Meso-scale Discovery Assay Detects the Changes of Plasma Cytokine Levels in Mice after Low or High LET Ionizing Irradiation

Objective To obtain precise data on the changes in the levels of 29 cytokines in mice after high or low linear energy transfer(LET)irradiation and to develop an accurate model of radiation exposure based on the cytokine levels after irradiation.Methods Plasma samples harvested from mice at different time points after carbon-ion or X-ray irradiation were analyzed using meso-scale discovery(MSD),a high-throughput and sensitive electrochemiluminescence measurement technique.Dose estimation equations were set up using multiple linear regression analysis.Results The relative levels of IL-6 at 1 h,IL-5 and IL-6 at 24 h,and IL-5,IL-6 and IL-15 at 7 d after irradiation with two intensities increased dose-dependently.The minimum measured levels of IL-5,IL-6 and IL-15 were up to 4.0076 pg/mL,16.4538 pg/mL and 0.4150 pg/mL,respectively.In addition,dose estimation models were established and verified.Conclusions The MSD assay can provide more accurate data regarding the changes in the levels of the cytokines IL-5,IL-6 and IL-15.These cytokines could meet the essential criteria for radiosensitive biomarkers and can be used as radiation indicators.Our prediction models can conveniently and accurately estimate the exposure dose in irradiated organism.

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the mold.In which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid slag.In contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive information.Therefore,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding times.The results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles increases.In addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually decreases.In one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the large.These findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

Design of Web System for Meso-scale Meteorological Observational Station Based on SVG

The web of meso-scale meteorological observational station based on WebGIS realized by SVG technology was briefly introduced.Through grasping and applying SVG technology,the high-density automatic observational station in Anhui Province was developed.The web of meso-scale meteorological observational stations constructed by SVG technique can display the network graphics of weather data and intuitionistic vector graphics interface.

The Impact of Meso-Scale Eddies on the Subtropical Mode Water in the Western North Pacific

Based on the temperature and salinity from the Argo profiling floats and altimeter-derived geostrophic velocity anomaly (GVA) data in the western North Pacific during 2002-2011, the North Pacific Subtropical Mode Water (NPSTMW) distribution is investigated and cyclonic and anti-cyclonic eddies (CEs and AEs) are constructed to study the influence of their vertical structures on maintaining NPSTMW. Combining eddies identified by the GVA data and Argo profiling float data, it is found that the average NPSTMW thickness of AEs is about 60 dbar, which is thicker than that of CEs. The NPSTMW thicker than 150 dbar in AEs accounts for 18%, whereas that in CEs accounts for only 1%. About 3377 (3517) profiles, which located within one diameter of the nearest CEs (AEs) are used to construct the CE (AE). The composite AE traps low-PV water in the center and with a convex shape in the vertical section. The 'trapped depth' of the composite CE (AE) is 300 m (550 m) where the rotational velocity exceeds the transitional velocity. The present study suggests that the anticyclonic eddies are not only likely to form larger amounts of NPSTMW, but also trap more NPSTMW than cyclonic eddies.

Meso-scale modeling of chloride diffusion in concrete with consideration of effects of time and temperature

A meso-scale truss network model was developed to predict chloride diffusion in concrete. The model regards concrete as a three-phase composite of mortar matrix, coarse aggregates, and the interfacial transition zone （ITZ） between the mortar matrix and the aggregates. The diffusion coefficient of chloride in the mortar and the ITZ can be analytically determined with only the water-to-cement ratio and volume fraction of fine aggregates. Fick＇s second law of diffusion was used as the governing equation for chloride diffusion in a homogenous medium （e.g., mortar）; it was discretized and applied to the truss network model. The solution procedure of the truss network model based on the diffusion law and the meso-scale composite structure of concrete is outlined. Additionally, the dependence of the diffusion coefficient of chloride in the mortar and the ITZ on exposure duration and temperature is taken into account to illustrate their effect on chloride diffusion coefficient. The numerical results show that the exposure duration and environmental temperature play important roles in the diffusion rate of chloride ions in concrete. It is also concluded that the meso-scale truss network model can be applied to chloride transport analysis of damaged （or cracked） concrete.

