In this paper,the evaluations of metal ablation processes under high temperature,i.e.,the Al plate ablated by a laser and a heat carrier and the reactor pressure vessel ablated by a core melt,are studied by a novel pe...In this paper,the evaluations of metal ablation processes under high temperature,i.e.,the Al plate ablated by a laser and a heat carrier and the reactor pressure vessel ablated by a core melt,are studied by a novel peridynamic method.Above all,the peridynamic formulation for the heat conduction problem is obtained by Taylor’s expansion technique.Then,a simple and efficient moving boundary model in the peridynamic framework is proposed to handle the variable geometries,in which the ablated states of material points are described by an additional scalar field.Next,due to the automatic non-interpenetration properties of peridynamic method,a contact algorithm is established to determine the contact relationship between the ablated system and the additional heat carrier.In addition,the corresponding computational procedure is listed in detail.Finally,several numerical examples are carried out and the results verify the validity and accuracy of the present method.展开更多
Besides conventional surgery, radiation therapy, and chemotherapy, which all tend to have side-effects and damage normal tissues, new medical strategies, such as photothermal sensitization and photo-thermal ablation t...Besides conventional surgery, radiation therapy, and chemotherapy, which all tend to have side-effects and damage normal tissues, new medical strategies, such as photothermal sensitization and photo-thermal ablation therapy (PTA) with near-IR laser light, have been explored for treating cancer. Much of the current excitement surrounding nanoscience is directly connected to the promise of new nanotechnology for cancer diagnosis and therapy. The basic principle behind PTA is that heat generated from light can be used to destroy cancer cells. Strong optical absorption and high efficiency of photothermal conversion at the cancer sites are critical to the success of PTA. Because of their unique optical properties, e.g., strong surface plasmon resonance (SPR) absorption, noble metal nanomaterials, such as gold and silver, have been found to significantly enhance photothermal conversion for PTA applications. Substantial effort has been made to develop metal nanostructures with optimal structural and photothermal properties. Ideal metal nanostructures should have strong and tunable SPR, be easy to deliver, have low toxicity, and be convenient for bioconjugation for actively targeting specific cancer cells. This review would highlight some gold nanostructures with various shapes and properties, including nanoparticles (NPs), nanorods (NRs), nanoshells, nanocages, and hollow nanospheres, which have been studied for PTA applications. Among these structures, hollow gold nanospheres (HGNs) exhibit arguably the best combined properties because of their small size (30―50 nm), spherical shape, and strong, narrow, and tunable SPR absorption.展开更多
基金supported by the National Natural Science Foundation of China(No.12102416).
文摘In this paper,the evaluations of metal ablation processes under high temperature,i.e.,the Al plate ablated by a laser and a heat carrier and the reactor pressure vessel ablated by a core melt,are studied by a novel peridynamic method.Above all,the peridynamic formulation for the heat conduction problem is obtained by Taylor’s expansion technique.Then,a simple and efficient moving boundary model in the peridynamic framework is proposed to handle the variable geometries,in which the ablated states of material points are described by an additional scalar field.Next,due to the automatic non-interpenetration properties of peridynamic method,a contact algorithm is established to determine the contact relationship between the ablated system and the additional heat carrier.In addition,the corresponding computational procedure is listed in detail.Finally,several numerical examples are carried out and the results verify the validity and accuracy of the present method.
文摘Besides conventional surgery, radiation therapy, and chemotherapy, which all tend to have side-effects and damage normal tissues, new medical strategies, such as photothermal sensitization and photo-thermal ablation therapy (PTA) with near-IR laser light, have been explored for treating cancer. Much of the current excitement surrounding nanoscience is directly connected to the promise of new nanotechnology for cancer diagnosis and therapy. The basic principle behind PTA is that heat generated from light can be used to destroy cancer cells. Strong optical absorption and high efficiency of photothermal conversion at the cancer sites are critical to the success of PTA. Because of their unique optical properties, e.g., strong surface plasmon resonance (SPR) absorption, noble metal nanomaterials, such as gold and silver, have been found to significantly enhance photothermal conversion for PTA applications. Substantial effort has been made to develop metal nanostructures with optimal structural and photothermal properties. Ideal metal nanostructures should have strong and tunable SPR, be easy to deliver, have low toxicity, and be convenient for bioconjugation for actively targeting specific cancer cells. This review would highlight some gold nanostructures with various shapes and properties, including nanoparticles (NPs), nanorods (NRs), nanoshells, nanocages, and hollow nanospheres, which have been studied for PTA applications. Among these structures, hollow gold nanospheres (HGNs) exhibit arguably the best combined properties because of their small size (30―50 nm), spherical shape, and strong, narrow, and tunable SPR absorption.
