Objectives In order to provide theoretical support for clinical standardization and promotion of the use of Hongfen(hydrargyrum oxydatum crudum),a mercury-containing Chinese medicine,as well as to make it easier to ap...Objectives In order to provide theoretical support for clinical standardization and promotion of the use of Hongfen(hydrargyrum oxydatum crudum),a mercury-containing Chinese medicine,as well as to make it easier to apply traditional Chinese topical preparations in a more contemporary manner.Methods We screened the topical research literature on Hongfen.Firstly,we analyzed the current research status of Hongfen statistically in terms of disciplinary distribution,research institutions,funding,publication volume,research types,and research focus of the literature;secondly,we analyzed the research status of Hongfen by MeSH term analysis,abstract and combined with the herbal literature,the indications,usage,dosage,and adverse effects of Hongfen were statistically analyzed,and keyword co-occurrence analysis and data visualization were performed using python+pyecharts.Results Early studies on Hongfen were mainly on the evaluation of the formulation process,while the current studies are mainly focused on clinical effectiveness and safety,with a considerable part of the studies also focused on drug toxicology,metabolism of mercury components target organ toxicity studies,while the basic studies on its mechanism of action are less.The clinical application is mainly focused on chronic ulcerated sores,refractory sinus fistula,and other surgical sore diseases,the use of which is mostly in the form of compounding and adding excipients,the use of which requires consideration of the accumulation of drug toxicity and attention to drug dosage and duration of use in order to reduce the occurrence of clinical side effects.Conclusion Hongfen is a type of mineral medicine that is extremely toxic but has a known curative effect.Its clinical use is low-risk,and its advantages greatly outweigh its drawbacks.Molecular biology technology should be actively carried out to analyze the pharmacological mechanism of Hongfen,which will play a positive role in the transmission and promotion of traditional Chinese medicine topical preparations.展开更多
BACKGROUND:Ultrasound guidance is commonly used for accessing difficult peripheral veins.For successful access,a tourniquet is required for venodilation.Tourniquets decrease the compressibility and increase the diamet...BACKGROUND:Ultrasound guidance is commonly used for accessing difficult peripheral veins.For successful access,a tourniquet is required for venodilation.Tourniquets decrease the compressibility and increase the diameter of veins;they also obfuscate artery-vein differentiation on ultrasound.We aimed to establish the upper limit of sphygmomanometer cuff pressure that facilitates artery-vein differentiation during ultrasound-guided peripheral intravenous access.METHODS:We employed the sphygmomanometer cuff as a tourniquet for venodilation and tested it on seven participants at six different levels as follows:0 mmHg,DBP/2,DBP,(DBP+SBP)/2,SBP,and SBP+20 mmHg.We used an ultrasound probe attached to a pressure-measuring instrument to record cross-sectional images of the cubital artery and vein.During ultrasonography,compression was applied to the blood vessels through the skin.The following day,we measured the wrist pulse pressure and observed the oximeter pulse wave at six different tourniquet pressure levels.Repeated-measures analysis of variance(ANOVA)on ranks and Tukey’s post-hoc analysis were used for multiple comparisons.RESULTS:Arterial pulsation was maintained at tourniquet pressures between 0 mmHg and(DBP+SBP)/2.However,arterial pulsation decreased or disappeared when the tourniquet pressure reached or exceeded the SBP.Moreover,at this pressure level,the superior compressibility of veins compared to that of arteries was no longer observed.Compression of the artery to 75% and 50% of its original diameter increased arterial pulsation.CONCLUSION:Arterial pulsation and the superior compressibility are useful indicators for differentiating veins from arteries until the tourniquet pressure reaches(DBP+SBP)/2.However,these indicators are not reliable once the tourniquet pressure exceeds the SBP.展开更多
Continuously monitoring pulse is very important for the pacemaker patients., and the continuously observing blood pressure is also a matter of concern for those who have hypertension, coronary heart disease, or other ...Continuously monitoring pulse is very important for the pacemaker patients., and the continuously observing blood pressure is also a matter of concern for those who have hypertension, coronary heart disease, or other cardiovascular diseases, for example cardiac arrhythmia and hypertension. What we expect is not only to eliminate arrhythmia, also to treat patients as a whole of body. Therefore, how to keeping monitoring blood pressure and pulses rise to a very important issue. This research edits a wrist-able sphygmomanometer and pulsimeter combining with cell phone, to achieve wireless, continuous, and real-time observation, early detects any accident occurring from the patients with pacemaker implementation or with other cardiovascular展开更多
目的评价OMRONHEM-770A型智能电子血压计测量血压的准确性。方法根据中华人民共和国医药行业标准YY0670—2008《无创自动测量血压计》关于电子血压计准确性评价的要求,利用标准汞柱式血压计(听诊法)与受试电子血压计对85名受试者同臂同...目的评价OMRONHEM-770A型智能电子血压计测量血压的准确性。方法根据中华人民共和国医药行业标准YY0670—2008《无创自动测量血压计》关于电子血压计准确性评价的要求,利用标准汞柱式血压计(听诊法)与受试电子血压计对85名受试者同臂同步测量血压,对比评价该电子血压计的准确性。结果 OMRON HEM-770A型电子血压计的测量结果高出标准听诊法1.9 mm Hg/1.5 mm Hg(收缩压/舒张压),其偏差小于5 mm Hg的上限;偏差的标准差为4.2 mm Hg/3.6 mm Hg(收缩压/舒张压),小于8 mm Hg的上限;收缩压和舒张压偏差在10 mmHg以内的测量次数分别占到96.9%和98.4%,高于85%的最低要求。结论 OMRON HEM-770A型智能电子血压计具有良好的准确性,收缩压和舒张压均达到了国内行业标准规定的要求。展开更多
基金sponsored by the National Natural Science Foundation of China(No.82104854)the 2nd major clinical research project of the Three-year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals(SHDC2020CR2051B)+1 种基金National Training Program for Innovative Key Talents of Traditional Chinese Medicine(19-Z-1-13)Shanghai Sailing Program(20YF1449800).