Flame Imaging in Meso-scale Porous Media Burner Using Electrical Capacitance Tomography

This study was conducted to investigate the characteristics of meso-scale combustion.The technique of electrical capacitance tomography(ECT) was used to locate flame position and monitor the effect corresponding to varied air/fuel ratio in a meso-scale combustor.Combustion phenomena including igniting,quenching and unsteady combustion have been visualized using ECT.The method of metallization protecting ECT sensor from high temperature damage and the novel calibration method adapted to ECT monitoring of unknown permittivity flame have been shown to be successful.At the same time,electrical nature of combustion and dielectric characteristics of hy-drocarbon flame were studied.The relationship between flame permittivity and state parameters of combustion gas was demonstrated preliminarily.

Statistical characteristics of meso-scale vortex effects on the track of a tropical cyclone

This paper examines initial meso-scale vortex effects on the motion of a tropical cyclone （TC） in a system where coexisting two components of TC and meso-scale vortices with a barotropic vorticity equation model. The initial mesoscale vortices are generated stochastically by employing Reinaud＇s method. The 62 simulations are performed and analysed in order to understand the statistical characteristics of the effects. Results show that the deflection of the TC track at t = 24 h induced by the initial meso-scale vortices ranges from 2 km to 37 km with the mean value of 13.4 km. A more significant deflection of the TC track can be reduced when several initial meso-scale vortices simultaneously appear in a smaller TC circulation area. It ranges from 22 km to 37 km with the mean value of 28 km, this fact implies that the initial meso-scale vortices-induced deflection may not be neglected sometimes.

Analysis on the Meso-scale System Activity and the Structure Characteristics of A Short-time Rainstorm

By using the rainfall data in the regional automatic station,FY-2E satellite data,NCEP reanalysis data,the evolution features and the structure characteristics of a meso-scale convective system(MCS) which happened on May 6 in 2010 in Loudi City of Hunan Province were analyzed.The results showed that MCS was the important influence system for the generation and development of strong precipitation.The equivalent blackbody brightness temperature(TBB) field of satellite inversion could directly reflect the convective activity of cumulus,the precipitation distribution and the intensity characteristics in the rainstorm process.TBB low value belt had the good corresponding relationship with the rainstorm falling zone.The disturbance flow field and the height field which passed Barnes band-pass wave filtering represented that there existed the obvious high-layer anticyclonic circulation and the low-layer cyclonic circulation near the rainstorm zone.The divergence in the high layer and the convergence in the low layer enhanced the occurrence and development of MCS.In addition,the disturbance temperature field revealed the main source of energy which the occurrence and development of strong convective weather needed.

Meso-scale available gravitational potential energy in the world oceans

The pitfalls of applying the commonly used definition of available gravitational potential energy （AGPE） to the world oceans are re-examined. It is proposed that such definition should apply to the meso-scale problems in the oceans, not the global scale. Based on WOA98 climatological data, the meso-scale AGPE in the world oceans is estimated. Unlike previous results by Oort et al. , the meso-scale AGPE is large wherever there is a strong horizontal density gradient. The distribution of meso-scale AGPE reveals the close connection between the baroclinic instability and the release of gravitational potential energy stored within the scale of Rossby deformation radius.

Case study on the three-dimensional structure of meso-scale eddy in the South China Sea based on a high-resolution model

Meso-scale eddies are important features in the South China Sea（SCS）. The eddies with diameters of 50–200 km can greatly impact the transport of heat, momentum, and tracers. A high-resolution wave-tide-circulation coupled model was developed to simulate the meso-scale eddy in the SCS in this study. The aim of this study is to examine the model ability to simulate the meso-scale eddy in the SCS without data assimilations The simulated Sea Surface Height（SSH） anomalies agree with the observed the AVISO SSH anomalies well. The simulated subsurface temperature profiles agree with the CTD observation data from the ROSE（Responses of Marine Hazards to climate change in the Western Pacific） project. The simulated upper-ocean currents also agree with the main circulation based on observations. A warm eddy is identified in winter in the northern SCS. The position and domain of the simulated eddy are confirmed by the observed sea surface height data from the AVISO. The result shows that the model has the ability to simulate the meso-scale eddy in the SCS without data assimilation.The three-dimensional structure of the meso-scale eddy in the SCS is analyzed using the model result. It is found that the eddy center is tilted vertically, which agrees with the observation. It is also found that the velocity center of the eddy does not coincide with the temperature center of the eddy. The result shows that the model has the ability to simulate the meso-scale eddy in the SCS without data assimilations. Further study on the forming mechanism and the three-dimensional structure of the meso-scale eddies will be carried out using the model result and cruise observation data in the near future.

