Youth Innovation Promotion Association of the Chinese Academy of Sciences(CN),and Southeast Asia Biodiversity Research Institute,CAS(2017CASSEABRIQG003).
文摘Mentha haplocalyx(Mentha canadensis)is widely used as a medicinal plant in traditional Chinese medicine,and the extracts of its aerial parts are found to signifcantly inhibit the activity ofα-glucosidase with an IC_(50) value of 21.0μg/mL.Bioactivity-guided isolation of the extracts aforded two new compounds(1 and 2),together with 23 known ones(3-25).Their structures were established by extensive spectroscopic analyses(1D and 2D NMR,MS,IR and UV).Compounds 1-17 and 21-25 were evaluated for theirα-glucosidase inhibitory activities.Compound 11 was the most active ones with an IC_(50) values of 83.4μM.These results verify theα-glucosidase inhibitory activity of M.haplocalyx(M.canadensis)and specify its active compounds for the frst time.
文摘Four chemical compounds,such as diosmin(Ⅰ),5,8,4′-trihydroxy-6,7-dimethoxyflavone(Ⅱ),5,7,3′-trihydroxy-4′-methoxyflavone(Ⅲ),octacosanoic acid(Ⅳ),are isolated from draff of above-ground part of Mentha haplocalyx Briq.after extracting volatile oil by silica gel and sephadex LH-20 column chromatography methods,and the structures of these compounds are elucidated by 1H-NMR,13C-NMR and ESI-MS.The compounds of Ⅰ,Ⅱand Ⅲ are firstly isolated from draff of M.haplocalyx.