文摘Objectives In order to provide theoretical support for clinical standardization and promotion of the use of Hongfen(hydrargyrum oxydatum crudum),a mercury-containing Chinese medicine,as well as to make it easier to apply traditional Chinese topical preparations in a more contemporary manner.Methods We screened the topical research literature on Hongfen.Firstly,we analyzed the current research status of Hongfen statistically in terms of disciplinary distribution,research institutions,funding,publication volume,research types,and research focus of the literature;secondly,we analyzed the research status of Hongfen by MeSH term analysis,abstract and combined with the herbal literature,the indications,usage,dosage,and adverse effects of Hongfen were statistically analyzed,and keyword co-occurrence analysis and data visualization were performed using python+pyecharts.Results Early studies on Hongfen were mainly on the evaluation of the formulation process,while the current studies are mainly focused on clinical effectiveness and safety,with a considerable part of the studies also focused on drug toxicology,metabolism of mercury components target organ toxicity studies,while the basic studies on its mechanism of action are less.The clinical application is mainly focused on chronic ulcerated sores,refractory sinus fistula,and other surgical sore diseases,the use of which is mostly in the form of compounding and adding excipients,the use of which requires consideration of the accumulation of drug toxicity and attention to drug dosage and duration of use in order to reduce the occurrence of clinical side effects.Conclusion Hongfen is a type of mineral medicine that is extremely toxic but has a known curative effect.Its clinical use is low-risk,and its advantages greatly outweigh its drawbacks.Molecular biology technology should be actively carried out to analyze the pharmacological mechanism of Hongfen,which will play a positive role in the transmission and promotion of traditional Chinese medicine topical preparations.
基金supported by the Department of Advanced Acute Medicine at Nagoya City University.
文摘BACKGROUND:Ultrasound guidance is commonly used for accessing difficult peripheral veins.For successful access,a tourniquet is required for venodilation.Tourniquets decrease the compressibility and increase the diameter of veins;they also obfuscate artery-vein differentiation on ultrasound.We aimed to establish the upper limit of sphygmomanometer cuff pressure that facilitates artery-vein differentiation during ultrasound-guided peripheral intravenous access.METHODS:We employed the sphygmomanometer cuff as a tourniquet for venodilation and tested it on seven participants at six different levels as follows:0 mmHg,DBP/2,DBP,(DBP+SBP)/2,SBP,and SBP+20 mmHg.We used an ultrasound probe attached to a pressure-measuring instrument to record cross-sectional images of the cubital artery and vein.During ultrasonography,compression was applied to the blood vessels through the skin.The following day,we measured the wrist pulse pressure and observed the oximeter pulse wave at six different tourniquet pressure levels.Repeated-measures analysis of variance(ANOVA)on ranks and Tukey’s post-hoc analysis were used for multiple comparisons.RESULTS:Arterial pulsation was maintained at tourniquet pressures between 0 mmHg and(DBP+SBP)/2.However,arterial pulsation decreased or disappeared when the tourniquet pressure reached or exceeded the SBP.Moreover,at this pressure level,the superior compressibility of veins compared to that of arteries was no longer observed.Compression of the artery to 75% and 50% of its original diameter increased arterial pulsation.CONCLUSION:Arterial pulsation and the superior compressibility are useful indicators for differentiating veins from arteries until the tourniquet pressure reaches(DBP+SBP)/2.However,these indicators are not reliable once the tourniquet pressure exceeds the SBP.
文摘Continuously monitoring pulse is very important for the pacemaker patients., and the continuously observing blood pressure is also a matter of concern for those who have hypertension, coronary heart disease, or other cardiovascular diseases, for example cardiac arrhythmia and hypertension. What we expect is not only to eliminate arrhythmia, also to treat patients as a whole of body. Therefore, how to keeping monitoring blood pressure and pulses rise to a very important issue. This research edits a wrist-able sphygmomanometer and pulsimeter combining with cell phone, to achieve wireless, continuous, and real-time observation, early detects any accident occurring from the patients with pacemaker implementation or with other cardiovascular
文摘目的评价OMRONHEM-770A型智能电子血压计测量血压的准确性。方法根据中华人民共和国医药行业标准YY0670—2008《无创自动测量血压计》关于电子血压计准确性评价的要求,利用标准汞柱式血压计(听诊法)与受试电子血压计对85名受试者同臂同步测量血压,对比评价该电子血压计的准确性。结果 OMRON HEM-770A型电子血压计的测量结果高出标准听诊法1.9 mm Hg/1.5 mm Hg(收缩压/舒张压),其偏差小于5 mm Hg的上限;偏差的标准差为4.2 mm Hg/3.6 mm Hg(收缩压/舒张压),小于8 mm Hg的上限;收缩压和舒张压偏差在10 mmHg以内的测量次数分别占到96.9%和98.4%,高于85%的最低要求。结论 OMRON HEM-770A型智能电子血压计具有良好的准确性,收缩压和舒张压均达到了国内行业标准规定的要求。