Electrical Characteristics,Electrode Sheath and Contamination Layer Behavior of a Meso-Scale Premixed Methane-Air Flame Under AC/DC Electric Fields

Electrical characteristics of a nozzle-attached meso-scale premixed methane-air flame under low-frequency AC （0-4300 V, 0-500 Hz） and DC （0-3300 V） electric fields were studied. I-V curves were measured under different experimental conditions to estimate the magnitude of the total current 10^0-10^2μA, the electron density 10^15-10^16 m^-3 and further the power dissipation 〈 0.7 W in the reaction zone. At the same time, the meso-scale premixed flame conductivity 10^-4-10^-3 Ω^-1. m^-1 as a function of voltage and frequency was experimentally obtained and was believed to represent a useful order-of magnitude estimate. Moreover, the influence of the collision sheath relating to Debye length （31-98 μm） and the contamination layer of an active electrode on measurements was discussed, based on the combination of simulation and theoretical analysis. As a result, the electrode sheath dimension was evaluated to less than 0.5 mm, which indicated a complex effect of the collision sheath on the current measurements. The surface contamination effect of an active electrode was further analyzed using the SEM imaging method, which showed elements immigration during the contamination layer formation process.

基于ParFlow.CLM的居民小区屋顶雨水断接水文效应研究

城市不透水面的快速扩张极大地改变了自然的水文循环过程,是造成城市内涝、河湖生态退化等城市水问题的主要原因之一。海绵城市建设及低影响开发利用源头海绵设施或城市绿地断接城市不透水面,减少不透水面的水文效应,是缓解城市水问题的重要措施。探究不透水面断接的水文效应对我国海绵城市建设具有重要意义。基于全分布式物理水文模型ParFlow.CLM,充分考虑城市地下构筑物,探究了不同土壤质地情景下西宁市某典型居民小区建筑屋顶断接在连续的降雨、蒸发过程中的水文效应。模拟结果显示,利用该居民小区自然绿地断接建筑屋顶能取得较好的径流控制效果:当土壤饱和导水率(K_(s))大于0.01m/h时,屋顶径流的年削减率能达到72.9%以上。屋顶断接在建筑物雨落管附近形成了集中入渗,增加了根区土壤湿度,且这一效应随着土壤渗透性的增加而增强。根区土壤湿度的增加进一步促进了绿地的蒸散发:与屋顶断接前相比,不同土壤质地情景下居民小区年蒸散发总量增加了6.2%~7.8%。另一方面,集中入渗在局部也形成了更深的湿润锋,使得更多下渗水量能够脱离植被根区的蒸散发作用,从而促进根区水分的深层渗漏。模拟结果表明,尽管该居民小区地下停车场限制了大部分区域的深层渗漏,当土壤K_(s)大于0.01m/h时,屋顶断接情景下的年深层渗漏总量仍能超过城市化前的水平。

THE DYNAMICAL ANALYSIS OF THE STRUCTURE OF Β MESO-SCALE DOUBLE RAINBANDS IN MEIYU FRONT

In this paper, an idealized perturbation following the ＂surge-flow conceptual model＂ for typical Meiyu frontal structure is designed to explain the β meso-scale structure ofrainbands in the Meiyu front using a non-hydrostatic, full-compressible storm-scale model including multi-phase microphysical parameterization. In addition, sensitivity numerical experiment on the vertical distribution of the ambient meridional wind is conducted to investigate the generation mechanism of D meso-scale double rainbands. The results of numerical experiments show that the cool and dry downdraft invading strengthened by the environmental aloft northerly wind plays a very important role to the generation and maintenance of the β meso-scale double rainbands. Moreover, the intensity and scale of the dry and cool downdraft invading are related to the intensity of the second circumfluence induced by mass adjustment when the acceleration of the westerly jet aloft occurs.

Modeling development on the meso-scale reacting transport phenomena in proton exchange membrane fuel cells

The catalyst layer （CL） of proton exchange mem-brane fuel cell （PEMFC） involves various particles and pores in meso-scale, which has an important effect on the mass, charge （proton and electron） and heat transport coupled with the electrochemical reactions. The coarse-grained molecular dynamics （CG-MD） method is employed as a meso-scale structure reconstruction technique to mimic the self-organization phenomena in the fabrication steps of a CL. The meso-scale structure obtained at the equilibrium state is further analyzed by molecular dynamic （MD） software to provide the necessary microscopic parameters for understanding of multi-scale and-physics processes in CLs. The primary pore size distribution （PSD） and active platinum （Pt） surface areas are also calculated and then compared with the experiments. In addition, we also highlight the implementation method to combine microscopic elementary kinetic reaction schemes with the CG-MD approaches to provide insight into the reactions in CLs. The concepts from CG modeling with particle hydrodynamics （SPH） and the problems on coupling of SPH with finite element modeling （FEM） methods are further outlined and discussed to understand the effects of the meso-scale transport phenomena in fuel cells.

Propagation of shock waves in dry and wet sandstone:Experimental observations,theoretical analysis and meso-scale modeling

Methods of experimental observations, theoretical analysis and meso-scale modeling were used to study the propagation processes of shock waves in dry and wet sandstone under dynamic impact in this paper.According to the results from the dynamic impact experiments with velocity of 0.2-0.5 km/s, it was found that the velocity of shock wave increases linearly with water content. Additionally, the velocity of the shock wave in the sandstone showed a linearly increased regularity with the increasement of the impact velocity, which was proved by theory in this paper. Furthermore, meso-scale simulation models were performed and the simulation results showed that sandstone's porosity reduced the shock waves velocity compared to nonporous materials. Pore space filled with water counteracts the effects of porosity, resulted in larger shock wave velocity.

Alkyl dimethyl betaine activates the low-temperature collection capacity of sodium oleate for scheelite

The impact of alkyl dimethyl betaine (ADB) on the collection capacity of sodium oleate (NaOl) at low temperatures was evaluated using flotation tests at various scales. The low-temperature synergistic mechanism of ADB and NaOl was explored by infrared spectroscopy, X-ray photoelectron spectroscopy, surface tension measurement, foam performance test, and flotation reagent size measurement.The flotation tests revealed that the collector mixed with octadecyl dimethyl betaine (ODB) and NaOl in a mass ratio of 4:96 exhibited the highest collection capacity. The combined collector could increase the scheelite recovery by 3.48% at low temperatures of 8–12℃. This is particularly relevant in the Luanchuan area, which has the largest scheelite concentrate output in China. The results confirmed that ODB enhanced the collection capability of NaOl by improving the dispersion and foaming performance. Betaine can be introduced as an additive to NaOl to improve the recovery of scheelite at low temperatures.

Analysis on the Meso-scale Characteristics of a Hail Process in Linyi Area

[Objective] The research aimed to study the meso-scale characteristics of a hail process in Linyi area. [Method] By comprehensively using MICAPS conventional observation data, automatic encryption ground station, MM5 model product and Doppler weather radar data, a strong convective hail weather process which happened in Shandong Peninsula and southeast of Shandong on May 30, 2010 was analyzed. The circulation background and physical mechanism of strong convection weather occurrence, the features of meso- and micro-scale systems were discussed. Some occurrence and development rules of such weather were found. [Result] The strong convective weather was mainly affected by the cold vortex and translot. The high-altitude northwest airflow, low-level southwest airflow, dry and cold air at the high layer, warm and wet air at the low layer, forward-tilting trough caused the strong convective weather. The radar echo analysis showed that the radar echo in the process belonged to the typical multi-monomer windstorm echo, and the strong echo zone was in the forefront of echo. When the convection development was the strongest, the echo intensity reached 65 dBz, and the echo top height surpassed 11 km. As the development of windstorm monomer, the big-value zone of vertical liquid water content product had the jumping formation and disappearance. Moreover, there was obvious weak echo zone. The windstorm monomer moved to the southeast direction as the precipitation system. In the right front of monomer moving direction, there was hook echo feature. The evolution characteristics of radial speed field at the different elevation angles before and after the hail weather occurrence were analyzed. It was found that the radial speed field had some premonitory variations before the hail weather occurrence. Doppler radar product was used to improve the initial field of MM5 model, which could improve the forecast effect in the certain degree and the accuracy of short-time forecast and nowcasting. [Conclusion] The research accumulated the experience for the short-term forecast and nowcasting work of strong convective weather in future.

An ionic liquid-assisted strategy for enhanced anticorrosion of low-energy PEO coatings on magnesium–lithium alloy

A low-energy plasma electrolytic oxidation(LePEO)technique is developed to simultaneously improve energy efficiency and anti-corrosion.Ionic liquids(1-butyl-3-methylimidazole tetrafluoroborate(BmimBF_(4)))as sustainable corrosion inhibitors are chosen to investigate the corrosion inhibition behavior of ionic liquid(ILs)during the LePEO process for LA91 magnesium-lithium(Mg-Li)alloy.Results show that the ionic liquid BmimBF_(4)participates in the LePEO coating formation process,causing an increment in coating thickness and surface roughness.The low conductivity of the ionic liquid is responsible for the voltage and breakdown voltage increases during the LePEO with IL process(LePEO-IL).After adding BmimBF_(4),corrosion current density decreases from 1.159×10^(−4)A·cm^(−2)to 8.143×10^(−6)A·cm^(−2).The impedance modulus increases to 1.048×10^(4)Ω·cm^(−2)and neutral salt spray remains intact for 24 h.The superior corrosion resistance of the LePEO coating assisted by ionic liquid could be mainly attributed to its compact and thick barrier layer and physical absorption of ionic liquid.The ionic liquid-assisted LePEO technique provides a promising approach to reducing energy consumption and improving film performance.

Study on circulation and meso-scale eddies in the South China Sea in summer of 1998

By using wide scope ADCP data which were got during SCSMEX (South China Sea Monsoon Experiment) period in the summer of 1998, and comparing these data with numerical modelling result, the distribution and variation characteristics of the circulation and meso-scale eddies in the South China Sea (SCS) were studied. The results show that: (1) in the SCS, 18 different scale eddies or motion systems with characteristics similar to meso-scale eddy were found during the investigation; (2) a strong westward current was found in the south of the Taiwan Shoal; (3) the energy of those eddies west of 114°E was much stronger than that of the east;(4) and there exist many powerful meso-scale eddies in the Nansha region south of 12°N. The distributions of numerous eddies reflect the complexity of the circulation in the SCS. It seems that the formation of those eddies should be caused by joint work of wind, coast feature, bottom topography, water density, inertial force and continental shelf waves.

夏热冬冷地区Low-E玻璃节能效果研究

目的为了解决夏热冬冷地区民宿玻璃幕墙节能设计过程中,对于性能接近的玻璃种类的选择问题。方法采用DeST模拟软件建立一个二层民宿的物理模型,依据《河南省公共建筑节能设计标准》选择满足要求的双玻Low-E玻璃和三玻Low-E玻璃。通过控制对负荷影响较大的3个参数:传热系数、太阳能总透射比、红外热能总透射比,来保持其控制参数相同或近似相等,再基于当地典型气象年的实测数据,采用DeST模拟软件对该民宿建筑进行全年能耗计算,并通过加拿大采暖季能耗评价体系(ER)与制冷季能耗评价体系(ERC)进行能耗分析,观察节能效果。结果表明将双玻用三玻进行改造后,ERC值为3.57,说明三玻两腔单Low-E中空(空气)玻璃在制冷季节能效果更好;ER值为-1.83,说明双玻单Low-E中空(氩气)玻璃在采暖季节能效果更优。三玻两腔单Low-E中空(空气)玻璃相对于双玻单Low-E中空(氩气)玻璃成本贵了60元/m^(2),每年带来的经济效益为1.92元/m^(2),需要至少30年才能完成成本回收,综合考虑各种因素,双玻单Low-E中空玻璃才是首选。结论研究结果为夏热冬冷地区民宿建筑玻璃幕墙种类的选择提供了一种新的方法,具有重要的参考价值和借鉴意义。